WO2022234736A1

WO2022234736A1 - Vesicle-containing cosmetic preparation

Info

Publication number: WO2022234736A1
Application number: PCT/JP2022/013197
Authority: WO
Inventors: 啓渡辺; 陽張; マチユバンクトウー; 允人宇山
Original assignee: 株式会社資生堂
Priority date: 2021-05-06
Filing date: 2022-03-22
Publication date: 2022-11-10
Also published as: JPWO2022234736A1; CN117157052A

Abstract

The present invention provides a vesicle-containing cosmetic preparation which is capable of solubilizing an oil component at a higher concentration in comparison to the cases where micelles are used, and which preferably has excellent transparency.　A vesicle-containing cosmetic preparation according to the present disclosure contains a dispersion medium that contains water and vesicles that are dispersed in the dispersion medium; the vesicles are formed of at least one polyglycerol fatty acid ester that has an OH/C ratio of 0.20 to 0.80; and an oil component is contained in bilayer membranes of the vesicles.

Description

Vesicle-containing cosmetics

The present disclosure relates to vesicle-containing cosmetics.

Amphipathic compounds having both hydrophilic and hydrophobic properties include, for example, compounds such as phospholipids that form spherical vesicles consisting of bilayer membranes such as lamellar layers in an aqueous phase. be. Such bilayer vesicles are called liposomes or vesicles, and are used in cosmetics and the like.

US Pat. No. 6,200,001 discloses, in a continuous aqueous dispersed phase, (a) a lipid phase comprising at least one amphiphilic lipid, ionic or nonionic, associated with at least one stabilizing agent; and (b) in the form of droplets dispersed in the dispersed aqueous phase, 0.2 to 20% by weight of the total weight of the composition. A cosmetic composition for hair care is disclosed containing at least one natural or synthetic essential oil present in proportions and having a weight ratio of lipid phase to essential oil of 0.3-10.

Patent Document 2 describes a vesicle composition to be blended in an external skin preparation or cosmetic for the purpose of improving the penetration of active ingredients into the skin or hair, comprising (A) a polyglycerol fatty acid ester, (B) a polyol, and ( C) A vesicle composition containing water as an essential component and having an average particle size of 30 to 300 nm is disclosed.

JP-A-06-128124 JP 2018-199669 A

As a technology for solubilizing oil, a technology that uses micelles prepared using a surfactant is known. However, since micelles can solubilize a small amount of oil, a technology capable of solubilizing oil at a higher concentration than micelles has been desired.

On the other hand, micelles have the advantage that it is easy to obtain transparent cosmetics even if the oil is solubilized. Since vesicles generally have a larger particle size than micelles, vesicles have not been used to obtain transparent cosmetics in which oil is solubilized.

Therefore, the subject of the present disclosure is to provide a vesicle-containing cosmetic that can solubilize oil at a higher concentration than when micelles are used, and preferably has excellent transparency.

<Aspect 1>
a dispersion medium containing water, and vesicles dispersed in the dispersion medium;
A vesicle-containing cosmetic comprising
The vesicle is formed of at least one polyglycerol fatty acid ester having an OH/C ratio of 0.20 to 0.80, and contains oil in the bilayer membrane of the vesicle,
A vesicle-containing cosmetic.
<Aspect 2>
The vesicle-containing cosmetic according to aspect 1, wherein the cosmetic exhibits an L value of 50 or more.
<Aspect 3>
The cosmetic according to aspect 1 or 2, wherein the polyglycerol fatty acid ester has an OH/C ratio of 0.20 to 0.60.
<Aspect 4>
The cosmetic according to any one of aspects 1 to 3, wherein the mass ratio of the oil to the polyglycerin fatty acid ester is 0.01 or more and 0.30 or less.
<Aspect 5>
The cosmetic according to any one of aspects 1 to 4, wherein the number of carbon atoms in the fatty acid portion of the polyglycerin fatty acid ester is 12 or more and 17 or less.
<Aspect 6>
The cosmetic according to any one of aspects 1 to 5, wherein the polyglycerin part of the polyglycerin fatty acid ester is formed of polyglycerin having a dimer or more and a decamer or less.
<Aspect 7>
The cosmetic according to any one of aspects 1 to 6, further comprising an anionic surfactant.
<Aspect 8>
The cosmetic according to aspect 7, comprising micelles containing the anionic surfactant.
<Aspect 9>
The cosmetic according to any one of aspects 1 to 8, further comprising alcohol.

