JP2024531188A - 重水素化ｊａｋ阻害剤による脱毛障害の治療 - Google Patents

重水素化ｊａｋ阻害剤による脱毛障害の治療 Download PDF

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JP2024531188A
JP2024531188A JP2024508384A JP2024508384A JP2024531188A JP 2024531188 A JP2024531188 A JP 2024531188A JP 2024508384 A JP2024508384 A JP 2024508384A JP 2024508384 A JP2024508384 A JP 2024508384A JP 2024531188 A JP2024531188 A JP 2024531188A
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compound
pharma
acceptable salt
day
ceutically acceptable
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JP2024531188A5 (https=
Inventor
カッセラ，ジェームズ・ヴィ
ブランメル，クリストファー・エル
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サン ファーマシューティカル インダストリーズ，インコーポレイテッド
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Publication of JP2024531188A publication Critical patent/JP2024531188A/ja
Publication of JP2024531188A5 publication Critical patent/JP2024531188A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024508384A 2021-08-11 2022-08-11 重水素化ｊａｋ阻害剤による脱毛障害の治療 Pending JP2024531188A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163232107P 2021-08-11 2021-08-11
US63/232,107 2021-08-11
PCT/US2022/040115 WO2023018904A1 (en) 2021-08-11 2022-08-11 Treatment of hair loss disorders with deuterated jak inhibitors

Publications (2)

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JP2024531188A true JP2024531188A (ja) 2024-08-29
JP2024531188A5 JP2024531188A5 (https=) 2025-10-15

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JP2024508384A Pending JP2024531188A (ja) 2021-08-11 2022-08-11 重水素化ｊａｋ阻害剤による脱毛障害の治療

Country Status (7)

Country Link
US (2) US12285432B2 (https=)
EP (1) EP4384175A1 (https=)
JP (1) JP2024531188A (https=)
CN (1) CN118159272A (https=)
AU (1) AU2022328272A1 (https=)
CA (1) CA3228505A1 (https=)
WO (1) WO2023018904A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021372512A1 (en) * 2020-10-28 2023-06-22 Sun Pharmaceutical Industries, Inc. Regimens for the treatment of hair loss disorders with deuterated jak inhibitors
CA3228505A1 (en) 2021-08-11 2023-02-16 Sun Pharmaceutical Industries, Inc. Treatment of hair loss disorders with deuterated jak inhibitors
US12364699B2 (en) 2023-10-10 2025-07-22 Sun Pharmaceuticals Industries, Inc. Method of treating hair loss disorders
US20260027120A1 (en) * 2024-07-25 2026-01-29 Sun Pharmaceutical Industries, Inc. Methods of treatment of jak inhibition responsive conditions with deuterated jak inhibitors

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20150197525A1 (en) * 2012-06-15 2015-07-16 Concert Pharmaceuticals, Inc. Deuterated derivatives of ruxolitinib
JP2019516684A (ja) * 2016-05-04 2019-06-20 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化ｊａｋ阻害剤による脱毛障害の処置

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GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
CN1255185C (zh) 2001-05-03 2006-05-10 弗·哈夫曼-拉罗切有限公司 无定形甲磺酸奈非那韦的药物剂型
MX2007003731A (es) 2004-09-29 2007-08-14 Johnson & Johnson Formas de dosis farmaceuticas de compuestos similares a rapamicina amorfos estables.
US20070202077A1 (en) * 2005-12-02 2007-08-30 Brodsky Robert A Use of High-Dose Oxazaphosphorine Drugs for Treating Immune Disorders
SG10202003901UA (en) 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
WO2007079139A2 (en) 2005-12-28 2007-07-12 Vertex Pharmaceuticals, Inc. Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
TWI720517B (zh) 2009-01-15 2021-03-01 美商英塞特公司 製造ｊａｋ抑制劑之方法及相關中間化合物
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
WO2012061537A2 (en) 2010-11-02 2012-05-10 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
DK2830662T3 (da) 2012-03-29 2019-01-02 Univ Columbia Fremgangsmåder til behandlng af hårtabsforstyrrelser
PH12020551186B1 (en) 2012-11-15 2024-03-20 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib
KR20160117596A (ko) 2014-02-07 2016-10-10 오스펙스 파마슈티칼스, 인코포레이티드 신규 제약 제제
AU2020219797B2 (en) 2019-02-06 2025-10-16 Sun Pharmaceutical Industries, Inc. Process for preparing enantiomerically enriched jak inhibitors
CA3228505A1 (en) 2021-08-11 2023-02-16 Sun Pharmaceutical Industries, Inc. Treatment of hair loss disorders with deuterated jak inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150197525A1 (en) * 2012-06-15 2015-07-16 Concert Pharmaceuticals, Inc. Deuterated derivatives of ruxolitinib
JP2019516684A (ja) * 2016-05-04 2019-06-20 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化ｊａｋ阻害剤による脱毛障害の処置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"［特別講座］広がる重水素の用途", 富士フイルム和光純薬株式会社ホームページ，SIYAKU BLOG，[ONLINE], JPN6025045164, September 2010 (2010-09-01), ISSN: 0005723684 *

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Publication number Publication date
US20250275979A1 (en) 2025-09-04
CA3228505A1 (en) 2023-02-16
EP4384175A1 (en) 2024-06-19
WO2023018904A1 (en) 2023-02-16
AU2022328272A1 (en) 2024-02-22
CN118159272A (zh) 2024-06-07
US12285432B2 (en) 2025-04-29
US20240058345A1 (en) 2024-02-22

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