|
US5229109A
(en)
|
1992-04-14 |
1993-07-20 |
Board Of Regents, The University Of Texas System |
Low toxicity interleukin-2 analogues for use in immunotherapy
|
|
WO2003015697A2
(en)
|
2001-08-13 |
2003-02-27 |
University Of Southern California |
Interleukin-2 mutants with reduced toxicity
|
|
DK1454138T3
(da)
|
2001-12-04 |
2012-02-13 |
Merck Patent Gmbh |
Immunocytokiner med moduleret selektivitet
|
|
ES2367027T3
(es)
|
2004-02-27 |
2011-10-27 |
Inserm (Institut National De La Santé Et De La Recherche Medicale) |
Sitio de unión de la il-15 para il-15ralfa y mutantes específicos de il-15 que tienen actividad agonista/antagonista.
|
|
TW200613552A
(en)
|
2004-08-11 |
2006-05-01 |
Hoffmann La Roche |
Mutant interleukin-15 polypeptides
|
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
|
EP1790664A1
(en)
|
2005-11-24 |
2007-05-30 |
Ganymed Pharmaceuticals AG |
Monoclonal antibodies against claudin-18 for treatment of cancer
|
|
AU2007271398B2
(en)
|
2006-07-06 |
2013-06-20 |
Merck Patent Gmbh |
Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses
|
|
CN101743249B
(zh)
|
2007-05-11 |
2017-08-08 |
阿尔托生物科学有限公司 |
融合分子与il‑15变异体
|
|
WO2009135031A1
(en)
|
2008-04-30 |
2009-11-05 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic |
Substituted il-15
|
|
WO2012065086A1
(en)
|
2010-11-12 |
2012-05-18 |
Nektar Therapeutics |
Conjugates of an il-2 moiety and a polymer
|
|
SG192673A1
(en)
|
2011-02-10 |
2013-09-30 |
Roche Glycart Ag |
Mutant interleukin-2 polypeptides
|
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
EP2543386A1
(en)
|
2011-07-05 |
2013-01-09 |
Sotio a.s. |
Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure
|
|
US20150359853A1
(en)
|
2012-10-24 |
2015-12-17 |
Admune Therapeutics Llc |
Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
|
|
JP6594855B2
(ja)
|
2013-03-15 |
2019-10-23 |
ゼンコア インコーポレイテッド |
ヘテロ二量体タンパク質
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
WO2014207173A1
(en)
|
2013-06-27 |
2014-12-31 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Interleukin 15 (il-15) antagonists and uses thereof for the treatment of autoimmune diseases and inflammatory diseases
|
|
US9562219B2
(en)
|
2013-12-27 |
2017-02-07 |
SOTIO a.s. |
Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
|
|
RU2689717C2
(ru)
|
2014-01-08 |
2019-05-28 |
Шанхай Хэнжуй Фармасьютикал Ко., Лтд. |
Гетеродимерный белок il-15 и его применения
|
|
WO2016060996A2
(en)
|
2014-10-14 |
2016-04-21 |
Armo Biosciences, Inc. |
Interleukin-15 compositions and uses thereof
|
|
WO2016102679A1
(en)
|
2014-12-23 |
2016-06-30 |
Nbe-Therapeutics Ag |
Binding protein drug conjugates comprising anthracycline derivatives
|
|
EP3064507A1
(en)
|
2015-03-06 |
2016-09-07 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof
|
|
WO2016165762A1
(en)
|
2015-04-15 |
2016-10-20 |
Ganymed Pharmaceuticals Ag |
Drug conjugates comprising antibodies against claudin 18.2
|
|
WO2017046200A1
(en)
|
2015-09-16 |
2017-03-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases
|
|
JP2018532729A
(ja)
*
|
2015-09-25 |
2018-11-08 |
アルター・バイオサイエンス・コーポレーション |
インターロイキン−１５スーパーアゴニストは、移植片対腫瘍活性を大幅に増強する
|
|
MX2018007304A
(es)
|
2015-12-21 |
2019-03-14 |
Armo Biosciences Inc |
Composiciones de interleucina-15 y sus usos.
