JP2024507373A - 制御性t細胞を増殖させる方法 - Google Patents
制御性t細胞を増殖させる方法 Download PDFInfo
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- JP2024507373A JP2024507373A JP2023550647A JP2023550647A JP2024507373A JP 2024507373 A JP2024507373 A JP 2024507373A JP 2023550647 A JP2023550647 A JP 2023550647A JP 2023550647 A JP2023550647 A JP 2023550647A JP 2024507373 A JP2024507373 A JP 2024507373A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- A—HUMAN NECESSITIES
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/22—Immunosuppressive or immunotolerising
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/53—CD2
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- C12N2510/00—Genetically modified cells
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- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163152787P | 2021-02-23 | 2021-02-23 | |
| US63/152,787 | 2021-02-23 | ||
| PCT/US2022/017526 WO2022182763A1 (en) | 2021-02-23 | 2022-02-23 | Methods for expanding regulatory t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024507373A true JP2024507373A (ja) | 2024-02-19 |
| JP2024507373A5 JP2024507373A5 (https=) | 2025-03-04 |
| JPWO2022182763A5 JPWO2022182763A5 (https=) | 2025-03-04 |
Family
ID=83048425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023550647A Pending JP2024507373A (ja) | 2021-02-23 | 2022-02-23 | 制御性t細胞を増殖させる方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240228962A9 (https=) |
| EP (1) | EP4297757A4 (https=) |
| JP (1) | JP2024507373A (https=) |
| CN (1) | CN116897201A (https=) |
| AU (1) | AU2022226163A1 (https=) |
| CA (1) | CA3206049A1 (https=) |
| WO (1) | WO2022182763A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024243552A1 (en) * | 2023-05-25 | 2024-11-28 | Board Of Regents, The University Of Texas System | Methods using st2 to identify patients for cancer therapy |
| WO2025096685A1 (en) * | 2023-10-30 | 2025-05-08 | City Of Hope | Methods of making and using regulatory t cells for treatment of autoimmune disorders and cancers |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130101567A1 (en) * | 2010-04-08 | 2013-04-25 | The Trustees Of The University Of Pennsylvania | Methods to Expand a T Regulatory Cell Master Cell Bank |
| US20130280208A1 (en) * | 2010-07-23 | 2013-10-24 | University Of Toledo | Stable Tregs and Related Materials and Methods |
| US20180360882A1 (en) * | 2017-06-16 | 2018-12-20 | Creative Medical Technologies, Inc. | Perispinal Perfusion by Administration of T regulatory Cells Alone or in Combination with Angiogenic Cell Therapies |
| JP2020511987A (ja) * | 2017-03-28 | 2020-04-23 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 移植された組織を拒絶反応から保護するための方法 |
| JP2021503923A (ja) * | 2017-11-29 | 2021-02-15 | フィジーン、エルエルシーFigene, Llc | 活性化のための線維芽細胞と免疫細胞との相互作用及びそれらの使用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1715889A4 (en) * | 2004-01-08 | 2008-03-05 | Univ California | LYMPHOCYTES T REGULATORS SUPPRESSING AUTOIMMUNITY |
| WO2013131045A1 (en) * | 2012-03-02 | 2013-09-06 | The Regents Of The University Of California | Expansion of alloantigen-reactive regulatory t cells |
| WO2014183056A1 (en) * | 2013-05-10 | 2014-11-13 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Design and use of specific regulatory t-cells to induce immune tolerance |
| EP3551749B1 (en) * | 2016-12-07 | 2023-09-27 | East Carolina University | Compositions and methods for in vitro cultivation and/or expansion of regulatory t cells |
| WO2018136566A1 (en) * | 2017-01-18 | 2018-07-26 | F1 Oncology, Inc. | Methods of transducing and expanding immune cells and uses thereof |
| AU2019269601A1 (en) * | 2018-05-17 | 2020-11-26 | Regents Of The University Of Minnesota | Drug-resistant immune cells and methods of use thereof |
| KR20210125509A (ko) * | 2019-02-01 | 2021-10-18 | 케이에스큐 세러퓨틱스 인코포레이티드 | 개선된 면역요법을 위한 유전자-조절 조성물 및 방법 |
-
2022
- 2022-02-23 CN CN202280016734.1A patent/CN116897201A/zh active Pending
- 2022-02-23 CA CA3206049A patent/CA3206049A1/en active Pending
- 2022-02-23 WO PCT/US2022/017526 patent/WO2022182763A1/en not_active Ceased
- 2022-02-23 AU AU2022226163A patent/AU2022226163A1/en active Pending
- 2022-02-23 JP JP2023550647A patent/JP2024507373A/ja active Pending
- 2022-02-23 US US18/547,627 patent/US20240228962A9/en active Pending
- 2022-02-23 EP EP22760340.4A patent/EP4297757A4/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130101567A1 (en) * | 2010-04-08 | 2013-04-25 | The Trustees Of The University Of Pennsylvania | Methods to Expand a T Regulatory Cell Master Cell Bank |
| US20130280208A1 (en) * | 2010-07-23 | 2013-10-24 | University Of Toledo | Stable Tregs and Related Materials and Methods |
| JP2020511987A (ja) * | 2017-03-28 | 2020-04-23 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 移植された組織を拒絶反応から保護するための方法 |
| US20180360882A1 (en) * | 2017-06-16 | 2018-12-20 | Creative Medical Technologies, Inc. | Perispinal Perfusion by Administration of T regulatory Cells Alone or in Combination with Angiogenic Cell Therapies |
| JP2021503923A (ja) * | 2017-11-29 | 2021-02-15 | フィジーン、エルエルシーFigene, Llc | 活性化のための線維芽細胞と免疫細胞との相互作用及びそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3206049A1 (en) | 2022-09-01 |
| EP4297757A4 (en) | 2025-02-26 |
| CN116897201A (zh) | 2023-10-17 |
| US20240132843A1 (en) | 2024-04-25 |
| EP4297757A1 (en) | 2024-01-03 |
| AU2022226163A1 (en) | 2023-09-28 |
| WO2022182763A1 (en) | 2022-09-01 |
| US20240228962A9 (en) | 2024-07-11 |
| AU2022226163A9 (en) | 2024-01-18 |
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