JP2024109657A5 - - Google Patents
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- JP2024109657A5 JP2024109657A5 JP2024076622A JP2024076622A JP2024109657A5 JP 2024109657 A5 JP2024109657 A5 JP 2024109657A5 JP 2024076622 A JP2024076622 A JP 2024076622A JP 2024076622 A JP2024076622 A JP 2024076622A JP 2024109657 A5 JP2024109657 A5 JP 2024109657A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- transgene
- promoter
- clr
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 17
- 108700019146 Transgenes Proteins 0.000 claims 15
- 239000003446 ligand Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 230000001939 inductive effect Effects 0.000 claims 10
- 102000003945 NF-kappa B Human genes 0.000 claims 6
- 108010057466 NF-kappa B Proteins 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- -1 CD3δ Proteins 0.000 claims 3
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 3
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 3
- 108091027981 Response element Proteins 0.000 claims 3
- 101710204410 Scaffold protein Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 3
- 230000000139 costimulatory effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102100022641 Coagulation factor IX Human genes 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101100273713 Homo sapiens CD2 gene Proteins 0.000 claims 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108091005703 transmembrane proteins Proteins 0.000 claims 2
- 102000035160 transmembrane proteins Human genes 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 101150074155 DHFR gene Proteins 0.000 claims 1
- 108010076282 Factor IX Proteins 0.000 claims 1
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 101000579123 Homo sapiens Phosphoglycerate kinase 1 Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 claims 1
- 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- KJWZYMMLVHIVSU-IYCNHOCDSA-N PGK1 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](CCCCCCC(O)=O)C(=O)CC1=O KJWZYMMLVHIVSU-IYCNHOCDSA-N 0.000 claims 1
- 102100028251 Phosphoglycerate kinase 1 Human genes 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 108010068032 caltractin Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229960004222 factor ix Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000009429 hemophilia B Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556310P | 2017-09-08 | 2017-09-08 | |
| US62/556,310 | 2017-09-08 | ||
| JP2020513604A JP2020532987A (ja) | 2017-09-08 | 2018-09-10 | キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法 |
| PCT/US2018/050288 WO2019051424A2 (en) | 2017-09-08 | 2018-09-10 | COMPOSITIONS AND METHODS FOR CONDITIONAL GENE EXPRESSION MEDIATED BY A CHIMERIC LIGAND RECEPTOR (CLR) |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513604A Division JP2020532987A (ja) | 2017-09-08 | 2018-09-10 | キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024109657A JP2024109657A (ja) | 2024-08-14 |
| JP2024109657A5 true JP2024109657A5 (enExample) | 2024-10-25 |
Family
ID=64270934
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513604A Pending JP2020532987A (ja) | 2017-09-08 | 2018-09-10 | キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法 |
| JP2024076622A Pending JP2024109657A (ja) | 2017-09-08 | 2024-05-09 | キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513604A Pending JP2020532987A (ja) | 2017-09-08 | 2018-09-10 | キメラリガンド受容体（ｃｌｒ）介在性の条件遺伝子発現のための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12385061B2 (enExample) |
| EP (1) | EP3679145A2 (enExample) |
| JP (2) | JP2020532987A (enExample) |
| CN (1) | CN111727256A (enExample) |
| AU (2) | AU2018329741B2 (enExample) |
| CA (1) | CA3072777A1 (enExample) |
| WO (1) | WO2019051424A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109689694B (zh) | 2016-05-19 | 2022-11-22 | 通用医疗公司 | 与其受体IL-2Rβ结合的IL2作为用来增强自然杀伤细胞和调节性T细胞活性的平台 |
| JP7165717B2 (ja) | 2017-03-15 | 2022-11-04 | パンディオン・オペレーションズ・インコーポレイテッド | 標的免疫寛容 |