According to the present disclosure, it is possible to provide a vesicle-containing cosmetic that can solubilize oil at a higher concentration than when micelles are used, and preferably has excellent transparency.

The embodiments of the present disclosure will be described in detail below. The present disclosure is not limited to the following embodiments, and various modifications can be made within the scope of the spirit of the invention.

The vesicle-containing cosmetic of the present disclosure includes a dispersion medium containing water and vesicles dispersed in the dispersion medium, and the vesicles have an OH/C ratio of 0.20 to 0.80. and contains oil in the bilayer membrane of the vesicle.

Although not limited by the principle, it is believed that the principle of action by which the vesicle-containing cosmetic of the present disclosure can solubilize oil at a high concentration is as follows.

It is known that silicone-based surfactants, block-type alkylene oxide derivatives, phospholipids, etc. can be used as amphiphilic substances capable of forming vesicles. However, none of the vesicles formed with these various amphipathic substances can solubilize oil at high concentrations. Furthermore, not all vesicles formed from these various amphipathic substances are excellent in transparency.

Among various amphiphilic substances capable of forming vesicles, the present inventors have found a specific polymer having an OH/C ratio, which is a parameter relating to the balance between hydrophilicity and lipophilicity, in the range of 0.20 to 0.80. It was found that a vesicle capable of solubilizing oil at a high concentration can be obtained by employing a glycerin fatty acid ester. Furthermore, the present inventors have also found that a vesicle-containing cosmetic having excellent transparency can be obtained by employing such a specific polyglycerol fatty acid ester.

In general, when oil is solubilized in a high-concentration association body having solubilizing ability such as micelles, the balance between hydrophilicity and lipophilicity is lost, so that the oil precipitates and becomes cloudy, or the solubilized particles become cloudy. It is common that the diameter increases and the transparency decreases. It is thought that this phenomenon can also occur in vesicles as well.

Vesicles formed from the above-mentioned specific polyglycerol fatty acid ester have excellent packing properties of the bilayer membrane that constitutes them. Since the increase can be suitably reduced or suppressed, it is believed that the oil can be solubilized at a high concentration. In addition, since the vesicles formed from the above-described specific polyglycerol fatty acid ester have a relatively small particle size compared to vesicles formed from other amphipathic substances, it is expected that a vesicle-containing cosmetic with excellent transparency can be obtained. thinking.

The cosmetic composition described in Patent Document 1 contains an essential oil together with vesicles. Since the essential oil is added to the endoplasmic reticulum, the essential oil is not solubilized in the bilayer membrane of the endoplasmic reticulum.

《Cosmetics containing vesicles》
<Dispersion medium>
The dispersion medium (aqueous phase) in the vesicle-containing cosmetic of the present disclosure (sometimes simply referred to as “cosmetics”) contains water.

(water)
The amount of water to be blended is not particularly limited. Or 80% by mass or more, and 95% by mass or less, 90% by mass or less, 85% by mass or less, 80% by mass or less, 75% by mass or less, 70% by mass or less, 65% by mass or less, 60% by mass % or less, 55 mass % or less, or 50 mass % or less.

The water that can be used in the vesicle-containing cosmetics of the present disclosure is not particularly limited, and for example, water used in cosmetics and quasi-drugs can be used. For example, deionized water, distilled water, ultrapure water, and tap water can be used.

<Vesicle>
The vesicle-containing cosmetic of the present disclosure contains vesicles as a dispersed phase, and oil is contained in the bilayer membrane of the vesicles.

