JP2024514830A - 新規腫瘍特異的抗原を使用する骨髄性障害および急性白血病の診断および処置 - Google Patents

新規腫瘍特異的抗原を使用する骨髄性障害および急性白血病の診断および処置 Download PDF

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JP2024514830A
JP2024514830A JP2023561752A JP2023561752A JP2024514830A JP 2024514830 A JP2024514830 A JP 2024514830A JP 2023561752 A JP2023561752 A JP 2023561752A JP 2023561752 A JP2023561752 A JP 2023561752A JP 2024514830 A JP2024514830 A JP 2024514830A
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マルティーナ ピガッツィ，
アレッサンドラ ビッフィ，
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アルテイア サイエンス エッセ．エッレ．エッレ．
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110189202A1 (en) * 2008-09-23 2011-08-04 Yeda Research And Development Co., Ltd. Compositions comprising soluble cd84 or anti-cd84 antibodies and methods for diagnosing and treating b-cll
JP2019505511A (ja) * 2016-01-06 2019-02-28 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． 悪性疾患、自己免疫疾患および炎症性疾患を処置するための組成物および方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US7361343B2 (en) * 2003-01-21 2008-04-22 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD63
US7361342B2 (en) * 2003-01-21 2008-04-22 Arius Research Inc. Cancerous disease modifying antibodies
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
MX379256B (es) 2013-03-15 2025-03-10 Regeneron Pharma Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
ES3063961T3 (en) * 2014-02-14 2026-04-21 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
WO2018002902A1 (en) 2016-07-01 2018-01-04 Glaxosmithkline Intellectual Property (No.2) Limited Antibody-drug conjugates and therapeutic methods using the same
US12534532B2 (en) * 2018-10-26 2026-01-27 Crage Medical Co., Limited CLL1-targeting antibody and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110189202A1 (en) * 2008-09-23 2011-08-04 Yeda Research And Development Co., Ltd. Compositions comprising soluble cd84 or anti-cd84 antibodies and methods for diagnosing and treating b-cll
JP2019505511A (ja) * 2016-01-06 2019-02-28 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． 悪性疾患、自己免疫疾患および炎症性疾患を処置するための組成物および方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"APC anti-human CD84 Antibody", BIOLEGEND, vol. [online]，2019年07月02日, JPN6026007744, pages 2026 - 02, ISSN: 0005805451 *
"CD84/SLAMF5 Antibody (152-1D5)", NOVUS, vol. [online]，2019年09月30日, JPN6026007745, pages 2026 - 02, ISSN: 0005805452 *
"CD84/SLAMF5 Antibody (153-4D9)", NOVUS, vol. [online]，2019年09月22日, JPN6026007746, pages 2026 - 02, ISSN: 0005805453 *

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