JP2024519888A5 - - Google Patents
Info
- Publication number
- JP2024519888A5 JP2024519888A5 JP2023571788A JP2023571788A JP2024519888A5 JP 2024519888 A5 JP2024519888 A5 JP 2024519888A5 JP 2023571788 A JP2023571788 A JP 2023571788A JP 2023571788 A JP2023571788 A JP 2023571788A JP 2024519888 A5 JP2024519888 A5 JP 2024519888A5
- Authority
- JP
- Japan
- Prior art keywords
- retinal
- capsid protein
- polynucleotides
- seq
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110594986 | 2021-05-28 | ||
| CN202110594986.X | 2021-05-28 | ||
| PCT/CN2022/095422 WO2022247917A1 (zh) | 2021-05-28 | 2022-05-27 | 衣壳变异的重组腺相关病毒及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024519888A JP2024519888A (ja) | 2024-05-21 |
| JP2024519888A5 true JP2024519888A5 (cg-RX-API-DMAC7.html) | 2025-06-09 |
Family
ID=84228446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023571788A Pending JP2024519888A (ja) | 2021-05-28 | 2022-05-27 | カプシド変異を有する組換えアデノ随伴ウイルス及びその応用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240252679A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4349852A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2024519888A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20240014477A (cg-RX-API-DMAC7.html) |
| CN (1) | CN117157309A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2022281825A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112023024375A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3219898A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2023014041A (cg-RX-API-DMAC7.html) |
| TW (1) | TW202313096A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2022247917A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7842082B2 (ja) * | 2020-07-21 | 2026-04-07 | エフティージェン コーポレーション | 眼疾患を処置するための組成物および方法 |
| CN116789739B (zh) * | 2022-12-08 | 2024-01-26 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN118307648A (zh) * | 2023-01-09 | 2024-07-09 | 广东克冠达医药科技有限公司 | 腺相关病毒衣壳蛋白衍生多肽及其用途 |
| CN118359687A (zh) * | 2023-01-18 | 2024-07-19 | 上海朗昇生物科技有限公司 | 一种新衣壳蛋白变体以及其用途 |
| CN118420721A (zh) * | 2023-01-31 | 2024-08-02 | 上海朗昇生物科技有限公司 | 一种组织嗜性的腺相关病毒衣壳及其用途 |
| EP4688807A1 (en) * | 2023-03-31 | 2026-02-11 | Exegenesis Bio Singapore Pte. Ltd. | Variant aav9 capsid proteins and uses thereof |
| AU2024276934A1 (en) * | 2023-05-23 | 2025-12-18 | Innovec Biotherapeutics | Adeno-associated virus capsid protein, adeno-associated virus containing same, vector and use thereof |
| CN117801076B (zh) * | 2023-06-09 | 2024-05-31 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN116836237B (zh) * | 2023-06-16 | 2023-12-05 | 广州译码基因科技有限公司 | 提高视网膜靶向性的aav病毒衣壳蛋白突变体及其应用 |
| TW202508610A (zh) | 2023-08-23 | 2025-03-01 | 大陸商上海瑞宏迪醫藥有限公司 | 醫藥組成物及其用途 |
| CN119569833A (zh) * | 2023-09-06 | 2025-03-07 | 北京锦篮基因科技有限公司 | 靶向骨骼肌的aav衣壳蛋白变体及其用途 |
| CN119569834A (zh) * | 2023-09-06 | 2025-03-07 | 北京锦篮基因科技有限公司 | 靶向心肌细胞的aav衣壳蛋白变体及其用途 |
| CN120230798A (zh) * | 2023-12-29 | 2025-07-01 | 上海朗昇生物科技有限公司 | 用于视网膜基因递送的重组腺相关病毒载体及其应用 |
| WO2026033140A1 (en) * | 2024-08-09 | 2026-02-12 | Revvity Gene Delivery Gmbh | Variant aav capsid polypeptides targeting the eye |
| CN119039401B (zh) * | 2024-08-19 | 2025-04-11 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
| CN118754952B (zh) * | 2024-09-06 | 2025-01-10 | 上海玮美基因科技有限责任公司 | 一种新型腺相关病毒及其应用 |
| CN120118955A (zh) * | 2025-03-05 | 2025-06-10 | 广州派真生物技术有限公司 | 一种高产aav的包装质粒及应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| CA2158745C (en) | 1993-03-25 | 2007-06-19 | Richard L. Kendall | Inhibitor of vascular endothelial cell growth factor |
| WO1998011244A2 (en) | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Aav4 vector and uses thereof |
| KR100816621B1 (ko) | 1997-04-07 | 2008-03-24 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| WO1999061601A2 (en) | 1998-05-28 | 1999-12-02 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Aav5 vector and uses thereof |
| ATE362542T1 (de) | 1998-11-05 | 2007-06-15 | Univ Pennsylvania | Nukleinsäuresequenzen des adeno-assoziierten virus des serotyps i, und vektoren und wirtszellen, die diese enthalten |
| AU780231B2 (en) | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| JP2003523320A (ja) | 1999-09-29 | 2003-08-05 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ウイルスベクターの迅速なｐｅｇ改変方法、高められた遺伝子形質導入のための組成物、高められた物理的安定性を伴う組成物、およびそのための用途 |
