JP2024523453A5 - - Google Patents

Info

Publication number
JP2024523453A5
JP2024523453A5 JP2023578817A JP2023578817A JP2024523453A5 JP 2024523453 A5 JP2024523453 A5 JP 2024523453A5 JP 2023578817 A JP2023578817 A JP 2023578817A JP 2023578817 A JP2023578817 A JP 2023578817A JP 2024523453 A5 JP2024523453 A5 JP 2024523453A5
Authority
JP
Japan
Prior art keywords
alkyldiyl
peg
pep
heterocyclyldiyl
immunocomplex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023578817A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024523453A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/034865 external-priority patent/WO2022272039A1/en
Publication of JP2024523453A publication Critical patent/JP2024523453A/ja
Publication of JP2024523453A5 publication Critical patent/JP2024523453A5/ja
Pending legal-status Critical Current

Links

JP2023578817A 2021-06-25 2022-06-24 ビス－ベンゾイミダゾールｓｔｉｎｇアゴニスト免疫複合体及びその使用 Pending JP2024523453A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163215100P 2021-06-25 2021-06-25
US63/215,100 2021-06-25
PCT/US2022/034865 WO2022272039A1 (en) 2021-06-25 2022-06-24 Bis-benzimidazole sting agonist immunoconjugates, and uses thereof

Publications (2)

Publication Number Publication Date
JP2024523453A JP2024523453A (ja) 2024-06-28
JP2024523453A5 true JP2024523453A5 (https=) 2025-06-16

Family

ID=82850579

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023578817A Pending JP2024523453A (ja) 2021-06-25 2022-06-24 ビス－ベンゾイミダゾールｓｔｉｎｇアゴニスト免疫複合体及びその使用

Country Status (9)

Country Link
US (1) US20250057967A2 (https=)
EP (1) EP4359007A1 (https=)
JP (1) JP2024523453A (https=)
KR (1) KR20240027018A (https=)
CN (1) CN117794583A (https=)
AU (1) AU2022300383A1 (https=)
CA (1) CA3222082A1 (https=)
IL (1) IL309278A (https=)
WO (1) WO2022272039A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024137619A1 (en) * 2022-12-20 2024-06-27 Bolt Biotherapeutics, Inc. Anti-claudin, bis-benzimid azole sting agonist immunoconjugates, and uses thereof
WO2024174863A1 (zh) * 2023-02-22 2024-08-29 深圳众格生物科技有限公司 Sting激动剂及其制备方法和医药用途
WO2025029832A2 (en) 2023-07-31 2025-02-06 Sutro Biopharma, Inc. Sting agonist compounds and conjugates
CN117771206B (zh) * 2023-08-02 2024-05-28 首都医科大学附属北京儿童医院 Sting激动剂仿生纳米递送系统及其制备方法和应用
WO2025233676A1 (en) * 2024-05-08 2025-11-13 Ligachem Biosciences Inc. Compositions and methods related to a combination therapy of sting agonists and immune checkpoint inhibitors
WO2025233679A1 (en) * 2024-05-08 2025-11-13 Ligachem Biosciences Inc. Compositions and methods related to a combination therapy of sting agonists and antibody drug conjugates
US20260053942A1 (en) 2024-05-30 2026-02-26 Astellas Pharama Inc. Sting agonist immunostimulatory antibody drug conjugates
WO2026055185A1 (en) * 2024-09-04 2026-03-12 Bolt Biotherapeutics, Inc. Sting agonist immunoconjugates and uses thereof
WO2026078593A1 (en) 2024-10-08 2026-04-16 Sun Pharma Advanced Research Company Limited Sting agonists and antibody drug conjugates thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3440076T (pt) * 2016-04-07 2022-07-29 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas úteis como modeladores de proteína
AR113224A1 (es) * 2017-04-28 2020-02-19 Novartis Ag Conjugados de anticuerpo que comprenden un agonista de sting
CA3077337A1 (en) * 2017-10-05 2019-04-11 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (sting)
AU2018344902B2 (en) * 2017-10-05 2021-06-03 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (STING) useful in treating HIV
EP3848054B1 (en) * 2018-09-06 2025-01-29 Daiichi Sankyo Company, Limited Antibody-drug conjugates of cyclic dinucleotide derivatives
WO2020092617A1 (en) * 2018-10-31 2020-05-07 Novartis Ag Dc-sign antibody conjugates comprising sting agonists
WO2020214858A1 (en) * 2019-04-17 2020-10-22 Avidea Technologies, Inc. Compositions and methods of manufacturing star polymers for ligand display and/or drug delivery
IL287938B2 (en) * 2019-05-10 2025-07-01 Takeda Pharmaceuticals Co Antibody-drug conjugates
US20200390899A1 (en) * 2019-06-13 2020-12-17 Bolt Biotherapeutics, Inc. Aminobenzazepine compounds, immunoconjugates, and uses thereof
CA3147890A1 (en) * 2019-07-19 2021-01-28 Immunesensor Therapeutics, Inc. Antibody-sting agonist conjugates and their use in immunotherapy
IL296901A (en) * 2020-04-02 2022-12-01 Mersana Therapeutics Inc Antibody-drug conjugates comprising sting agonists

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