JP2024523006A - 新規なレプリカーゼサイクリング反応(rcr) - Google Patents

新規なレプリカーゼサイクリング反応(rcr) Download PDF

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Publication number
JP2024523006A
JP2024523006A JP2023575381A JP2023575381A JP2024523006A JP 2024523006 A JP2024523006 A JP 2024523006A JP 2023575381 A JP2023575381 A JP 2023575381A JP 2023575381 A JP2023575381 A JP 2023575381A JP 2024523006 A JP2024523006 A JP 2024523006A
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JP
Japan
Prior art keywords
rna
seq
rdrp
mrna
sequence
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Pending
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JP2023575381A
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English (en)
Japanese (ja)
Inventor
リン シー‐ラン
サム‐リン
リン チュン‐ハン
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Individual
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Individual
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Priority claimed from US17/489,357 external-priority patent/US20220396798A1/en
Application filed by Individual filed Critical Individual
Publication of JP2024523006A publication Critical patent/JP2024523006A/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/127RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07Nucleotidyltransferases (2.7.7)
    • C12Y207/07048RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/31Combination therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/20011Coronaviridae
    • C12N2770/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023575381A 2021-06-12 2022-01-21 新規なレプリカーゼサイクリング反応(rcr) Pending JP2024523006A (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202163209969P 2021-06-12 2021-06-12
US63/209,969 2021-06-12
US202163210988P 2021-06-15 2021-06-15
US63/210,988 2021-06-15
US202163212657P 2021-06-19 2021-06-19
US63/212,657 2021-06-19
US202163222398P 2021-07-15 2021-07-15
US63/222,398 2021-07-15
US17/489,357 US20220396798A1 (en) 2021-06-12 2021-09-29 Novel mrna composition and production method for use in anti-viral and anti-cancer vaccines
US17/489,357 2021-09-29
US202163270034P 2021-10-20 2021-10-20
US63/270,034 2021-10-20
US202163280226P 2021-11-17 2021-11-17
US63/280,226 2021-11-17
PCT/US2022/013350 WO2022260718A1 (fr) 2021-06-12 2022-01-21 Nouvelle réaction de cyclage de réplicase (rcr)

Publications (1)

Publication Number Publication Date
JP2024523006A true JP2024523006A (ja) 2024-06-25

Family

ID=84425225

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023575381A Pending JP2024523006A (ja) 2021-06-12 2022-01-21 新規なレプリカーゼサイクリング反応(rcr)

Country Status (2)

Country Link
JP (1) JP2024523006A (fr)
WO (2) WO2022260719A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4219756A1 (fr) 2022-01-24 2023-08-02 Mello Biotech Taiwan Co., Ltd. Fragment d'arn synthétique et ses utilisations pour l'amplification dépendante de l'arn

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153510B1 (en) * 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
AU2002314782A1 (en) * 2001-05-14 2002-11-25 Henry H. Ji Replicase cycling reaction amplification
WO2009075119A1 (fr) * 2007-12-10 2009-06-18 Kyoto University Procédé efficace d'initialisation de noyaux
EP2742127B1 (fr) * 2011-08-12 2019-10-09 Mello Biotechnology, Inc. Expression inductible dans des procaryotes d'un promoteur eucaryotique pol-2
WO2019056090A1 (fr) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta Arn polymérase arn-dépendante recombinante de virus à arn
US20190330591A1 (en) * 2018-01-10 2019-10-31 Rubius Therapeutics, Inc. Amplifiable rnas for therapeutic cell systems
SG11202012786RA (en) * 2018-06-26 2021-01-28 Massachusetts Inst Technology Crispr effector system based amplification methods, systems, and diagnostics

Also Published As

Publication number Publication date
WO2022260718A1 (fr) 2022-12-15
WO2022260719A1 (fr) 2022-12-15

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