JP2024535017A - イデベノン誘導体及び植物の処置におけるそれらの使用 - Google Patents

イデベノン誘導体及び植物の処置におけるそれらの使用 Download PDF

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JP2024535017A
JP2024535017A JP2024516411A JP2024516411A JP2024535017A JP 2024535017 A JP2024535017 A JP 2024535017A JP 2024516411 A JP2024516411 A JP 2024516411A JP 2024516411 A JP2024516411 A JP 2024516411A JP 2024535017 A JP2024535017 A JP 2024535017A
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compound
aryl
groups
dithiol
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Japanese (ja)
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JP2024535017A5 (https=
Inventor
マシュー ホワイトマン
ロベルタ トレグロッサ
マーク ウッド
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ミトアールエックス セラピューティクス リミテッド
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Publication of JP2024535017A5 publication Critical patent/JP2024535017A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2024516411A 2021-09-14 2022-09-14 イデベノン誘導体及び植物の処置におけるそれらの使用 Pending JP2024535017A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2113117.2 2021-09-14
GB2113117.2A GB2610815A (en) 2021-09-14 2021-09-14 Compounds
PCT/GB2022/052325 WO2023041906A1 (en) 2021-09-14 2022-09-14 Idebenone derivatives and their use in treating plants

Publications (2)

Publication Number Publication Date
JP2024535017A true JP2024535017A (ja) 2024-09-26
JP2024535017A5 JP2024535017A5 (https=) 2026-01-09

Family

ID=78149340

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024516411A Pending JP2024535017A (ja) 2021-09-14 2022-09-14 イデベノン誘導体及び植物の処置におけるそれらの使用

Country Status (10)

Country Link
US (1) US20240400536A1 (https=)
EP (1) EP4396174A1 (https=)
JP (1) JP2024535017A (https=)
KR (1) KR20240108380A (https=)
CN (1) CN118234716A (https=)
AU (1) AU2022347098A1 (https=)
CA (1) CA3231394A1 (https=)
GB (1) GB2610815A (https=)
MX (1) MX2024003214A (https=)
WO (1) WO2023041906A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025104452A1 (en) 2023-11-17 2025-05-22 Mitorx Therapeutics Ltd Compounds for use in treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1664069B8 (en) * 2003-08-22 2015-07-01 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
US8263094B2 (en) 2008-09-23 2012-09-11 Eastman Chemical Company Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof

Also Published As

Publication number Publication date
CN118234716A (zh) 2024-06-21
MX2024003214A (es) 2024-07-30
CA3231394A1 (en) 2023-03-23
KR20240108380A (ko) 2024-07-09
EP4396174A1 (en) 2024-07-10
GB202113117D0 (en) 2021-10-27
AU2022347098A1 (en) 2024-04-04
WO2023041906A1 (en) 2023-03-23
US20240400536A1 (en) 2024-12-05
GB2610815A (en) 2023-03-22

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