JP2024516678A - 敗血症の早期検出用のｓｔｒｅｍ１マーカーパネル - Google Patents

敗血症の早期検出用のｓｔｒｅｍ１マーカーパネル Download PDF

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Publication number
JP2024516678A
JP2024516678A JP2023566802A JP2023566802A JP2024516678A JP 2024516678 A JP2024516678 A JP 2024516678A JP 2023566802 A JP2023566802 A JP 2023566802A JP 2023566802 A JP2023566802 A JP 2023566802A JP 2024516678 A JP2024516678 A JP 2024516678A
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Prior art keywords
biomarker
amount
subject
hbp
bilirubin
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JP2023566802A
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Japanese (ja)
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JP2024516678A5 (https=
Inventor
グリューネバルト，フェリックス
イェーガー，ヴィクトル・ヨハン・ラウル
クラマー，マルティン
シュッツ，フィリップ
ホルタイ，マリア フォン
ヴェーバー，シュテフェン
ベクマイヤー，ハイケ
ビーンヒューズ－テレン，ウルスラ－ヘンリケ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2024516678A publication Critical patent/JP2024516678A/ja
Publication of JP2024516678A5 publication Critical patent/JP2024516678A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2023566802A 2021-04-30 2022-04-29 敗血症の早期検出用のｓｔｒｅｍ１マーカーパネル Pending JP2024516678A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21171489.4 2021-04-30
EP21171489 2021-04-30
PCT/EP2022/061551 WO2022229421A2 (en) 2021-04-30 2022-04-29 Strem1 marker panels for early detection of sepsis

Publications (2)

Publication Number Publication Date
JP2024516678A true JP2024516678A (ja) 2024-04-16
JP2024516678A5 JP2024516678A5 (https=) 2025-04-24

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ID=75746431

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JP2023566802A Pending JP2024516678A (ja) 2021-04-30 2022-04-29 敗血症の早期検出用のｓｔｒｅｍ１マーカーパネル

Country Status (5)

Country Link
US (1) US20240230674A1 (https=)
EP (1) EP4330680A2 (https=)
JP (1) JP2024516678A (https=)
CN (1) CN117280218A (https=)
WO (1) WO2022229421A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025257393A1 (en) * 2024-06-14 2025-12-18 Roche Diagnostics Gmbh Method and system for improving biomarker based disease assessments

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007519916A (ja) * 2004-01-27 2007-07-19 ビオエクセル ソシエタ ペル アチオニ サンプル中の可溶性のｔｒｅｍ−１レベルを測定することによって伝染病を診断する方法
JP2009510478A (ja) * 2005-10-03 2009-03-12 バイオサイト インコーポレイテッド 全身性炎症反応症候群の診断および／または予後診断のための方法および組成物
JP2010529468A (ja) * 2007-06-12 2010-08-26 ハンサ メディカル アクチボラゲット 診断方法
US20110059858A1 (en) * 2008-05-23 2011-03-10 Pronota N.V. New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof
JP2012507030A (ja) * 2008-10-28 2012-03-22 アシスタンス ピュブリック−オピト ド パリ 重症敗血症及び敗血症性ショック中の死亡の危険性が高い患者を迅速に決定するための方法及びキット
JP2012159356A (ja) * 2011-01-31 2012-08-23 Mochida Pharmaceut Co Ltd 敗血症診断用組合せマーカー
JP2015510122A (ja) * 2012-02-09 2015-04-02 メメド ダイアグノスティクス リミテッド 感染を診断するための特徴および決定因子ならびにその使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2476597C (en) 2002-02-28 2011-05-17 Metanomics Gmbh & Co. Kgaa Mass spectrometry method for analysing mixtures of substances
US20090197794A1 (en) 2005-07-13 2009-08-06 Aird William C Methods of Diagnosing and Treating an Inflammatory Response
CN103123359B (zh) 2007-08-03 2015-07-29 B.R.A.H.M.S有限公司 降钙素原(pct)在患原发性非传染疾病的患者的风险分级和预后中的应用
RU2016112915A (ru) 2013-09-05 2017-10-09 Эф-Ай-Оу Корпорейшн Биомаркеры для раннего выявления критической или угрожающей жизни ответной реакции на заболевание и/или ответной реакции на лечение

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007519916A (ja) * 2004-01-27 2007-07-19 ビオエクセル ソシエタ ペル アチオニ サンプル中の可溶性のｔｒｅｍ−１レベルを測定することによって伝染病を診断する方法
JP2009510478A (ja) * 2005-10-03 2009-03-12 バイオサイト インコーポレイテッド 全身性炎症反応症候群の診断および／または予後診断のための方法および組成物
JP2010529468A (ja) * 2007-06-12 2010-08-26 ハンサ メディカル アクチボラゲット 診断方法
US20110059858A1 (en) * 2008-05-23 2011-03-10 Pronota N.V. New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof
JP2012507030A (ja) * 2008-10-28 2012-03-22 アシスタンス ピュブリック−オピト ド パリ 重症敗血症及び敗血症性ショック中の死亡の危険性が高い患者を迅速に決定するための方法及びキット
JP2012159356A (ja) * 2011-01-31 2012-08-23 Mochida Pharmaceut Co Ltd 敗血症診断用組合せマーカー
JP2015510122A (ja) * 2012-02-09 2015-04-02 メメド ダイアグノスティクス リミテッド 感染を診断するための特徴および決定因子ならびにその使用方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HAILEI GUO ET AL.: "MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced i", EUROPEAN JOURNAL OF MEDICAL RESEARCH, vol. 24(1), JPN7026000999, 2019, pages 37, ISSN: 0005811729 *
JAYSHIL J. PATEL ET AL.: "The Association of Serum Bilirubin Levels on the Outcomes of Severe Sepsis", JOURNAL OF INTENSIVE CARE MEDICINE, vol. 30(1), JPN7026000997, 2015, pages 23 - 29, ISSN: 0005811727 *
M. MARTIN-FERNANDEZ ET AL.: "Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock", BJS OPEN, vol. 4(3), JPN7026000998, 2020, pages 524 - 534, ISSN: 0005811728 *
MARIA BERGQUIST ET AL.: "TNFR1, TNFR2, neutrophil gelatinase-associated lipocalin and heparin binding protein in identifying", SCIENTIFIC REPORTS, vol. 10(1), JPN6026009282, 2020, pages 15350, ISSN: 0005811725 *
RONI LEHMANN-WERMAN ET AL.: "Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA", JCI INSIGHT, vol. 3(12), JPN7026000996, 2018, pages 120687, ISSN: 0005811726 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025257393A1 (en) * 2024-06-14 2025-12-18 Roche Diagnostics Gmbh Method and system for improving biomarker based disease assessments

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WO2022229421A2 (en) 2022-11-03
US20240230674A1 (en) 2024-07-11
WO2022229421A3 (en) 2022-12-08
CN117280218A (zh) 2023-12-22
EP4330680A2 (en) 2024-03-06

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