JP2024076141A - Method for producing skin cosmetic - Google Patents
Method for producing skin cosmetic Download PDFInfo
- Publication number
- JP2024076141A JP2024076141A JP2022187552A JP2022187552A JP2024076141A JP 2024076141 A JP2024076141 A JP 2024076141A JP 2022187552 A JP2022187552 A JP 2022187552A JP 2022187552 A JP2022187552 A JP 2022187552A JP 2024076141 A JP2024076141 A JP 2024076141A
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- JP
- Japan
- Prior art keywords
- oil
- water
- surfactant
- present
- examples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000004094 surface-active agent Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 23
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 11
- 235000011187 glycerol Nutrition 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 abstract description 15
- 239000008346 aqueous phase Substances 0.000 abstract description 14
- 230000000087 stabilizing effect Effects 0.000 abstract description 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 48
- 235000019198 oils Nutrition 0.000 description 48
- -1 alkyl glyceryl ethers Chemical class 0.000 description 39
- 235000014113 dietary fatty acids Nutrition 0.000 description 27
- 239000000194 fatty acid Substances 0.000 description 27
- 229930195729 fatty acid Natural products 0.000 description 27
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 20
- 150000004665 fatty acids Chemical class 0.000 description 19
- 239000003795 chemical substances by application Substances 0.000 description 18
- 230000000694 effects Effects 0.000 description 15
- 229960003237 betaine Drugs 0.000 description 11
- 229920001296 polysiloxane Polymers 0.000 description 11
- 239000002280 amphoteric surfactant Substances 0.000 description 10
- 239000012071 phase Substances 0.000 description 10
- 239000003240 coconut oil Substances 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 239000003925 fat Substances 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 6
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 5
- 239000004166 Lanolin Substances 0.000 description 5
- 150000005215 alkyl ethers Chemical class 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
- 235000019388 lanolin Nutrition 0.000 description 5
- 229940039717 lanolin Drugs 0.000 description 5
- 150000003904 phospholipids Chemical class 0.000 description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 235000015278 beef Nutrition 0.000 description 4
- 235000019864 coconut oil Nutrition 0.000 description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- FKKAGFLIPSSCHT-UHFFFAOYSA-N 1-dodecoxydodecane;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC FKKAGFLIPSSCHT-UHFFFAOYSA-N 0.000 description 3
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 3
- MPNXSZJPSVBLHP-UHFFFAOYSA-N 2-chloro-n-phenylpyridine-3-carboxamide Chemical compound ClC1=NC=CC=C1C(=O)NC1=CC=CC=C1 MPNXSZJPSVBLHP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000005639 Lauric acid Substances 0.000 description 3
- 235000019482 Palm oil Nutrition 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000002540 palm oil Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- CAYHVMBQBLYQMT-UHFFFAOYSA-N 2-decyltetradecan-1-ol Chemical compound CCCCCCCCCCCCC(CO)CCCCCCCCCC CAYHVMBQBLYQMT-UHFFFAOYSA-N 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 125000005037 alkyl phenyl group Chemical group 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000010639 cypress oil Substances 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 229940079886 disodium lauryl sulfosuccinate Drugs 0.000 description 2
- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229960002449 glycine Drugs 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000012182 japan wax Substances 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- JXHZVHFODJSANQ-UHFFFAOYSA-N n-ethyl-n-methylethanamine;hydrochloride Chemical compound Cl.CCN(C)CC JXHZVHFODJSANQ-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 2
- 229960003656 ricinoleic acid Drugs 0.000 description 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 239000013535 sea water Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 2
- 239000002383 tung oil Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 1
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- JXNPEDYJTDQORS-HZJYTTRNSA-N (9Z,12Z)-octadecadien-1-ol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCO JXNPEDYJTDQORS-HZJYTTRNSA-N 0.000 description 1
- IKYKEVDKGZYRMQ-PDBXOOCHSA-N (9Z,12Z,15Z)-octadecatrien-1-ol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCO IKYKEVDKGZYRMQ-PDBXOOCHSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- JPPRXACMNPYJNK-UHFFFAOYSA-N 1-docosoxydocosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCC JPPRXACMNPYJNK-UHFFFAOYSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- UUWJHAWPCRFDHZ-UHFFFAOYSA-N 1-dodecoxydodecane;phosphoric acid Chemical compound OP(O)(O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC UUWJHAWPCRFDHZ-UHFFFAOYSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- XWOVRWIRPYMVKK-UHFFFAOYSA-N 1-octadecoxyoctadecane;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC XWOVRWIRPYMVKK-UHFFFAOYSA-N 0.000 description 1
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- DHGBAFGZLVRESL-UHFFFAOYSA-N 14-methylpentadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C DHGBAFGZLVRESL-UHFFFAOYSA-N 0.000 description 1
- XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- YPDCDBRKWQYBPV-UHFFFAOYSA-N 2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)NCCN(CCO)CC(O)=O YPDCDBRKWQYBPV-UHFFFAOYSA-N 0.000 description 1
- BTMZHHCFEOXAAN-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;2-dodecylbenzenesulfonic acid Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O BTMZHHCFEOXAAN-UHFFFAOYSA-N 0.000 description 1
- HVYJSOSGTDINLW-UHFFFAOYSA-N 2-[dimethyl(octadecyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O HVYJSOSGTDINLW-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
- XULHFMYCBKQGEE-UHFFFAOYSA-N 2-hexyl-1-Decanol Chemical compound CCCCCCCCC(CO)CCCCCC XULHFMYCBKQGEE-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- ZIIVEKCKOPDBLT-UHFFFAOYSA-N 2-octyldodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCC(COC(=O)C(C)O)CCCCCCCC ZIIVEKCKOPDBLT-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- CVZYWFZBNHBFDS-UHFFFAOYSA-N 3-(dodecylamino)propanoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCNCCC(O)=O CVZYWFZBNHBFDS-UHFFFAOYSA-N 0.000 description 1
- UNWFFCPRJXMCNV-UHFFFAOYSA-N 3-[dodecanoyl(methyl)amino]propanoic acid Chemical class CCCCCCCCCCCC(=O)N(C)CCC(O)=O UNWFFCPRJXMCNV-UHFFFAOYSA-N 0.000 description 1
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 description 1
- FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 1
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- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- WPVMVUZSNJGLSB-UHFFFAOYSA-N sodium;2-(1-undecyl-4,5-dihydroimidazol-1-ium-1-yl)ethanol Chemical compound [Na+].CCCCCCCCCCC[N+]1(CCO)CCN=C1 WPVMVUZSNJGLSB-UHFFFAOYSA-N 0.000 description 1
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 description 1
- HWCHICTXVOMIIF-UHFFFAOYSA-M sodium;3-(dodecylamino)propanoate Chemical compound [Na+].CCCCCCCCCCCCNCCC([O-])=O HWCHICTXVOMIIF-UHFFFAOYSA-M 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 description 1
- RUTSRVMUIGMTHJ-UHFFFAOYSA-M sodium;tetradec-1-ene-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCC=CS([O-])(=O)=O RUTSRVMUIGMTHJ-UHFFFAOYSA-M 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 235000002316 solid fats Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 229940105956 tea-dodecylbenzenesulfonate Drugs 0.000 description 1
- DZUJSXDQZILVCD-UHFFFAOYSA-N tetradecyl 2-(dimethylamino)acetate Chemical compound CCCCCCCCCCCCCCOC(=O)CN(C)C DZUJSXDQZILVCD-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- SZEMGTQCPRNXEG-UHFFFAOYSA-M trimethyl(octadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C SZEMGTQCPRNXEG-UHFFFAOYSA-M 0.000 description 1
- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 229940036248 turpentine Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Colloid Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Description
本発明は、皮膚化粧料に関するものである。詳細には、高濃度の油性成分を水相に安定的に素早く分散させる方法に関する。 The present invention relates to skin cosmetics. In particular, it relates to a method for stably and quickly dispersing a high concentration of oily components in an aqueous phase.
