JP2024527535A5 - - Google Patents
Info
- Publication number
- JP2024527535A5 JP2024527535A5 JP2023579728A JP2023579728A JP2024527535A5 JP 2024527535 A5 JP2024527535 A5 JP 2024527535A5 JP 2023579728 A JP2023579728 A JP 2023579728A JP 2023579728 A JP2023579728 A JP 2023579728A JP 2024527535 A5 JP2024527535 A5 JP 2024527535A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- substituted
- cycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20210090244 | 2021-07-09 | ||
| KR10-2021-0090239 | 2021-07-09 | ||
| KR10-2021-0090244 | 2021-07-09 | ||
| KR20210090239 | 2021-07-09 | ||
| KR10-2022-0031603 | 2022-03-14 | ||
| KR20220031603 | 2022-03-14 | ||
| PCT/KR2022/009980 WO2023282702A1 (ko) | 2021-07-09 | 2022-07-08 | Shp2 억제제 및 이의 용도 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024527535A JP2024527535A (ja) | 2024-07-25 |
| JP2024527535A5 true JP2024527535A5 (https=) | 2025-07-15 |
| JP7843785B2 JP7843785B2 (ja) | 2026-04-10 |
Family
ID=84801788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023579728A Active JP7843785B2 (ja) | 2021-07-09 | 2022-07-08 | Ｓｈｐ２阻害剤及びその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12029739B2 (https=) |
| EP (1) | EP4368625A4 (https=) |
| JP (1) | JP7843785B2 (https=) |
| KR (1) | KR102682323B1 (https=) |
| AU (1) | AU2022309195A1 (https=) |
| CA (1) | CA3226206A1 (https=) |
| IL (1) | IL309984A (https=) |
| MX (1) | MX2024000271A (https=) |
| TW (1) | TW202319056A (https=) |
| WO (1) | WO2023282702A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025510572A (ja) | 2022-03-08 | 2025-04-15 | レボリューション メディシンズ インコーポレイテッド | 免疫不応性肺癌を治療するための方法 |
| WO2023169170A1 (zh) * | 2022-03-10 | 2023-09-14 | 捷思英达控股有限公司 | 作为shp2抑制剂的杂环化合物、包括该杂环化合物的组合物、及其使用方法 |
| US11878958B2 (en) | 2022-05-25 | 2024-01-23 | Ikena Oncology, Inc. | MEK inhibitors and uses thereof |
| WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| CN118206550A (zh) * | 2022-12-15 | 2024-06-18 | 江苏威凯尔医药科技有限公司 | Shp2抑制剂及其应用 |
| CN120476122A (zh) * | 2023-01-05 | 2025-08-12 | 治纳辅医药科技有限公司 | Shp2抑制剂及其用途 |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| CR20250420A (es) | 2023-04-07 | 2025-11-20 | Revolution Medicines Inc | Inhibidores macrocíclicos de ras |
| AR132338A1 (es) | 2023-04-07 | 2025-06-18 | Revolution Medicines Inc | Inhibidores de ras |
| CN121100123A (zh) | 2023-04-14 | 2025-12-09 | 锐新医药公司 | Ras抑制剂的结晶形式 |
| CN121464140A (zh) | 2023-04-14 | 2026-02-03 | 锐新医药公司 | Ras抑制剂的结晶形式、含有其的组合物及其使用方法 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025110772A1 (ko) * | 2023-11-22 | 2025-05-30 | 엘젠테라퓨틱스 주식회사 | 이미다졸로-피리딘 유도체 및 이의 용도 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1347982B1 (en) * | 2000-12-12 | 2005-11-16 | Neurogen Corporation | Spiro isobenzofuran-1,4'-piperidin]-3-ones and 3h-spiroisobenzofuran-1,4'-piperidines |
| CA2511925C (en) * | 2002-12-31 | 2012-11-13 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of phosphatases, compositions and uses thereof |
| MX388576B (es) * | 2016-06-07 | 2025-03-20 | Jacobio Pharmaceuticals Co Ltd | Derivados heterociclicos novedosos utiles como inhibidores de shp2. |
| EP4302834A3 (en) * | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| EA202190196A1 (ru) * | 2017-03-23 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| TW201930292A (zh) * | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| AU2019240299B2 (en) | 2018-03-21 | 2023-06-22 | D.E. Shaw Research, Llc | SHP2 phosphatase inhibitors and methods of use thereof |