The fact that vesicles are contained in cosmetics is confirmed by, for example, a frozen replica method using a frozen replica transmission electron microscope (TEM, H-7650: manufactured by Hitachi, Ltd.), or a small-angle X-ray scattering measurement device ( SAXSess, manufactured by Anton Paar) and Zetasizer Nano (manufactured by Malvern Panalytical) can be used for confirmation. Vesicles are typically dispersed in the aqueous phase as a dispersion of concentric spherically closed vesicles of lamellar liquid crystals. In the method using a small-angle X-ray scattering apparatus or the like, if lamellar liquid crystals are present in the cosmetic, the size of the layered structure in the lamellar liquid crystals can be measured. In other words, in a method using a small-angle X-ray scattering apparatus or the like, it is possible to confirm the presence or absence of lamellar liquid crystals and their size to confirm that the cosmetic contains vesicles.

In some embodiments, the average particle size of the vesicles in the cosmetic can be 200 nm or less, 150 nm or less, 100 nm or less, 80 nm or less, or 60 nm or less. It can be 40 nm or more, or 50 nm or more. Vesicles having such an average particle size can further improve the transparency of cosmetics. Here, the average particle size of vesicles can be measured from a photograph taken by a frozen replica transmission electron microscope (TEM, H-7650: manufactured by Hitachi, Ltd.) using the frozen replica method. Such average particle size is the average value of 10 or more arbitrarily selected vesicles.

(Polyglycerol fatty acid ester)
The vesicles of the present disclosure are formed by at least one polyglycerol fatty acid ester having an OH/C ratio of 0.20-0.80.

Polyglycerin fatty acid ester is a sustainable material, and as an incidental effect, it can provide a moist feeling when applied to the skin, and can improve the occlusion effect.

The amount of polyglycerol fatty acid ester in the vesicle-containing cosmetic of the present disclosure is based on the total amount of the cosmetic from the viewpoint of vesicle formation, oil solubilization in vesicles, transparency of the vesicle-containing cosmetic, etc. , 0.1% by mass or more, 0.3% by mass or more, or 0.5% by mass or more, and 10% by mass or less, 5.0% by mass or less, or 3.0% by mass or less can do.

Polyglycerin fatty acid esters can be prepared by esterifying fatty acids with polyglycerin as shown in the following reaction scheme:

Here, in the polyglycerin fatty acid ester, the portion derived from fatty acids can be called a fatty acid portion, and the portion derived from polyglycerin can be called a polyglycerin portion. The fatty acid portion corresponds to the lipophilic portion, and the polyglycerol portion corresponds to the hydrophilic portion.

The OH/C ratio of the polyglycerol fatty acid ester is 0.20 or more, 0.25 or more, 0.30 or more, 0.35 or more, 0.40 or more, 0.45 or more, or 0.50 or more. It is preferably 0.80 or less, 0.75 or less, 0.70 or less, 0.65 or less, or 0.60 or less. A polyglycerol fatty acid ester having such an OH/C ratio can improve the ability to solubilize oil in vesicles, and can provide a vesicle-containing cosmetic with excellent transparency.

Here, the "OH/C ratio" in the present disclosure means the ratio of the number of hydroxyl groups in the polyglycerin portion to the number of carbon atoms in the fatty acid portion, and is a parameter relating to the balance between hydrophilicity and lipophilicity. For example, in the case of polyglyceryl-6 myristate, the number of carbon atoms in the fatty acid portion is 14, and the polyglycerin portion is a hexamer, in which case the number of hydroxyl groups is 7 (=6+1). Therefore, the OH/C ratio is 0.50 (=7/14).

The polyglycerin fatty acid ester preferably has a fatty acid moiety with 12 or more, 13 or more, or 14 or more carbon atoms, from the viewpoint of solubilizing oil content in vesicles, transparency of vesicle-containing cosmetics, and the like. Also, it is preferably 17 or less, 16 or less, or 15 or less.

Fatty acids that can be used when preparing polyglycerol fatty acid esters may be saturated fatty acids or unsaturated fatty acids, and may be linear fatty acids or branched fatty acids. Such fatty acids can include, for example, lauric acid, myristic acid, and palmitic acid. Among them, myristic acid and lauric acid are preferred.

