JP2024516003A - 糖尿病網膜症および関連する状態を治療するための方法および組成物 - Google Patents

糖尿病網膜症および関連する状態を治療するための方法および組成物 Download PDF

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Publication number
JP2024516003A
JP2024516003A JP2023566803A JP2023566803A JP2024516003A JP 2024516003 A JP2024516003 A JP 2024516003A JP 2023566803 A JP2023566803 A JP 2023566803A JP 2023566803 A JP2023566803 A JP 2023566803A JP 2024516003 A JP2024516003 A JP 2024516003A
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Prior art keywords
therapeutic agent
patient
orally administered
certain embodiments
per day
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JP2023566803A
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English (en)
Japanese (ja)
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JP2024516003A5 (enExample
Inventor
スーチ，ミナ
チャリザニス，コンスタンティノス
アール ケリー，マーク
アダム メスマン，リチャード
ジョージ ブリゲル，ミッチェル
アジャイクマール パテル，ロニール
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Opus Genetics Inc
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Ocuphire Pharma Inc
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Application filed by Ocuphire Pharma Inc filed Critical Ocuphire Pharma Inc
Publication of JP2024516003A publication Critical patent/JP2024516003A/ja
Publication of JP2024516003A5 publication Critical patent/JP2024516003A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023566803A 2021-04-30 2022-04-29 糖尿病網膜症および関連する状態を治療するための方法および組成物 Pending JP2024516003A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163182037P 2021-04-30 2021-04-30
US63/182,037 2021-04-30
PCT/US2022/027062 WO2022232597A1 (en) 2021-04-30 2022-04-29 Methods and compositions for treatment of diabetic retinopathy and related conditions

Publications (2)

Publication Number Publication Date
JP2024516003A true JP2024516003A (ja) 2024-04-11
JP2024516003A5 JP2024516003A5 (enExample) 2025-05-09

Family

ID=83848745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023566803A Pending JP2024516003A (ja) 2021-04-30 2022-04-29 糖尿病網膜症および関連する状態を治療するための方法および組成物

Country Status (11)

Country Link
US (1) US20240216315A1 (enExample)
EP (1) EP4329741A4 (enExample)
JP (1) JP2024516003A (enExample)
KR (1) KR20240049212A (enExample)
CN (1) CN117500492A (enExample)
AU (1) AU2022264037A1 (enExample)
BR (1) BR112023022561A2 (enExample)
CA (1) CA3217136A1 (enExample)
IL (1) IL308083A (enExample)
MX (1) MX2023012793A (enExample)
WO (1) WO2022232597A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025529483A (ja) 2022-09-14 2025-09-04 オーパス・ジェネティクス・インコーポレイテッド Ａｐｘ３３３０の塩及びエステルならびにその治療的使用
WO2024158972A1 (en) * 2023-01-25 2024-08-02 Ocuphire Pharma, Inc. Methods and compositions for preventing the progression of diabetic retinopathy and related conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540544A (ja) * 2007-09-26 2010-12-24 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 癌および血管新生の治療のための、化学療法剤と組み合わせたベンゾキノン誘導体ｅ３３３０

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3090766A1 (en) * 2018-02-08 2019-08-15 Indiana University Research And Technology Corporation Targeting ocular diseases with novel ape1/ref-1 inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540544A (ja) * 2007-09-26 2010-12-24 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション 癌および血管新生の治療のための、化学療法剤と組み合わせたベンゾキノン誘導体ｅ３３３０

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy (ZETA-1)", U.S. NATIONAL LIBRARY OF MEDICINE, CLINICALTRIALS.GOV, NCT04692688, JPN7026000478, ISSN: 0005793423 *
SHEIK PRAN BABU SARDAR PASHA ET AL.: "Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. Volume 367, Issue 1, JPN7026000477, October 2018 (2018-10-01), pages 108 - 118, ISSN: 0005793424 *
XIAOXI QIAO ET AL.: "APE1/Ref-1 redox inhibitor APX3330 modulates choroidal endothelial cells by transcriptional regulati", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. Volume 54, Issue15, JPN7026000476, June 2013 (2013-06-01), ISSN: 0005793425 *

Also Published As

Publication number Publication date
WO2022232597A1 (en) 2022-11-03
BR112023022561A2 (pt) 2024-01-02
MX2023012793A (es) 2024-01-11
US20240216315A1 (en) 2024-07-04
KR20240049212A (ko) 2024-04-16
EP4329741A1 (en) 2024-03-06
CA3217136A1 (en) 2022-11-03
IL308083A (en) 2023-12-01
EP4329741A4 (en) 2025-01-08
AU2022264037A1 (en) 2023-11-16
CN117500492A (zh) 2024-02-02

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