CN118414169A - 反式环辛烯缀合物 - Google Patents

反式环辛烯缀合物 Download PDF

Info

Publication number
CN118414169A
CN118414169A CN202280083958.4A CN202280083958A CN118414169A CN 118414169 A CN118414169 A CN 118414169A CN 202280083958 A CN202280083958 A CN 202280083958A CN 118414169 A CN118414169 A CN 118414169A
Authority
CN
China
Prior art keywords
alkylene
conjugate
alkyl
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280083958.4A
Other languages
English (en)
Chinese (zh)
Inventor
J·M·M·万托
M·扎卡里安
A·玛哈穆迪
J·M·麦克法兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN118414169A publication Critical patent/CN118414169A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN202280083958.4A 2021-10-29 2022-10-31 反式环辛烯缀合物 Pending CN118414169A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163273777P 2021-10-29 2021-10-29
US63/273,777 2021-10-29
PCT/US2022/078991 WO2023077126A1 (en) 2021-10-29 2022-10-31 Trans-cyclooctene conjugates

Publications (1)

Publication Number Publication Date
CN118414169A true CN118414169A (zh) 2024-07-30

Family

ID=84463062

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280083958.4A Pending CN118414169A (zh) 2021-10-29 2022-10-31 反式环辛烯缀合物

Country Status (4)

Country Link
EP (1) EP4422693A1 (https=)
JP (1) JP2024543016A (https=)
CN (1) CN118414169A (https=)
WO (1) WO2023077126A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4669357A1 (en) * 2023-02-21 2025-12-31 Tambo, Inc. TRANS-CYCLOOCTENE CONJUGATES
CN119638848A (zh) * 2023-09-18 2025-03-18 深圳华大生命科学研究院 Cd3抗体与荧光素酶的融合蛋白及其应用
WO2025127934A1 (en) * 2023-12-13 2025-06-19 Tagworks Pharmaceuticals B.V. Trans-cyclooctene with improved t-linker
WO2025174248A1 (en) * 2024-02-16 2025-08-21 Tagworks Pharmaceuticals B.V. Trans-cyclooctenes with "or gate" release

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR104E (https=)
WO2012074840A2 (en) * 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
US10130711B2 (en) 2013-06-19 2018-11-20 The Regents Of The University Of California Chemical structures for localized delivery of therapeutic agents
ES2880468T3 (es) 2014-03-14 2021-11-24 Univ California Conjugados de TCO y métodos para el suministro de agentes terapéuticos
JP6823067B2 (ja) 2015-09-10 2021-01-27 タンボ・インコーポレイテッド 生体直交型組成物
ES2983582T3 (es) 2017-04-07 2024-10-23 Tambo Inc Composiciones bioortogonales
ES2975330T3 (es) * 2018-05-04 2024-07-04 Tagworks Pharmaceuticals B V Compuestos que comprenden un enlazador para aumentar la estabilidad del trans-cicloocteno
CN110496233B (zh) * 2019-09-05 2022-07-19 复旦大学附属中山医院 一种spect显像剂及其标记前体及其制备方法、组合物和用途

Also Published As

Publication number Publication date
JP2024543016A (ja) 2024-11-19
EP4422693A1 (en) 2024-09-04
WO2023077126A1 (en) 2023-05-04

Similar Documents

Publication Publication Date Title
CN115990269B (zh) 依沙替康衍生物及其连接子-负载物和缀合物
CA2978340C (en) Maytansinoid derivatives, conjugates thereof, and methods of use
CN118414169A (zh) 反式环辛烯缀合物
AU2022287001A1 (en) Antibody drug conjugate, and preparation method therefor and use thereof
JP2021006527A (ja) 抗ｂ７−ｈ３抗体及び抗体薬物コンジュゲート
JP2020143062A (ja) 低細胞透過性を有するＢｃｌ−ｘＬ阻害性化合物およびこれを含む抗体薬物コンジュゲート
JP7622031B2 (ja) トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
TW201538169A (zh) 雙官能性胞毒劑
US20260007759A1 (en) Trans-cyclooctene prodrug of monomethyl auristatin e
ES2821878T3 (es) Conectores autoinmolativos no lineales y conjugados de los mismos
TWI712605B (zh) 含有ｃｔｉ藥效基團之雙功能性細胞毒性劑
US20250186592A1 (en) Tetrazine conjugates for in vivo targeted delivery of a payload
US20250144229A1 (en) Conjugate of antibody-eribulin or derivative thereof, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and use thereof
WO2023081809A1 (en) Trans-cyclooctene-modified bispecific antibodies
CN116036303B (zh) 一种抗体-药物偶联物及其制备方法和应用
CN118369123A (zh) 用于有效载荷的体内靶向递送的四嗪缀合物
HK40109540A (zh) 反式环辛烯缀合物
JP2026508188A (ja) トランス－シクロオクテンコンジュゲート
CN121419788A (zh) 用于体内递送有效载荷的基于四嗪的靶向剂
CN121419790A (zh) 反式环辛烯修饰的靶向性蛋白质降解剂缀合物
HK40108922A (zh) 用於有效载荷的体内靶向递送的四嗪缀合物
WO2025059685A1 (en) Methods for in vivo targeted delivery of a payload

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40109540

Country of ref document: HK