JP2024546129A - アルファ－ｌ－イズロニダーゼ酵素を含む融合タンパク質及びその方法 - Google Patents

アルファ－ｌ－イズロニダーゼ酵素を含む融合タンパク質及びその方法 Download PDF

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Publication number
JP2024546129A
JP2024546129A JP2024534711A JP2024534711A JP2024546129A JP 2024546129 A JP2024546129 A JP 2024546129A JP 2024534711 A JP2024534711 A JP 2024534711A JP 2024534711 A JP2024534711 A JP 2024534711A JP 2024546129 A JP2024546129 A JP 2024546129A
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Japan
Prior art keywords
polypeptide
amino acid
identity
idua
seq
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Pending
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JP2024534711A
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English (en)
Japanese (ja)
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JP2024546129A5 (OSRAM
Inventor
ゴウリスダ アドゥスミリ，
オリバー ブレイアー デイビス，
ミハリス エス． カリオリス，
カタル エス． マホーン，
シュリシュティ ティヤギ，
繭輔 山ノ口
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Denali Therapeutics Inc
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Denali Therapeutics Inc
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Publication of JP2024546129A publication Critical patent/JP2024546129A/ja
Publication of JP2024546129A5 publication Critical patent/JP2024546129A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01076—L-Iduronidase (3.2.1.76)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2024534711A 2021-12-17 2022-12-16 アルファ－ｌ－イズロニダーゼ酵素を含む融合タンパク質及びその方法 Pending JP2024546129A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163291283P 2021-12-17 2021-12-17
US63/291,283 2021-12-17
PCT/US2022/053196 WO2023114485A1 (en) 2021-12-17 2022-12-16 Fusion proteins comprising alpha-l-iduronidase enzymes and methods

Publications (2)

Publication Number Publication Date
JP2024546129A true JP2024546129A (ja) 2024-12-17
JP2024546129A5 JP2024546129A5 (OSRAM) 2026-01-07

Family

ID=85175822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024534711A Pending JP2024546129A (ja) 2021-12-17 2022-12-16 アルファ－ｌ－イズロニダーゼ酵素を含む融合タンパク質及びその方法

Country Status (12)

Country Link
US (1) US20250136963A1 (OSRAM)
EP (1) EP4448746A1 (OSRAM)
JP (1) JP2024546129A (OSRAM)
KR (1) KR20240119118A (OSRAM)
CN (1) CN118401660A (OSRAM)
AR (1) AR128003A1 (OSRAM)
AU (1) AU2022415476A1 (OSRAM)
CA (1) CA3241240A1 (OSRAM)
IL (1) IL313553A (OSRAM)
MX (1) MX2024007319A (OSRAM)
TW (1) TW202340459A (OSRAM)
WO (1) WO2023114485A1 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202542190A (zh) * 2023-12-20 2025-11-01 美商戴納立製藥公司 包含酸性α—葡萄糖苷酶之融合蛋白及其方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180185495A1 (en) * 2014-11-10 2018-07-05 Alexion Pharmaceuticals, Inc. Therapeutic compositions of alpha-l-iduronidase, iduronate-2-sulfatase, and alpha-galactosidase a and methods of use thereof
KR20250073514A (ko) * 2015-06-24 2025-05-27 제이씨알 파마 가부시키가이샤 혈액뇌관문을 통과하는 항인간 트랜스페린 수용체 항체
JP7669113B2 (ja) 2017-02-17 2025-04-28 デナリ セラピューティクス インコーポレイテッド トランスフェリン受容体トランスジェニックモデル
MX2020002918A (es) 2017-10-02 2020-07-22 Denali Therapeutics Inc Proteinas de fusion que comprenden enzimas de terapia de reemplazo de enzimas.
EP3807322A1 (en) * 2018-06-18 2021-04-21 Denali Therapeutics Inc. Fusion proteins comprising progranulin
CN115698037A (zh) * 2020-02-07 2023-02-03 戴纳立制药公司 用于治疗亨特综合征的方法

Also Published As

Publication number Publication date
US20250136963A1 (en) 2025-05-01
KR20240119118A (ko) 2024-08-06
TW202340459A (zh) 2023-10-16
CN118401660A (zh) 2024-07-26
AR128003A1 (es) 2024-03-20
WO2023114485A1 (en) 2023-06-22
IL313553A (en) 2024-08-01
MX2024007319A (es) 2024-07-22
CA3241240A1 (en) 2023-06-22
EP4448746A1 (en) 2024-10-23
AU2022415476A1 (en) 2024-07-04

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