The polyglycerin portion of the polyglycerin fatty acid ester is preferably a dimer or more, a trimer or more, or a tetramer or more from the viewpoint of the oil solubilization ability in the vesicles, the transparency of the vesicle-containing cosmetic, and the like. Also, it is preferably a 10-mer or less, a 9-mer or less, an octamer or less, a 7-mer or less, or a 6-mer or less. Here, the numerical value of n of the polyglycerol fatty acid ester in the above reaction formula matches, for example, the numerical value of 2 in the dimer.

Specific examples of polyglycerol fatty acid esters having an OH/C ratio of 0.20 to 0.80 include polyglyceryl-6 myristate, polyglyceryl-2 laurate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, Polyglyceryl-6 laurate and polyglyceryl-10 palmitate can be mentioned.

(oil content)
Since the vesicle of the present disclosure is formed using the above-described specific polyglycerol fatty acid ester, the oil content is higher in the bilayer membrane of the vesicle than, for example, micelles formed using such a polyglycerol fatty acid ester. concentration can be solubilized.

The solubilization ability of vesicles can be evaluated by the mass ratio of oil to polyglycerol fatty acid ester. Such a mass ratio can be, for example, 0.01 or more, 0.03 or more, 0.05 or more, 0.07 or more, or 0.10 or more, and 0.30 or less and 0.27 or less. , 0.25 or less, 0.23 or less, or 0.20 or less.

There are no particular restrictions on the type of oil that can be solubilized in the vesicle bilayer membrane. As oils, for example, volatile and non-volatile oils can be used. An oil component can be used individually or in combination of 2 or more types. Here, "volatile" is intended to exhibit a volatile content of more than 5% when left at 105°C under atmospheric pressure for 3 hours. The volatile content, which is a guideline for volatility, can be 10% or more, 20% or more, 40% or more, 50% or more, 60% or more, 80% or more, or 100%. Alternatively, the boiling point at 1 atmosphere (101.325 kPa) can be used as an indicator of volatility. The boiling point can be 250° C. or lower, 240° C. or lower, or 230° C. or lower, and can be 80° C. or higher, 100° C. or higher, 120° C. or higher, 150° C. or higher, or 160° C. or higher. In addition, in the present disclosure, "non-volatile" intends to exhibit a volatile content of 5% or less when left at 105°C for 3 hours.

The volatile oil is not particularly limited, and examples include volatile silicone oil and volatile hydrocarbon oil. A volatile oil can be used individually or in combination of 2 or more types.

Volatile silicone oils include, for example, volatile acyclic silicone oils and volatile cyclic silicone oils.

As volatile acyclic silicone oils, for example, volatile linear silicone oils and volatile branched silicone oils can be used.

Volatile linear silicone oils include, for example, dimethylpolysiloxane with a viscosity of 0.65 cs (sometimes referred to as "dimethicone"), dimethylpolysiloxane with a viscosity of 1 cs, dimethylpolysiloxane with a viscosity of 1.5 cs, and dimethylpolysiloxane with a viscosity of 2 cs. and low-molecular-weight linear dimethylpolysiloxane such as dimethylpolysiloxane. Among them, dimethylpolysiloxane having a viscosity of 2 cs is preferable from the viewpoint of the ability to solubilize vesicles and the transparency of vesicle-containing cosmetics. Here, these viscosities are intended to be kinematic viscosities at 25°C.

Volatile branched silicone oils include, for example, low-molecular-weight branched siloxanes such as methyltrimethicone, tris(trimethylsilyl)methylsilane, and tetrakis(trimethylsilyl)silane.

Volatile cyclic silicone oils include, for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane.

Volatile hydrocarbon oils include, for example, heptane, isododecane, isohexadecane, and isodecane. Among these, isohexadecane is preferable from the viewpoint of the ability to solubilize vesicles and the transparency of vesicle-containing cosmetics.

In addition to the above-mentioned volatile oils, examples of oils include oils commonly used in cosmetics, such as liquid oils, solid oils, waxes, hydrocarbon oils other than those mentioned above, silicone oils other than those mentioned above, and polar oils. can be done. Here, some UV absorbers act as oils, especially polar oils. Such ultraviolet absorbers can also be regarded as oils.

Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, and linseed oil. , safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagi oil, Japanese pear oil, jojoba oil, germ oil, and triglycerin.

Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese wax kernel oil, hydrogenated oil, beef Leg fat, Japanese wax, and hydrogenated castor oil.

Waxes include, for example, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, Reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

Examples of hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and olefin oligomers.

Examples of silicone oils include linear silicones such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane (diphenylsiloxyphenyltrimethicone), and methylhydrogenpolysiloxane having a viscosity of 6 cs or more.

As the polar oil, for example, a polar oil with an IOB of 0.10 or more can be used. Examples of such polar oils include isopropyl myristate (IOB value = 0.18), octyl palmitate (IOB value = 0.13), isopropyl palmitate (IOB value = 0.16), butyl stearate ( IOB value = 0.14), hexyl laurate (IOB value = 0.17), myristyl myristate (IOB value = 0.11), decyl oleate (IOB value = 0.11), isononyl isononanoate (IOB value = 0.20), isotridecyl isononanoate (IOB value = 0.15), cetyl ethylhexanoate (IOB value = 0.13), pentaerythrityl tetraethylhexanoate (IOB value = 0.35), diethylhexyl succinate (IOB value = 0.32), dioctyl succinate (IOB value = 0.36), glycol distearate (IOB value = 0.16), glyceryl diisostearate (IOB value = 0.29), neopentyl glycol dicaprate. (IOB value = 0.25), diisostearyl malate (IOB value = 0.28), trimethylolpropane triisostearate (IOB value = 0.16), glyceryl tri-2-ethylhexanoate (triethylhexanoin) (IOB value = 0.35), trimethylolpropane trioctanoate (IOB value = 0.33), trimethylolpropane triisostearate (IOB value = 0.16), diisobutyl adipate (IOB value = 0.46), N-lauroyl-L-glutamic acid-2-octyldodecyl ester (IOB value = 0.29), 2-hexyldecyl adipate (IOB value = 0.16), diisopropyl sebacate (IOB value = 0.40), methoxy Ethylhexyl cinnamate (IOB value = 0.28), 2-ethylhexyl palmitate (IOB value = 0.13), 2-ethylhexyl ethylhexanoate (IOB value = 0.2), triisostearin (IOB value = 0.16 ), PPG-3 dipivalate (IOB value=0.52), and tri(caprylic/capric)glyceryl (IOB value=0.33). Among them, pentaerythrityl tetraethylhexanoate (IOB value = 0.35) is preferable from the viewpoint of the ability to solubilize vesicles and the transparency of vesicle-containing cosmetics.

Examples of UV absorbers that can be regarded as oils include UV absorbers with an IOB of 0.10 or more, specifically ethylhexyl methoxycinnamate, octocrylene, polysilicone-15, t-butylmethoxydibenzoylmethane. , ethylhexyltriazon, bisethylhexyloxyphenolmethoxyphenyltriazine, hexyl diethylaminohydroxybenzoylbenzoate, oxybenzone-3, methylenebisbenzotriazolyltetramethylbutylphenol, homosalate, and ethylhexyl salicylate. be able to. A ultraviolet absorber can be used individually or in combination of 2 or more types.

The IOB value of the polar oil and UV absorber can be, for example, 0.11 or more, 0.12 or more, or 0.13 or more, and 0.50 or less, 0.45 or less, or 0.40 or less. can be Here, the IOB value is an abbreviation for Inorganic/Organic Balance (inorganic/organic ratio), which is a value representing the ratio of the inorganic value to the organic value, and is an index indicating the degree of polarity of an organic compound. It becomes. The IOB value is specifically expressed as IOB value=inorganic value/organic value. For each of the "inorganicity value" and the "organicity value", various The "inorganic value" and "organic value" are set according to the atom or functional group, and the "inorganic value" and "organic value" of all atoms and functional groups in the organic compound are accumulated. (See, for example, Yoshio Koda, "Organic Conceptual Diagram-Basics and Applications-", pp. 11-17, Sankyo Publishing, 1984).

