JP2024516633A - オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 - Google Patents

オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 Download PDF

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JP2024516633A
JP2024516633A JP2023565387A JP2023565387A JP2024516633A JP 2024516633 A JP2024516633 A JP 2024516633A JP 2023565387 A JP2023565387 A JP 2023565387A JP 2023565387 A JP2023565387 A JP 2023565387A JP 2024516633 A JP2024516633 A JP 2024516633A
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formula
another embodiment
alkylene
ring
alkyl
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JPWO2022232025A5 (https=
JP2024516633A5 (https=
Inventor
チェ，ヨンギ
フー，ユエン
ヒューン，ホアン
アクイラ，ブライアン，エム．
ライマー，ブライアン，ケネス
マッジ，インゴ，アンドレアス
ウッズ，ジェームズ，アール．
ペニントン，ルイス，ディー．
ベンツィエン，イョルグ，マーティン
レーマン，ジョナサン，ウォード
ヘール，マイケル，アール．
バリウリン，ローマン，エイ．
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アルカーメス，インコーポレイテッド
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Publication of JPWO2022232025A5 publication Critical patent/JPWO2022232025A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2023565387A 2021-04-26 2022-04-25 オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物 Pending JP2024516633A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163179616P 2021-04-26 2021-04-26
US63/179,616 2021-04-26
PCT/US2022/026144 WO2022232025A1 (en) 2021-04-26 2022-04-25 Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity

Publications (3)

Publication Number Publication Date
JP2024516633A true JP2024516633A (ja) 2024-04-16
JPWO2022232025A5 JPWO2022232025A5 (https=) 2024-11-27
JP2024516633A5 JP2024516633A5 (https=) 2024-11-27

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JP2023565387A Pending JP2024516633A (ja) 2021-04-26 2022-04-25 オレキシン－２受容体アゴニスト活性を有する置換されるアミド大環状化合物

Country Status (8)

Country Link
US (1) US20240124485A1 (https=)
EP (1) EP4329877B1 (https=)
JP (1) JP2024516633A (https=)
CN (1) CN117440955A (https=)
AU (1) AU2022267220A1 (https=)
CA (1) CA3215210A1 (https=)
ES (1) ES3062687T3 (https=)
WO (1) WO2022232025A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4622712A1 (en) * 2022-11-23 2025-10-01 Vertex Pharmaceuticals Incorporated Substituted macrocyclic amine modulators of orexin receptor 2
KR20250139869A (ko) 2023-01-31 2025-09-23 재즈 파마슈티칼즈 아일랜드 리미티드 거대환식 오렉신 수용체 효능제 및 이의 용도
PE20252742A1 (es) 2023-03-16 2025-12-05 Takeda Pharmaceuticals Co Compuestos heterociclicos macrociclicos y sus usos
IL324946A (en) 2023-06-01 2026-01-01 H Lundbeck As Spiro-macrocyclic orexin 2 receptor agonists
WO2025096445A1 (en) 2023-10-30 2025-05-08 Alkermes, Inc. Synthesis of intermediates for the preparation of macrocyclic compounds
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
TW202542165A (zh) 2023-12-19 2025-11-01 瑞士商愛杜西亞製藥有限公司 大環食慾素激動劑
WO2026017128A1 (zh) * 2024-07-17 2026-01-22 江苏恩华药业股份有限公司 作为食欲素受体激动剂的环烯烃衍生物及其组合物和用途

Citations (4)

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WO2018164191A1 (ja) * 2017-03-08 2018-09-13 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
JP2019504098A (ja) * 2016-02-04 2019-02-14 武田薬品工業株式会社 置換ピペリジン化合物およびその用途
WO2020004536A1 (ja) * 2018-06-29 2020-01-02 武田薬品工業株式会社 複素環化合物およびその用途
WO2021026047A1 (en) * 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists

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AP1542A (en) * 1999-04-30 2006-01-31 Pfizer Prod Inc Glucocorticoid receptor modulators.
EP2038255A2 (en) * 2006-06-16 2009-03-25 High Point Pharmaceuticals, LLC Pharmaceutical use of substituted piperidine carboxamides
US8258163B2 (en) 2008-06-04 2012-09-04 Board Of Regents, The University Of Texas System Small-molecule agonists for type-2 orexin receptor
JP5635991B2 (ja) * 2008-10-30 2014-12-03 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． イソニコチンアミドオレキシン受容体アンタゴニスト
NZ592705A (en) * 2008-12-10 2013-02-22 Achillion Pharmaceuticals Inc 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication
WO2014198880A1 (en) 2013-06-14 2014-12-18 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
WO2015048091A1 (en) 2013-09-24 2015-04-02 The Board Of Regents Of The University Of Texas System Orexin-control of bone formation and loss
EP3068783B1 (en) 2013-11-15 2020-09-23 The Board of Trustees of the Leland Stanford Junior University Agonists of hypocretin receptor 2 for use for treating heart failure
PE20161064A1 (es) 2013-12-12 2016-10-28 Univ Tsukuba Derivado de sulfonamida o sales de adicion de acido farmaceuticamente aceptables del mismo
WO2015147240A1 (ja) 2014-03-28 2015-10-01 国立大学法人筑波大学 敗血症の予防治療剤
US10428023B2 (en) 2017-08-03 2019-10-01 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
EA039459B1 (ru) * 2017-12-25 2022-01-28 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение в качестве средства для лечения заболеваний, связанных с рецептором орексина 2 типа
EP4065585B1 (en) * 2019-11-25 2025-08-20 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment
US12006330B2 (en) * 2020-12-21 2024-06-11 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2019504098A (ja) * 2016-02-04 2019-02-14 武田薬品工業株式会社 置換ピペリジン化合物およびその用途
WO2018164191A1 (ja) * 2017-03-08 2018-09-13 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
WO2020004536A1 (ja) * 2018-06-29 2020-01-02 武田薬品工業株式会社 複素環化合物およびその用途
WO2021026047A1 (en) * 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists

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AU2022267220A1 (en) 2023-10-19
CA3215210A1 (en) 2022-11-03
US20240124485A1 (en) 2024-04-18
CN117440955A (zh) 2024-01-23
EP4329877C0 (en) 2026-02-04
EP4329877B1 (en) 2026-02-04
ES3062687T3 (en) 2026-04-13
WO2022232025A1 (en) 2022-11-03
EP4329877A1 (en) 2024-03-06

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