JP2024502170A - 癌のための改良された養子細胞移植療法 - Google Patents
癌のための改良された養子細胞移植療法 Download PDFInfo
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- JP2024502170A JP2024502170A JP2023541633A JP2023541633A JP2024502170A JP 2024502170 A JP2024502170 A JP 2024502170A JP 2023541633 A JP2023541633 A JP 2023541633A JP 2023541633 A JP2023541633 A JP 2023541633A JP 2024502170 A JP2024502170 A JP 2024502170A
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- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/42—Cancer antigens
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- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C12N5/0602—Vertebrate cells
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6467—Granzymes, e.g. granzyme A (3.4.21.78); granzyme B (3.4.21.79)
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- C12Y—ENZYMES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/2315—Interleukin-15 (IL-15)
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- C12N5/0646—Natural killers cells [NK], NKT cells
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- Health & Medical Sciences (AREA)
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- Immunology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Veterinary Medicine (AREA)
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- Biophysics (AREA)
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- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163136217P | 2021-01-12 | 2021-01-12 | |
| US63/136,217 | 2021-01-12 | ||
| PCT/IL2022/050038 WO2022153295A1 (en) | 2021-01-12 | 2022-01-11 | Improved adoptive cell transfer therapy for cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502170A true JP2024502170A (ja) | 2024-01-17 |
| JP2024502170A5 JP2024502170A5 (https=) | 2024-11-06 |
Family
ID=82447153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541633A Pending JP2024502170A (ja) | 2021-01-12 | 2022-01-11 | 癌のための改良された養子細胞移植療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240307536A1 (https=) |
| EP (1) | EP4277638A4 (https=) |
| JP (1) | JP2024502170A (https=) |
| IL (1) | IL304373A (https=) |
| WO (1) | WO2022153295A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121378506A (zh) * | 2025-10-21 | 2026-01-23 | 北京京科信拓生物技术有限公司 | 表达car的免疫细胞及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009097119A2 (en) * | 2008-01-29 | 2009-08-06 | Fred Hutchinson Cancer Research Center | Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity |
| CN102428173B (zh) * | 2009-03-26 | 2014-07-30 | 细胞维护北欧制药公司 | Nk细胞的扩增 |
| AU2021286655A1 (en) * | 2020-06-12 | 2023-01-05 | Nkarta, Inc. | Genetically modified natural killer cells for CD70-directed cancer immunotherapy |
-
2022
- 2022-01-11 JP JP2023541633A patent/JP2024502170A/ja active Pending
- 2022-01-11 US US18/271,883 patent/US20240307536A1/en active Pending
- 2022-01-11 EP EP22739254.5A patent/EP4277638A4/en active Pending
- 2022-01-11 WO PCT/IL2022/050038 patent/WO2022153295A1/en not_active Ceased
-
2023
- 2023-07-10 IL IL304373A patent/IL304373A/en unknown
Non-Patent Citations (3)
| Title |
|---|
| ANDERSON, P. M. ET AL.: "Anti-CD3 + interleukin-2 stimulation of marrow and blood: comparison of proliferation and cytotoxici", BLOOD, vol. Vo.80, No.7, JPN6025041171, 1992, pages 1846 - 1853, ISSN: 0005828885 * |
| UEDA, M. ET AL.: "Preclinical studies for adoptive immunotherapy in bone marrow transplantation. Generation of anti-CD", TRANSPLANTATION, vol. 56, no. 2, JPN6025041170, 1993, pages 351 - 356, ISSN: 0005828884 * |
| 菊池 哲郎 ほか: "抗CD3抗体を用いて誘導したLymphokine Activated Killer (LAK)細胞の抗腫瘍効果ならびにリンパ球表面マーカ", 脳神経, vol. 第42巻, 第6号, JPN6011066564, 1990, pages 575 - 580, ISSN: 0005828883 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240307536A1 (en) | 2024-09-19 |
| EP4277638A4 (en) | 2024-12-04 |
| WO2022153295A1 (en) | 2022-07-21 |
| EP4277638A1 (en) | 2023-11-22 |
| IL304373A (en) | 2023-09-01 |
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