皮膚化粧料には、使用感触に優れており、肌の保湿効果があることだけでなく、保湿効果以外の肌への美容効果があることが求められている。そのため、皮膚化粧料には肌への美容効果や製品の市場訴求性を期待して様々な有効成分が添加される。そのような有効成分は、一般的には油溶性の高い成分(油性成分)であり、全重量における水の占める割合が高い皮膚化粧料に安定的に、かつ素早く分散させることは工夫が必要である。 Skin cosmetics are required to have an excellent feel when used and moisturize the skin, as well as other cosmetic effects on the skin. For this reason, various active ingredients are added to skin cosmetics in the hope of achieving cosmetic effects on the skin and increasing the market appeal of the product. Such active ingredients are generally highly oil-soluble (oily ingredients), and it takes ingenuity to disperse them stably and quickly in skin cosmetics, which contain a high proportion of water by weight.
従来の油剤、界面活性剤、グリセリン及び水を含有する皮膚化粧料においては、前記4成分を同時に混ぜただけでは、油剤の安定性を担保することができない。また、油剤及び界面活性剤の混合物を、グリセリン及び水の混合物に添加しただけでは、油剤及び界面活性剤の混合物を全体的に均一に分散させるのに時間がかかる。そこで、本発明は、油剤、界面活性剤、グリセリン及び水を含有する皮膚化粧料において、油剤を安定させ素早く水相に分散させる方法を提供する。 In conventional skin cosmetics containing an oil, a surfactant, glycerin, and water, the stability of the oil cannot be ensured by simply mixing the four components at the same time. In addition, simply adding a mixture of an oil and a surfactant to a mixture of glycerin and water takes time to disperse the mixture of the oil and surfactant uniformly throughout. Therefore, the present invention provides a method for stabilizing the oil and quickly dispersing it in the water phase in skin cosmetics containing an oil, a surfactant, glycerin, and water.
本発明者は、上記課題について鋭意検討したところ、(A)油剤と、(B)ノニオン界面活性剤と、(C)グリセリンと、(D)水とを含む皮膚化粧料の製造方法であって、(A)油剤と(B)ノニオン界面活性剤とを混合し、そこへ(C)グリセリンを添加し分散させたあとに、(D)水を加えることで、前記(A)成分を安定的に素早く水相に分散させることができることを見出し、本発明を完成させた。 After extensive research into the above-mentioned problems, the inventors discovered a method for producing a skin cosmetic comprising (A) an oil, (B) a nonionic surfactant, (C) glycerin, and (D) water, in which the oil and nonionic surfactant are mixed, (C) glycerin is added and dispersed therein, and then (D) water is added, whereby the (A) component can be dispersed stably and quickly in the aqueous phase, and the present invention has been completed.
すなわち、本発明は、皮膚化粧料の製造方法において、(A)油剤を安定的に、素早く水相に分散させる皮膚化粧料の製造方法を提供するものである。
[1](A)油剤と、(B)ノニオン界面活性剤と、(C)グリセリンと、(D)水とを含む皮膚化粧料の製造方法であって、(A)油剤と(B)ノニオン界面活性剤とを混合し、そこへ(C)グリセリンを添加し分散させたあとに、(D)水を加えることを特徴とする皮膚化粧料の製造方法。
本発明によれば、(A)油剤が多量(高濃度)であっても、水相に安定的に素早く分散させることができる。
[2]前記(B)成分が、PRG-13-デシルテトラデセス-24であることを特徴とする[1]に記載の製造方法。
この特徴によれば、(A)油剤を水相に安定的に素早く分散させる効果をより発揮することができる。
[3]前記(A)成分の含有量に対する前記(B)成分の含有量の値(B/A)が3以上であることを特徴とする、[2]に記載の製造方法。
この特徴によれば、(A)油剤を水相に安定的に素早く分散させる効果をより発揮することができる。
[4]前記(C)成分の含有量に対する、前記(A)成分及び前記(B)成分の含有量の合計の値((A+B)/C)が0.8以下であることを特徴とする、[3]に記載の製造方法。
この特徴によれば、(A)油剤を水相に安定的に素早く分散させる効果をより発揮することができる。また、(A)油剤及び(B)界面活性剤の混合物を水相に素早く分散させる効果を発揮することができる。
That is, the present invention provides a method for producing a skin cosmetic, which can stably and quickly disperse an oily agent (A) in an aqueous phase.
[1] A method for producing a skin cosmetic comprising (A) an oil, (B) a nonionic surfactant, (C) glycerin, and (D) water, the method comprising mixing (A) the oil and (B) the nonionic surfactant, adding and dispersing (C) glycerin thereto, and then adding (D) water.
According to the present invention, even if the oil agent (A) is present in a large amount (high concentration), it can be dispersed stably and quickly in an aqueous phase.
[2] The method according to [1], wherein the component (B) is PRG-13-decyltetradeceth-24.
According to this feature, the effect of stably and quickly dispersing the oil agent (A) in the aqueous phase can be more effectively exhibited.
[3] The method according to [2], wherein the ratio (B/A) of the content of the (B) component to the content of the (A) component is 3 or more.
According to this feature, the effect of stably and quickly dispersing the oil agent (A) in the aqueous phase can be more effectively exhibited.
[4] The manufacturing method according to [3], characterized in that the total content of the (A) component and the (B) component relative to the content of the (C) component ((A+B)/C) is 0.8 or less.
According to this feature, the effect of stably and quickly dispersing the oil agent (A) in the aqueous phase can be more effectively exhibited, and the effect of quickly dispersing a mixture of the oil agent (A) and the surfactant (B) in the aqueous phase can also be effectively exhibited.
本発明によれば、油剤、ノニオン界面活性剤、グリセリン及び水を含有する皮膚化粧料の製造方法において、油剤を安定させ素早く水相に分散することができる皮膚化粧料の製造方法を提供することができる。 The present invention provides a method for producing a skin cosmetic that contains an oil, a nonionic surfactant, glycerin, and water, and that can stabilize the oil and quickly disperse it in the aqueous phase.
以下、本発明に係る皮膚化粧料の製造方法の実施形態について、詳細に説明する。
なお、本実施形態に記載する皮膚化粧料の製造方法については、本発明を説明するために例示したに過ぎず、これに限定されるものではない。
Hereinafter, an embodiment of the method for producing a skin cosmetic according to the present invention will be described in detail.
