CA3215633A1 - Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy - Google Patents

Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy Download PDF

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Publication number
CA3215633A1
CA3215633A1 CA3215633A CA3215633A CA3215633A1 CA 3215633 A1 CA3215633 A1 CA 3215633A1 CA 3215633 A CA3215633 A CA 3215633A CA 3215633 A CA3215633 A CA 3215633A CA 3215633 A1 CA3215633 A1 CA 3215633A1
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Prior art keywords
cancer
gmps
car
cells
cell
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CA3215633A
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English (en)
French (fr)
Inventor
Qi-Long Ying
Shi Yue
Xueyuan JING
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University of Southern California USC
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University of Southern California USC
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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CA3215633A 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy Pending CA3215633A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163190387P 2021-05-19 2021-05-19
US63/190,387 2021-05-19
PCT/US2022/030109 WO2022246112A1 (en) 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy

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CA3215633A1 true CA3215633A1 (en) 2022-11-24

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CA3215633A Pending CA3215633A1 (en) 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy

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US (1) US20240240147A1 (https=)
EP (1) EP4340871A4 (https=)
JP (1) JP2024521025A (https=)
KR (1) KR20240009461A (https=)
CN (1) CN117295515A (https=)
AU (1) AU2022275952A1 (https=)
CA (1) CA3215633A1 (https=)
WO (1) WO2022246112A1 (https=)

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WO2024123682A1 (en) * 2022-12-05 2024-06-13 Shoreline Biosciences, Inc. Methods and compositions for generating modified pluripotent cells and derivates thereof
CN115814108B (zh) * 2022-12-27 2025-04-25 华中科技大学 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法
CN116218786B (zh) * 2023-03-09 2024-01-23 山东大学齐鲁医院 一种多重基因编辑的通用型巨噬细胞及在制备抗肿瘤药物中的应用
JP2026508020A (ja) * 2023-03-09 2026-03-09 クリエイト・メディシンズ，インコーポレーテッド インビボ送達構築物の発現を制御するためのｍｉＲＮＡ
WO2025046513A1 (en) * 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
CN118845835A (zh) * 2024-09-24 2024-10-29 杭州阿克索生物科技有限责任公司 一种含有细胞因子的组合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016179319A1 (en) * 2015-05-04 2016-11-10 Cellerant Therapeutics, Inc. Chimeric antigen receptors with ctla4 signal transduction domains
IL315940A (en) * 2015-07-28 2024-11-01 Univ Pennsylvania Altered monocytes/macrophages expressing chimeric antigen receptors and their uses
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
WO2019135879A1 (en) * 2018-01-05 2019-07-11 Thunder Biotech, Inc. Modified macrophages and macrophage precursors and associated methods
SG11202007171PA (en) * 2018-02-02 2020-08-28 Univ Pennsylvania Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates
CN111004781A (zh) * 2018-10-08 2020-04-14 南加利福尼亚大学 长期扩增粒细胞-巨噬细胞祖细胞的方法及其应用
CN109266618B (zh) * 2018-10-18 2021-04-23 赛元生物科技(杭州)有限公司 能够靶向肿瘤细胞的巨噬细胞及其制备方法
US10980836B1 (en) * 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof

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