In some embodiments, silicone oil is preferable among the above-described oils from the viewpoint of transparency of vesicle-containing cosmetics.

<Optional component>
The vesicle-containing cosmetic of the present disclosure can appropriately contain various components within a range that does not adversely affect the effects of the present disclosure. Examples of various components include additive components that can be usually blended in cosmetics, such as surfactants other than polyglycerin fatty acid esters (eg, anionic surfactants), moisturizing agents, thickeners, water-soluble polymers, oils. Soluble polymers, film-forming agents, higher fatty acids, sequestering agents, alcohols (e.g., lower alcohols such as ethanol, higher alcohols, polyhydric alcohols such as glycol), various extracts, sugars, amino acids, organic amines, polymers Emulsions, chelating agents, UV absorbers other than the above UV absorbers, pH adjusters, skin nutrients, vitamins, pharmaceuticals, quasi-drugs, water-soluble agents applicable to cosmetics, buffers, anti-fading agents agents, preservatives, propellants, fillers, pigments, dyes, pigments, perfumes, and the like. Optional components can be blended in the oil phase and/or the water phase, and can be used alone or in combination of two or more.

Among the optional ingredients, the use of an anionic surfactant can function as a dispersant for vesicles in cosmetics, and can further improve the transparency and long-term stability of vesicle-containing cosmetics. In some embodiments, the anionic surfactant is included in the cosmetic, at least a portion of which is in the form of micelles containing such active agent in the aqueous phase.

Examples of such anionic surfactants include N-acylamino acid salts and N-acylmethyltaurate salts. Specifically, for example, N-acylglutamate such as potassium cocoylglutamate, N-acyl-N-methyl-β-alanine salt, N-acylsarcosinate salt, sodium N-cocoyltaurate, N-cocoyl-N -sodium methyl taurate, N-lauroyl-N-methyl taurate sodium, N-coconut fatty acid-N-methyl taurate sodium, N-coconut fatty acid-N-methyltaurine triethanolamine, N-palm fatty acid-N-ethyl Taurine triethanolamine, magnesium N-cocoyltaurate, magnesium N-cocoyl-N-methyltaurate, magnesium N-lauroyl-N-taurate, magnesium N-lauroyl-N-methyltaurate, and magnesium N-coconut fatty acid-N-methyl Mention may be made of magnesium taurine. Among them, sodium N-cocoyl-N-methyltaurate is preferred. Anionic surfactant can be used individually or in combination of 2 or more types.

From the viewpoint of the transparency and long-term stability of the vesicle-containing cosmetic, the amount of the anionic surfactant blended is 0.01% by mass or more, 0.03% by mass or more, and 0.05% by mass with respect to the total amount of the cosmetic. % or more, or 0.07% by mass or more, and 1.0% by mass or less, 0.7% by mass or less, 0.5% by mass or less, or 0.3% by mass or less preferable.

Furthermore, if alcohol is blended as an optional component, the ability to solubilize oil in vesicles or the transparency of vesicle-containing cosmetics can be further improved. Such alcohols include, for example, lower alcohols, polyhydric alcohols, and higher alcohols. Among them, lower alcohols and/or polyhydric alcohols are preferred. Alcohol can be used individually or in combination of 2 or more types.

As the lower alcohol, for example, a monohydric alcohol having an alkyl group having 1 to 5 carbon atoms is preferable, and a monohydric alcohol having an alkyl group having 1 to 3 carbon atoms is more preferable. Specific examples include ethanol, propanol, isopropanol, isobutyl alcohol, and t-butyl alcohol, with ethanol being preferred. A lower alcohol can be used individually or in combination of 2 or more types.

Examples of polyhydric alcohols include ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, and polybutylene glycol. Among them, dipropylene glycol is preferred. A polyhydric alcohol can be used individually or in combination of 2 or more types.

