|
WO2018071306A1
(en)
*
|
2016-10-11 |
2018-04-19 |
Northwestern University |
Incremental rotary rolling mill and method
|
|
WO2018071606A1
(en)
*
|
2016-10-11 |
2018-04-19 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
KR102674902B1
(ko)
*
|
2016-12-01 |
2024-06-14 |
아비나스 오퍼레이션스, 인코포레이티드 |
에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 및 테트라히드로이소퀴놀린 유도체
|
|
CN117510491A
(zh)
*
|
2016-12-23 |
2024-02-06 |
阿尔维纳斯运营股份有限公司 |
用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法
|
|
US11191741B2
(en)
*
|
2016-12-24 |
2021-12-07 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
|
|
AU2018211975B2
(en)
*
|
2017-01-26 |
2022-05-26 |
Arvinas Operations, Inc. |
Modulators of estrogen receptor proteolysis and associated methods of use
|
|
BR112019015484A2
(pt)
*
|
2017-01-31 |
2020-04-28 |
Arvinas Operations Inc |
ligantes de cereblon e compostos bifuncionais compreendendo os mesmos
|
|
TWI793151B
(zh)
*
|
2017-08-23 |
2023-02-21 |
瑞士商諾華公司 |
3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
|
|
US11065231B2
(en)
*
|
2017-11-17 |
2021-07-20 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
|
|
KR20210006356A
(ko)
*
|
2018-04-04 |
2021-01-18 |
아비나스 오퍼레이션스, 인코포레이티드 |
단백질분해 조절제 및 연관된 사용 방법
|
|
CA3095912A1
(en)
*
|
2018-04-13 |
2019-10-17 |
Arvinas Operations, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
MX2021001957A
(es)
*
|
2018-08-22 |
2021-07-15 |
Cullgen Shanghai Inc |
Compuestos de degradacion y metodos de uso del receptor de tropomiosina quinasa (trk).
|
|
KR102642203B1
(ko)
*
|
2018-09-07 |
2024-03-04 |
아비나스 오퍼레이션스, 인코포레이티드 |
급속 진행형 섬유육종 폴리펩티드의 표적화 분해를 위한 다중 고리 화합물 및 방법
|
|
WO2020162725A1
(ko)
*
|
2019-02-07 |
2020-08-13 |
한국화학연구원 |
표적 단백질 ｅｅｄ 분해 유도 데그라듀서, 이의 제조방법 및 이를 유효성분으로 함유하는 ｅｅｄ, ｅｚｈ2, 또는 ｐｒｃ2 관련 질환의 예방 또는 치료용 약학적 조성물
|
|
WO2020167518A1
(en)
*
|
2019-02-13 |
2020-08-20 |
Nurix Therapeutics, Inc. |
Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
|
|
CN113490528B
(zh)
*
|
2019-02-15 |
2024-12-03 |
诺华股份有限公司 |
3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途
|
|
US11485735B2
(en)
*
|
2019-04-25 |
2022-11-01 |
Wuxi Shuangliang Biotechnology Co., Ltd. |
Selective CDK4/6 inhibitor and preparation thereof
|
|
CN119954801A
(zh)
*
|
2019-07-17 |
2025-05-09 |
阿尔维纳斯运营股份有限公司 |
Tau蛋白靶向化合物及相关使用方法
|
|
FI3835298T3
(fi)
*
|
2019-12-12 |
2024-07-29 |
Accutar Biotechnology Inc |
Uusia kromaanijohdannaisia, joilla on estrogeenireseptoria hajottava vaikutus, ja niiden käyttötapoja
|
|
CN113292536A
(zh)
*
|
2020-02-21 |
2021-08-24 |
四川海思科制药有限公司 |
一种具有降解Bcr-Abl或PARP的化合物及其制备方法和药学上的应用
|
|
CA3173262A1
(en)
*
|
2020-02-26 |
2021-09-02 |
Cullgen (Shanghai), Inc. |
Tropomyosin receptor kinase (trk) degradation compounds and methods of use
|
|
CN113387931A
(zh)
*
|
2020-03-13 |
2021-09-14 |
四川海思科制药有限公司 |
一种具有抑制或降解蛋白激酶的化合物及其制备方法和药学上的应用
|
|
EP4121167A1
(en)
*
|
2020-03-21 |
2023-01-25 |
Arvinas Operations, Inc. |
Selective modulators of mutant lrrk2 proteolysis and associated methods of use
|
|
KR20230004511A
(ko)
*
|
2020-03-21 |
2023-01-06 |
아비나스 오퍼레이션스, 인코포레이티드 |
인다졸계 화합물 및 관련된 사용 방법
|
|
US11739101B2
(en)
*
|
2020-05-06 |
2023-08-29 |
Nurix Therapeutics, Inc. |
Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof
|
|
JP7834721B2
(ja)
*
|
2020-08-28 |
2026-03-24 |
アルビナス・オペレーションズ・インコーポレイテッド |
急速進行性線維肉腫タンパク質分解化合物及び関連する使用方法
|
|
AU2021365850A1
(en)
*
|
2020-10-21 |
2023-06-08 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor protein
|
|
EP4240733A1
(en)
*
|
2020-11-06 |
2023-09-13 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor and associated methods of use
|
|
WO2022099117A1
(en)
*
|
2020-11-06 |
2022-05-12 |
Prelude Therapeutics Incorporated |
Brm targeting compounds and associated methods of use
|
|
CA3196965A1
(en)
*
|
2020-11-20 |
2022-05-27 |
Foghorn Therapeutics Inc. |
Compounds and uses thereof
|
|
WO2022133184A1
(en)
*
|
2020-12-20 |
2022-06-23 |
Newave Pharmaceutical Inc. |
Btk degrader
|
|
WO2022198112A1
(en)
*
|
2021-03-19 |
2022-09-22 |
Arvinas Operations, Inc. |
Indazole based compounds and associated methods of use
|
|
CN117279910A
(zh)
*
|
2021-04-16 |
2023-12-22 |
阿尔维纳斯运营股份有限公司 |
Bcl6蛋白水解的调节剂和其相关使用方法
|
|
WO2023023941A1
(en)
*
|
2021-08-24 |
2023-03-02 |
Biofront Ltd (Cayman) |
Hpk1 degraders, compositions comprising the hpki degrader, and methods of using the same
|
|
WO2023249970A1
(en)
*
|
2022-06-21 |
2023-12-28 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway
|
|
CN119451967A
(zh)
*
|
2022-06-22 |
2025-02-14 |
霖康疗法公司 |
用于经由泛素蛋白酶体途径降解细胞周期蛋白依赖性激酶2的含有吡啶并[2,3-d]嘧啶-7(8H)-酮衍生物的双功能化合物
|
|
US20250367193A1
(en)
*
|
2022-06-22 |
2025-12-04 |
Nikang Therapeutics, Inc. |
Bifunctional compounds containing substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway
|