| HK1047109A1 (zh) | 1999-10-15 | 2003-02-07 | University Of Massachusetts | 作为指定基因干预工具的rna干预轨迹基因 |
| ES2336887T5 (es) | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| WO2001089304A1 (en) | 2000-05-23 | 2001-11-29 | University Of Rochester | Method of producing herpes simplex virus amplicons, resulting amplicons, and their use |
| WO2001092513A1 (en) | 2000-05-30 | 2001-12-06 | Johnson & Johnson Research Pty Limited | METHODS FOR MEDIATING GENE SUPPRESION BY USING FACTORS THAT ENHANCE RNAi |
| CA2456008A1 (en) | 2000-08-19 | 2002-02-28 | Axordia Limited | Stem cell differentiation |
| WO2002029858A2 (en) | 2000-09-29 | 2002-04-11 | Infineon Technologies North America Corp. | Deep trench etching method to reduce/eliminate formation of black silicon |
| US20030144221A1 (en) | 2001-07-17 | 2003-07-31 | Isis Pharmaceuticals Inc. | Antisense modulation of BCL2-associated X protein expression |
| US20070061084A1 (en) * | 2002-01-24 | 2007-03-15 | Ecopia Biosciences, Inc. | Method, system, and knowledge repository for identifying a secondary metabolite from a microorganism |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| US20040023390A1 (en) | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
| SI1633772T1 (sl) | 2003-06-19 | 2016-06-30 | Genzyme Corporation | AAV virioni z zmanjšano imunoreaktivnostjo in uporaba za ta namen |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US20060166363A1 (en) | 2004-01-27 | 2006-07-27 | Sergei Zolotukhin | Modified baculovirus expression system for production of pseudotyped rAAV vector |
| US7872118B2 (en) | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| EP3028707A1 (en) | 2009-05-01 | 2016-06-08 | Ophthotech Corporation | Methods for treating or preventing ophthalmological diseases |
| EP2561073B1 (en) | 2010-04-23 | 2016-08-24 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| CN105755044A (zh) * | 2011-04-22 | 2016-07-13 | 加利福尼亚大学董事会 | 具有变异衣壳的腺相关病毒病毒体及其使用方法 |
| MX367100B (es) | 2012-02-17 | 2019-08-05 | The Children´S Hospital Of Philadelphia | Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos. |
| TWI698240B (zh) | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| ES2926774T3 (es) | 2013-03-15 | 2022-10-28 | Univ North Carolina Chapel Hill | Métodos y composiciones para vectores AAV de doble unión de glicano |
| EP3151866B1 (en) | 2014-06-09 | 2023-03-08 | Voyager Therapeutics, Inc. | Chimeric capsids |
| US11021519B2 (en) * | 2015-03-02 | 2021-06-01 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| US11364308B2 (en) * | 2016-05-13 | 2022-06-21 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and methods of use thereof |
| AU2017302013B2 (en) | 2016-07-29 | 2022-05-26 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| CA3040179A1 (en) * | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| JP2020510424A (ja) | 2017-02-28 | 2020-04-09 | アドヴェラム バイオテクノロジーズ， インコーポレイテッド | 改変ａａｖカプシドおよびその使用 |
| CN111770999A (zh) * | 2017-11-27 | 2020-10-13 | 4D分子治疗有限公司 | 腺相关病毒变体衣壳和用于抑制血管生成的应用 |
| HRP20260137T1 (hr) * | 2019-09-11 | 2026-03-13 | Adverum Biotechnologies, Inc. | Liječenje očnih neovaskularnih bolesti upotrebom aav2 varijanti koje kodiraju aflibercept |
| CN114729009A (zh) * | 2019-10-31 | 2022-07-08 | 伯尔尼大学 | 用于眼部基因递送的aav载体变体 |
-
2022
- 2022-05-27 US US18/564,584 patent/US20240252679A1/en active Pending
- 2022-05-27 MX MX2023014041A patent/MX2023014041A/es unknown
- 2022-05-27 EP EP22810641.5A patent/EP4349852A4/en active Pending
- 2022-05-27 JP JP2023571788A patent/JP2024519888A/ja active Pending
- 2022-05-27 CN CN202280028081.9A patent/CN117157309A/zh active Pending
- 2022-05-27 TW TW111119884A patent/TW202313096A/zh unknown
- 2022-05-27 AU AU2022281825A patent/AU2022281825A1/en active Pending
- 2022-05-27 WO PCT/CN2022/095422 patent/WO2022247917A1/zh not_active Ceased
- 2022-05-27 BR BR112023024375A patent/BR112023024375A2/pt unknown
- 2022-05-27 KR KR1020237043802A patent/KR20240014477A/ko active Pending
- 2022-05-27 CA CA3219898A patent/CA3219898A1/en active Pending
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