JP2024515829A - 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド - Google Patents

大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド Download PDF

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JP2024515829A
JP2024515829A JP2023566514A JP2023566514A JP2024515829A JP 2024515829 A JP2024515829 A JP 2024515829A JP 2023566514 A JP2023566514 A JP 2023566514A JP 2023566514 A JP2023566514 A JP 2023566514A JP 2024515829 A JP2024515829 A JP 2024515829A
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pharma
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JP2024515829A5 (enExample
Inventor
ロバート アルフォンソ ラサー，
ジェイムズ ドハーティ，
ジェフリー マーティン ジョナス，
スティーブン ジェイ ケインズ，
ハンダン グンドゥーズ－ブルース，
ヘレン アン コルクホーン，
ライアン アーノルド，
ビジャイベール ボンサパリー，
ジョイ リサ ダンバー，
バンバン セノアジ アディウィジャヤ，
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Sage Therapeutics LLC
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Sage Therapeutics LLC
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Publication of JP2024515829A publication Critical patent/JP2024515829A/ja
Priority to JP2025074660A priority Critical patent/JP2025111701A/ja
Publication of JP2024515829A5 publication Critical patent/JP2024515829A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023566514A 2021-04-29 2022-04-29 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド Pending JP2024515829A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025074660A JP2025111701A (ja) 2021-04-29 2025-04-28 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US202163181743P 2021-04-29 2021-04-29
US63/181,743 2021-04-29
US202163197025P 2021-06-04 2021-06-04
US63/197,025 2021-06-04
US202163210810P 2021-06-15 2021-06-15
US63/210,810 2021-06-15
US202163239096P 2021-08-31 2021-08-31
US63/239,096 2021-08-31
US202163285812P 2021-12-03 2021-12-03
US63/285,812 2021-12-03
US202163289506P 2021-12-14 2021-12-14
US202163289520P 2021-12-14 2021-12-14
US63/289,506 2021-12-14
US63/289,520 2021-12-14
US202263298601P 2022-01-11 2022-01-11
US63/298,601 2022-01-11
PCT/US2022/026920 WO2022232504A1 (en) 2021-04-29 2022-04-29 19-nor c3,3-disubstituted c21 -n-pyrazolyl steroid for use in treating major depressive disorder and postpartum depression

Related Child Applications (1)

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JP2025074660A Division JP2025111701A (ja) 2021-04-29 2025-04-28 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

Publications (2)

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JP2024515829A true JP2024515829A (ja) 2024-04-10
JP2024515829A5 JP2024515829A5 (enExample) 2025-05-09

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JP2023566514A Pending JP2024515829A (ja) 2021-04-29 2022-04-29 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド
JP2025074660A Pending JP2025111701A (ja) 2021-04-29 2025-04-28 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

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JP2025074660A Pending JP2025111701A (ja) 2021-04-29 2025-04-28 大うつ病性障害および産後うつ病の処置における使用のための１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

Country Status (11)

Country Link
US (1) US20240216395A1 (enExample)
EP (2) EP4768044A2 (enExample)
JP (2) JP2024515829A (enExample)
KR (1) KR20240006026A (enExample)
AU (1) AU2022266680A1 (enExample)
BR (1) BR112023022264A2 (enExample)
CA (1) CA3218072A1 (enExample)
IL (1) IL307991A (enExample)
MX (1) MX2023012727A (enExample)
TW (1) TW202308654A (enExample)
WO (1) WO2022232504A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62761B1 (sr) 2012-08-21 2022-01-31 Sage Therapeutics Inc Alopregnanolon za lečenje refraktornog epileptičkog statusa
SMT202100509T1 (it) 2013-04-17 2021-11-12 Sage Therapeutics Inc Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2018013613A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C17, c20, and c21 substituted neuroactive steroids and their methods of use
TW202604538A (zh) 2016-08-23 2026-02-01 美商賽吉醫療公司 結晶19-去甲c3,3-二取代之c21-n-吡唑類固醇
US20200291059A1 (en) 2017-12-08 2020-09-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019241442A1 (en) * 2018-06-12 2019-12-19 Sage Therapeutics, Inc. A 19-nor c3,3-disubstituted c21 -n-pyrazolyl steroid and methods of use thereof
JP2020533310A (ja) * 2017-09-07 2020-11-19 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイドおよびそれらの使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202100509T1 (it) 2013-04-17 2021-11-12 Sage Therapeutics Inc Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
TW202604538A (zh) 2016-08-23 2026-02-01 美商賽吉醫療公司 結晶19-去甲c3,3-二取代之c21-n-吡唑類固醇
JP2022514510A (ja) * 2018-12-14 2022-02-14 プラクシス プレシジョン メディスンズ，インコーポレイテッド うつ病の治療方法
CA3187178A1 (en) 2020-07-20 2022-01-27 Sage Therapeutics, Inc. Formulations of 19-nor c3,3- disubstituted c21-n-pyrazolyl steroid and methods of use thereof
JP2025508406A (ja) * 2022-02-16 2025-03-26 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ関連障害を処置するための神経活性ステロイド

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020533310A (ja) * 2017-09-07 2020-11-19 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイドおよびそれらの使用方法
WO2019241442A1 (en) * 2018-06-12 2019-12-19 Sage Therapeutics, Inc. A 19-nor c3,3-disubstituted c21 -n-pyrazolyl steroid and methods of use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL PSYCHIATRY, vol. 87, JPN6026009185, 2020, pages 9 - 278, ISSN: 0005811300 *
EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol. 40, JPN6026009184, 2020, pages 1 - 177, ISSN: 0005811299 *
NEUROPSYCHOPHARMACOLOGY, vol. 44, JPN6026009186, 2019, pages 426 - 427, ISSN: 0005811301 *
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 381, no. 10, JPN6026009187, 2019, pages 903 - 911, ISSN: 0005811302 *

Also Published As

Publication number Publication date
EP4329770A1 (en) 2024-03-06
CA3218072A1 (en) 2022-11-03
US20240216395A1 (en) 2024-07-04
WO2022232504A1 (en) 2022-11-03
JP2025111701A (ja) 2025-07-30
TW202308654A (zh) 2023-03-01
MX2023012727A (es) 2023-11-08
KR20240006026A (ko) 2024-01-12
IL307991A (en) 2023-12-01
EP4768044A2 (en) 2026-07-01
AU2022266680A1 (en) 2023-11-02
BR112023022264A2 (pt) 2024-01-23

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