JP2024521025A - がん免疫治療のためのキメラ抗原受容体で改変された顆粒球－マクロファージ前駆体 - Google Patents

がん免疫治療のためのキメラ抗原受容体で改変された顆粒球－マクロファージ前駆体 Download PDF

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JP2024521025A
JP2024521025A JP2023568170A JP2023568170A JP2024521025A JP 2024521025 A JP2024521025 A JP 2024521025A JP 2023568170 A JP2023568170 A JP 2023568170A JP 2023568170 A JP2023568170 A JP 2023568170A JP 2024521025 A JP2024521025 A JP 2024521025A
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cancer
car
cells
gmp
cell
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イン、チーロン
ユエ、シ
ジン、シュエユエン
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ユニバーシティ オブ サザン カリフォルニア
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JP2023568170A 2021-05-19 2022-05-19 がん免疫治療のためのキメラ抗原受容体で改変された顆粒球－マクロファージ前駆体 Pending JP2024521025A (ja)

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US202163190387P 2021-05-19 2021-05-19
US63/190,387 2021-05-19
PCT/US2022/030109 WO2022246112A1 (en) 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy

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JP2024521025A true JP2024521025A (ja) 2024-05-28
JP2024521025A5 JP2024521025A5 (https=) 2025-05-19

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US (1) US20240240147A1 (https=)
EP (1) EP4340871A4 (https=)
JP (1) JP2024521025A (https=)
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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024123682A1 (en) * 2022-12-05 2024-06-13 Shoreline Biosciences, Inc. Methods and compositions for generating modified pluripotent cells and derivates thereof
CN115814108B (zh) * 2022-12-27 2025-04-25 华中科技大学 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法
CN116218786B (zh) * 2023-03-09 2024-01-23 山东大学齐鲁医院 一种多重基因编辑的通用型巨噬细胞及在制备抗肿瘤药物中的应用
JP2026508020A (ja) * 2023-03-09 2026-03-09 クリエイト・メディシンズ，インコーポレーテッド インビボ送達構築物の発現を制御するためのｍｉＲＮＡ
WO2025046513A1 (en) * 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
CN118845835A (zh) * 2024-09-24 2024-10-29 杭州阿克索生物科技有限责任公司 一种含有细胞因子的组合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170166657A1 (en) * 2015-08-13 2017-06-15 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) In Immunotherapy
JP2018521667A (ja) * 2015-07-28 2018-08-09 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用
WO2020076739A1 (en) * 2018-10-08 2020-04-16 University Of Southern California Methods for the long-term expansion of granulocyte-macrophage progenitors and applications thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016179319A1 (en) * 2015-05-04 2016-11-10 Cellerant Therapeutics, Inc. Chimeric antigen receptors with ctla4 signal transduction domains
WO2019135879A1 (en) * 2018-01-05 2019-07-11 Thunder Biotech, Inc. Modified macrophages and macrophage precursors and associated methods
SG11202007171PA (en) * 2018-02-02 2020-08-28 Univ Pennsylvania Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates
CN109266618B (zh) * 2018-10-18 2021-04-23 赛元生物科技(杭州)有限公司 能够靶向肿瘤细胞的巨噬细胞及其制备方法
US10980836B1 (en) * 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018521667A (ja) * 2015-07-28 2018-08-09 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア キメラ抗原受容体を発現する改変された単球／マクロファージおよびその使用
US20170166657A1 (en) * 2015-08-13 2017-06-15 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) In Immunotherapy
WO2020076739A1 (en) * 2018-10-08 2020-04-16 University Of Southern California Methods for the long-term expansion of granulocyte-macrophage progenitors and applications thereof

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