It should be noted that the method for producing a skin cosmetic described in this embodiment is merely an example for the purpose of explaining the present invention, and the present invention is not limited thereto.
((A)油剤)
油剤とは、皮膚の表面に滑らかに伸び、皮膚から水分を蒸散させない油溶性の成分である。エモリエント剤と呼ばれることもある。本発明に用いられる油剤は、通常化粧料に配合され得る油剤であれば特に限定されるものでなく、例えば、油脂、精油、シリコーン油、ロウ類、炭化水素、高級アルコール、高級脂肪酸、エステル類、フッ素油ならびにアルキルグリセリルエーテルとその脂肪酸エステル、リン脂質等が挙げられる。これらは、1種単独で含有してもよく、2種以上含有してもよい。
((A) Oil agent)
An oil is an oil-soluble component that spreads smoothly on the surface of the skin and does not allow moisture to evaporate from the skin. It is also called an emollient. The oil used in the present invention is not particularly limited as long as it is an oil that can be normally blended in cosmetics, and examples thereof include fats and oils, essential oils, silicone oils, waxes, hydrocarbons, higher alcohols, higher fatty acids, esters, fluorine oils, alkyl glyceryl ethers and their fatty acid esters, phospholipids, etc. These may be contained alone or in combination.
油脂は、脂質の一種で、天然由来の脂肪酸とグリセリンとのエステル化合物を指す。油脂としては、アボガド油、ツバキ油、月見草油、タートル油、マカデミアナッツ油、トウモロコシ油、ミンク油、オリーブ油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、ホホバ油、胚芽油、トリグリセリン、トリオクタン酸グリセリン、トリイソパルミチン酸グリセリン等の液体油脂;カカオ脂、ヤシ油、馬脂、硬化ヤシ油、パーム油、牛脂、羊脂、硬化牛脂、パーム核油、豚脂、牛骨脂、モクロウ核油、硬化油、牛脚脂、モクロウ、硬化ヒマシ油、等の固体油脂などが挙げられる。 Fats and oils are a type of lipid and refer to ester compounds of naturally occurring fatty acids and glycerin. Examples of fats and oils include liquid fats and oils such as avocado oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, triglycerin, glycerin trioctanoate, and glycerin triisopalmitate; and solid fats and oils such as cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, mutton tallow, hardened beef tallow, palm kernel oil, lard, beef bone fat, Japan wax kernel oil, hardened oil, beef leg fat, Japan wax, and hardened castor oil.
精油は、ティーツリーオイル(tea tree oil)、スギ油、ヒバ油、ヒノキ油、ユーカリ油、ラベンダー油、ジャスミン油、ローズ油、レモン油、オレンジ油等が挙げられる。 Essential oils include tea tree oil, cedar oil, Japanese cypress oil, cypress oil, eucalyptus oil, lavender oil, jasmine oil, rose oil, lemon oil, orange oil, etc.
シリコーン油は、有機基のついたケイ素と酸素が化学結合により交互に連なった合成高分子である。シリコーン油は、直鎖状であってもよく、分岐状であってもよい。例えば、ジメチルポリシロキサン(INCI名:ジメチコン)、ヒドロキシ末端基を有するジメチルポリシロキサン(INCI名:ジメチコノール)、メチルフェニルポリシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサシロキサン、ポリエーテル変性シリコーン(ポリアルキレングリコール変性シリコーン等)、平均重合度が650~10000の高重合シリコーン、アミノ変性シリコーン、ベタイン変性シリコーン、アルキル変性シリコーン、アルコキシ変性シリコーン、メルカプト変性シリコーン、カルボキシ変性シリコーン、フッ素変性シリコーン等を挙げることができる。
上記アミノ変性シリコーンとしては、例えば、アミノプロピルメチルシロキサン・ジメチルシロキサン共重合体(INCI名:アミノプロピルジメチコン)、アミノエチルアミノプロピルシロキサン・ジメチルシロキサン共重合体(INCI名:アモジメチコン)、アミノエチルアミノプロピルメチルシロキサン・ジメチルシロキサン共重合体(INCI名:トリメチルシリルアモジメチコン)等が挙げられる。
Silicone oil is a synthetic polymer in which silicon with an organic group and oxygen are alternately linked by chemical bonds. Silicone oil may be linear or branched. Examples include dimethylpolysiloxane (INCI name: dimethicone), dimethylpolysiloxane with hydroxyl end groups (INCI name: dimethiconol), methylphenylpolysiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, polyether-modified silicone (polyalkylene glycol-modified silicone, etc.), highly polymerized silicone with an average degree of polymerization of 650 to 10,000, amino-modified silicone, betaine-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, mercapto-modified silicone, carboxy-modified silicone, and fluorine-modified silicone.
Examples of the amino-modified silicone include aminopropylmethylsiloxane-dimethylsiloxane copolymer (INCI name: aminopropyl dimethicone), aminoethylaminopropylsiloxane-dimethylsiloxane copolymer (INCI name: amodimethicone), aminoethylaminopropylmethylsiloxane-dimethylsiloxane copolymer (INCI name: trimethylsilylamodimethicone), and the like.
ロウ(ワックス)類は、高級脂肪酸と高級アルコールとのエステル化合物である。ロウ類としては、例えば、キャンデリラワックス、カルナバワックス、ホホバ油、蜜ロウおよびラノリンロウを挙げることができる。 Waxes are ester compounds of higher fatty acids and higher alcohols. Examples of waxes include candelilla wax, carnauba wax, jojoba oil, beeswax, and lanolin wax.
炭化水素は、炭素と水素よりなる化合物である。例えば、流動パラフィン、パラフィン、マイクロクリスタリンワックス、ワセリン、イソパラフィン類、オゾケライト、セレシン、ポリエチレン、α-オレフィンオリゴマー、ポリブテン、合成スクワラン、スクワレン、水添スクワラン、リモネンおよびテレビン油等が挙げられる。 Hydrocarbons are compounds consisting of carbon and hydrogen. Examples include liquid paraffin, paraffin, microcrystalline wax, petrolatum, isoparaffins, ozokerite, ceresin, polyethylene, α-olefin oligomer, polybutene, synthetic squalane, squalene, hydrogenated squalane, limonene, and turpentine.
高級アルコールは、炭素数6(C6)以上の一価アルコールである。高級アルコールとしては、例えば、セチルアルコール(セタノール)、ステアリルアルコール、セトステアリルアルコール、オレイルアルコール、リノレイルアルコール、リノレニルアルコール、アラキルアルコール、ベヘニルアルコール、ラウリルアルコール、ミリスチルアルコール、2-ヘキシルデカノール、イソステアリルアルコール、2-オクチルドデカノール、デシルテトラデカノール、フィトステロール、フィトスタノール、コレステロール、コレスタノール、ラノステロールおよびエルゴステロール等を挙げることができる。 The higher alcohol is a monohydric alcohol having 6 or more carbon atoms (C 6 ). Examples of higher alcohols include cetyl alcohol (cetanol), stearyl alcohol, cetostearyl alcohol, oleyl alcohol, linoleyl alcohol, linolenyl alcohol, arachyl alcohol, behenyl alcohol, lauryl alcohol, myristyl alcohol, 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol, decyltetradecanol, phytosterol, phytostanol, cholesterol, cholestanol, lanosterol, and ergosterol.
