JP2024105648A5 - - Google Patents
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- Publication number
- JP2024105648A5 JP2024105648A5 JP2024081730A JP2024081730A JP2024105648A5 JP 2024105648 A5 JP2024105648 A5 JP 2024105648A5 JP 2024081730 A JP2024081730 A JP 2024081730A JP 2024081730 A JP2024081730 A JP 2024081730A JP 2024105648 A5 JP2024105648 A5 JP 2024105648A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cmklr1
- compound
- amino acid
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims 51
- 102100031011 Chemerin-like receptor 1 Human genes 0.000 claims 22
- 101000919756 Homo sapiens Chemerin-like receptor 1 Proteins 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 239000000556 agonist Substances 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 9
- 102000004127 Cytokines Human genes 0.000 claims 8
- 108090000695 Cytokines Proteins 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 210000000066 myeloid cell Anatomy 0.000 claims 6
- 230000026731 phosphorylation Effects 0.000 claims 6
- 238000006366 phosphorylation reaction Methods 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 230000028327 secretion Effects 0.000 claims 6
- 206010009887 colitis Diseases 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 238000001727 in vivo Methods 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 210000002540 macrophage Anatomy 0.000 claims 4
- 230000000770 proinflammatory effect Effects 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 230000003111 delayed effect Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 102000003814 Interleukin-10 Human genes 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 102000013462 Interleukin-12 Human genes 0.000 claims 2
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 206010024291 Leukaemias acute myeloid Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 102100033914 Retinoic acid receptor responder protein 2 Human genes 0.000 claims 2
- 101710170513 Retinoic acid receptor responder protein 2 Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000010287 polarization Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000001270 agonistic effect Effects 0.000 claims 1
- 210000004507 artificial chromosome Anatomy 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000020411 cell activation Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 206010023332 keratitis Diseases 0.000 claims 1
- 201000010666 keratoconjunctivitis Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 2
- RSMZEHCMIOKNMW-GSSVUCPTSA-N Asp-Thr-Thr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O RSMZEHCMIOKNMW-GSSVUCPTSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18305395.8 | 2018-04-03 | ||
| EP18305395 | 2018-04-03 | ||
| PCT/EP2019/058358 WO2019193029A1 (en) | 2018-04-03 | 2019-04-03 | Anti-chemokin like receptor 1 antibodies and their therapeutic applications |
| JP2020554298A JP2021520210A (ja) | 2018-04-03 | 2019-04-03 | 抗ケモカイン様受容体1抗体及びその治療応用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554298A Division JP2021520210A (ja) | 2018-04-03 | 2019-04-03 | 抗ケモカイン様受容体1抗体及びその治療応用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024105648A JP2024105648A (ja) | 2024-08-06 |
| JP2024105648A5 true JP2024105648A5 (enExample) | 2024-12-16 |
Family
ID=62046804
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554298A Pending JP2021520210A (ja) | 2018-04-03 | 2019-04-03 | 抗ケモカイン様受容体1抗体及びその治療応用 |
| JP2024081730A Revoked JP2024105648A (ja) | 2018-04-03 | 2024-05-20 | 抗ケモカイン様受容体1抗体及びその治療応用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554298A Pending JP2021520210A (ja) | 2018-04-03 | 2019-04-03 | 抗ケモカイン様受容体1抗体及びその治療応用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20210147558A1 (enExample) |