|
|
MY203000A
(en)
|
2016-10-14 |
2024-06-01 |
Xencor Inc |
Il15/il15r� heterodimeric fc-fusion proteins
|
|
MX2019006072A
(es)
|
2016-11-30 |
2019-08-14 |
Oncomed Pharm Inc |
Metodos para tratamiento de cancer que comprenden agentes de enlace al inmunoreceptor de celulas t con dominios ige itim (tigit).
|
|
HUE070957T2
(hu)
|
2017-02-16 |
2025-07-28 |
Sonnet Biotherapeutics Inc |
Albuminkötõ domén fúziós fehérjék
|
|
IL270634B2
(en)
|
2017-05-15 |
2025-06-01 |
Nektar Therapeutics |
Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods
|
|
CN111201035A
(zh)
|
2017-06-19 |
2020-05-26 |
梅迪塞纳医疗股份有限公司 |
Il-2超激动剂、激动剂及其融合体的用途和方法
|
|
KR20240141853A
(ko)
|
2017-08-03 |
2024-09-27 |
신톡스, 인크. |
자가면역 질환의 치료를 위한 사이토카인 접합체
|
|
EP3746103A4
(en)
|
2017-12-06 |
2022-03-30 |
The Board of Trustees of the Leland Stanford Junior University |
PROTEINS ENGINEERED TO INCREASE A CELL'S SENSITIVITY TO IL-2
|
|
EP3720504A1
(en)
|
2017-12-06 |
2020-10-14 |
Synaffix B.V. |
Enediyne conjugates
|
|
WO2019145471A1
(en)
|
2018-01-25 |
2019-08-01 |
SOTIO a.s. |
Dendritic cell vaccination in parallel to chemotherapy
|
|
CN111867620A
(zh)
|
2018-01-25 |
2020-10-30 |
Sotio公司 |
化学疗法后的树突状细胞疫苗接种
|
|
CN112004547A
(zh)
|
2018-02-26 |
2020-11-27 |
新索思股份有限公司 |
Il-15缀合物及其用途
|
|
AU2019228381B2
(en)
|
2018-02-28 |
2021-12-16 |
Pfizer Inc. |
IL-15 variants and uses thereof
|
|
CN111918665B
(zh)
|
2018-03-28 |
2024-11-26 |
阿森迪斯药物肿瘤股份有限公司 |
Il-2缀合物
|
|
EP3810171B1
(en)
|
2018-06-22 |
2025-07-09 |
Cugene Inc. |
Novel interleukin-15 (1l-15) fusion proteins and uses thereof
|
|
CA3111576A1
(en)
|
2018-09-11 |
2020-03-19 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
|
IL288210B2
(en)
|
2019-05-20 |
2026-03-01 |
Cytune Pharma |
Dosing regimens of IL-2/IL-15 beta-gamma receptor agonists for the treatment of cancer or infectious diseases
|
|
US20230030674A1
(en)
|
2019-12-06 |
2023-02-02 |
Sotio Biotech A.S. |
Humanized cldn18.2 antibodies
|
|
WO2021130291A1
(en)
|
2019-12-23 |
2021-07-01 |
SOTIO a.s. |
Tumor-specific claudin 18.2 antibodies
|
|
EP4117732A1
(en)
|
2020-03-11 |
2023-01-18 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
KR20230019889A
(ko)
|
2020-06-03 |
2023-02-09 |
아센디스 파마 온콜로지 디비전 에이/에스 |
Il-2 서열 및 이의 용도
|
|
TW202241519A
(zh)
|
2020-12-23 |
2022-11-01 |
捷克商舒迪安生物技術公司 |
腫瘤特異性密連蛋白１８﹒２抗體藥物結合物
|