CN117295515A - 用于癌症免疫治疗的嵌合抗原受体修饰的粒细胞-巨噬细胞祖细胞 - Google Patents

用于癌症免疫治疗的嵌合抗原受体修饰的粒细胞-巨噬细胞祖细胞 Download PDF

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CN117295515A
CN117295515A CN202280032274.1A CN202280032274A CN117295515A CN 117295515 A CN117295515 A CN 117295515A CN 202280032274 A CN202280032274 A CN 202280032274A CN 117295515 A CN117295515 A CN 117295515A
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cancer
gmp
car
carcinoma
cell
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应其龙
岳士
景雪媛
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University of Southern California USC
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University of Southern California USC
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CN202280032274.1A 2021-05-19 2022-05-19 用于癌症免疫治疗的嵌合抗原受体修饰的粒细胞-巨噬细胞祖细胞 Pending CN117295515A (zh)

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US202163190387P 2021-05-19 2021-05-19
US63/190,387 2021-05-19
PCT/US2022/030109 WO2022246112A1 (en) 2021-05-19 2022-05-19 Chimeric antigen receptor-modified granulocyte-macrophage progenitors for cancer immunotherapy

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CN117295515A true CN117295515A (zh) 2023-12-26

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US (1) US20240240147A1 (https=)
EP (1) EP4340871A4 (https=)
JP (1) JP2024521025A (https=)
KR (1) KR20240009461A (https=)
CN (1) CN117295515A (https=)
AU (1) AU2022275952A1 (https=)
CA (1) CA3215633A1 (https=)
WO (1) WO2022246112A1 (https=)

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CN118845835A (zh) * 2024-09-24 2024-10-29 杭州阿克索生物科技有限责任公司 一种含有细胞因子的组合物及其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024123682A1 (en) * 2022-12-05 2024-06-13 Shoreline Biosciences, Inc. Methods and compositions for generating modified pluripotent cells and derivates thereof
CN115814108B (zh) * 2022-12-27 2025-04-25 华中科技大学 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法
CN116218786B (zh) * 2023-03-09 2024-01-23 山东大学齐鲁医院 一种多重基因编辑的通用型巨噬细胞及在制备抗肿瘤药物中的应用
JP2026508020A (ja) * 2023-03-09 2026-03-09 クリエイト・メディシンズ，インコーポレーテッド インビボ送達構築物の発現を制御するためのｍｉＲＮＡ
WO2025046513A1 (en) * 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016179319A1 (en) * 2015-05-04 2016-11-10 Cellerant Therapeutics, Inc. Chimeric antigen receptors with ctla4 signal transduction domains
IL315940A (en) * 2015-07-28 2024-11-01 Univ Pennsylvania Altered monocytes/macrophages expressing chimeric antigen receptors and their uses
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
WO2019135879A1 (en) * 2018-01-05 2019-07-11 Thunder Biotech, Inc. Modified macrophages and macrophage precursors and associated methods
SG11202007171PA (en) * 2018-02-02 2020-08-28 Univ Pennsylvania Modified monocytes/macrophages/dendritic cells expressing chimeric antigen receptors and uses in diseases and disorders associated with protein aggregates
CN111004781A (zh) * 2018-10-08 2020-04-14 南加利福尼亚大学 长期扩增粒细胞-巨噬细胞祖细胞的方法及其应用
CN109266618B (zh) * 2018-10-18 2021-04-23 赛元生物科技(杭州)有限公司 能够靶向肿瘤细胞的巨噬细胞及其制备方法
US10980836B1 (en) * 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118845835A (zh) * 2024-09-24 2024-10-29 杭州阿克索生物科技有限责任公司 一种含有细胞因子的组合物及其制备方法和应用

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