JP2024534035A - 発見プラットフォーム - Google Patents

発見プラットフォーム Download PDF

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Publication number
JP2024534035A
JP2024534035A JP2024508966A JP2024508966A JP2024534035A JP 2024534035 A JP2024534035 A JP 2024534035A JP 2024508966 A JP2024508966 A JP 2024508966A JP 2024508966 A JP2024508966 A JP 2024508966A JP 2024534035 A JP2024534035 A JP 2024534035A
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model
treatment
embeddings
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placebo
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Japanese (ja)
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JPWO2023023507A5 (https=
JP2024534035A5 (https=
Inventor
パオロ カサーレ フランチェスコ
ベレケット マイケル
アルバート マシュー
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インシトロ インコーポレイテッド
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Publication of JPWO2023023507A5 publication Critical patent/JPWO2023023507A5/ja
Publication of JP2024534035A5 publication Critical patent/JP2024534035A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H15/00—ICT specially adapted for medical reports, e.g. generation or transmission thereof
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Biomedical Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Pathology (AREA)
  • Databases & Information Systems (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Quality & Reliability (AREA)
  • Software Systems (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Artificial Intelligence (AREA)
  • Mathematical Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Evolutionary Computation (AREA)
  • Image Analysis (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
JP2024508966A 2021-08-16 2022-08-16 発見プラットフォーム Pending JP2024534035A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163233707P 2021-08-16 2021-08-16
US63/233,707 2021-08-16
PCT/US2022/075006 WO2023023507A1 (en) 2021-08-16 2022-08-16 Discovery platform

Publications (3)

Publication Number Publication Date
JP2024534035A true JP2024534035A (ja) 2024-09-18
JPWO2023023507A5 JPWO2023023507A5 (https=) 2025-07-25
JP2024534035A5 JP2024534035A5 (https=) 2025-07-25

Family

ID=83271147

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024508966A Pending JP2024534035A (ja) 2021-08-16 2022-08-16 発見プラットフォーム

Country Status (8)

Country Link
US (4) US12002559B2 (https=)
EP (1) EP4388549A1 (https=)
JP (1) JP2024534035A (https=)
KR (1) KR20240068638A (https=)
AU (1) AU2022328586A1 (https=)
CA (1) CA3228785A1 (https=)
IL (1) IL310877A (https=)
WO (1) WO2023023507A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240068638A (ko) 2021-08-16 2024-05-17 인시트로, 인코포레이티드 발견 플랫폼
WO2023092108A2 (en) 2021-11-19 2023-05-25 Insitro, Inc. Autonomous cell imaging and modeling system
US12354013B2 (en) * 2022-05-03 2025-07-08 Salesforce, Inc. Systems and methods for masked self-training of unsupervised image classification
CN115762796A (zh) * 2022-09-27 2023-03-07 京东方科技集团股份有限公司 目标模型的获取方法、预后评估值确定方法、装置、设备及介质
WO2024173610A1 (en) 2023-02-15 2024-08-22 Insitro, Inc. Machine-learning-enabled predictive biomarker discovery and patient stratification using standard-of-care data
CN121175758A (zh) * 2023-03-03 2025-12-19 豪夫迈·罗氏有限公司 用于生物标志物检测的系统和方法
WO2025190827A1 (en) * 2024-03-15 2025-09-18 Bayer Aktiengesellschaft Generation of a synthetic medical image
EP4618009A1 (en) * 2024-03-15 2025-09-17 Bayer Aktiengesellschaft Generation of a synthetic medical image

