JP2024533309A5 - - Google Patents
Info
- Publication number
- JP2024533309A5 JP2024533309A5 JP2024515065A JP2024515065A JP2024533309A5 JP 2024533309 A5 JP2024533309 A5 JP 2024533309A5 JP 2024515065 A JP2024515065 A JP 2024515065A JP 2024515065 A JP2024515065 A JP 2024515065A JP 2024533309 A5 JP2024533309 A5 JP 2024533309A5
- Authority
- JP
- Japan
- Prior art keywords
- binds
- pharmaceutically acceptable
- acceptable salt
- protein
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163241914P | 2021-09-08 | 2021-09-08 | |
| US63/241,914 | 2021-09-08 | ||
| US202163293591P | 2021-12-23 | 2021-12-23 | |
| US63/293,591 | 2021-12-23 | ||
| US202263351639P | 2022-06-13 | 2022-06-13 | |
| US63/351,639 | 2022-06-13 | ||
| US202263374282P | 2022-09-01 | 2022-09-01 | |
| US63/374,282 | 2022-09-01 | ||
| PCT/IB2022/058428 WO2023037268A1 (en) | 2021-09-08 | 2022-09-07 | Linkers for use in antibody drug conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024533309A JP2024533309A (ja) | 2024-09-12 |
| JP2024533309A5 true JP2024533309A5 (enExample) | 2025-09-17 |
Family
ID=85506299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024515065A Pending JP2024533309A (ja) | 2021-09-08 | 2022-09-07 | 抗体薬物複合体に使用するためのリンカー |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250144230A1 (enExample) |
| EP (1) | EP4398942A4 (enExample) |
| JP (1) | JP2024533309A (enExample) |
| KR (1) | KR20240067085A (enExample) |
| AU (1) | AU2022344582A1 (enExample) |
| CA (1) | CA3231039A1 (enExample) |
| IL (1) | IL311231A (enExample) |
| MX (1) | MX2024002862A (enExample) |
| TW (1) | TW202330037A (enExample) |
| WO (1) | WO2023037268A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250135228A (ko) | 2023-01-09 | 2025-09-12 | 몬테 로사 테라퓨틱스 아게 | Vav1의 표적 분해 |
| KR20260023524A (ko) * | 2023-05-18 | 2026-02-20 | 파이어플라이 바이오, 인크. | 이소인돌리논-글루타르이미드 항체 접합체 및 이의 용도 |
| KR20260041885A (ko) | 2023-07-25 | 2026-03-27 | 몬테 로사 테라퓨틱스 아게 | 표적화된 단백질 분해를 위한 치환된 피페리딘디온 |
| EP4778540A1 (en) | 2023-09-13 | 2026-07-22 | Astellas Pharma Inc. | Antibody-drug conjugate containing heterocyclic compound having activity of inducing decomposition of g12d mutant kras protein |
| WO2025146112A1 (en) * | 2024-01-05 | 2025-07-10 | Primelink Biotherapeutics (Shenzhen) Co., Ltd. | Gspt1 degrading compounds and compositions and uses thereof |
| WO2025189204A2 (en) * | 2024-03-08 | 2025-09-12 | Inmune Bio Inc. | Stabilized dn-tnf mutein bioconjugates for selective soluble tnf neutralization |
| WO2025221780A1 (en) * | 2024-04-16 | 2025-10-23 | Genzyme Corporation | Salts of irak4 degrader |
| TW202608896A (zh) * | 2024-04-30 | 2026-03-01 | 大陸商和記黃埔醫藥（上海）有限公司 | 抗體藥物偶聯物及其用途 |
| WO2026013576A1 (en) | 2024-07-10 | 2026-01-15 | Monte Rosa Therapeutics Ag | Dihydrouracil derivatives useful for the targeted degradation of vav1 |
| WO2026013577A1 (en) | 2024-07-10 | 2026-01-15 | Monte Rosa Therapeutics Ag | Piperidine-2, 6-dione derivatives useful for the targeted degradation of vav1 |
| WO2026038047A2 (en) * | 2024-08-14 | 2026-02-19 | Creasallis Ltd | Agents, methods and uses thereof |
| WO2026052637A1 (en) | 2024-09-03 | 2026-03-12 | Monte Rosa Therapeutics Ag | Targeted protein degradation |
| WO2026099466A1 (en) | 2024-11-08 | 2026-05-15 | Monte Rosa Therapeutics Ag | Targeted protein degradation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2957226C (en) * | 2008-10-29 | 2018-08-14 | Celgene Corporation | Isoindoline compounds for use in the treatment of cancer |
| US9499514B2 (en) * | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| WO2018227023A1 (en) * | 2017-06-07 | 2018-12-13 | Silverback Therapeutics, Inc. | Antibody construct conjugates |
| CN119792569A (zh) * | 2018-01-10 | 2025-04-11 | 财团法人生物技术开发中心 | 抗体protac偶联物 |
| AU2019389174A1 (en) * | 2018-11-30 | 2021-07-01 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CA3157984A1 (en) * | 2019-10-18 | 2021-04-22 | Regeneron Pharmaceuticals, Inc. | Site-specific quantitation of drug conjugations |
| US20230338564A1 (en) * | 2020-03-31 | 2023-10-26 | Orum Therapeutics, Inc. | Neodegrader conjugates |
-
2022
- 2022-09-07 WO PCT/IB2022/058428 patent/WO2023037268A1/en not_active Ceased
- 2022-09-07 US US18/690,506 patent/US20250144230A1/en active Pending
- 2022-09-07 TW TW111133968A patent/TW202330037A/zh unknown
- 2022-09-07 KR KR1020247011575A patent/KR20240067085A/ko active Pending
- 2022-09-07 JP JP2024515065A patent/JP2024533309A/ja active Pending
- 2022-09-07 AU AU2022344582A patent/AU2022344582A1/en active Pending
- 2022-09-07 EP EP22866845.5A patent/EP4398942A4/en active Pending
- 2022-09-07 IL IL311231A patent/IL311231A/en unknown
- 2022-09-07 CA CA3231039A patent/CA3231039A1/en active Pending
- 2022-09-07 MX MX2024002862A patent/MX2024002862A/es unknown
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