JP2024523329A - ウイルス性疾患用の温度制御可能な自己複製rnaワクチン - Google Patents

ウイルス性疾患用の温度制御可能な自己複製rnaワクチン Download PDF

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JP2024523329A
JP2024523329A JP2023577464A JP2023577464A JP2024523329A JP 2024523329 A JP2024523329 A JP 2024523329A JP 2023577464 A JP2023577464 A JP 2023577464A JP 2023577464 A JP2023577464 A JP 2023577464A JP 2024523329 A JP2024523329 A JP 2024523329A
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エス.エイチ.コ ミノル
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エリクサージェン セラピューティクス,インコーポレイティド
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215794A1 (en) * 2002-01-31 2003-11-20 Yoshihiro Kawaoka Filovirus vectors and noninfectious Filovirus-based particles
JP2017527557A (ja) * 2014-09-03 2017-09-21 バヴァリアン・ノルディック・アクティーゼルスカブ 組み換え改変ワクシニアウイルスアンカラ(mva)フィロウイルスワクチン
WO2018115527A2 (en) * 2016-12-23 2018-06-28 Curevac Ag Mers coronavirus vaccine
WO2018170347A1 (en) * 2017-03-17 2018-09-20 Modernatx, Inc. Zoonotic disease rna vaccines
WO2018185732A1 (en) * 2017-04-06 2018-10-11 Janssen Vaccines & Prevention B.V. Mva-bn and ad26.zebov or ad26.filo prime-boost regimen
JP2018537521A (ja) * 2015-10-22 2018-12-20 モデルナティーエックス, インコーポレイテッド 広域インフルエンザウイルスワクチン

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017015457A1 (en) * 2015-07-21 2017-01-26 Modernatx, Inc. Ebola vaccine
KR102764120B1 (ko) * 2019-12-31 2025-02-06 엘릭서젠 쎄라퓨틱스, 인크. 핵산 및 단백질의 세포 및 조직으로의 온도-기반 일시적 전달
US20230310581A1 (en) * 2020-04-27 2023-10-05 Ohio State Innovation Foundation A live attenuated measles virus vectored vaccine for sars-cov-2
EP4168042A1 (en) * 2020-06-19 2023-04-26 Ziphius Vaccines Self-amplifying sars-cov-2 rna vaccine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215794A1 (en) * 2002-01-31 2003-11-20 Yoshihiro Kawaoka Filovirus vectors and noninfectious Filovirus-based particles
JP2017527557A (ja) * 2014-09-03 2017-09-21 バヴァリアン・ノルディック・アクティーゼルスカブ 組み換え改変ワクシニアウイルスアンカラ(mva)フィロウイルスワクチン
JP2018537521A (ja) * 2015-10-22 2018-12-20 モデルナティーエックス, インコーポレイテッド 広域インフルエンザウイルスワクチン
WO2018115527A2 (en) * 2016-12-23 2018-06-28 Curevac Ag Mers coronavirus vaccine
WO2018170347A1 (en) * 2017-03-17 2018-09-20 Modernatx, Inc. Zoonotic disease rna vaccines
WO2018185732A1 (en) * 2017-04-06 2018-10-11 Janssen Vaccines & Prevention B.V. Mva-bn and ad26.zebov or ad26.filo prime-boost regimen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE UNIPROTKB/SWISS-PROT[ONLINE], JPN6026021264, 9 October 2014 (2014-10-09), pages 24615 - 1, ISSN: 0005875189 *
DATABASE UNIPROTKB/SWISS-PROT[ONLINE], JPN6026021265, 21 November 2008 (2008-11-21), pages 54251 - 1, ISSN: 0005875190 *
DATABASE UNIPROTKB/SWISS-PROT[ONLINE], JPN6026021266, 21 November 2008 (2008-11-21), pages 28620 - 1, ISSN: 0005875191 *
MOLECULAR THERAPY - NUCLEIC ACIDS, vol. 3, JPN6026021267, 2014, pages 173 - 1, ISSN: 0005875192 *

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