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US255924A (en) 1882-04-04 Corset
JP4932703B2 (ja) 2005-03-22 2012-05-16 株式会社メディネット 細胞培養評価システム、細胞培養評価方法および細胞培養評価プログラム
CN102272795B (zh) * 2009-01-13 2014-09-10 皇家飞利浦电子股份有限公司 基于图像的临床试验评估
US20170204359A1 (en) 2014-12-19 2017-07-20 Panasonic Corporation Cell culture apparatus
US10467754B1 (en) 2017-02-15 2019-11-05 Google Llc Phenotype analysis of cellular image data using a deep metric network
CN110546277B (zh) 2017-03-01 2024-06-11 豪夫迈·罗氏有限公司 用于癌症的诊断和治疗方法
US11107583B2 (en) * 2018-03-20 2021-08-31 Case Western Reserve University Sequential integration of adversarial networks with handcrafted features (SANwicH): identifying sites of prognostic significance for predicting cancer recurrence
JP7455757B2 (ja) 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装
US10957041B2 (en) 2018-05-14 2021-03-23 Tempus Labs, Inc. Determining biomarkers from histopathology slide images
US11955241B2 (en) * 2018-06-03 2024-04-09 The Regents Of The University Of California Pathogenic biomarkers and serum extracellular vesicular biomarkers associated with vascular malformation of endothelial cells, and uses thereof
WO2020010163A1 (en) 2018-07-02 2020-01-09 Tempus Labs, Inc. 3d radiomic platform for imaging biomarker development
EP3857564A1 (en) * 2018-09-29 2021-08-04 F. Hoffmann-La Roche AG Multimodal machine learning based clinical predictor
US20200388287A1 (en) 2018-11-13 2020-12-10 CurieAI, Inc. Intelligent health monitoring
JP7462632B2 (ja) 2018-11-30 2024-04-05 カリス エムピーアイ インコーポレイテッド 次世代分子プロファイリング
US20220059240A1 (en) 2018-12-31 2022-02-24 Tempus Labs, Inc. Method and process for predicting and analyzing patient cohort response, progression, and survival
US12118715B2 (en) 2019-02-01 2024-10-15 Owkin, Inc. Systems and methods for image classification
CA3145370A1 (en) 2019-06-25 2020-12-30 Owkin Inc. Systems and methods for mesothelioma feature detection and enhanced prognosis or response to treatment
WO2020261183A1 (en) 2019-06-25 2020-12-30 Owkin Inc. Systems and methods for image preprocessing
US12230399B2 (en) 2019-09-27 2025-02-18 The Brigham And Women's Hospital, Inc. Multimodal fusion for diagnosis, prognosis, and therapeutic response prediction
EP4070232A4 (en) 2019-12-05 2024-01-31 Tempus Labs, Inc. SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ACTIVE SCREENING
EP4097636A1 (en) 2020-01-28 2022-12-07 PAIGE.AI, Inc. Systems and methods for processing electronic images for computational detection methods
EP3872711A1 (en) 2020-02-28 2021-09-01 Sensyne Health Group Limited Semi-supervised machine learning method and system suitable for identification of patient subgroups in electronic healthcare records
WO2021205033A1 (en) 2020-04-10 2021-10-14 Koninklijke Philips N.V. Clinically meaningful and personalized disease progression monitoring incorporating established disease staging definitions
US12468952B2 (en) 2020-06-02 2025-11-11 Salesforce, Inc. Systems and methods for noise-robust contrastive learning
EP4211657B1 (en) 2020-09-08 2024-12-11 Insitro, Inc. Biological image transformation using machine-learning models
US12271832B2 (en) 2021-02-12 2025-04-08 Tempus Ai, Inc. Artificial intelligence engine for directed hypothesis generation and ranking
US12361542B2 (en) 2021-03-03 2025-07-15 Tempus Ai, Inc. Systems and methods for deep orthogonal fusion for multimodal prognostic biomarker discovery
JP2023015674A (ja) 2021-07-20 2023-02-01 株式会社エビデント 細胞塊の内部予測方法、プログラム、及び、画像処理装置
WO2023009870A1 (en) 2021-07-29 2023-02-02 Tempus Labs, Inc. Platform for co-culture imaging to characterize in vitro efficacy of heterotypic effector cellular therapies in cancer
KR20240068638A (ko) 2021-08-16 2024-05-17 인시트로, 인코포레이티드 발견 플랫폼
WO2023092108A2 (en) 2021-11-19 2023-05-25 Insitro, Inc. Autonomous cell imaging and modeling system
WO2024173610A1 (en) 2023-02-15 2024-08-22 Insitro, Inc. Machine-learning-enabled predictive biomarker discovery and patient stratification using standard-of-care data

Also Published As

Publication number Publication date
AU2022328586A1 (en) 2024-02-29
US20240274255A1 (en) 2024-08-15
WO2023023507A1 (en) 2023-02-23
US20250259723A1 (en) 2025-08-14
IL310877A (en) 2024-04-01
US12260946B2 (en) 2025-03-25
KR20240068638A (ko) 2024-05-17
US20230360758A1 (en) 2023-11-09
US20240274254A1 (en) 2024-08-15
CA3228785A1 (en) 2023-02-23
US12260945B2 (en) 2025-03-25
US12002559B2 (en) 2024-06-04
EP4388549A1 (en) 2024-06-26

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