JP2024058629A - Cosmetics containing glyceryl ascorbic acid derivatives - Google Patents

Abstract

[Problem] To provide a gel or gel cream cosmetic containing an ascorbic acid derivative or a salt thereof which is 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid and in which the alkyl group is a tetradecyl group or a hexadecyl group, and which has an excellent feel when used such as good compatibility with the skin and no squeaking, and which shows little change in viscosity over time even during storage. [Solution] A gel or gel cream cosmetic containing an ascorbic acid derivative or a salt thereof which is 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid and in which the alkyl group is a tetradecyl group or a hexadecyl group, and which is formulated with a nonionic surfactant having an HLB of 10 to 18 and a specific thickener. [Selected Figure] None

Description

The present invention relates to a cosmetic preparation containing a glyceryl ascorbic acid derivative and having excellent storage stability. More specifically, the present invention relates to a stable gel or gel cream cosmetic preparation that exhibits an excellent feeling when used and suppresses viscosity loss during storage by combining (A) an ascorbic acid derivative or a salt thereof that is 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid, in which the alkyl group is a tetradecyl group or a hexadecyl group, (B) a nonionic surfactant with an HLB of 10 to 18, and (C) a specific thickener.

Traditionally, various whitening agents such as ascorbic acid, kojic acid, and arbutin have been used in cosmetics to prevent skin darkening, age spots, and freckles caused by sunlight and to maintain the skin's natural whiteness. Among these, ascorbic acid is a safe and useful substance known as a compound with antioxidant effects, collagen production promotion effects, and excellent whitening effects, and is known to improve skin condition and keep it healthy. However, ascorbic acid is highly unstable against light, heat, and oxidation, which has prevented its use in cosmetics, foods, medicines, etc.

On the other hand, the present inventors have developed various glyceryl ascorbic acid derivatives or salts thereof that have improved stability over time compared to ascorbic acid and are less likely to discolor during storage when incorporated into cosmetics, and have proposed incorporating them into whitening cosmetics, as moisturizing agents, and in cosmetics for the purpose of promoting collagen production, etc. (Patent Documents 1 and 2)

However, when preparing gel or gel cream cosmetic preparations containing glyceryl ascorbic acid derivatives, it was difficult to create a formulation with an appropriate viscosity that provides a pleasant sensation when used. Even when a thickener was included, the viscosity of the formulation decreased over time, posing a problem in terms of maintaining storage stability. Furthermore, depending on the type of thickener, the pleasant sensation when applied to the skin, such as good skin compatibility and no squeaking sensation, could be lost.

Patent No. 4681670 JP 2019-142790 A

The present invention aims to provide a gel or gel cream cosmetic that contains a glyceryl ascorbic acid derivative or a salt thereof, which has an excellent feel when used, such as good compatibility with the skin and no squeaking, and exhibits reduced viscosity change over time even during storage, compared to conventional cosmetic products.

As a result of intensive research in light of the above-mentioned circumstances, the present inventors have discovered that a gel or gel cream cosmetic product that combines an ascorbic acid derivative or a salt thereof, which is 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid, in which the alkyl group is a tetradecyl group or a hexadecyl group, with a specific nonionic surfactant and a thickener, provides a cosmetic product that exhibits an excellent feel when used and in which changes in viscosity over time are suppressed, and thus completed the present invention.

A first aspect of the present invention is a gel or gel-cream cosmetic preparation comprising the following components (A) to (C):
(A) an ascorbic acid derivative or a salt thereof which is 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid, in which the alkyl group is a tetradecyl group or a hexadecyl group; (B) one or more types selected from nonionic surfactants having an HLB of 10 to 18; (C) one or more types of thickeners selected from aqueous or amphiphilic polymers containing acryloyldimethyltaurine or a salt thereof as a constituent unit, (acrylates/alkyl acrylate (C10-30)) crosspolymers, carbomers, and xanthan gum.

The second aspect of the present invention is the gel or gel-cream cosmetic of the first aspect of the present invention, characterized in that the alkyl group of the component (A) is a tetradecyl group. When the component (A) is the compound described above, the cosmetic exhibits an excellent feeling when used and exhibits suppressed changes in viscosity over time, and thus falls within this preferred embodiment.