| RU2020133727A (ru) * | 2018-03-21 | 2022-04-21 | Сучжоу Пухе Биофарма Ко., Лтд. | Ингибиторы shp2 и их применение |
| WO2020049079A1 (en) | 2018-09-07 | 2020-03-12 | Belimo Holding Ag | An actuator with an electric motor and a method of controlling the electric motor to maintain a current position |
| CR20210175A (es) * | 2018-09-18 | 2021-06-01 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2) |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| TW202028183A (zh) * | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| BR112021005733A2 (pt) | 2018-10-17 | 2021-07-27 | Array Biopharma Inc. | inibidores de proteína tirosina fosfatase |
| CU20210080A7 (es) | 2019-04-02 | 2022-05-11 | Array Biopharma Inc | Triazinas sustituidas como inhibidores de proteína tirosina fosfatasa |
| WO2021043077A1 (zh) * | 2019-09-06 | 2021-03-11 | 四川科伦博泰生物医药股份有限公司 | 一种取代吡嗪化合物、其制备方法和用途 |
| CN110734480B (zh) | 2019-11-07 | 2021-08-24 | 中国科学院遗传与发育生物学研究所 | 大肠杆菌分子伴侣GroEL/ES在协助合成植物Rubisco中的应用 |
| CN114829362A (zh) | 2019-12-10 | 2022-07-29 | 成都倍特药业股份有限公司 | 一种可用作shp2抑制剂的含氮杂原子的六元并五元芳环衍生物 |
| CN114846005B (zh) | 2020-01-21 | 2024-04-02 | 贝达药业股份有限公司 | Shp2抑制剂及其应用 |
| TW202144334A (zh) | 2020-04-03 | 2021-12-01 | 大陸商上海翰森生物醫藥科技有限公司 | 含氮雜芳類衍生物游離鹼的晶型 |
| CN115362149B (zh) | 2020-04-26 | 2024-05-14 | 贝达药业股份有限公司 | Shp2抑制剂及其组合物和应用 |
| WO2021218755A1 (zh) | 2020-04-30 | 2021-11-04 | 贝达药业股份有限公司 | Shp2抑制剂及其组合物和应用 |
| CN115515947B (zh) | 2020-07-24 | 2024-02-06 | 贝达药业股份有限公司 | Shp2抑制剂及其组合物和应用 |
-
2022
- 2022-07-08 TW TW111125765A patent/TW202319056A/zh unknown
- 2022-07-08 IL IL309984A patent/IL309984A/en unknown
- 2022-07-08 WO PCT/KR2022/009980 patent/WO2023282702A1/ko not_active Ceased
- 2022-07-08 AU AU2022309195A patent/AU2022309195A1/en active Pending
- 2022-07-08 EP EP22838054.9A patent/EP4368625A4/en active Pending
- 2022-07-08 CA CA3226206A patent/CA3226206A1/en active Pending
- 2022-07-08 KR KR1020220084532A patent/KR102682323B1/ko active Active
- 2022-07-08 JP JP2023579728A patent/JP7843785B2/ja active Active
- 2022-07-08 MX MX2024000271A patent/MX2024000271A/es unknown
-
2024
- 2024-01-08 US US18/407,400 patent/US12029739B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024527535A5 (https=) | ||
| KR102142177B1 (ko) | Ezh2 억제용 하이드로클로라이드 염 형태 | |
| KR20250120376A (ko) | 축합환 화합물 및 이의 응용 | |
| KR101635227B1 (ko) | 벤젠 또는 티오펜 유도체 및 ｖａｐ－１ 억제제로서 이의 용도 | |
| AU2021324764A1 (en) | Functionalized peptides as antiviral agents | |
| CN105085429B (zh) | 芳杂环类衍生物及其在药物上的应用 | |
| JP2022525893A (ja) | Ｒｓｖ阻害剤としてのベンゾジアゼピン誘導体 | |
| WO2018210296A1 (zh) | 一种ezh2抑制剂与btk抑制剂联合在制备治疗肿瘤的药物中的用途 | |
| CN110950860A (zh) | 稠合三环类化合物及其在药物中的应用 | |
| WO2024059236A1 (en) | Novel camptothecin analogs and immunoconjugates thereof | |
| TW202034910A (zh) | 非酒精性脂肪性肝病的治療 | |
| TW201731850A (zh) | 嘧啶類七元環化合物、其製備方法、藥用組合物及其應用 | |
| WO2019001556A1 (zh) | 取代芳基醚类化合物、其制备方法、药用组合物及其应用 | |
| CN117883585A (zh) | 靶向成纤维细胞活化蛋白的药物及其应用 | |
| CN119708105A (zh) | 甾体化合物及其应用 | |
| WO2023202642A1 (zh) | Rho相关蛋白激酶抑制剂及其制备和应用 | |
| CN119708106A (zh) | 甾体化合物及其应用 | |
| RU2024103122A (ru) | Ингибитор shp2 и его применение | |
| AU2022422015A1 (en) | Novel auristatin analogs and immunoconjugates thereof | |
| JP2024540402A (ja) | 新規オーリスタチン類似体およびその免疫複合体 | |
| WO2023209368A1 (en) | Nitrogen comprising heterocyclic derivatives for the treatment of disorders associated with gpr55 receptor | |
| CN117580577A (zh) | 肾损伤的预防和／或治疗用医药组合物以及自噬活化剂 | |
| HK1249499B (zh) | 嘧啶类七元环化合物、其制备方法、药用组合物及其应用 | |
| JP2010047517A (ja) | 神経栄養因子の活性が関与する疾患の治療または予防剤、およびその製造方法 | |
| HK1252543A1 (zh) | 新的膜铁转运蛋白抑制剂 |