高級脂肪酸は、炭素数12(C12)以上の脂肪酸である。高級脂肪酸としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘニン酸、イソステアリン酸、ヒドロキシステアリン酸、12-ヒドロキシステアリン酸、オレイン酸、ウンデシレン酸、リノール酸、リシノール酸およびラノリン脂肪酸等が挙げられる。 Higher fatty acids are fatty acids having 12 or more carbon atoms (C 12 ). Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, hydroxystearic acid, 12-hydroxystearic acid, oleic acid, undecylenic acid, linoleic acid, ricinoleic acid, and lanolin fatty acid.
エステル類は、脂肪酸とアルコールとの脱水反応によって得られる化合物である。例えば、アジピン酸ジイソプロピル、アジピン酸2-ヘキシルデシル、ミリスチン酸イソプロピル、ミリスチン酸ミリスチル、オクタン酸セチル、イソオクタン酸セチル、イソノナン酸イソノニル、セバシン酸ジイソプロピル、パルミチン酸イソプロピル、パルミチン酸2-エチルへキシル、エチルヘキサン酸セチル、ステアリン酸ブチル、イソステアリン酸イソセチル、ラウリン酸ヘキシル、オレイン酸デシル、脂肪酸(C10-30)(コレステリル/ラノステリル)、乳酸ラウリル、乳酸オクチルドデシル、酢酸ラノリン、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸N-アルキルグリコール、ラノリン誘導体等が挙げられる。 Esters are compounds obtained by the dehydration reaction of fatty acids with alcohols. Examples include diisopropyl adipate, 2-hexyldecyl adipate, isopropyl myristate, myristyl myristate, cetyl octanoate, cetyl isooctanoate, isononyl isononanoate, diisopropyl sebacate, isopropyl palmitate, 2-ethylhexyl palmitate, cetyl ethylhexanoate, butyl stearate, isocetyl isostearate, hexyl laurate, decyl oleate, fatty acids (C10-30) (cholesteryl/lanosteryl), lauryl lactate, octyldodecyl lactate, lanolin acetate, dipentaerythritol fatty acid esters, N-alkyl glycol monoisostearate, and lanolin derivatives.
リン脂質とは、構造中にリン酸エステル部位をもつ脂質のことをいう。リン脂質は、両親媒性を持ち、脂質二重層を形成して糖脂質やコレステロールと共に細胞膜の主要な構成成分となるほか、生体内でのシグナル伝達にも関わると言われている。リン脂質若しくはリン脂質誘導体は、特に制限されないが、グリセロリン脂質やスフィンゴリン脂質等が挙げられる。具体的には、レシチン、ホスファチジルエタノールアミン、ホスファチジン酸、リゾホスファチジン酸、スフィンゴミエリン、ホスファチジルイノシトール、水添レシチン等が挙げられる。 Phospholipids are lipids that have a phosphate ester moiety in their structure. Phospholipids are amphiphilic and form lipid bilayers, and are a major component of cell membranes along with glycolipids and cholesterol. They are also said to be involved in signal transduction in vivo. Phospholipids or phospholipid derivatives are not particularly limited, but examples include glycerophospholipids and sphingophospholipids. Specific examples include lecithin, phosphatidylethanolamine, phosphatidic acid, lysophosphatidic acid, sphingomyelin, phosphatidylinositol, and hydrogenated lecithin.
本発明における(A)油剤の含有量は、特に制限されるものではないが、皮膚用化粧料全体を基準として、0.01~1.0質量%であることが、本発明の効果を発揮する限りにおいて望ましい。含有量の下限値としては、0.03質量%以上であることがより好ましく、0.05質量%以上であることがさらに好ましい。また、含有量の上限値としては、0.5質量%以下であることがより好ましく、0.3質量%以下であることがさらに好ましく、0.1質量%以下であることがよりさらに好ましい。0.1質量%以上であれば、十分な肌のうるおい効果や深いしわ改善効果が得られる。一方、1.0質量%以下であれば、べたつきや皮膚化粧料の経時での析出物の発生などが生じにくい。ここで、(A)油剤として2種以上含む場合には、上記含有量はそれらの成分の合計量を示す。 The content of the oil agent (A) in the present invention is not particularly limited, but is preferably 0.01 to 1.0% by mass based on the entire skin cosmetic as long as the effects of the present invention are exhibited. The lower limit of the content is more preferably 0.03% by mass or more, and even more preferably 0.05% by mass or more. The upper limit of the content is more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and even more preferably 0.1% by mass or less. If it is 0.1% by mass or more, sufficient skin moisturizing effect and deep wrinkle improvement effect can be obtained. On the other hand, if it is 1.0% by mass or less, stickiness and the generation of precipitates over time of the skin cosmetic are unlikely to occur. Here, when two or more types of oil agent (A) are included, the above content indicates the total amount of those components.
((B)ノニオン界面活性剤)
ノニオン界面活性剤は、水溶液中においてイオンに解離しない水酸基やエーテル結合を親水基としてもっている界面活性剤のことである。ノニオン界面活性剤としては、例えば、POEアルキルエーテル類、POEアルキルフェニルエーテル類、POE・POPアルキルエーテル類、POEソルビタン脂肪酸エステル類、POEモノ脂肪酸エステル類、POEグリセリン脂肪酸エステル類、ポリグリセリン脂肪酸エステル類、モノグリセリン脂肪酸エステル類、ソルビタン脂肪酸エステル類、ショ糖脂肪酸エステル類、アルキルポリグルコシド類等が挙げられる。POEアルキルエーテル類の具体例としては、POEラウリルエーテル、POEセチルエーテル、POEステアリルエーテル、POEベヘニルエーテル、POEラノリン、POEフィトステロール等が挙げられる。
本発明における(B)界面活性剤としては、POEアルキルエーテル類、POEアルキルフェニルエーテル類、POE・POPアルキルエーテル類が好ましく、PRG-13-デシルテトラデセス-24がより好ましい。
また、ノニオン界面活性剤は、1種単独で含有してもよく、2種以上含有してもよい。
((B) Nonionic Surfactant)
A nonionic surfactant is a surfactant having a hydrophilic group such as a hydroxyl group or an ether bond that does not dissociate into ions in an aqueous solution. Examples of nonionic surfactants include POE alkyl ethers, POE alkyl phenyl ethers, POE-POP alkyl ethers, POE sorbitan fatty acid esters, POE mono fatty acid esters, POE glycerin fatty acid esters, polyglycerin fatty acid esters, monoglycerin fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, and alkyl polyglucosides. Specific examples of POE alkyl ethers include POE lauryl ether, POE cetyl ether, POE stearyl ether, POE behenyl ether, POE lanolin, and POE phytosterol.
As the surfactant (B) in the present invention, POE alkyl ethers, POE alkyl phenyl ethers, and POE.POP alkyl ethers are preferred, and PRG-13-decyltetradeceth-24 is more preferred.
The nonionic surfactant may be contained alone or in combination of two or more kinds.