The third aspect of the present invention is a gel or gel-cream cosmetic according to the first or second aspect of the present invention, characterized in that the nonionic surfactant of component (B) is PPG-6-decyltetradeceth-30, PEG-30 phytosterol, or polyglyceryl-10 laurate. These nonionic surfactants are easily available industrially and can provide an excellent feeling when used, so they fall into this preferred embodiment.

The fourth aspect of the present invention is a gel or gel-cream cosmetic according to any one of the first to third aspects of the present invention, characterized in that the thickener described in component (C) is a (hydroxyethyl acrylate/sodium acryloyldimethyl taurate) copolymer, polyacrylate crosspolymer-6, (acrylates/alkyl acrylate (C10-30)) crosspolymer, carbomer, or xanthan gum. When component (C) is the above-mentioned thickener, it is superior in terms of suppressing viscosity changes over time during storage, and therefore falls under this preferred embodiment.

The present invention is a gel or gel cream cosmetic that contains an ascorbic acid derivative or a salt thereof that is 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid, in which the alkyl group is a tetradecyl group or a hexadecyl group, and that contains a specific nonionic surfactant and thickener, resulting in a cosmetic that has an excellent feel when used and is stable with little change in viscosity over time during storage.

The components (A) to (C) constituting the cosmetic of the present invention, as well as the form of the cosmetic of the present invention, are described in detail below.

[Component (A): 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid derivatives in which the alkyl group is a tetradecyl group or a hexadecyl group, or salts thereof]
Component (A) incorporated in the cosmetic preparation of the present invention is a glyceryl ascorbic acid derivative in which a glyceryl group is added to either the 2- or 3-position of ascorbic acid and a tetradecyl or hexadecyl group is added to the other position, and can be produced by the method described in the aforementioned Patent Document 1. Glyceryl refers to a group represented by HOCH ₂ -CH(OH)-CH ₂ - or HOCH ₂ -CH(CH ₂ OH)-.

Among the ascorbic acid derivatives of component (A), the alkyl group is preferably a tetradecyl group, as this is industrially easy to obtain and fully exerts the effects of the present invention. Specifically, 2-O-tetradecyl-3-O-glyceryl ascorbic acid and 2-O-glyceryl-3-O-tetradecyl ascorbic acid are preferred.

Examples of salts of the glyceryl ascorbic acid derivatives of component (A) include metal salts such as potassium salts and sodium salts, and ammonium salts such as triethanolamine salts, 2-amino-2-methyl-1,3-propanediol salts, and 2-amino-2-methyl-1-propanol salts.

As the glyceryl ascorbic acid derivative or its salt of component (A), a commercially available product can be used, such as Amitose MGA or Amitose GMA (both manufactured by Seiwa Kasei Co., Ltd.).

In the cosmetic composition of the present invention, the glyceryl ascorbic acid derivative or its salt as component (A) may be used alone or in combination of two or more.

The amount of the glyceryl ascorbic acid derivative or its salt in the cosmetic of the present invention, component (A), is preferably 0.01% by mass or more, more preferably 0.05% by mass or more. The upper limit is preferably 2.0% by mass or less, more preferably 1.5% by mass or less. If the amount is less than 0.01% by mass, it is difficult to obtain a good feel when applied to the skin, while if the amount exceeds 2.0% by mass, the effect commensurate with the amount may not be obtained.

[Component (B): Nonionic surfactant with HLB of 10 to 18]
There are no particular limitations on the component (B) that is blended in the cosmetic of the present invention, so long as it is a nonionic surfactant with an HLB of 10 to 18. Examples include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene polyoxypropylene alkyl ether, polyoxyalkylene sterol ether, and the like.

Among nonionic surfactants, component (B) is preferably a nonionic surfactant with an HLB (hydrophile-lipophile balance) value calculated using the Griffin method of 10 to 18, more preferably an HLB value of 12 to 18. If a nonionic surfactant with an HLB value of less than 10 is used, there is a possibility that the glyceryl ascorbic acid derivative of component (A) may precipitate over time, resulting in a loss of stability.

Examples of polyoxyethylene hydrogenated castor oil include PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-80 hydrogenated castor oil, and PEG-100 hydrogenated castor oil.