Examples of higher alcohols that can be used include those having a carbon chain length of 16 or more, and specific examples include lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, and monostearyl. linear or branched higher alcohols such as glycerene ether (bacyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol and octyldodecanol;

From the viewpoint of the ability to solubilize oil in vesicles and the transparency of vesicle-containing cosmetics, the amount of alcohol blended is 1.0% by mass or more, 3.0% by mass or more, and 5.0% by mass relative to the total amount of the cosmetic. % or more, or 7.0 mass % or more, and preferably 20.0 mass % or less, 17.0 mass % or less, or 15.0 mass % or less.

<L value of cosmetics>
The vesicle-containing cosmetic of the present disclosure can exhibit excellent transparency even though the vesicle solubilizes oil. The transparency of cosmetics can be evaluated, for example, by the L value calculated from a color difference meter such as COLOR-EYE 7000A (manufactured by Gretag Macbeth). It is intended that the closer the L value is to 100, the higher the transparency. Cosmetics of the present disclosure can exhibit an L value of 50 or greater, 55 or greater, 60 or greater, 65 or greater, 70 or greater, 75 or greater, 80 or greater, 85 or greater, or 90 or greater. The upper limit of the L value is not particularly limited, and can be set to 100 or less, for example.

<<Method for Preparing Vesicle-Containing Cosmetics>>
The vesicle-containing cosmetic of the present disclosure is not limited to the following method, but can be prepared as follows. Various materials described above can be used in the preparation of cosmetics.

For example, the above-described polyglycerol fatty acid ester capable of forming a vesicle bilayer membrane, oil, and optionally an oil-soluble drug are mixed to form a mixed solution. Next, the vesicle-containing cosmetic composition of the present disclosure can be obtained by adding this mixed solution to water optionally containing a water-soluble drug and the like, followed by stirring and mixing. By preparing the cosmetic in this order, the oil can be solubilized in the bilayer membrane of the vesicle.

<<Dosage Form of Vesicle-Containing Cosmetic>>
The dosage form of the vesicle-containing cosmetic of the present disclosure is not particularly limited, and examples thereof include liquid, milky lotion, cream, gel, spray, and mousse. Here, in the present disclosure, "spray" can include mist type spray, aerosol type spray, and the like.

<<Use of vesicle-containing cosmetics>>
The vesicle-containing cosmetic of the present disclosure can be used, for example, as a cosmetic that is spread and applied to the skin, hair, or the like.

The product form of the cosmetics of the present disclosure is not particularly limited, but for example, facial cosmetics such as lotions, beauty essences, milky lotions, and packs; makeup cosmetics such as foundations, lipsticks, and eye shadows; body cosmetics; hair cosmetics such as hair liquids, hair tonics, hair conditioners, shampoos, rinses and hair restorers; and ointments.

The vesicle-containing cosmetic of the present disclosure will be described in more detail below with reference to examples, but the cosmetic of the present disclosure is not limited to these. Hereinafter, unless otherwise specified, the compounding amount is indicated by mass%.

<<Examples 1 to 13 and Comparative Examples 1 to 2>>
The formulations shown in Tables 1 and 2 and the vesicle-containing cosmetics obtained by the production methods shown below were subjected to the following evaluations, and the results are shown in Tables 1 and 2.
<Evaluation method>
(Evaluation of vesicles)
The prepared cosmetic was observed with a frozen replica transmission electron microscope (TEM, H-7650: manufactured by Hitachi, Ltd.) using the frozen replica method to confirm the presence or absence of vesicles. In the table, "yes" indicates that vesicles were confirmed, and "no" indicates that no vesicles were confirmed.

(Evaluation of L value)
The L value, which is an index of transparency, was evaluated using a color difference meter COLOR-EYE 7000A (manufactured by Gretag Macbeth). For cosmetics that are cloudy and difficult to measure accurately, "20 or less" is indicated in the table.

(Appearance evaluation)
The prepared cosmetic was added to a 50 mL transparent glass bottle (outer diameter 2.5 cm), and the appearance of the cosmetic was visually observed in an atmosphere of 25° C. and evaluated according to the following criteria. Here, A and B ratings can be considered pass and C rating fail:
A: The cosmetic was not cloudy, and the other side of the cosmetic was visible through the glass bottle.
B: The cosmetic was slightly cloudy, but the other side of the cosmetic was visible through the glass bottle.
C: The cosmetic was cloudy, and the opposite side of the cosmetic could not be seen through the glass bottle.

