JP2024533312A5 - - Google Patents
Info
- Publication number
- JP2024533312A5 JP2024533312A5 JP2024515068A JP2024515068A JP2024533312A5 JP 2024533312 A5 JP2024533312 A5 JP 2024533312A5 JP 2024515068 A JP2024515068 A JP 2024515068A JP 2024515068 A JP2024515068 A JP 2024515068A JP 2024533312 A5 JP2024533312 A5 JP 2024533312A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- grna
- template rna
- mutation
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163241970P | 2021-09-08 | 2021-09-08 | |
| US63/241,970 | 2021-09-08 | ||
| US202163253087P | 2021-10-06 | 2021-10-06 | |
| US63/253,087 | 2021-10-06 | ||
| US202263303905P | 2022-01-27 | 2022-01-27 | |
| US63/303,905 | 2022-01-27 | ||
| PCT/US2022/076073 WO2023039447A2 (en) | 2021-09-08 | 2022-09-07 | Serpina-modulating compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024533312A JP2024533312A (ja) | 2024-09-12 |
| JP2024533312A5 true JP2024533312A5 (https=) | 2025-09-17 |
Family
ID=85506923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024515068A Pending JP2024533312A (ja) | 2021-09-08 | 2022-09-07 | Ｓｅｒｐｉｎａ調節組成物及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240084334A1 (https=) |
| EP (1) | EP4399309A4 (https=) |
| JP (1) | JP2024533312A (https=) |
| AU (1) | AU2022344251A1 (https=) |
| CA (1) | CA3231594A1 (https=) |
| MX (1) | MX2024002988A (https=) |
| WO (1) | WO2023039447A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| EP3844272A1 (en) | 2018-08-28 | 2021-07-07 | Flagship Pioneering Innovations VI, LLC | Methods and compositions for modulating a genome |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| KR20230053735A (ko) | 2020-03-04 | 2023-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈의 조정을 위한 개선된 방법 및 조성물 |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| WO2023108153A2 (en) | 2021-12-10 | 2023-06-15 | Flagship Pioneering Innovations Vi, Llc | Cftr-modulating compositions and methods |
| WO2025155772A1 (en) * | 2024-01-19 | 2025-07-24 | Gene Company (Pty)Ltd. | Alpha-1 anti-trypsin upregulating polynucleotides and method of use and treatment thereof |
| US20250269059A1 (en) * | 2024-02-27 | 2025-08-28 | Crispr Therapeutics Ag | Rt editing compositions and methods |
| WO2025194124A1 (en) * | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | Modified st1cas9 guide nucleic acids |
| US20250354138A1 (en) * | 2024-03-15 | 2025-11-20 | Beam Therapeutics Inc. | Prime editing of single base mutations in alpha-1 antitrypsin deficiency |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9458457B2 (en) * | 2013-07-03 | 2016-10-04 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA |
| CN109715801B (zh) * | 2015-12-01 | 2022-11-01 | 克里斯普治疗股份公司 | 用于治疗α1抗胰蛋白酶缺乏的材料和方法 |
| IL308824A (en) * | 2016-08-17 | 2024-01-01 | Factor Bioscience Inc | Nucleic acid products and methods of administration thereof |
| CA3035534A1 (en) * | 2016-09-07 | 2018-03-15 | Sangamo Therapeutics, Inc. | Modulation of liver genes |
| WO2020191233A1 (en) * | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214609A1 (en) * | 2019-04-14 | 2020-10-22 | Duke University | Aav vector-mediated deletion of large mutational hotspot for treatment of duchenne muscular dystrophy |
| US12435330B2 (en) * | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
-
2022
- 2022-09-07 MX MX2024002988A patent/MX2024002988A/es unknown
- 2022-09-07 EP EP22868288.6A patent/EP4399309A4/en active Pending
- 2022-09-07 WO PCT/US2022/076073 patent/WO2023039447A2/en not_active Ceased
- 2022-09-07 AU AU2022344251A patent/AU2022344251A1/en active Pending
- 2022-09-07 CA CA3231594A patent/CA3231594A1/en active Pending
- 2022-09-07 JP JP2024515068A patent/JP2024533312A/ja active Pending
-
2023
- 2023-09-18 US US18/469,344 patent/US20240084334A1/en active Pending
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