JP2024500350A - Ｍｏｆナノ粒子 - Google Patents

Ｍｏｆナノ粒子 Download PDF

Info

Publication number
JP2024500350A
JP2024500350A JP2023535380A JP2023535380A JP2024500350A JP 2024500350 A JP2024500350 A JP 2024500350A JP 2023535380 A JP2023535380 A JP 2023535380A JP 2023535380 A JP2023535380 A JP 2023535380A JP 2024500350 A JP2024500350 A JP 2024500350A
Authority
JP
Japan
Prior art keywords
polymer
mof
nanoparticles
coated
pcn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023535380A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024500350A5 (https=
Inventor
フェアレン ヒメネス，デイヴィッド
チェン，シュー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Enterprise Ltd
Original Assignee
Cambridge Enterprise Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Ltd filed Critical Cambridge Enterprise Ltd
Publication of JP2024500350A publication Critical patent/JP2024500350A/ja
Publication of JP2024500350A5 publication Critical patent/JP2024500350A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
JP2023535380A 2020-12-09 2021-12-09 Ｍｏｆナノ粒子 Pending JP2024500350A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20212892.2 2020-12-09
EP20212892.2A EP4011365A1 (en) 2020-12-09 2020-12-09 Mof nanoparticles
PCT/EP2021/085108 WO2022122983A1 (en) 2020-12-09 2021-12-09 Mof nanoparticles

Publications (2)

Publication Number Publication Date
JP2024500350A true JP2024500350A (ja) 2024-01-09
JP2024500350A5 JP2024500350A5 (https=) 2025-01-29

Family

ID=73790017

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023535380A Pending JP2024500350A (ja) 2020-12-09 2021-12-09 Ｍｏｆナノ粒子

Country Status (6)

Country Link
US (1) US20240050379A1 (https=)
EP (2) EP4011365A1 (https=)
JP (1) JP2024500350A (https=)
AU (1) AU2021395441A1 (https=)
CA (1) CA3201758A1 (https=)
WO (1) WO2022122983A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115505131B (zh) * 2022-09-19 2023-07-11 西南交通大学 氨基功能化的发光金属有机骨架及其制备方法和应用
CN115895152B (zh) * 2022-09-19 2023-12-26 西南交通大学 pH膜传感器、pH膜传感器的制备方法以及pH值的检测方法
CN116036263B (zh) * 2022-12-20 2026-01-13 西南大学 一种基于锆金属有机框架的复合纳米佐剂制剂及其在动物疫苗中的应用
WO2025010407A2 (en) * 2023-07-05 2025-01-09 The University Of Chicago Nanoscale metal-organic frameworks with x-ray triggerable prodrugs for combination radiotherapy, chemotherapy, and immunotherapy
WO2025125382A1 (en) 2023-12-11 2025-06-19 Cambridge Enterprise Limited Mof nanoparticles
WO2025125384A1 (en) 2023-12-11 2025-06-19 Cambridge Enterprise Limited Hydrogel compositions
CN119896750B (zh) * 2025-01-23 2025-11-04 常州大学 一种负载侧柏精油的钾掺杂金属有机骨架抗菌纳米粒及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020526558A (ja) * 2017-07-13 2020-08-31 ノースウェスタン ユニバーシティ オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2921661B1 (fr) * 2007-10-01 2013-05-31 Centre Nat Rech Scient Solide hybride organique inorganique a surface modifiee.
GB2472446A (en) * 2009-08-07 2011-02-09 Ct Fuer Angewandte Nanotechnologie Metal oxide particles coated with polyethylene glycol and their synthesis
CN110731961A (zh) * 2014-10-14 2020-01-31 芝加哥大学 金属有机框架、药物制剂及其在制备药物中的用途
GB201511125D0 (en) 2015-06-24 2015-08-05 Cambridge Entpr Ltd Amorhous metal-organic frameworks