なお、PRG-13-デシルテトラデセス-24は、デシルテトラデカノールに酸化エチレン及び酸化プロピレンを付加重合したものであり、下記式1で表される。なお、下記式1のnは平均24、mは平均13である。
(B)界面活性剤のHLB値としては、特に制限されるものではないが、本発明の効果を発揮する限りにおいては、HLB値が10以上15以下であることが好ましい。本発明において、HLB値(親水性・親油性バランス)は、グリフィン(Griffin)の式(J,Soc,Cosmet,Chem.,1,311(1949);5,249(1953))により計算されるものである。2種以上の界面活性剤から構成される混合界面活性剤のHLB値(以下、混合HLBと記す)は、各界面活性剤のHLB値をその配合比率に基づいて加重平均したものであり、次式で求められる。
混合HLB値=Σ(HLBx×Wx)/ΣWx
(HLBxは、界面活性剤XのHLB値を示す。Wxは、HLBxの値を有する界面活性剤Xの質量(g)を示す。)
The HLB value of the surfactant (B) is not particularly limited, but as long as the effects of the present invention are exhibited, it is preferable that the HLB value is 10 or more and 15 or less. In the present invention, the HLB value (hydrophilic-lipophilic balance) is calculated by Griffin's formula (J. Soc. Cosmet. Chem., 1, 311 (1949); 5, 249 (1953)). The HLB value of a mixed surfactant consisting of two or more types of surfactants (hereinafter referred to as mixed HLB) is a weighted average of the HLB values of each surfactant based on their blending ratio, and is calculated by the following formula.
Mixed HLB value = Σ(HLBx × Wx) / ΣWx
(HLBx represents the HLB value of surfactant X. Wx represents the mass (g) of surfactant X having the HLBx value.)
本発明における(B)界面活性剤の含有量は、特に制限されるものではないが、皮膚用化粧料全体を基準として、0.05~1質量%であることが、本発明の効果を発揮する限りにおいて好ましい。含有量の下限値としては、0.1質量%以上であることが、より好ましい。含有量の上限値としては、0.5質量%以下であることがより好ましく、0.3質量%以下であることがさらに好ましい。 The content of the surfactant (B) in the present invention is not particularly limited, but is preferably 0.05 to 1 mass% based on the entire skin cosmetic as long as the effects of the present invention are exhibited. The lower limit of the content is more preferably 0.1 mass% or more. The upper limit of the content is more preferably 0.5 mass% or less, and even more preferably 0.3 mass% or less.
本発明における(A)油剤の含有量に対する(B)界面活性剤の含有量の値(B/A)は、特に制限されるものではないが、水相への(A)油剤の安定性及び素早い分散性の効果の観点からは、3以上が好ましく、4以上がより好ましい。 In the present invention, the ratio (B/A) of the content of the surfactant (B) to the content of the oil agent (A) is not particularly limited, but from the viewpoint of the effect of the stability and rapid dispersibility of the oil agent (A) in the aqueous phase, it is preferably 3 or more, and more preferably 4 or more.
((C)グリセリン)
グリセリンとは、3価のアルコールの一種である。水に非常に溶けやすく、無色透明の糖蜜状液体で、甘味を持ち、保湿剤や潤滑剤として用いられるものである。
((C) Glycerin)
Glycerin is a type of trihydric alcohol. It is highly soluble in water, is a colorless, transparent, molasses-like liquid, has a sweet taste, and is used as a moisturizer and lubricant.
本発明における(C)グリセリンの含有量は、特に制限されるものではないが、皮膚用化粧料全体を基準として、0.05~10質量%であることが、本発明の効果を発揮する限りにおいて好ましい。含有量の下限値としては、0.1質量%以上がより好ましく、0.5質量%以上であることがさらに好ましい。含有量の上限値としては、7質量%以下であることがより好ましく、5質量%以下であることがさらに好ましく、1.0質量%以下であることがさらにより好ましくい。(C)グリセリンの含有量が、1.0質量%以下の場合、感触が良くなる効果がある。 The content of (C) glycerin in the present invention is not particularly limited, but is preferably 0.05 to 10% by mass based on the entire skin cosmetic as long as the effects of the present invention are exhibited. The lower limit of the content is more preferably 0.1% by mass or more, and even more preferably 0.5% by mass or more. The upper limit of the content is more preferably 7% by mass or less, even more preferably 5% by mass or less, and even more preferably 1.0% by mass or less. When the content of (C) glycerin is 1.0% by mass or less, there is an effect of improving the feel.
本発明における(C)グリセリンの含有量に対する(A)油剤の含有量及び(B)界面活性剤の含有量の合計((A+B)/C)は、特に制限されるものではないが、水相への(A)油剤の安定性及び素早い分散性を発揮する観点からは、2.0以下が好ましく、0.8以下がより好ましい。 In the present invention, the total content of the (A) oil agent and the (B) surfactant relative to the content of the (C) glycerin ((A+B)/C) is not particularly limited, but from the viewpoint of exhibiting stability and rapid dispersibility of the (A) oil agent in the aqueous phase, it is preferably 2.0 or less, and more preferably 0.8 or less.
((D)水)
水とは、化学式H2Oで表される化合物である。水は様々な水溶性物質を溶かし込むために最も汎用されている溶媒であり、またその水溶性物質を溶かし込む性質および安全性・安定性の側面から水溶性基剤としても最も汎用されている。本発明における水の種類は、特に制限されるものではなく、例えば、水道水、純水、蒸留水、RO水、イオン交換水、精製水、海洋深層水、天然深層水等が挙げられる。
((D) Water)
Water is a compound represented by the chemical formula H 2 O. Water is the most widely used solvent for dissolving various water-soluble substances, and is also the most widely used water-soluble base from the viewpoints of its ability to dissolve water-soluble substances and its safety and stability. The type of water in the present invention is not particularly limited, and examples thereof include tap water, pure water, distilled water, RO water, ion-exchanged water, purified water, deep sea water, and natural deep sea water.
本発明における(D)水の含有量は、特に制限されるものではないが、皮膚用化粧料全体を基準として、80~97質量%であることが、本発明の効果を発揮する限りにおいて好ましい。80質量%以上であると、水以外の成分の含有量の調整が容易であり、97質量%以下であると、水相への(A)油剤の安定性及び素早い分散性の効果を発揮しやすい。 The content of (D) water in the present invention is not particularly limited, but is preferably 80 to 97% by mass based on the entire skin cosmetic as long as the effects of the present invention are exhibited. If it is 80% by mass or more, it is easy to adjust the content of components other than water, and if it is 97% by mass or less, it is easy to exhibit the effects of stability and quick dispersibility of (A) oil in the aqueous phase.
(その他の成分)
本発明の製造方法により製造される皮膚化粧料は、上述した成分の他に、本発明の目的を損なわない範囲で、他の成分、例えば、成分(B)を除く界面活性剤、増粘剤、粉体(色素、樹脂、顔料)、防腐剤、香料、保湿剤、生理活性成分、ミネラル塩類、溶媒、酸化防止剤、キレート剤、パール化剤、中和剤、pH調整剤、植物エキス、酵素、ビタミン類、アミノ酸等の成分を適宜配合することができる。
(Other ingredients)
In addition to the components described above, the skin cosmetic produced by the production method of the present invention can contain other components, such as surfactants other than component (B), thickeners, powders (colorants, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, plant extracts, enzymes, vitamins, amino acids, and the like, as appropriate, within the scope of the object of the present invention.
