CA3216175A1 - Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigens - Google Patents

Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigens Download PDF

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Publication number
CA3216175A1
CA3216175A1 CA3216175A CA3216175A CA3216175A1 CA 3216175 A1 CA3216175 A1 CA 3216175A1 CA 3216175 A CA3216175 A CA 3216175A CA 3216175 A CA3216175 A CA 3216175A CA 3216175 A1 CA3216175 A1 CA 3216175A1
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seq
sequence
abp
amino acid
car
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French (fr)
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Martina PIGAZZI
Alessandra Biffi
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Altheia Science Srl
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Altheia Science Srl
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CA3216175A 2021-04-05 2022-04-05 Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigens Pending CA3216175A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163170976P 2021-04-05 2021-04-05
US63/170,976 2021-04-05
PCT/EP2022/059031 WO2022214499A2 (en) 2021-04-05 2022-04-05 Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigenscross-reference to related applications

Publications (1)

Publication Number Publication Date
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US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
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US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
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