JP2024543016A - トランス－シクロオクテンコンジュゲート - Google Patents

トランス－シクロオクテンコンジュゲート Download PDF

Info

Publication number
JP2024543016A
JP2024543016A JP2024525632A JP2024525632A JP2024543016A JP 2024543016 A JP2024543016 A JP 2024543016A JP 2024525632 A JP2024525632 A JP 2024525632A JP 2024525632 A JP2024525632 A JP 2024525632A JP 2024543016 A JP2024543016 A JP 2024543016A
Authority
JP
Japan
Prior art keywords
alkylene
cancer
alkyl
conjugate
pharma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024525632A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2023077126A5 (https=
JP2024543016A5 (https=
Inventor
ホセ マヌエル メヒア オネト
マイケル ザハリアン
アミール マハムーディ
ジェシー エム． マクファーランド
Original Assignee
タンボ・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by タンボ・インコーポレイテッド filed Critical タンボ・インコーポレイテッド
Publication of JP2024543016A publication Critical patent/JP2024543016A/ja
Publication of JPWO2023077126A5 publication Critical patent/JPWO2023077126A5/ja
Publication of JP2024543016A5 publication Critical patent/JP2024543016A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2024525632A 2021-10-29 2022-10-31 トランス－シクロオクテンコンジュゲート Pending JP2024543016A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163273777P 2021-10-29 2021-10-29
US63/273,777 2021-10-29
PCT/US2022/078991 WO2023077126A1 (en) 2021-10-29 2022-10-31 Trans-cyclooctene conjugates

Publications (3)

Publication Number Publication Date
JP2024543016A true JP2024543016A (ja) 2024-11-19
JPWO2023077126A5 JPWO2023077126A5 (https=) 2025-11-11
JP2024543016A5 JP2024543016A5 (https=) 2025-11-11

Family

ID=84463062

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024525632A Pending JP2024543016A (ja) 2021-10-29 2022-10-31 トランス－シクロオクテンコンジュゲート

Country Status (4)

Country Link
EP (1) EP4422693A1 (https=)
JP (1) JP2024543016A (https=)
CN (1) CN118414169A (https=)
WO (1) WO2023077126A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4669357A1 (en) * 2023-02-21 2025-12-31 Tambo, Inc. TRANS-CYCLOOCTENE CONJUGATES
CN119638848A (zh) * 2023-09-18 2025-03-18 深圳华大生命科学研究院 Cd3抗体与荧光素酶的融合蛋白及其应用
WO2025127934A1 (en) * 2023-12-13 2025-06-19 Tagworks Pharmaceuticals B.V. Trans-cyclooctene with improved t-linker
WO2025174248A1 (en) * 2024-02-16 2025-08-21 Tagworks Pharmaceuticals B.V. Trans-cyclooctenes with "or gate" release

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR104E (https=)
WO2012074840A2 (en) * 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
US10130711B2 (en) 2013-06-19 2018-11-20 The Regents Of The University Of California Chemical structures for localized delivery of therapeutic agents
ES2880468T3 (es) 2014-03-14 2021-11-24 Univ California Conjugados de TCO y métodos para el suministro de agentes terapéuticos
JP6823067B2 (ja) 2015-09-10 2021-01-27 タンボ・インコーポレイテッド 生体直交型組成物
ES2983582T3 (es) 2017-04-07 2024-10-23 Tambo Inc Composiciones bioortogonales
ES2975330T3 (es) * 2018-05-04 2024-07-04 Tagworks Pharmaceuticals B V Compuestos que comprenden un enlazador para aumentar la estabilidad del trans-cicloocteno
CN110496233B (zh) * 2019-09-05 2022-07-19 复旦大学附属中山医院 一种spect显像剂及其标记前体及其制备方法、组合物和用途

Also Published As

Publication number Publication date
CN118414169A (zh) 2024-07-30
EP4422693A1 (en) 2024-09-04
WO2023077126A1 (en) 2023-05-04

Similar Documents

Publication Publication Date Title
JP2024543016A (ja) トランス－シクロオクテンコンジュゲート
CN115990269B (zh) 依沙替康衍生物及其连接子-负载物和缀合物
TWI822827B (zh) IL-2Rγc配體、包含IL-2Rγc配體的化合物及其用途
TW202334217A (zh) 抗體的特異性偶聯
JP7622031B2 (ja) トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
ES2972212T3 (es) Anticuerpos anti-interleucina-2 humana y usos de los mismos
US20260007759A1 (en) Trans-cyclooctene prodrug of monomethyl auristatin e
JP2024542021A (ja) ペイロードのｉｎ ｖｉｖｏ標的化送達用のテトラジンコンジュゲート
KR20220156533A (ko) IL-7Rα 결합 화합물
ES2821878T3 (es) Conectores autoinmolativos no lineales y conjugados de los mismos
US20250009890A1 (en) Trans-cyclooctene-modified bispecific antibodies
CN107530441A (zh) 具有新型自杀式连接子的基于念珠藻素的抗体药物缀合物
CN118369123A (zh) 用于有效载荷的体内靶向递送的四嗪缀合物
JP2026508188A (ja) トランス－シクロオクテンコンジュゲート
HK40109540A (zh) 反式环辛烯缀合物
KR102346268B1 (ko) 경구 항암 전구약물을 포함하는 복합체, 이의 제조방법 및 이의 용도
CN121419790A (zh) 反式环辛烯修饰的靶向性蛋白质降解剂缀合物
EP4704904A1 (en) Tetrazine-based targeting agents for in vivo delivery of a payload
HK40108922A (zh) 用於有效载荷的体内靶向递送的四嗪缀合物
WO2025059685A1 (en) Methods for in vivo targeted delivery of a payload
JP7307500B2 (ja) Ｉｌ－２受容体結合化合物
HK40104832A (en) Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
KR20250135788A (ko) 세포독성 화합물

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251031

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20251031