Examples of polyoxyethylene sorbitan fatty acid esters include polyoxyethylene sorbitan oleate, polyoxyethylene sorbitan laurate, and polyoxyethylene sorbitan stearate.

Examples of polyglycerol fatty acid esters include polyglyceryl-10 stearate, polyglyceryl-10 isostearate, polyglyceryl-10 myristate, and polyglyceryl-10 laurate.

Examples of polyoxyethylene polyoxypropylene alkyl ethers include PPG-4 ceteth-20, PPG-8 ceteth-20, and PPG-6 decyltetradeceth-30.

Examples of polyoxyalkylene sterol ethers include PEG-20 phytosterol and PEG-30 phytosterol.

Among the nonionic surfactants of component (B), PEG-40 hydrogenated castor oil (HLB 12.5), PPG-6 decyltetradeceth-30 (HLB 12.0), PEG-30 phytosterol (HLB 18.0), and polyglyceryl-10 laurate (HLB 15.3) are preferred, as they are able to suppress changes in the viscosity of the cosmetic over time, with PPG-6 decyltetradeceth-30, PEG-30 phytosterol, and polyglyceryl-10 laurate being even more preferred.

Commercially available products can be used as the nonionic surfactant of component (B). For example, PEG-40 hydrogenated castor oil can be NIKKOL HCO-40 (trade name, manufactured by Nikko Chemicals Co., Ltd.), PPG-6 decyltetradeceth-30 can be NIKKOL SG-DTD630 (trade name, manufactured by Nikko Chemicals Co., Ltd.), PEG-30 phytosterol can be NIKKOL BPS-30 (trade name, manufactured by Nikko Chemicals Co., Ltd.), and polyglyceryl-10 laurate can be S-Face 10G-L (trade name, manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.).

The amount of the nonionic surfactant of component (B) in the cosmetic of the present invention is preferably 0.1% by mass or more, and more preferably 0.5% by mass or more. The upper limit is preferably 3.5% by mass or less, and more preferably 3.0% by mass or less. If the amount is less than 0.1% by mass, it is difficult to achieve stability over time, while if the amount exceeds 3.5% by mass, the effect may not be commensurate with the amount.

[Component (C): Thickener]
The thickener of component (C) contained in the cosmetic of the present invention is characterized by being selected from aqueous or amphiphilic polymers containing acryloyldimethyltaurine or a salt thereof as a constituent unit, (acrylates/alkyl acrylate (C10-30)) crosspolymers, carbomers, and xanthan gum. By containing these specific thickeners, it is possible to suppress the viscosity change over time of the cosmetic containing the glyceryl ascorbic acid derivative or a salt thereof of component (A). Furthermore, when applied to the skin, the cosmetic exhibits an excellent feel in use, such as good compatibility with the skin and no squeaking sensation, while maintaining the whitening effect of the glyceryl ascorbic acid derivative.

Specific examples of thickeners for component (C) include (sodium acrylate/sodium acryloyldimethyltaurate) copolymer, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer, (sodium acrylate/acryloyldimethyltaurate/dimethylacrylamide) crosspolymer, (acrylamide/sodium acryloyldimethyltaurate) copolymer, polyacrylate-13 (a copolymer of acrylic acid, acrylic acid amide, sodium acrylate and sodium acryloyldimethyltaurate), polyacrylate crosspolymer-6 (acryloyldimethyl Examples of such copolymers include ammonium methacrylate, dimethylacrylamide, a copolymer of lauryl methacrylate and laureth-4 methacrylate crosslinked with trimethylolpropane triacrylate, (acrylates/alkyl acrylate (C10-30)) crosspolymer, carbomer, xanthan gum, etc., and among these, (hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer, polyacrylate crosspolymer-6, (acrylates/alkyl acrylate (C10-30)) crosspolymer, carbomer, and xanthan gum are preferably used.

As the thickener of component (C), commercially available products can be used. For example, SIMULGEL NS and SEPIPLUS S manufactured by SEPPIC Corporation (both containing (hydroxyethyl acrylate/sodium acryloyldimethyl taurate) copolymer), SEPIMAX ZEN (containing polyacrylate crosspolymer-6), PEMULEN TR-1 manufactured by Lubrizol Corporation (containing (acrylates/alkyl acrylate (C10-30)) crosspolymer), Carbopol 980 (containing carbomer), and Labolgum GS-C (containing xanthan gum) manufactured by Sumitomo Pharma Food & Chemical Co., Ltd. can be used.