成分(B)を除く界面活性剤としては、カチオン界面活性剤、アニオン界面活性剤、両性イオン界面活性剤が例示できる。本発明に用いられる成分(B)を除く界面活性剤は、通常化粧料に配合され得る界面活性剤であれば特に限定されるものでない。これらは、1種単独で含有してもよく、2種以上含有してもよい。 Examples of surfactants other than component (B) include cationic surfactants, anionic surfactants, and zwitterionic surfactants. The surfactants other than component (B) used in the present invention are not particularly limited as long as they are surfactants that can be normally incorporated into cosmetics. These surfactants may be contained alone or in combination with two or more types.
カチオン界面活性剤とは、水溶液中においてイオンに電離した際、親水基の部分がプラスの電気を帯びる界面活性剤である。カチオン性界面活性剤としては、例えば、モノアルキル型4級アンモニウム塩、ジアルキル型4級アンモニウム塩、トリアルキル型4級アンモニウム塩、ベンザルコニウム型4級アンモニウム塩、モノアルキルエーテル型4級アンモニウム塩等のアルキル4級アンモニウム塩類、アルキルアミン塩、脂肪酸アミドアミン塩、エステル含有3級アミン塩、アーコベル型3級アミン塩等のアミン塩類、アルキルピリジニウム塩、アルキルイソキノリウム塩等の環式4級アンモニウム塩類および塩化ベンゼトニウム等が挙げられる。 A cationic surfactant is a surfactant in which the hydrophilic group carries a positive charge when ionized in an aqueous solution. Examples of cationic surfactants include alkyl quaternary ammonium salts such as monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium salts, trialkyl quaternary ammonium salts, benzalkonium quaternary ammonium salts, and monoalkyl ether quaternary ammonium salts; amine salts such as alkylamine salts, fatty acid amide amine salts, ester-containing tertiary amine salts, and arcobell-type tertiary amine salts; cyclic quaternary ammonium salts such as alkylpyridinium salts and alkylisoquinolium salts; and benzethonium chloride.
モノアルキル型4級アンモニウム塩としては、例えば、塩化ラウリルトリメチルアンモニウム、臭化ラウリルトリメチルアンモニウム、塩化アルキル(16,18)トリメチルアンモニウム、塩化セチルトリメチルアンモニウム、臭化セチルトリメチルアンモニウム、セチルトリメチルアンモニウムサッカリン、塩化ステアリルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、塩化ベヘニルトリメチルアンモニウム、ステアリルトリメチルアンモニウムサッカリン、塩化アルキル(28)トリメチルアンモニウム、塩化ジPOE(2)オレイルメチルアンモニウム、塩化ジPOEステアリルメチルアンモニウム、塩化POE(1)POP(25)ジエチルメチルアンモニウム、塩化POPメチルジエチルアンモニウム、塩化メタクリロイルオキシエチルトリメチルアンモニウムおよびメチル硫酸ベヘニルトリメチルアンモニウム等が挙げられる。特に好ましくは、塩化ステアリルトリメチルアンモニウム、塩化アルキル(16,18)トリメチルアンモニウムおよび塩化セチルトリメチルアンモニウムである。 Examples of monoalkyl quaternary ammonium salts include lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, alkyl (16,18) trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, cetyl trimethyl ammonium saccharin, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, behenyl trimethyl ammonium chloride, stearyl trimethyl ammonium saccharin, alkyl (28) trimethyl ammonium chloride, diPOE (2) oleyl methyl ammonium chloride, diPOE stearyl methyl ammonium chloride, POE (1) POP (25) diethyl methyl ammonium chloride, POP methyl diethyl ammonium chloride, methacryloyloxyethyl trimethyl ammonium chloride, and behenyl trimethyl ammonium methyl sulfate. Particularly preferred are stearyl trimethyl ammonium chloride, alkyl (16,18) trimethyl ammonium chloride, and cetyl trimethyl ammonium chloride.
アニオン界面活性剤とは、水溶液中においてイオンに電離した際、親水基の部分がマイナスの電気を帯びる界面活性剤のことである。アニオン性界面活性剤としては、例えば、アルキルエーテル硫酸塩、POEアルキルエーテル硫酸塩、アルキル硫酸塩、アルケニルエーテル硫酸塩、アルケニル硫酸塩、オレフィンスルホン酸塩、アルカンスルホン酸塩、飽和または不飽和脂肪酸塩、アルキルまたはアルケニルエーテルカルボン酸塩、α-スルホン脂肪酸塩、N-アシルアミノ酸型界面活性剤、リン酸モノまたはジエステル型界面活性剤およびスルホコハク酸エステルが挙げられる。これらの界面活性剤のアニオン基の対イオンは、例えばナトリウムイオン、カリウムイオンおよびトリエタノールアミンのいずれであってもよい。 An anionic surfactant is a surfactant in which the hydrophilic group carries a negative charge when ionized in an aqueous solution. Examples of anionic surfactants include alkyl ether sulfates, POE alkyl ether sulfates, alkyl sulfates, alkenyl ether sulfates, alkenyl sulfates, olefin sulfonates, alkanesulfonates, saturated or unsaturated fatty acid salts, alkyl or alkenyl ether carboxylates, α-sulfonic acid salts, N-acylamino acid surfactants, mono- or diester phosphate surfactants, and sulfosuccinate esters. The counter ion of the anionic group of these surfactants may be, for example, any of sodium ions, potassium ions, and triethanolamine.
より具体的には、スルホコハク酸ラウリル二ナトリウム、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、ラウリル硫酸カリウム、ラウリル硫酸アンモニウム、ラウリル硫酸トリエタノールアミン、セチル硫酸ナトリウム、ステアリル硫酸ナトリウム、POEラウリルエーテル硫酸ナトリウム、POEラウリルエーテル硫酸トリエタノールアミン、POEラウリルエーテル硫酸アンモニウム、POEステアリルエーテル硫酸ナトリウム、スルホコハク酸ラウリル二ナトリウム、ステアロイルメチルタウリンナトリウム、ドデシルベンゼンスルホン酸トリエタノールアミン、テトラデセンスルホン酸ナトリウム、ラウリルリン酸ナトリウム、POEラウリルエーテルリン酸およびその塩、N-ラウロイルグルタミン酸塩類(ラウロイルグルタミン酸ナトリウム等)、N-ラウロイルメチル-β-アラニン塩、N-アシルグリシン塩、N-アシルグルタミン酸塩、高級脂肪酸であるラウリン酸およびミリスチン酸並びにこれらの高級脂肪酸の塩が挙げられ、1種単独または2種以上を使用することができる。 More specifically, disodium lauryl sulfosuccinate, sodium lauryl sulfate, sodium myristyl sulfate, potassium lauryl sulfate, ammonium lauryl sulfate, triethanolamine lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, sodium POE lauryl ether sulfate, triethanolamine POE lauryl ether sulfate, ammonium POE lauryl ether sulfate, sodium POE stearyl ether sulfate, disodium lauryl sulfosuccinate, sodium stearoyl methyl taurine, triethanolamine dodecylbenzenesulfonate, sodium tetradecenesulfonate, sodium lauryl phosphate, POE lauryl ether phosphate and its salts, N-lauroyl glutamate salts (such as sodium lauroyl glutamate), N-lauroyl methyl-β-alanine salts, N-acyl glycine salts, N-acyl glutamate salts, higher fatty acids lauric acid and myristic acid, and salts of these higher fatty acids can be mentioned, and one or more of them can be used alone.
