CN118414169A - 反式环辛烯缀合物 - Google Patents

反式环辛烯缀合物 Download PDF

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Publication number
CN118414169A
CN118414169A CN202280083958.4A CN202280083958A CN118414169A CN 118414169 A CN118414169 A CN 118414169A CN 202280083958 A CN202280083958 A CN 202280083958A CN 118414169 A CN118414169 A CN 118414169A
Authority
CN
China
Prior art keywords
alkylene
conjugate
alkyl
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280083958.4A
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English (en)
Chinese (zh)
Inventor
J·M·M·万托
M·扎卡里安
A·玛哈穆迪
J·M·麦克法兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN118414169A publication Critical patent/CN118414169A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202280083958.4A 2021-10-29 2022-10-31 反式环辛烯缀合物 Pending CN118414169A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163273777P 2021-10-29 2021-10-29
US63/273,777 2021-10-29
PCT/US2022/078991 WO2023077126A1 (en) 2021-10-29 2022-10-31 Trans-cyclooctene conjugates

Publications (1)

Publication Number Publication Date
CN118414169A true CN118414169A (zh) 2024-07-30

Family

ID=84463062

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280083958.4A Pending CN118414169A (zh) 2021-10-29 2022-10-31 反式环辛烯缀合物

Country Status (4)

Country Link
EP (1) EP4422693A1 (https=)
JP (1) JP2024543016A (https=)
CN (1) CN118414169A (https=)
WO (1) WO2023077126A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024178155A1 (en) * 2023-02-21 2024-08-29 Tambo, Inc. Trans-cyclooctene conjugates
CN119638848A (zh) * 2023-09-18 2025-03-18 深圳华大生命科学研究院 Cd3抗体与荧光素酶的融合蛋白及其应用
WO2025127934A1 (en) * 2023-12-13 2025-06-19 Tagworks Pharmaceuticals B.V. Trans-cyclooctene with improved t-linker
WO2025174248A1 (en) * 2024-02-16 2025-08-21 Tagworks Pharmaceuticals B.V. Trans-cyclooctenes with "or gate" release

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR104E (https=)
WO2012074840A2 (en) * 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
ES2966631T3 (es) 2013-06-19 2024-04-23 Univ California Estructuras químicas para el suministro localizado de agentes terapéuticos
CN106659796B (zh) 2014-03-14 2021-04-30 加利福尼亚大学董事会 Tco缀合物和治疗剂递送方法
WO2017044983A1 (en) 2015-09-10 2017-03-16 Shasqi, Inc. Bioorthogonal compositions
AU2018250312C1 (en) 2017-04-07 2024-08-22 Tambo, Inc. Bioorthogonal compositions
CA3099421C (en) * 2018-05-04 2025-05-06 Tagworks Pharmaceuticals B.V. COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY
CN110496233B (zh) * 2019-09-05 2022-07-19 复旦大学附属中山医院 一种spect显像剂及其标记前体及其制备方法、组合物和用途

Also Published As

Publication number Publication date
EP4422693A1 (en) 2024-09-04
WO2023077126A1 (en) 2023-05-04
JP2024543016A (ja) 2024-11-19

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