In the gel or gel-cream cosmetic of the present invention, the thickener component (C) may be used alone or in a mixture of two or more types.

The amount of thickener (C) in the cosmetic of the present invention is preferably 0.1% by mass or more, more preferably 0.3% by mass or more. The upper limit is preferably 3.0% by mass or less, more preferably 2.5% by mass or less. If the amount is less than 0.1% by mass, it is difficult to achieve stability over time, while if the amount exceeds 3.0% by mass, the effect may not be commensurate with the amount.

The cosmetic of the present invention contains water in addition to the above-mentioned components (A) to (C). Furthermore, a wide range of other ingredients that are typically used in cosmetics can be blended depending on the intended use, as long as the cosmetic's effects, stability, etc. are not impaired.

In addition to the above components (A) to (C) and water, other components that are typically used in cosmetics can be appropriately blended, such as oils, surfactants other than component (B), polymeric compounds, moisturizers, whitening agents, texture improvers, drugs, UV absorbers, proteins, protein hydrolysates or derivatives thereof, amino acids or derivatives thereof, antioxidants, sequestering agents, pH adjusters, preservatives, pigments, colorants, fragrances, etc.

There are no particular limitations on the oil used, and any oil typically used in cosmetics can be used. Specific examples of such compounds include hydrocarbon oils such as (C13-15) alkanes, (C15-19) alkanes, (C18-21) alkanes, (C21-28) alkanes, liquid paraffin, heavy liquid isoparaffin, α-olefin oligomers, squalane, polyisobutylene, polybutene, and hydrogenated polyfarnesene; oils and fats such as olive oil, castor oil, and macadamia nut oil; jojoba oil, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, 2-ethyl Cetyl oleate, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, dipentaerythritol fatty acid esters, isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isopropyl palmitate, 2-octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, 2-ethylhexyl methoxycinnamate ester oils such as glyceryl triisooctanoate, glyceryl triisostearate, diglyceryl diisostearate, diglyceryl triisostearate, diglyceryl tetraisostearate, decaglyceryl decaisostearate, glyceryl triisopalmitate, glyceryl trimyristate, diglyceryl myristate isostearate, tritridecyl trimellitate, tri(caprylic acid/capric acid)glyceryl and other triglycerides; amino acid-based oils such as N-lauroyl-L-glutamic acid-2-octyldodecyl ester and N-lauroyl-L-glutamic acid di(phytostearyl/2-octyldodecyl); fatty acids such as isostearic acid and oleic acid; higher alcohols such as oleyl alcohol and isostearyl alcohol; cyclotetrasiloxane, cyclopentasiloxane, cyclohexyl siloxane, Cyclic silicone oils such as sasiloxane; chain silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, alkoxy-modified organopolysiloxane, and fluorine-modified silicone; fluorine-based oils such as perfluoropolyether; lanolin derivatives such as lanolin acetate, isopropyl lanolinate, and lanolin alcohol, Theobroma grandiflorum seed fat, mango seed fat, cacao butter, palm oil, palm kernel oil, coconut oil, shea butter, Shorea sthenoptera fat, African mango kernel fat, avocado butter, sal seed fat, Astrocaryum murumuru fat, Astrocaryum murumuru seed fat, Astrocaryum tucuma seed fat, Garcinia indica seed fat, Tritilia emetica seed fat, Bassia latifolia seed fat, Garcinia indica seed fat, hydrogenated cacao butter, (macadamia seed oil/hydrogenated macadamia seed oil) esters, and milk fat.

