JP2024522079A - がん治療における使用のためのミトフェリン-2のインヒビター - Google Patents
がん治療における使用のためのミトフェリン-2のインヒビター Download PDFInfo
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- JP2024522079A JP2024522079A JP2023571846A JP2023571846A JP2024522079A JP 2024522079 A JP2024522079 A JP 2024522079A JP 2023571846 A JP2023571846 A JP 2023571846A JP 2023571846 A JP2023571846 A JP 2023571846A JP 2024522079 A JP2024522079 A JP 2024522079A
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- mitoferrin
- inhibitor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/6851—Quantitative amplification
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Bioinformatics & Cheminformatics (AREA)
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- Physics & Mathematics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
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- Urology & Nephrology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Physics & Mathematics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21175355 | 2021-05-21 | ||
| EP21175355.3 | 2021-05-21 | ||
| PCT/EP2022/063693 WO2022243502A1 (en) | 2021-05-21 | 2022-05-20 | Inhibitors of mitoferrin-2 for use in treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024522079A true JP2024522079A (ja) | 2024-06-11 |
| JP2024522079A5 JP2024522079A5 (https=) | 2025-03-10 |
Family
ID=76059785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023571846A Pending JP2024522079A (ja) | 2021-05-21 | 2022-05-20 | がん治療における使用のためのミトフェリン-2のインヒビター |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20240240190A1 (https=) |
| EP (1) | EP4341402A1 (https=) |
| JP (1) | JP2024522079A (https=) |
| WO (1) | WO2022243502A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023118294A1 (en) * | 2021-12-22 | 2023-06-29 | Vib Vzw | Inhibition of mitoferrin 2 as means for inhibiting cancer and cancer metastasis |
-
2022
- 2022-05-20 EP EP22729690.2A patent/EP4341402A1/en active Pending
- 2022-05-20 WO PCT/EP2022/063693 patent/WO2022243502A1/en not_active Ceased
- 2022-05-20 JP JP2023571846A patent/JP2024522079A/ja active Pending
- 2022-05-20 US US18/562,167 patent/US20240240190A1/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| HUNG, HSIN-I ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 1, JPN6026005020, 2013, pages 677 - 686, ISSN: 0005793464 * |
| LYTOVCHENKO, OLEKSANDR ET AL., BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - BIOENERGETICS, vol. 1858, no. 8, JPN6026005018, 2017, pages 641 - 654, ISSN: 0005793466 * |
| SHEN, YING ET AL., JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 119, no. 11, JPN6026005019, 2018, pages 9178 - 9204, ISSN: 0005793465 * |
| WANG, CHUNLEI ET AL., EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol. 19, no. 1, JPN6026005021, 2014, ISSN: 0005793463 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4341402A1 (en) | 2024-03-27 |
| US20240240190A1 (en) | 2024-07-18 |
| WO2022243502A1 (en) | 2022-11-24 |
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