JP2024094370A5 - - Google Patents
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- Publication number
- JP2024094370A5 JP2024094370A5 JP2024066342A JP2024066342A JP2024094370A5 JP 2024094370 A5 JP2024094370 A5 JP 2024094370A5 JP 2024066342 A JP2024066342 A JP 2024066342A JP 2024066342 A JP2024066342 A JP 2024066342A JP 2024094370 A5 JP2024094370 A5 JP 2024094370A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- blocking antibody
- administered
- tnfα
- chemokine receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 32
- 230000000903 blocking effect Effects 0.000 claims 16
- 102100022718 Atypical chemokine receptor 2 Human genes 0.000 claims 8
- 108010089833 chemokine receptor D6 Proteins 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 102000006495 integrins Human genes 0.000 claims 8
- 108010044426 integrins Proteins 0.000 claims 8
- 206010009900 Colitis ulcerative Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
- 230000002195 synergetic effect Effects 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 229960004914 vedolizumab Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060454P | 2014-10-06 | 2014-10-06 | |
| US62/060,454 | 2014-10-06 | ||
| JP2020082164A JP7025781B2 (ja) | 2014-10-06 | 2020-05-07 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
| JP2022016197A JP2022051829A (ja) | 2014-10-06 | 2022-02-04 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022016197A Division JP2022051829A (ja) | 2014-10-06 | 2022-02-04 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024094370A JP2024094370A (ja) | 2024-07-09 |
| JP2024094370A5 true JP2024094370A5 (https=) | 2025-03-19 |
Family
ID=55632011
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518197A Active JP6954834B2 (ja) | 2014-10-06 | 2015-10-05 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
| JP2020082164A Active JP7025781B2 (ja) | 2014-10-06 | 2020-05-07 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
| JP2022016197A Pending JP2022051829A (ja) | 2014-10-06 | 2022-02-04 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
| JP2024066342A Pending JP2024094370A (ja) | 2014-10-06 | 2024-04-16 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518197A Active JP6954834B2 (ja) | 2014-10-06 | 2015-10-05 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
| JP2020082164A Active JP7025781B2 (ja) | 2014-10-06 | 2020-05-07 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
| JP2022016197A Pending JP2022051829A (ja) | 2014-10-06 | 2022-02-04 | ＣＣケモカイン受容体９（ＣＣＲ９）の阻害剤と抗α４β７インテグリン遮断抗体の併用療法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10532051B2 (https=) |
| EP (2) | EP3204424B1 (https=) |
| JP (4) | JP6954834B2 (https=) |
| KR (3) | KR102514565B1 (https=) |
| CN (1) | CN107001467A (https=) |
| AU (1) | AU2015328396B2 (https=) |
| CA (3) | CA3296072A1 (https=) |
| ES (1) | ES2971041T3 (https=) |
| IL (2) | IL292655B2 (https=) |
| MA (1) | MA40592A (https=) |
| MX (2) | MX2017004344A (https=) |
| NZ (1) | NZ768528A (https=) |
| RU (1) | RU2713653C2 (https=) |
| SG (1) | SG11201702793XA (https=) |
| WO (1) | WO2016057424A1 (https=) |
| ZA (1) | ZA201701852B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| RU2627268C2 (ru) * | 2012-02-29 | 2017-08-04 | Хемоцентрикс, Инк. | Аза-арил-1Н-пиразол-1-ил-сульфонамиды |
| WO2016057424A1 (en) * | 2014-10-06 | 2016-04-14 | Chemocentryx, Inc. | Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies |
| JP7129912B2 (ja) * | 2016-12-07 | 2022-09-02 | 株式会社ステリック再生医科学研究所 | 慢性疾患の治療及び予防用医薬組成物 |
| US20210154292A1 (en) * | 2019-11-21 | 2021-05-27 | Chemocentryx, Inc. | Compositions and Methods for Treating CCR9-Mediated Diseases using CCR9 Inhibitor and Anti-TNF-Alpha Blocking Antibodies |
| WO2021174024A1 (en) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| TWI904146B (zh) * | 2020-03-31 | 2025-11-11 | 美商卡默森屈有限公司 | 使用ｃｃｒ９抑制劑及抗ｉｌ-２３阻斷抗體治療發炎性腸道疾病的組成物及方法 |
| CN114314701B (zh) * | 2021-11-30 | 2023-10-20 | 昆明贵研药业有限公司 | 一种三氯氨铂酸钾的制备方法及其在制备顺式-氨-水-铂配合物中的应用 |
| WO2024249568A1 (en) | 2023-05-30 | 2024-12-05 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
| CN121889424A (zh) | 2023-08-14 | 2026-04-17 | 派拉冈医疗公司 | α4β7整联蛋白结合蛋白及使用方法 |
| WO2025177214A1 (en) * | 2024-02-20 | 2025-08-28 | Takeda Pharmaceutical Company Limited | Therapeutic methods |
