CN117440955A - 具有食欲素-2受体激动剂活性的取代的酰胺大环化合物 - Google Patents

具有食欲素-2受体激动剂活性的取代的酰胺大环化合物 Download PDF

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Publication number
CN117440955A
CN117440955A CN202280038386.8A CN202280038386A CN117440955A CN 117440955 A CN117440955 A CN 117440955A CN 202280038386 A CN202280038386 A CN 202280038386A CN 117440955 A CN117440955 A CN 117440955A
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China
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formula
alkylene
ring
group
alkyl
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Pending
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CN202280038386.8A
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English (en)
Chinese (zh)
Inventor
崔永吉
胡元
黄霍安
B·M·阿奎拉
B·K·雷默
I·A·马格
J·R·伍兹
L·D·彭宁顿
J·M·本齐恩
J·W·莱曼
M·R·哈尔
R·A·瓦利尤林
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Alkermes Inc
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Alkermes Inc
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Publication of CN117440955A publication Critical patent/CN117440955A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202280038386.8A 2021-04-26 2022-04-25 具有食欲素-2受体激动剂活性的取代的酰胺大环化合物 Pending CN117440955A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163179616P 2021-04-26 2021-04-26
US63/179,616 2021-04-26
PCT/US2022/026144 WO2022232025A1 (en) 2021-04-26 2022-04-25 Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity

Publications (1)

Publication Number Publication Date
CN117440955A true CN117440955A (zh) 2024-01-23

Family

ID=81750587

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280038386.8A Pending CN117440955A (zh) 2021-04-26 2022-04-25 具有食欲素-2受体激动剂活性的取代的酰胺大环化合物

Country Status (8)

Country Link
US (1) US20240124485A1 (https=)
EP (1) EP4329877B1 (https=)
JP (1) JP2024516633A (https=)
CN (1) CN117440955A (https=)
AU (1) AU2022267220A1 (https=)
CA (1) CA3215210A1 (https=)
ES (1) ES3062687T3 (https=)
WO (1) WO2022232025A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026017128A1 (zh) * 2024-07-17 2026-01-22 江苏恩华药业股份有限公司 作为食欲素受体激动剂的环烯烃衍生物及其组合物和用途

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4622712A1 (en) * 2022-11-23 2025-10-01 Vertex Pharmaceuticals Incorporated Substituted macrocyclic amine modulators of orexin receptor 2
KR20250139869A (ko) 2023-01-31 2025-09-23 재즈 파마슈티칼즈 아일랜드 리미티드 거대환식 오렉신 수용체 효능제 및 이의 용도
PE20252742A1 (es) 2023-03-16 2025-12-05 Takeda Pharmaceuticals Co Compuestos heterociclicos macrociclicos y sus usos
IL324946A (en) 2023-06-01 2026-01-01 H Lundbeck As Spiro-macrocyclic orexin 2 receptor agonists
WO2025096445A1 (en) 2023-10-30 2025-05-08 Alkermes, Inc. Synthesis of intermediates for the preparation of macrocyclic compounds
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
TW202542165A (zh) 2023-12-19 2025-11-01 瑞士商愛杜西亞製藥有限公司 大環食慾素激動劑

Citations (8)

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US6380223B1 (en) * 1999-04-30 2002-04-30 Pfizer Inc. Glucocorticoid receptor modulators
US20090306048A1 (en) * 2006-06-16 2009-12-10 John Paul Kilburn Pharmaceutical use of substituted piperidine carboxamides
CN102245598A (zh) * 2008-12-10 2011-11-16 艾其林医药公司 病毒复制抑制剂4-氨基-4-氧代丁酰基肽环状类似物
CN102272103A (zh) * 2008-10-30 2011-12-07 默沙东公司 异烟酰胺食欲素受体拮抗剂
EA202090428A1 (ru) * 2017-12-25 2020-05-21 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение
US20200385345A1 (en) * 2017-03-08 2020-12-10 Takeda Pharmaceutical Company Limited Substituted pyrrolidine compound and use thereof
WO2021026047A1 (en) * 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
US20210155636A1 (en) * 2019-11-25 2021-05-27 Alkermes, Inc. Substituted Macrocyclic Compounds and Related Methods of Treatment

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Publication number Priority date Publication date Assignee Title
US8258163B2 (en) 2008-06-04 2012-09-04 Board Of Regents, The University Of Texas System Small-molecule agonists for type-2 orexin receptor
WO2014198880A1 (en) 2013-06-14 2014-12-18 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
WO2015048091A1 (en) 2013-09-24 2015-04-02 The Board Of Regents Of The University Of Texas System Orexin-control of bone formation and loss
EP3068783B1 (en) 2013-11-15 2020-09-23 The Board of Trustees of the Leland Stanford Junior University Agonists of hypocretin receptor 2 for use for treating heart failure
PE20161064A1 (es) 2013-12-12 2016-10-28 Univ Tsukuba Derivado de sulfonamida o sales de adicion de acido farmaceuticamente aceptables del mismo
WO2015147240A1 (ja) 2014-03-28 2015-10-01 国立大学法人筑波大学 敗血症の予防治療剤
LT3984994T (lt) * 2016-02-04 2024-10-10 Takeda Pharmaceutical Company Limited Pakeistas piperidino junginys kaip 2 tipo oreksino agonistas narkolepsijai gydyti
US10428023B2 (en) 2017-08-03 2019-10-01 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP7339250B2 (ja) * 2018-06-29 2023-09-05 武田薬品工業株式会社 複素環化合物およびその用途
US12006330B2 (en) * 2020-12-21 2024-06-11 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380223B1 (en) * 1999-04-30 2002-04-30 Pfizer Inc. Glucocorticoid receptor modulators
US20090306048A1 (en) * 2006-06-16 2009-12-10 John Paul Kilburn Pharmaceutical use of substituted piperidine carboxamides
CN102272103A (zh) * 2008-10-30 2011-12-07 默沙东公司 异烟酰胺食欲素受体拮抗剂
CN102245598A (zh) * 2008-12-10 2011-11-16 艾其林医药公司 病毒复制抑制剂4-氨基-4-氧代丁酰基肽环状类似物
US20200385345A1 (en) * 2017-03-08 2020-12-10 Takeda Pharmaceutical Company Limited Substituted pyrrolidine compound and use thereof
EA202090428A1 (ru) * 2017-12-25 2020-05-21 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение
WO2021026047A1 (en) * 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
US20210155636A1 (en) * 2019-11-25 2021-05-27 Alkermes, Inc. Substituted Macrocyclic Compounds and Related Methods of Treatment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026017128A1 (zh) * 2024-07-17 2026-01-22 江苏恩华药业股份有限公司 作为食欲素受体激动剂的环烯烃衍生物及其组合物和用途

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Publication number Publication date
AU2022267220A1 (en) 2023-10-19
JP2024516633A (ja) 2024-04-16
CA3215210A1 (en) 2022-11-03
US20240124485A1 (en) 2024-04-18
EP4329877C0 (en) 2026-02-04
EP4329877B1 (en) 2026-02-04
ES3062687T3 (en) 2026-04-13
WO2022232025A1 (en) 2022-11-03
EP4329877A1 (en) 2024-03-06

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