JP2024517695A - 複素環式化合物及び使用方法 - Google Patents

複素環式化合物及び使用方法 Download PDF

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Publication number
JP2024517695A
JP2024517695A JP2023565518A JP2023565518A JP2024517695A JP 2024517695 A JP2024517695 A JP 2024517695A JP 2023565518 A JP2023565518 A JP 2023565518A JP 2023565518 A JP2023565518 A JP 2023565518A JP 2024517695 A JP2024517695 A JP 2024517695A
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cancer
diazabicyclo
methoxy
fluorotetrahydro
pyrrolidin
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JP2023565518A
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Japanese (ja)
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JPWO2022232331A5 (https=
JP2024517695A5 (https=
Inventor
ランマン，ブライアン
ブルツ，ライアン・ポール
ジャオ，ウェイ
リー，シャオフェン
ヤマノ，マイケル・エム
リー，ユンシャオ
チェン，ニン
ヒューズモーエン，ビアギッテ・バインライヒ
レス－ペーテルゼン，セバスティアン
メディナ，ホセ・エム
リー，カーシュエ
ペタス，リピング
ラヒモフ，レーネ
ナバラトネ，プリマリ・バスンデラ
ルイ，ホワン
モーア，クリストファー・ピー
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アムジエン・インコーポレーテツド
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Publication of JP2024517695A publication Critical patent/JP2024517695A/ja
Publication of JPWO2022232331A5 publication Critical patent/JPWO2022232331A5/ja
Publication of JP2024517695A5 publication Critical patent/JP2024517695A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023565518A 2021-04-29 2022-04-28 複素環式化合物及び使用方法 Pending JP2024517695A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163181625P 2021-04-29 2021-04-29
US63/181,625 2021-04-29
US202163277309P 2021-11-09 2021-11-09
US63/277,309 2021-11-09
PCT/US2022/026623 WO2022232331A1 (en) 2021-04-29 2022-04-28 Heterocyclic compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2024517695A true JP2024517695A (ja) 2024-04-23
JPWO2022232331A5 JPWO2022232331A5 (https=) 2025-05-08
JP2024517695A5 JP2024517695A5 (https=) 2025-05-08

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JP2023565518A Pending JP2024517695A (ja) 2021-04-29 2022-04-28 複素環式化合物及び使用方法

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US (1) US20250059205A1 (https=)
EP (1) EP4329757A4 (https=)
JP (1) JP2024517695A (https=)
AU (1) AU2022264784A1 (https=)
CA (1) CA3217856A1 (https=)
MX (1) MX2023012726A (https=)
WO (1) WO2022232331A1 (https=)

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CN118556063A (zh) * 2022-01-21 2024-08-27 上海湃隆生物科技有限公司 杂环类化合物、药物组合物及其应用
AU2023218370B2 (en) 2022-02-09 2024-11-28 Quanta Therapeutics, Inc. Kras modulators and uses thereof
CN119136806A (zh) 2022-03-08 2024-12-13 锐新医药公司 用于治疗免疫难治性肺癌的方法
WO2023198191A1 (zh) * 2022-04-15 2023-10-19 杭州多域生物技术有限公司 一种六元并六元化合物、制备方法、药物组合物和应用
IL317601A (en) 2022-05-25 2025-02-01 Quanta Therapeutics Inc Pyrimidine-based modulators and their uses
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
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KR20250042155A (ko) 2022-07-27 2025-03-26 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 축합 고리계 화합물, 이의 제조 방법 및 이의 의학적 응용
WO2024046370A1 (zh) * 2022-08-30 2024-03-07 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物，及其制备和治疗用途
CN121419983A (zh) 2023-01-26 2026-01-27 阿尔维纳斯运营股份有限公司 基于小脑蛋白的kras降解protac及其相关用途
WO2024192424A1 (en) 2023-03-15 2024-09-19 Quanta Therapeutics, Inc. Kras modulators and uses thereof
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
CN121263418A (zh) 2023-04-07 2026-01-02 锐新医药公司 大环ras抑制剂
KR20260005904A (ko) 2023-04-07 2026-01-12 레볼루션 메디슨즈, 인크. 매크로사이클릭 ras 억제제
AU2024252105A1 (en) 2023-04-14 2025-10-16 Revolution Medicines, Inc. Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
KR20250172857A (ko) 2023-04-14 2025-12-09 레볼루션 메디슨즈, 인크. Ras 억제제의 결정형
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025006704A1 (en) * 2023-06-30 2025-01-02 Gilead Sciences, Inc. Kras modulating compounds
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
WO2025076288A1 (en) 2023-10-06 2025-04-10 Amgen Inc. Combination therapy for cancer treatment
AU2024357850A1 (en) 2023-10-09 2026-04-23 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
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WO2017172979A1 (en) * 2016-03-30 2017-10-05 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
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JP2023531269A (ja) * 2020-06-30 2023-07-21 インベンティスバイオ カンパニー リミテッド キナゾリン化合物、その製造方法および用途
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JP2024508755A (ja) * 2021-02-16 2024-02-28 セラス， インコーポレイテッド Ｋｒａｓを阻害するための組成物及び方法
JP2024510207A (ja) * 2021-03-12 2024-03-06 ブリストル－マイヤーズ スクイブ カンパニー Ｋｒａｓ阻害剤
JP2024510606A (ja) * 2021-03-12 2024-03-08 ブリストル－マイヤーズ スクイブ カンパニー Ｋｒａｓ ｇ１２ｄ阻害剤
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Publication number Publication date
AU2022264784A1 (en) 2023-11-16
WO2022232331A1 (en) 2022-11-03
EP4329757A4 (en) 2025-03-26
MX2023012726A (es) 2024-01-04
EP4329757A1 (en) 2024-03-06
US20250059205A1 (en) 2025-02-20
CA3217856A1 (en) 2022-11-03

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