JP2024520713A - Ｍｅｔｔｌ３阻害剤とさらなる抗がん剤を含む併用療法 - Google Patents

Ｍｅｔｔｌ３阻害剤とさらなる抗がん剤を含む併用療法 Download PDF

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Publication number
JP2024520713A
JP2024520713A JP2023574679A JP2023574679A JP2024520713A JP 2024520713 A JP2024520713 A JP 2024520713A JP 2023574679 A JP2023574679 A JP 2023574679A JP 2023574679 A JP2023574679 A JP 2023574679A JP 2024520713 A JP2024520713 A JP 2024520713A
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Prior art keywords
methyl
inhibitor
acceptable salt
pharma
carboxamide
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JP2024520713A5 (https=
Inventor
ラウシュ，オリバー・ラース
アルバーテラ，マーク・ロバート
オフィール・ローゼンフェルト，ヤーラ
ヴァシロウスカイテ，リナ
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Storm Therapeutics Ltd
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Storm Therapeutics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
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  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023574679A 2021-06-02 2022-06-01 Ｍｅｔｔｌ３阻害剤とさらなる抗がん剤を含む併用療法 Pending JP2024520713A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2107907.4 2021-06-02
GBGB2107907.4A GB202107907D0 (en) 2021-06-02 2021-06-02 Combination therapies
PCT/GB2022/051400 WO2022254216A1 (en) 2021-06-02 2022-06-01 Combination therapies comprising a mettl3 inhibitor and a further anticancer agent

Publications (2)

Publication Number Publication Date
JP2024520713A true JP2024520713A (ja) 2024-05-24
JP2024520713A5 JP2024520713A5 (https=) 2025-06-06

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JP2023574679A Pending JP2024520713A (ja) 2021-06-02 2022-06-01 Ｍｅｔｔｌ３阻害剤とさらなる抗がん剤を含む併用療法

Country Status (8)

Country Link
US (1) US20240277715A1 (https=)
EP (1) EP4346814A1 (https=)
JP (1) JP2024520713A (https=)
CN (1) CN117460508A (https=)
AU (1) AU2022285928A1 (https=)
CA (1) CA3221771A1 (https=)
GB (1) GB202107907D0 (https=)
WO (1) WO2022254216A1 (https=)

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CN117720533A (zh) * 2022-09-16 2024-03-19 北京华益健康药物研究中心 Mettl3抑制剂化合物及其药物组合物和应用
AU2024244637A1 (en) 2023-03-30 2025-10-16 Aqemia Novel mettl3 inhibitors and use thereof in therapy
WO2025121807A1 (ko) * 2023-12-08 2025-06-12 인제대학교 산학협력단 Ezh2 저해제 및 mettl3 억제제를 포함하는 암의 예방 또는 치료용 약제학적 조성물
KR20250088372A (ko) * 2023-12-08 2025-06-17 인제대학교 산학협력단 Btk 분해제와 mettl3 억제제를 포함하는 암의 예방 또는 치료용 약제학적 조성물
WO2025237957A1 (en) * 2024-05-14 2025-11-20 Institut Curie Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor
WO2026017846A1 (en) * 2024-07-19 2026-01-22 Epics Therapeutics Piperidine derivatives as mettl3 inhibitors for the treatment of carcinomas
WO2026017844A1 (en) * 2024-07-19 2026-01-22 Epics Therapeutics Combination therapies comprising a mettl3 inhibitor and a bcl2 inhibitor
CN118948887B (zh) * 2024-07-26 2026-03-27 新乡市中心医院(新乡中原医院管理中心) Mettl3抑制剂联合化疗药顺铂对宫颈癌的应用

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US20240277715A1 (en) 2024-08-22
GB202107907D0 (en) 2021-07-14
CN117460508A (zh) 2024-01-26
CA3221771A1 (en) 2022-12-08
EP4346814A1 (en) 2024-04-10
AU2022285928A1 (en) 2024-01-04
WO2022254216A1 (en) 2022-12-08

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