JP2024506647A - Ｃｃｒ４ターゲティングキメラ抗原受容体細胞療法 - Google Patents

Ｃｃｒ４ターゲティングキメラ抗原受容体細胞療法 Download PDF

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JP2024506647A
JP2024506647A JP2023548583A JP2023548583A JP2024506647A JP 2024506647 A JP2024506647 A JP 2024506647A JP 2023548583 A JP2023548583 A JP 2023548583A JP 2023548583 A JP2023548583 A JP 2023548583A JP 2024506647 A JP2024506647 A JP 2024506647A
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cells
ccr4
domain
car
seq
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カール エイチ． ジューン
慶介 渡邊
レジーナ エム． ヤング
ジョン シェラー
博嘉 西川
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National Cancer Center Japan
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National Cancer Center Japan
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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JP2023548583A 2021-02-11 2022-02-10 Ｃｃｒ４ターゲティングキメラ抗原受容体細胞療法 Pending JP2024506647A (ja)

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Application Number Priority Date Filing Date Title
US202163148489P 2021-02-11 2021-02-11
US63/148,489 2021-02-11
PCT/US2022/015981 WO2022173950A1 (en) 2021-02-11 2022-02-10 Ccr4-targeting chimeric antigen receptor cell therapy

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JP2024506647A true JP2024506647A (ja) 2024-02-14
JP2024506647A5 JP2024506647A5 (https=) 2025-02-19

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US (1) US20240122981A1 (https=)
EP (1) EP4291207A4 (https=)
JP (1) JP2024506647A (https=)
KR (1) KR20230171919A (https=)
CN (1) CN117500838A (https=)
AU (1) AU2022220694A1 (https=)
CA (1) CA3207861A1 (https=)
WO (1) WO2022173950A1 (https=)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015513394A (ja) * 2012-02-13 2015-05-14 シアトル チルドレンズ ホスピタル ドゥーイング ビジネ 二重特異性キメラ抗原受容体およびその治療的使用
JP2018504894A (ja) * 2014-12-19 2018-02-22 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド キメラ抗原受容体およびその使用方法
JP2019536469A (ja) * 2016-09-21 2019-12-19 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ケモカイン受容体ｃｃｒ４を標的にするキメラ抗原受容体（ｃａｒ）およびその使用
WO2020132327A1 (en) * 2018-12-19 2020-06-25 The Trustees Of The University Of Pennsylvania Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias
WO2020181164A1 (en) * 2019-03-06 2020-09-10 Lentigen Technology, Inc. Compositions and methods for treating cancer with self-driving chimeric antigen receptors
WO2020183131A1 (en) * 2019-03-08 2020-09-17 Autolus Limited Compositions and methods comprising engineered chimeric antigen receptor and modulator of car
WO2020243007A1 (en) * 2019-05-24 2020-12-03 City Of Hope Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies
WO2020239005A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 靶向Claudin18.2的抗体或嵌合抗原受体

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US20070172476A1 (en) * 2005-07-28 2007-07-26 Kyowa Hakko Kogyo Co., Ltd. Method of treating B-cell neoplasms or Hodgkin's lymphoma
CA2773579C (en) * 2009-09-10 2019-01-15 Kyowa Kirin Co., Ltd. Medicament including antibody composition specifically bound to human cc chemokine receptor 4 (ccr4)
KR20230148844A (ko) * 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
TW201825119A (zh) * 2016-11-30 2018-07-16 日商協和醱酵麒麟有限公司 使用抗ccr4抗體及抗pd-1抗體治療癌症之方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015513394A (ja) * 2012-02-13 2015-05-14 シアトル チルドレンズ ホスピタル ドゥーイング ビジネ 二重特異性キメラ抗原受容体およびその治療的使用
JP2018504894A (ja) * 2014-12-19 2018-02-22 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド キメラ抗原受容体およびその使用方法
JP2019536469A (ja) * 2016-09-21 2019-12-19 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ケモカイン受容体ｃｃｒ４を標的にするキメラ抗原受容体（ｃａｒ）およびその使用
WO2020132327A1 (en) * 2018-12-19 2020-06-25 The Trustees Of The University Of Pennsylvania Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias
WO2020181164A1 (en) * 2019-03-06 2020-09-10 Lentigen Technology, Inc. Compositions and methods for treating cancer with self-driving chimeric antigen receptors
WO2020183131A1 (en) * 2019-03-08 2020-09-17 Autolus Limited Compositions and methods comprising engineered chimeric antigen receptor and modulator of car
WO2020243007A1 (en) * 2019-05-24 2020-12-03 City Of Hope Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies
WO2020239005A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 靶向Claudin18.2的抗体或嵌合抗原受体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PERERA, L.P., ET AL.: ""Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic mod", AM. J. HEMATOL., vol. 92, no. 9, JPN6026001135, September 2017 (2017-09-01), pages 892 - 901, ISSN: 0005772369 *

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Publication number Publication date
US20240122981A1 (en) 2024-04-18
KR20230171919A (ko) 2023-12-21
EP4291207A1 (en) 2023-12-20
WO2022173950A1 (en) 2022-08-18
EP4291207A4 (en) 2025-02-19
AU2022220694A9 (en) 2024-07-25
CA3207861A1 (en) 2022-08-18
CN117500838A (zh) 2024-02-02
AU2022220694A1 (en) 2023-08-10

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