CN117460508A - 包含mettl3抑制剂和另外的抗癌剂的联合疗法 - Google Patents

包含mettl3抑制剂和另外的抗癌剂的联合疗法 Download PDF

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Publication number
CN117460508A
CN117460508A CN202280040000.7A CN202280040000A CN117460508A CN 117460508 A CN117460508 A CN 117460508A CN 202280040000 A CN202280040000 A CN 202280040000A CN 117460508 A CN117460508 A CN 117460508A
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methyl
inhibitor
pharmaceutically acceptable
acceptable salt
carboxamide
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Pending
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CN202280040000.7A
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English (en)
Chinese (zh)
Inventor
奥利弗·拉尔斯·劳施
马克·罗伯特·阿尔贝泰拉
雅拉·奥菲尔-罗森菲尔德
莉娜·瓦西里奥斯凯特
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Storm Treatment Co ltd
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Storm Treatment Co ltd
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Publication of CN117460508A publication Critical patent/CN117460508A/zh
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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  • Endocrinology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202280040000.7A 2021-06-02 2022-06-01 包含mettl3抑制剂和另外的抗癌剂的联合疗法 Pending CN117460508A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2107907.4 2021-06-02
GBGB2107907.4A GB202107907D0 (en) 2021-06-02 2021-06-02 Combination therapies
PCT/GB2022/051400 WO2022254216A1 (en) 2021-06-02 2022-06-01 Combination therapies comprising a mettl3 inhibitor and a further anticancer agent

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Publication Number Publication Date
CN117460508A true CN117460508A (zh) 2024-01-26

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CN202280040000.7A Pending CN117460508A (zh) 2021-06-02 2022-06-01 包含mettl3抑制剂和另外的抗癌剂的联合疗法

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Country Link
US (1) US20240277715A1 (https=)
EP (1) EP4346814A1 (https=)
JP (1) JP2024520713A (https=)
CN (1) CN117460508A (https=)
AU (1) AU2022285928A1 (https=)
CA (1) CA3221771A1 (https=)
GB (1) GB202107907D0 (https=)
WO (1) WO2022254216A1 (https=)

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WO2025121807A1 (ko) * 2023-12-08 2025-06-12 인제대학교 산학협력단 Ezh2 저해제 및 mettl3 억제제를 포함하는 암의 예방 또는 치료용 약제학적 조성물
KR20250088372A (ko) * 2023-12-08 2025-06-17 인제대학교 산학협력단 Btk 분해제와 mettl3 억제제를 포함하는 암의 예방 또는 치료용 약제학적 조성물
WO2025237957A1 (en) * 2024-05-14 2025-11-20 Institut Curie Composition for treatment of estrogen-dependent cancer comprising a mettl-3 inhibitor and a topoisomerase-1 inhibitor
WO2026017846A1 (en) * 2024-07-19 2026-01-22 Epics Therapeutics Piperidine derivatives as mettl3 inhibitors for the treatment of carcinomas
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AU2022285928A1 (en) 2024-01-04
WO2022254216A1 (en) 2022-12-08

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