JP2024521750A - 塩基エディターの自己不活性化のための組成物及び方法 - Google Patents

塩基エディターの自己不活性化のための組成物及び方法 Download PDF

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JP2024521750A
JP2024521750A JP2023572544A JP2023572544A JP2024521750A JP 2024521750 A JP2024521750 A JP 2024521750A JP 2023572544 A JP2023572544 A JP 2023572544A JP 2023572544 A JP2023572544 A JP 2023572544A JP 2024521750 A JP2024521750 A JP 2024521750A
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seq
intron
polynucleotide
domain
base editor
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JP2024521750A5 (enExample
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デビッド ブライソン、
ジャック サリバン、
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ビーム セラピューティクス インク．
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JP2023572544A 2021-05-28 2022-05-27 塩基エディターの自己不活性化のための組成物及び方法 Pending JP2024521750A (ja)

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US202163194431P 2021-05-28 2021-05-28
US63/194,431 2021-05-28
PCT/US2022/031419 WO2022251687A2 (en) 2021-05-28 2022-05-27 Compositions and methods for the self-inactivation of base editors

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US (1) US20240132868A1 (enExample)
EP (1) EP4346840A4 (enExample)
JP (1) JP2024521750A (enExample)
KR (1) KR20240012377A (enExample)
CN (1) CN117729926A (enExample)
AU (1) AU2022280952A1 (enExample)
CA (1) CA3219628A1 (enExample)
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Publication number Priority date Publication date Assignee Title
CN118813611B (zh) * 2023-04-19 2025-09-16 清华大学 一种基于rna核酶的dear核酸操纵系统及其应用
AU2024384487A1 (en) * 2023-11-20 2026-06-04 Beam Therapeutics Inc. Compositions and methods for altering complement activation

Citations (6)

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Publication number Priority date Publication date Assignee Title
JP2018522566A (ja) * 2015-08-07 2018-08-16 カリブー・バイオサイエンシーズ・インコーポレイテッド 操作されたｃｒｉｓｐｒ−ｃａｓ９組成物及び使用方法
WO2020028823A1 (en) * 2018-08-03 2020-02-06 Beam Therapeutics Inc. Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
WO2020051561A1 (en) * 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for delivering a nucleobase editing system
JP2021500041A (ja) * 2017-10-23 2021-01-07 ストーク セラピューティクス，インク． ナンセンス変異依存ｒｎａ分解機構に基づく状態および疾患の処置のためのアンチセンスオリゴマー
WO2021041885A2 (en) * 2019-08-29 2021-03-04 Beam Therapeutics Inc. Compositions and methods for editing a mutation to permit transcription or expression
WO2021050571A1 (en) * 2019-09-09 2021-03-18 Beam Therapeutics Inc. Novel nucleobase editors and methods of using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018027078A1 (en) * 2016-08-03 2018-02-08 President And Fellows Of Harard College Adenosine nucleobase editors and uses thereof
JP2021505159A (ja) * 2017-12-06 2021-02-18 ジェネレーション バイオ カンパニー 修飾型閉端ｄｎａ（ｃｅｄｎａ）を使用する遺伝子編集
KR102853088B1 (ko) * 2018-05-11 2025-09-02 빔 테라퓨틱스, 인크. 프로그래밍가능한 염기 편집기 시스템을 이용하여 단일염기다형성을 편집하는 방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522566A (ja) * 2015-08-07 2018-08-16 カリブー・バイオサイエンシーズ・インコーポレイテッド 操作されたｃｒｉｓｐｒ−ｃａｓ９組成物及び使用方法
JP2021500041A (ja) * 2017-10-23 2021-01-07 ストーク セラピューティクス，インク． ナンセンス変異依存ｒｎａ分解機構に基づく状態および疾患の処置のためのアンチセンスオリゴマー
WO2020028823A1 (en) * 2018-08-03 2020-02-06 Beam Therapeutics Inc. Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
WO2020051561A1 (en) * 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for delivering a nucleobase editing system
WO2021041885A2 (en) * 2019-08-29 2021-03-04 Beam Therapeutics Inc. Compositions and methods for editing a mutation to permit transcription or expression
WO2021050571A1 (en) * 2019-09-09 2021-03-18 Beam Therapeutics Inc. Novel nucleobase editors and methods of using same

Non-Patent Citations (1)

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Title
NUCLEIC ACID RES., vol. 46, no. 14, JPN6026014898, 2018, pages 84, ISSN: 0005846245 *

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WO2022251687A2 (en) 2022-12-01
US20240132868A1 (en) 2024-04-25
AU2022280952A9 (en) 2023-11-30
CA3219628A1 (en) 2022-12-01
WO2022251687A3 (en) 2023-01-19
KR20240012377A (ko) 2024-01-29
AU2022280952A1 (en) 2023-11-23
EP4346840A2 (en) 2024-04-10
CN117729926A (zh) 2024-03-19
EP4346840A4 (en) 2025-06-04

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