両性界面活性剤とは、その分子中の親水基に陽イオンになる部分(カチオン基)と陰イオンになる部分(アニオン気)の両方を持っている界面活性剤である。両性界面活性剤としては、アミノ酸型両性界面活性剤およびベタイン型両性界面活性剤が挙げられる。 An amphoteric surfactant is a surfactant whose hydrophilic group in the molecule has both a cationic group and an anionic group. Examples of amphoteric surfactants include amino acid-type amphoteric surfactants and betaine-type amphoteric surfactants.
アミノ酸型両性界面活性剤の具体例としては、例えば、N-ラウロイル-N’-カルボキシメチル-N’-ヒドロキシエチルエチレンジアミンナトリウム(ラウロアンホ酢酸Na)、2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリニウムベタイン、ウンデシルヒドロキシエチルイミダゾリニウムベタインナトリウム、塩酸アルキルジアミノエチルグリシン、N-ヤシ油脂肪酸アシル-N’-カルボキシエチル-N’-ヒドロキシエチルエチレンジアミンナトリウム、N-ヤシ油脂肪酸アシル-N’-カルボキシエトキシエチル-N’-カルボキシエチルエチレンジアミン二ナトリウム、N-ヤシ油脂肪酸アシル-N’-カルボキシメトキシエチル-N’-カルボキシメチルエチレンジアミン二ナトリウム、ラウリルジアミノエチルグリシンナトリウムおよびパーム油脂肪酸アシル-N-カルボキシエチル-N-ヒドロキシエチルエチレンジアミンナトリウム等のグリシン型両性界面活性剤並びにラウリルアミノプロピオン酸ナトリウム、ラウリルアミノジプロピオン酸ナトリウムおよびラウリルアミノプロピオン酸トリエタノールアミン等のアミノプロピオン酸型両性界面活性剤等が挙げられる。 Specific examples of amino acid type amphoteric surfactants include glycine type amphoteric surfactants such as sodium N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine (sodium lauroamphoacetate), 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, sodium undecylhydroxyethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, sodium N-coconut oil fatty acid acyl-N'-carboxyethyl-N'-hydroxyethylethylenediamine, disodium N-coconut oil fatty acid acyl-N'-carboxyethoxyethyl-N'-carboxyethylethylenediamine, disodium N-coconut oil fatty acid acyl-N'-carboxymethoxyethyl-N'-carboxymethylethylenediamine, sodium lauryldiaminoethylglycine, and sodium palm oil fatty acid acyl-N-carboxyethyl-N-hydroxyethylethylenediamine, as well as aminopropionic acid type amphoteric surfactants such as sodium laurylaminopropionate, sodium laurylaminodipropionate, and triethanolamine laurylaminopropionate.
ベタイン型両性界面活性剤の具体例としては、例えば、ヤシ油アルキルベタイン、ラウリルジメチルアミノ酢酸ベタイン、ミリスチルジメチルアミノ酢酸ベタイン、ステアリルジメチルアミノ酢酸ベタイン、ステアリルジメチルベタインナトリウム、ヤシ油脂肪酸アミドプロピルベタイン、パーム油脂肪酸アミドプロピルベタイン、ラウリン酸アミドプロピルベタイン、リシノレイン酸アミドプロピルベタインおよびステアリルジヒドロキシエチルベタイン等のアミノ酢酸ベタイン型両性界面活性剤並びにラウリルヒドロキシスルホベタイン等のスルホベタイン型両性界面活性剤等が挙げられる。 Specific examples of betaine-type amphoteric surfactants include aminoacetic acid betaine-type amphoteric surfactants such as coconut oil alkyl betaine, lauryl dimethylaminoacetate betaine, myristyl dimethylaminoacetate betaine, stearyl dimethylaminoacetate betaine, sodium stearyl dimethyl betaine, coconut oil fatty acid amidopropyl betaine, palm oil fatty acid amidopropyl betaine, lauric acid amidopropyl betaine, ricinoleic acid amidopropyl betaine, and stearyl dihydroxyethyl betaine, as well as sulfobetaine-type amphoteric surfactants such as lauryl hydroxysulfobetaine.
また、本発明の目的を損なわない範囲で、生理活性成分を適宜配合することができる。生理活性物質とは、皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質であり、例えば、美白剤、抗炎症剤、老化防止剤、紫外線防御剤、収斂剤、抗酸化剤、血行促進剤、抗菌剤、殺菌剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤等が挙げられる。 Furthermore, physiologically active ingredients can be appropriately blended within the scope of the present invention without impairing the object of the present invention. A physiologically active substance is a substance that imparts some physiological activity to the skin when applied to the skin, and examples include whitening agents, anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, germicides, cooling agents, warming agents, wound healing promoters, irritation relief agents, analgesics, cell activators, etc.
以下、本発明の製造方法に係る実施例を示し、さらに本発明を具体的に説明するが、本発明はこれらの実施例に何ら限定されるものではない。 The following provides examples of the manufacturing method of the present invention and further explains the present invention in detail, but the present invention is not limited to these examples.
(混合方法1)
表1~表5の処方に従って、表1~表5の実施例に係る皮膚化粧料及び表1の比較例に係る皮膚化粧料は以下の混合方法にて調製した。
表1~表5に示す原材料を室温(25℃)の条件下で、(A)油剤と(B)界面活性剤とを混合した後に、(C)グリセリンを混合する。((A)、(B)及び(C)の混合物を第1相とする)。その後、当該第1相に(D)水(第2相)を混合する方法を混合方法1とする。各成分の混合は、混合機(TKホモミキサー、プライミクス社製)を用いて撹拌混合した。
(Mixing method 1)
According to the formulations in Tables 1 to 5, the skin cosmetics according to the examples in Tables 1 to 5 and the skin cosmetics according to the comparative example in Table 1 were prepared by the following mixing method.
The raw materials shown in Tables 1 to 5 were mixed with (A) oil and (B) surfactant at room temperature (25°C), and then (C) glycerin was mixed. (The mixture of (A), (B), and (C) was designated as the first phase.) The method of subsequently mixing (D) water (second phase) into the first phase was designated as mixing method 1. The components were mixed by stirring using a mixer (TK Homomixer, manufactured by Primix Corporation).