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| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US6159686A (en) | 1992-09-14 | 2000-12-12 | Sri International | Up-converting reporters for biological and other assays |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6251303B1 (en) | 1998-09-18 | 2001-06-26 | Massachusetts Institute Of Technology | Water-soluble fluorescent nanocrystals |
| US6326144B1 (en) | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
| US6306610B1 (en) | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| US6451399B1 (en) | 2001-02-05 | 2002-09-17 | Daniel G. Boyce | Display mat |
| NZ566263A (en) | 2002-05-24 | 2009-09-25 | Millennium Pharm Inc | CCR9 inhibitors and methods of use thereof |
| US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
| KR100874292B1 (ko) | 2002-11-18 | 2008-12-18 | 케모센트릭스 | 아릴 술폰아마이드 |
| US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
| TW200510311A (en) | 2002-12-23 | 2005-03-16 | Millennium Pharm Inc | CCr8 inhibitors |
| SE0301653D0 (sv) | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| AU2005245401A1 (en) | 2004-05-12 | 2005-12-01 | Chemocentryx | Aryl sulfonamides |
| SE0402635D0 (sv) | 2004-10-29 | 2004-10-29 | Astrazeneca Ab | Chemical compounds |
| US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| US20120283411A9 (en) * | 2006-06-29 | 2012-11-08 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
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| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
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| CN103382222B (zh) | 2009-03-20 | 2016-12-28 | 安姆根有限公司 | α-4-β-7异二聚体特异性拮抗剂抗体 |
| MX367097B (es) | 2011-05-02 | 2019-08-05 | Millennium Pharm Inc | FORMULACION PARA ANTICUERPO ANTI-A4ß7. |
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| CN103841971B (zh) | 2011-07-22 | 2016-09-14 | 坎莫森特里克斯公司 | 4-叔丁基-n-[4-氯-2-(1-氧基-吡啶-4-羰基)-苯基]-苯磺酰胺的钠盐的多晶型形式 |
| WO2013016156A1 (en) | 2011-07-22 | 2013-01-31 | Glaxo Group Limited | Polymorphic forms of the sodium salt of 4-tert- butyl -n-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzene sulfonamide |
| PL2748146T3 (pl) | 2011-07-22 | 2017-09-29 | Chemocentryx, Inc. | Postać krystaliczna soli sodowej 4-tert-butylo-n-[4-chloro-2-(1-oksy-pirydyno-4-karbonylo)-fenylo]-benzenosulfonamidu |
| RU2627268C2 (ru) | 2012-02-29 | 2017-08-04 | Хемоцентрикс, Инк. | Аза-арил-1Н-пиразол-1-ил-сульфонамиды |
| WO2016057424A1 (en) * | 2014-10-06 | 2016-04-14 | Chemocentryx, Inc. | Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies |
-
2015
- 2015-10-05 WO PCT/US2015/054077 patent/WO2016057424A1/en not_active Ceased
- 2015-10-05 AU AU2015328396A patent/AU2015328396B2/en active Active
- 2015-10-05 IL IL292655A patent/IL292655B2/en unknown
- 2015-10-05 CA CA3296072A patent/CA3296072A1/en active Pending
- 2015-10-05 ES ES15848916T patent/ES2971041T3/es active Active
- 2015-10-05 MX MX2017004344A patent/MX2017004344A/es unknown
- 2015-10-05 CA CA3224013A patent/CA3224013A1/en active Pending
- 2015-10-05 CA CA2960876A patent/CA2960876C/en active Active
- 2015-10-05 KR KR1020177012272A patent/KR102514565B1/ko active Active
- 2015-10-05 KR KR1020237009744A patent/KR102642382B1/ko active Active
- 2015-10-05 EP EP15848916.1A patent/EP3204424B1/en active Active
- 2015-10-05 US US14/875,506 patent/US10532051B2/en active Active
- 2015-10-05 RU RU2017115809A patent/RU2713653C2/ru active
- 2015-10-05 EP EP23197483.3A patent/EP4268820A3/en active Pending
- 2015-10-05 SG SG11201702793XA patent/SG11201702793XA/en unknown
- 2015-10-05 JP JP2017518197A patent/JP6954834B2/ja active Active
- 2015-10-05 KR KR1020247006273A patent/KR20240033093A/ko not_active Ceased
- 2015-10-05 NZ NZ768528A patent/NZ768528A/en unknown
- 2015-10-05 MA MA040592A patent/MA40592A/fr unknown
- 2015-10-05 IL IL251136A patent/IL251136B/en unknown
- 2015-10-05 CN CN201580054158.XA patent/CN107001467A/zh active Pending
-
2017
- 2017-03-15 ZA ZA2017/01852A patent/ZA201701852B/en unknown
- 2017-04-03 MX MX2022008951A patent/MX2022008951A/es unknown
-
2019
- 2019-12-09 US US16/708,167 patent/US11020394B2/en active Active
-
2020
- 2020-05-07 JP JP2020082164A patent/JP7025781B2/ja active Active
- 2020-05-14 US US15/929,647 patent/US11045469B2/en active Active
-
2021
- 2021-05-24 US US17/328,293 patent/US20210322410A1/en not_active Abandoned
-
2022
- 2022-02-04 JP JP2022016197A patent/JP2022051829A/ja active Pending
-
2024
- 2024-04-16 JP JP2024066342A patent/JP2024094370A/ja active Pending
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