| MX2019013517A (es) | 2017-05-24 | 2020-08-17 | Pandion Operations Inc | Inmunotolerancia dirigida. |
| EP3679145A2 (en) | 2017-09-08 | 2020-07-15 | Poseida Therapeutics, Inc. | Compositions and methods for chimeric ligand receptor (clr)-mediated conditional gene expression |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| JP7558167B2 (ja) | 2018-12-03 | 2024-09-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | オリゴベンズアミド類似体およびがん処置におけるそれらの使用 |
| SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
| AU2020264484A1 (en) | 2019-05-01 | 2021-11-04 | Adoc Ssf, Llc | Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy |
| WO2020227166A1 (en) * | 2019-05-03 | 2020-11-12 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of metachromatic leukodystrophy |
| EP3972992A4 (en) | 2019-05-20 | 2023-07-19 | Pandion Operations, Inc. | MADCAM TARGETED IMMUNOTLERANCE |
| EP3753566A1 (en) * | 2019-06-21 | 2020-12-23 | Medizinische Hochschule Hannover | All-in one viral vector for car and therapeutic effector molecule |
| CN114245803A (zh) * | 2019-08-06 | 2022-03-25 | 儿童医疗中心有限公司 | 用于重构小神经胶质细胞的方法和组合物 |
| KR20220097875A (ko) | 2019-09-03 | 2022-07-08 | 마이얼로이드 테라퓨틱스, 인크. | 게놈 통합을 위한 방법 및 조성물 |
| CN114761418B (zh) * | 2019-12-02 | 2025-04-29 | 株式会社Lg化学 | Cho细胞衍生的蛋白分泌因子和包含它的表达载体 |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| US20230167464A1 (en) * | 2020-04-27 | 2023-06-01 | The Trustees Of The University Of Pennsylvania | Compositions and methods for reducing nuclease expression and off-target activity using a promoter with low transcriptional activity |
| US20210363212A1 (en) * | 2020-05-21 | 2021-11-25 | Crispr Therapeutics Ag | Genetically engineered car t cells that secret interleukin-12 and therapeutic uses thereof |
| US20230322898A1 (en) * | 2020-07-31 | 2023-10-12 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising cell expressing chimeric receptor |
| WO2022226375A1 (en) * | 2021-04-23 | 2022-10-27 | Locanabio, Inc. | Tissue-targeted modified aav capsids and methods of use thereof |
| EP4082560B1 (en) * | 2021-04-27 | 2025-02-26 | Academia Sinica | Prap1 polypeptide for use in treating hypertriglyceridemia |
| US20240207405A1 (en) * | 2021-04-28 | 2024-06-27 | The General Hospital Corporation | Il2 tethered to its receptor il2rbeta and pore-forming proteins as a platform to enhance immune cell activity |
| EP4337268A4 (en) | 2021-05-11 | 2025-06-04 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| EP4373845A4 (en) * | 2021-07-23 | 2025-06-25 | The Children's Medical Center Corporation | Zinc finger ccch-type containing 14 (zc3h14) mutants and methods of use |
| CN114940974A (zh) * | 2021-09-28 | 2022-08-26 | 宁波熙宁检测技术有限公司 | 4-1bb报告基因293t稳转细胞株构建和应用 |
| US20250333758A1 (en) * | 2021-12-15 | 2025-10-30 | Genans Biotechnology Co., Ltd | Microglia having car and use thereof |
| CN115216492B (zh) * | 2022-06-29 | 2023-05-30 | 浙江欧赛思生物科技有限公司 | 一种小鼠原发神经胶质瘤模型的制备方法及其应用 |
| GB202219568D0 (en) * | 2022-12-22 | 2023-02-08 | Autolus Ltd | Chimeric antigen receptor |
| WO2025070635A1 (ja) * | 2023-09-27 | 2025-04-03 | 味の素株式会社 | 免疫細胞培養用培地 |
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| KR20210073520A (ko) | 2018-09-05 | 2021-06-21 | 포세이다 테라퓨틱스, 인크. | 동종이계 세포 조성물 및 이의 사용 방법 |
-
2018
- 2018-09-10 EP EP18800779.3A patent/EP3679145A2/en active Pending
- 2018-09-10 CN CN201880071587.1A patent/CN111727256A/zh active Pending
- 2018-09-10 WO PCT/US2018/050288 patent/WO2019051424A2/en not_active Ceased
- 2018-09-10 AU AU2018329741A patent/AU2018329741B2/en active Active
- 2018-09-10 JP JP2020513604A patent/JP2020532987A/ja active Pending
- 2018-09-10 US US16/640,788 patent/US12385061B2/en active Active
- 2018-09-10 CA CA3072777A patent/CA3072777A1/en active Pending
-
2024
- 2024-05-09 JP JP2024076622A patent/JP2024109657A/ja active Pending
-
2025
- 2025-05-21 AU AU2025203769A patent/AU2025203769A1/en active Pending
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