JP2024517695A - 複素環式化合物及び使用方法 - Google Patents

複素環式化合物及び使用方法 Download PDF

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Publication number
JP2024517695A
JP2024517695A JP2023565518A JP2023565518A JP2024517695A JP 2024517695 A JP2024517695 A JP 2024517695A JP 2023565518 A JP2023565518 A JP 2023565518A JP 2023565518 A JP2023565518 A JP 2023565518A JP 2024517695 A JP2024517695 A JP 2024517695A
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Japan
Prior art keywords
cancer
diazabicyclo
methoxy
fluorotetrahydro
pyrrolidin
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JP2023565518A
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Japanese (ja)
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JP2024517695A5 (https=
Inventor
ランマン，ブライアン
ブルツ，ライアン・ポール
ジャオ，ウェイ
リー，シャオフェン
ヤマノ，マイケル・エム
リー，ユンシャオ
チェン，ニン
ヒューズモーエン，ビアギッテ・バインライヒ
レス－ペーテルゼン，セバスティアン
メディナ，ホセ・エム
リー，カーシュエ
ペタス，リピング
ラヒモフ，レーネ
ナバラトネ，プリマリ・バスンデラ
ルイ，ホワン
モーア，クリストファー・ピー
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アムジエン・インコーポレーテツド
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Publication of JP2024517695A publication Critical patent/JP2024517695A/ja
Publication of JP2024517695A5 publication Critical patent/JP2024517695A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023565518A 2021-04-29 2022-04-28 複素環式化合物及び使用方法 Pending JP2024517695A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163181625P 2021-04-29 2021-04-29
US63/181,625 2021-04-29
US202163277309P 2021-11-09 2021-11-09
US63/277,309 2021-11-09
PCT/US2022/026623 WO2022232331A1 (en) 2021-04-29 2022-04-28 Heterocyclic compounds and methods of use

Publications (2)

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JP2024517695A true JP2024517695A (ja) 2024-04-23
JP2024517695A5 JP2024517695A5 (https=) 2025-05-08

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US (1) US20250059205A1 (https=)
EP (1) EP4329757A4 (https=)
JP (1) JP2024517695A (https=)
AU (1) AU2022264784A1 (https=)
CA (1) CA3217856A1 (https=)
MX (1) MX2023012726A (https=)
WO (1) WO2022232331A1 (https=)

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CN118434748A (zh) * 2022-04-15 2024-08-02 杭州多域生物技术有限公司 一种六元并六元化合物、制备方法、药物组合物和应用
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TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
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US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
TW202529804A (zh) 2023-10-06 2025-08-01 美商安進公司 用於癌症治療的組合療法
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
US20250114346A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
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Publication number Publication date
EP4329757A1 (en) 2024-03-06
AU2022264784A1 (en) 2023-11-16
US20250059205A1 (en) 2025-02-20
CA3217856A1 (en) 2022-11-03
MX2023012726A (es) 2024-01-04
WO2022232331A1 (en) 2022-11-03
EP4329757A4 (en) 2025-03-26

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