なお、実施例2~4においては、(A)油剤と(B)界面活性剤とを混合した混合物に対し、(D1)水が混合された(C)グリセリンを混合する((A)と(B)の混合物と、(C)と(D1)の混合物どうしを混合したものを第1相とする)。その後、当該第1相に(D)水(第2相)を混合する方法を混合方法1とする。各成分の混合は、混合機(TKホモミキサー、プライミクス社製)を用いて撹拌混合した。 In Examples 2 to 4, (C) glycerin mixed with (D1) water was mixed with a mixture of (A) oil and (B) surfactant (the mixture of (A) and (B) and the mixture of (C) and (D1) were mixed together to form the first phase). The method of subsequently mixing (D) water (second phase) with the first phase was defined as mixing method 1. The components were mixed by stirring using a mixer (TK Homomixer, manufactured by Primix Corporation).
(混合方法2)
表1の処方に従って、表1の比較例に係る皮膚化粧料を以下の混合方法にて調製した。
表1に示す原材料を室温(25℃)の条件下で、、(A)油剤と(B)界面活性剤と混合したものを第1相とし、(C)グリセリンと(D)水とを混合したものを第2相とし、第1相と第2相とを混合する方法を混合方法2とする。各成分の混合は、混合機(TKホモミキサー、プライミクス社製)を用いて撹拌混合した。
(Mixing method 2)
According to the formulation in Table 1, the skin cosmetic composition according to the comparative example in Table 1 was prepared by the following mixing method.
The raw materials shown in Table 1 were mixed with (A) oil and (B) surfactant under room temperature (25° C.) conditions to form a first phase, and (C) glycerin and (D) water to form a second phase, and a method of mixing the first and second phases was described as mixing method 2. The components were mixed by stirring using a mixer (TK Homomixer, manufactured by Primix Corporation).
(分散性の評価)
上記の混合方法1又は2の混合方法で混合した後に下記の判定基準に基づき目視にて分散性を評価した。
(Evaluation of Dispersibility)
After mixing by the above mixing method 1 or 2, the dispersibility was evaluated by visual observation based on the following criteria.
(評価基準)
5:極めて速やかに分散し、混合が可能。
4:速やかに分散し、混合が可能。
3:分散し、混合が可能。
2:やや分散しにくく、混合がしにくい。
1:分散しにくく混合がしにくい又は分散混合ができない。
(Evaluation criteria)
5: Disperses and mixes extremely quickly.
4: Quickly disperses and mixes.
3: Dispersible and mixable.
2: Somewhat difficult to disperse and mix.
1: Difficult to disperse and mix, or dispersive mixing is not possible.
(安定性の評価)
本発明の実施例および比較例の皮膚化粧料を50gガラス瓶に充填し、45℃条件、30℃条件及び0℃条件の恒温器に入れて3か月保管した。3か月後に本発明の実施例および比較例の皮膚化粧料を取り出し、その状態を確認した。皮膚化粧料の安定性評価は、下記の項目を用いて、以下の通りに分類した。
(Stability Evaluation)
The skin cosmetics of the Examples and Comparative Examples of the present invention were filled into glass bottles of 50 g each and stored for three months in incubators at 45° C., 30° C., and 0° C. After three months, the skin cosmetics of the Examples and Comparative Examples of the present invention were removed and their condition was confirmed. The stability of the skin cosmetics was evaluated using the following items and classified as follows:
(安定性の評価基準)
5:極めて良好 (45℃、30℃、0℃のいずれの条件においても、ほとんど変化が見られない)
4:良好 (45℃、30℃、0℃のいずれの条件において、ごくわずかに変色、変臭のいずれかが見られたが、皮膚化粧料の使用品質には問題がない)
3:普通 (45℃、30℃、0℃のいずれの条件において、やや変色、変臭、不均一化のいずれかあるいはいずれもの傾向が見られたが、皮膚化粧料の使用品質には問題がない)
2:やや悪い (45℃、30℃、0℃のいずれの条件において、大きな変色、変臭、不均一化のいずれかあるいはいずれもの傾向が見られた)
1:悪い (45℃、30℃、0℃のいずれの条件において、結晶状のツブの析出や、油分あるいは水分の分離、大きな変色、変臭、不均一化のいずれかあるいはいずれもの傾向が見られた)
(Stability evaluation criteria)
5: Very good (almost no change observed at 45°C, 30°C, or 0°C)
4: Good (Very slight discoloration or odor was observed at 45°C, 30°C, or 0°C, but there was no problem with the quality of the skin cosmetic product)
3: Normal (At 45°C, 30°C, and 0°C, some discoloration, odor, and/or unevenness was observed, but there is no problem with the quality of the skin cosmetic product)
2: Fairly bad (at 45°C, 30°C, and 0°C, significant discoloration, odor change, and/or unevenness were observed)
1: Poor (At 45°C, 30°C, and 0°C, one or more of the following were observed: precipitation of crystalline particles, separation of oil or water, significant discoloration, odor change, and/or inhomogeneity)
(使用感(べたつきのなさ)の評価)
専門パネル5名により、本発明の実施例に係る皮膚化粧料を使用直後での肌のべたつきについて下記の評点のつけ方にて官能評価を実施した。評価基準は5名の評点の平均値を用いて、以下の通りに分類した。
(Evaluation of usability (non-stickiness))
A sensory evaluation was carried out by five expert panelists on the stickiness of the skin immediately after use of the skin cosmetic compositions according to the examples of the present invention, using the following scoring system. The evaluation criteria were classified as follows, using the average scores of the five panelists.
(べたつきのなさに関する評点基準)
5:べたつきを感じない。
4:べたつきをわずかに感じる。
3:べたつきをやや感じる。
2:べたつきを感じる。
1:べたつきを強く感じ、不快である。
(Rating criteria for non-stickiness)
5: Does not feel sticky.
4: Feels slightly sticky.
3: Feels slightly sticky.
2: Feels sticky.
1: Very sticky and uncomfortable.
表1に示したとおり、本発明に係る製造方法で調製した実施例(混合方法1)は、分散性及び安定性のいずれにおいても良好な結果を示した。一方、本発明に係る製造方法ではない、混合方法(2)にて調製した比較例1及び2は、分散性及び安定性のいずれにおいても不良であった。 As shown in Table 1, the example (mixing method 1) prepared by the manufacturing method of the present invention showed good results in both dispersibility and stability. On the other hand, comparative examples 1 and 2 prepared by mixing method (2), which is not the manufacturing method of the present invention, showed poor results in both dispersibility and stability.
表2~表4に示したとおり、本発明に係る製造方法で調製した実施例(混合方法1)は、分散性及び安定性のいずれにおいても良好な結果を示した。一方、表2に示すように、(C)成分としてグリセリン以外を用いた比較例3及び4においては、安定性が不良であった。 As shown in Tables 2 to 4, the examples prepared using the manufacturing method according to the present invention (mixing method 1) showed good results in terms of both dispersibility and stability. On the other hand, as shown in Table 2, the stability was poor in Comparative Examples 3 and 4, which used a component other than glycerin as component (C).
本発明の製造方法に係る皮膚化粧料は、化粧水やローション等に好適である。
The skin cosmetic produced by the production method of the present invention is suitable for use as a skin lotion or skin toner.
Claims (4)
4. The method according to claim 3, wherein a value ((A+B)/C) of the total content of the component (A) and the component (B) relative to the content of the component (C) is 0.8 or less.
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