<Method for producing cosmetics>
Using the formulations shown in Tables 1 and 2, vesicle-containing cosmetics were produced by the following method. Here, the numbers shown below correspond to the numbers on the left indicating the names of the ingredients of the formulations in Tables 1 and 2.

(Example 1)
No. 4 and no. The 10 materials were uniformly mixed to obtain an oil phase part.

　No. 1, No. 2 and No. 9 materials were uniformly mixed to obtain a water phase part.

The oil phase part was added to the water phase part and dispersed uniformly with a dispenser to obtain the vesicle-containing cosmetic of Example 1.

(Examples 2-7 and Comparative Examples 1-2)
Vesicle-containing cosmetics of Examples 2 to 7 and Comparative Examples 1 and 2 were obtained in the same manner as in Example 1, except that the formulation was changed to that shown in Table 1.

(Example 8)
No. 2, No. 4 and no. 5 materials were uniformly mixed to obtain an oil phase part.

　No. 1 was taken as the water phase part.

The oil phase part was added to the water phase part and dispersed uniformly with a magnetic stirrer to obtain the vesicle-containing cosmetic of Example 8.

(Examples 9-13)
Vesicle-containing cosmetics of Examples 9 to 13 were obtained in the same manner as in Example 8, except that the formulation was changed to that shown in Table 2.

<result>
Looking at Table 1, it can be seen that the cosmetics of Comparative Examples 1 and 2 also formed vesicles and contained the same and the same amount of oil as the cosmetics of Example 1. All of the cosmetics were cloudy. This is probably because the vesicles in Comparative Examples 1 and 2 failed to completely solubilize the blended oil and partly precipitated in the aqueous phase.

On the other hand, when polyglycerol fatty acid esters having an OH/C ratio of 0.20 to 0.80 were used, it was confirmed that oil could be solubilized at a higher concentration than in the cosmetics of Comparative Examples 1 and 2. rice field. It was also confirmed that a vesicle-containing cosmetic having excellent transparency can be obtained when such a polyglycerol fatty acid ester is used.

Further, from the results of Examples 6 and 7 in Table 1, the vesicle-containing cosmetic of the present disclosure can solubilize any kind of oil at a high concentration and exhibit good transparency. I was able to confirm that I got it. Among others, it was found that when silicone oil was used as the oil component, more excellent transparency could be exhibited.

From the results in Table 2, it was found that when the vesicle-containing cosmetic further contained alcohol, the oil could be solubilized at a high concentration and the transparency could be further improved.

Claims

a dispersion medium containing water, and vesicles dispersed in the dispersion medium;
A vesicle-containing cosmetic comprising
The vesicle is formed of at least one polyglycerol fatty acid ester having an OH/C ratio of 0.20 to 0.80, and contains oil in the bilayer membrane of the vesicle,
A vesicle-containing cosmetic.
The vesicle-containing cosmetic according to claim 1, wherein the cosmetic exhibits an L value of 50 or more.
The cosmetic according to claim 1 or 2, wherein the polyglycerol fatty acid ester has an OH/C ratio of 0.20 to 0.60.
The cosmetic according to any one of claims 1 to 3, wherein the mass ratio of said oil to said polyglycerol fatty acid ester is 0.01 or more and 0.30 or less.
The cosmetic according to any one of claims 1 to 4, wherein the number of carbon atoms in the fatty acid portion of the polyglycerin fatty acid ester is 12 or more and 17 or less.
The cosmetic material according to any one of claims 1 to 5, wherein the polyglycerin part of the polyglycerin fatty acid ester is formed of polyglycerin having a dimer or more and a decamer or less.
The cosmetic according to any one of claims 1 to 6, further comprising an anionic surfactant.
The cosmetic according to claim 7, comprising micelles containing the anionic surfactant.
The cosmetic according to any one of claims 1 to 8, further comprising alcohol.