| EP (2) | EP3774899A1 (enExample) |
| JP (2) | JP2021520210A (enExample) |
| KR (2) | KR20250065423A (enExample) |
| CN (2) | CN112218894A (enExample) |
| AU (1) | AU2019247068A1 (enExample) |
| BR (1) | BR112020020118A2 (enExample) |
| CA (1) | CA3102607A1 (enExample) |
| IL (2) | IL277701A (enExample) |
| MA (1) | MA52174A (enExample) |
| WO (1) | WO2019193029A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11730705B2 (en) * | 2019-05-02 | 2023-08-22 | The Board Of Trustees Of The Leland Stanford Junior University | Small molecule CMKLR1 antagonists in inflammatory disease |
| EP3804754A1 (en) * | 2019-10-09 | 2021-04-14 | OSE Immunotherapeutics | Cmklr1 agonists having a resolvin e1-like capability and their therapeutic applications |
| KR20220087466A (ko) * | 2019-10-09 | 2022-06-24 | 오제 이뮈노테라프틱스 | 항-케모킨(anti-chemokin) 유사 수용체 1 사람화된 항체 및 이의 치료학적 적용 |
| EP4279142A4 (en) | 2021-01-15 | 2024-12-04 | Reel Tech Co., Ltd. | PORTABLE EMERGENCY ESCAPE DEVICE |
| WO2023076329A1 (en) * | 2021-10-26 | 2023-05-04 | Thetis Pharmaceuticals Llc | Compositions and methods for cancer therapy |
| WO2024028509A2 (en) | 2022-08-05 | 2024-02-08 | Ose Immunotherapeutics | Treatment of an inflammation-associated disease in a patient expressing high chemerin level |
| WO2024028508A2 (en) | 2022-08-05 | 2024-02-08 | Ose Immunotherapeutics | Anti-chemokin like receptor 1 antibody or antigen-binding fragment thereof for use in the treatment of conditions associated with netosis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| US7419658B2 (en) * | 2001-07-09 | 2008-09-02 | Euroscreen S.A. | Isolated ligand of ChemerinR |
| US20070286863A1 (en) * | 2006-05-17 | 2007-12-13 | Christopher Sinal | CMKLR regulation of adipogenesis and adipocyte metabolic function |
| EP1930342B1 (en) | 2006-12-04 | 2012-01-25 | Institut Pasteur | OB-fold used as scaffold for engineering new specific binders |
| US8038992B2 (en) * | 2008-05-10 | 2011-10-18 | The Board Of Trustees Of The Leland Stanford Junior University | Target for regulating multiple sclerosis |
| WO2013109543A1 (en) * | 2012-01-20 | 2013-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Small molecule cmklr1 antagonists in demyelinating disease |
| JP5883515B2 (ja) * | 2012-02-06 | 2016-03-15 | エーエスエムエル ネザーランズ ビー.ブイ. | 対象物を保持するための支持構造を備えるリソグラフィ装置及びそれに用いられる支持構造 |
| CN102816209A (zh) * | 2012-07-09 | 2012-12-12 | 深圳先进技术研究院 | 一种趋化素衍生肽及其表达基因和应用 |
-
2019
- 2019-04-03 KR KR1020257013411A patent/KR20250065423A/ko active Pending
- 2019-04-03 AU AU2019247068A patent/AU2019247068A1/en active Pending
- 2019-04-03 KR KR1020207031788A patent/KR102802041B1/ko active Active
- 2019-04-03 BR BR112020020118-9A patent/BR112020020118A2/pt unknown
- 2019-04-03 JP JP2020554298A patent/JP2021520210A/ja active Pending
- 2019-04-03 WO PCT/EP2019/058358 patent/WO2019193029A1/en not_active Ceased
- 2019-04-03 EP EP19715092.3A patent/EP3774899A1/en active Pending
- 2019-04-03 US US17/045,130 patent/US20210147558A1/en not_active Abandoned
- 2019-04-03 CN CN201980037001.4A patent/CN112218894A/zh active Pending
- 2019-04-03 EP EP25194341.1A patent/EP4656247A2/en active Pending
- 2019-04-03 MA MA052174A patent/MA52174A/fr unknown
- 2019-04-03 CA CA3102607A patent/CA3102607A1/en active Pending
- 2019-04-03 CN CN202510632905.9A patent/CN120484119A/zh active Pending
-
2020
- 2020-09-30 IL IL277701A patent/IL277701A/en unknown
-
2024
- 2024-05-08 US US18/658,406 patent/US20240400698A1/en active Pending
- 2024-05-20 JP JP2024081730A patent/JP2024105648A/ja not_active Revoked
-
2025
- 2025-05-29 IL IL321209A patent/IL321209A/en unknown
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