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020526558A (ja) * 2017-07-13 2020-08-31 ノースウェスタン ユニバーシティ オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATURE COMMUNICATIONS, vol. Vol.11:2495, JPN6025039013, 19 May 2020 (2020-05-19), pages 1 - 8, ISSN: 0005697613 *

Also Published As

Publication number Publication date
AU2021395441A9 (en) 2023-07-27
CA3201758A1 (en) 2022-06-16
EP4011365A1 (en) 2022-06-15
EP4259109A1 (en) 2023-10-18
US20240050379A1 (en) 2024-02-15
WO2022122983A1 (en) 2022-06-16
AU2021395441A1 (en) 2023-06-29

Similar Documents

Publication Publication Date Title
JP2024500350A (ja) Ｍｏｆナノ粒子
Wu et al. Functionalized MoS2 nanosheet-capped periodic mesoporous organosilicas as a multifunctional platform for synergistic targeted chemo-photothermal therapy
Zhao et al. PEGylated mesoporous silica as a redox-responsive drug delivery system for loading thiol-containing drugs
Yang et al. Synthesis and characterization of biotin modified cholesteryl pullulan as a novel anticancer drug carrier
US10159738B2 (en) Organic-inorganic hybrid solid having a modified outer surface
Tang et al. Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery
Schneid et al. Colloidal stability and redispersibility of mesoporous silica nanoparticles in biological media
JP5547078B2 (ja) カルボン酸鉄系有機／無機ハイブリッドナノ粒子
US10272157B2 (en) Porous solid with outer surface grafted with a polymer
Kritskiy et al. Methotrexate-loaded metal-organic frameworks on the basis of γ-cyclodextrin: Design, characterization, in vitro and in vivo investigation
Gao et al. Biodegradable mesoporous nanocomposites with dual-targeting function for enhanced anti-tumor therapy
Kong et al. Polyethyleneimine-stabilized hydroxyapatite nanoparticles modified with hyaluronic acid for targeted drug delivery
Liu et al. Enhancing drug delivery efficacy through bilayer coating of zirconium-based metal–organic frameworks: sustained release and improved chemical stability and cellular uptake for cancer therapy
Zhang et al. Thermo-responsive mesoporous silica/lipid bilayer hybrid nanoparticles for doxorubicin on-demand delivery and reduced premature release
Narayan et al. Mesoporous silica nanoparticles capped with chitosan-glucuronic acid conjugate for pH-responsive targeted delivery of 5-fluorouracil
CN104644573B (zh) 载三氧化二砷pH响应介孔二氧化硅纳米粒及其制备方法
Truong-Thi et al. pH-responsive delivery of Platinum-based drugs through the surface modification of heparin on mesoporous silica nanoparticles
Yang et al. Multifunctional mesoporous silica nanoparticles with different morphological characteristics for in vitro cancer treatment
Yan et al. Templated fabrication of pH-responsive poly (l-glutamic acid) based nanogels via surface-grafting and macromolecular crosslinking
WO2017174437A1 (en) Ceria nanoparticles for use in the treatment of hepatocellular carcinoma
García-Uriostegui et al. Synthesis and characterization of mesoporous silica-g-poly (hydroxyethylmethacrylate) nanohybrid particles as a drug delivery system
Fei et al. Folic acid modified fe 3 o 4 nanoclusters by a one-step ultrasonic technique for drug delivery and mr imaging
Zhou et al. Nanocomposites of ionic copolymer integrating Gd-containing polyoxometalate as a multiple platform for enhanced MRI and pH-response chemotherapy
CN108888773B (zh) 自组装球形药物纳米制剂及其制备方法与用途
Rajab et al. Olmesartan Medoxomil Nanomicelle Using Soluplus for Dissolution Enhancement: Preparation, In-vitro and Ex-vivo Evaluation

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20241209

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20241209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250108

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250911

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250930

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20251226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20260226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260326