JP2024527220A - グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体を含む組み合わせ物の治療学的用途 - Google Patents

グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体を含む組み合わせ物の治療学的用途 Download PDF

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JP2024527220A
JP2024527220A JP2023566569A JP2023566569A JP2024527220A JP 2024527220 A JP2024527220 A JP 2024527220A JP 2023566569 A JP2023566569 A JP 2023566569A JP 2023566569 A JP2023566569 A JP 2023566569A JP 2024527220 A JP2024527220 A JP 2024527220A
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peptide
conjugate
present
immunoglobulin
sglt
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JP2024527220A5 (https=
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ジョンソク イ
ヨハン キム
ジョングク キム
サンヒョン イ
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ハンミ ファーマシューティカル カンパニー リミテッド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Peptides Or Proteins (AREA)
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JP2023566569A 2021-06-30 2022-06-30 グルカゴン、ｇｌｐ－１及びｇｉｐ受容体の全てに対して活性を有する三重活性体を含む組み合わせ物の治療学的用途 Pending JP2024527220A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020210086014A KR20230004135A (ko) 2021-06-30 2021-06-30 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체를 포함하는 조합물의 치료학적 용도
KR10-2021-0086014 2021-06-30
PCT/KR2022/009449 WO2023277620A1 (ko) 2021-06-30 2022-06-30 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체를 포함하는 조합물의 치료학적 용도

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JP2024527220A true JP2024527220A (ja) 2024-07-24
JP2024527220A5 JP2024527220A5 (https=) 2025-07-07

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US (1) US20240293512A1 (https=)
EP (1) EP4364750A4 (https=)
JP (1) JP2024527220A (https=)
KR (1) KR20230004135A (https=)
CN (1) CN117615775A (https=)
AU (1) AU2022302809A1 (https=)
BR (1) BR112023022445A2 (https=)
CA (1) CA3216330A1 (https=)
IL (1) IL308347A (https=)
MX (1) MX2023012935A (https=)
WO (1) WO2023277620A1 (https=)

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TW202600132A (zh) 2024-03-08 2026-01-01 美商安尼波那生物公司 用於治療肥胖症及提高減重之方法

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US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
US20130035281A1 (en) * 2011-02-09 2013-02-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
SG11201805586SA (en) 2015-12-31 2018-07-30 Hanmi Pharmaceutical Co Ltd Triple glucagon/glp-1/gip receptor agonist
ES2983409T3 (es) * 2016-03-10 2024-10-23 Medimmune Ltd Agonista de Glp-1/glucagón para su uso en el tratamiento de la esteatohepatitis no alcohólica
JOP20190095A1 (ar) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y
AR110300A1 (es) * 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos trigonales de los receptores de glp1 / glucagón / gip
EP3573651A4 (en) * 2017-01-27 2020-10-14 NGM Biopharmaceuticals, Inc. GLUCAGON RECEPTOR BINDING PROTEINS AND METHODS OF USE
WO2020071865A1 (ko) * 2018-10-04 2020-04-09 한미약품 주식회사 글루카곤 및 이를 포함하는 조합물의 치료학적 용도
CN113453703A (zh) * 2018-12-21 2021-09-28 韩美药品株式会社 包括胰岛素和对胰高血糖素和glp-1和gip受体均具有活性的三重激动剂的药物组合物
MX2021008010A (es) * 2018-12-31 2021-10-13 Coherus Biosciences Inc Composiciones y métodos para tratar las enfermedades del hígado graso no alcohólico (nafld).
DK3936142T3 (da) * 2019-06-28 2024-03-25 Hanmi Pharmaceutical Co Ltd Tredobbelt agonist med aktivitet med hensyn til alle glucagon-, GLP-1- og GLP-receptorer til behandling af leversygdom
EP4197560A4 (en) * 2020-08-14 2025-11-26 Hanmi Pharmaceutical Co Ltd Pharmaceutical composition comprising a persistent triple activator conjugate used as the active ingredient.

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AU2022302809A1 (en) 2023-11-30
BR112023022445A2 (pt) 2023-12-26
MX2023012935A (es) 2023-11-13
CN117615775A (zh) 2024-02-27
EP4364750A1 (en) 2024-05-08
KR20230004135A (ko) 2023-01-06
CA3216330A1 (en) 2023-01-05
EP4364750A4 (en) 2025-10-22
IL308347A (en) 2024-01-01
US20240293512A1 (en) 2024-09-05
WO2023277620A1 (ko) 2023-01-05

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