Examples of surfactants other than component (B) include anionic surfactants such as higher fatty acid soaps, alkyl sulfates, alkyl phosphates, polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl phenyl ether sulfates, alkyl ether phosphates, alkyl ether carboxylates, acyl methyl taurines, N-acyl-N-methyl-β-alanines, N-acyl glycines, N-acyl glutamates, polyoxyethylene alkyl carboxylates, alkyl phenyl ether sulfonates, alkyl sulfosuccinic acids and their salts, N-acyl sarcosines and their salts, polyoxyethylene coconut oil fatty acid monoethanolamide sulfates, lauroyl oat amino acids and their salts, and cocoyl apple amino acids and their salts;
alkylamine salts such as monoalkylamine salts, dialkylamine salts, and trialkylamine salts; fatty acid amide alkylamines such as stearamidoethyl diethylamine and stearamidopropyl dimethylamine; alkyl quaternary ammonium salts such as monoalkyl quaternary ammonium salts, dialkyl quaternary ammonium salts, trialkyl quaternary ammonium salts, and benzalkonium quaternary ammonium salts; cyclic quaternary ammonium salts such as alkylpyridinium salts; and cationic surfactants such as benzethonium chloride;
amphoteric surfactants such as alkyl dimethyl amino acetic acid betaine, alkyl amido amino acetic acid betaine, fatty acid amido propyl dimethyl amino acetic acid betaine, 2-alkyl-N-carboxy-N-hydroxy imidazolinium betaine, alkyl glycine salts, carboxymethyl glycine salts, N-acyl aminoethyl-N-2-hydroxyethyl glycine salts, alkyl amino propionate salts, alkyl imino dipropionate salts, and alkyl hydroxy sulfobetaine;
Polyglycerin fatty acid esters such as diglyceryl stearate, diglyceryl oleate, diglyceryl isostearate, tetraglyceryl stearate, tetraglyceryl oleate, hexaglyceryl laurate, hexaglyceryl myristate, hexaglyceryl stearate, hexaglyceryl oleate, decaglyceryl oleate, diglyceryl dioleate, decaglyceryl distearate, decaglyceryl diisostearate, tetraglyceryl tristearate, hexaglyceryl tristearate, decaglyceryl tristearate, and decaglyceryl trioleate, decyl glucoside, caprylyl/capryl glucoside, cetearyl glucoside, arachyl glucoside, C12-2 0) Nonionic surfactants such as alkyl glucosides, coconut oil alkyl glucosides, myristyl glucoside, heptyl glucoside, lauryl glucoside, and the like, glycerin fatty acid esters and their alkylene oxide adducts, polyoxyalkylene alkyl ethers, polyoxyalkylene fatty acid esters, polyoxyalkylene alkylphenols, polyoxyethylene sorbitol fatty acid esters, polyoxyethylene alkylphenyl formaldehyde condensates, polyoxyethylene sterols and derivatives thereof, polyoxyethylene lanolin and derivatives thereof, polyoxyethylene beeswax derivatives, sucrose fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene castor oil;
PEG-11 Methyl Ether Dimethicone, PEG/PPG-20/22 Butyl Ether Dimethicone, PEG-9 Dimethicone, PEG-3 Dimethicone, PEG-9 Methyl Ether Dimethicone, PEG-10 Dimethicone, PEG-32 Methyl Ether Dimethicone, Cetyl PEG/PPG-10/1 Dimethicone, PEG-9 Polydimethylsiloxyethyl Dimethicone, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Methylpolysiloxane, Cetyl Methylpolysiloxane, Poly(oxyethylene) Examples of the silicone surfactant include polyether-modified silicones such as poly(oxyethylene-oxypropylene)methylpolysiloxane copolymer, poly(oxyethylene-oxypropylene)methylpolysiloxane copolymer, (dimethicone/(PEG-10/15)) crosspolymer, polyglycerin-modified silicones such as polyglyceryl-3 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, and silicone surfactants such as dimethylsiloxane-methylcetylsiloxane copolymer.

Examples of polymeric compounds include sodium carboxymethylcellulose, polyvinyl alcohol, polymeric dimethylpolysiloxane, gum arabic, tragacanth gum, carbro gum, guar gum, pectin, agar, quince seed, starch, algae colloid, dextran, succinoglucan, collagen, gelatin, casein, albumin, carboxymethyl starch, methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethylcellulose, sodium alginate, polyvinyl methyl ether, sodium polyacrylate, polyethylene acrylate, cationic polymers, and polymers other than the compounds exemplified as component (C) above.

Examples of polymers other than component (C) include polyacrylamide, (acrylamide/ammonium acrylate) copolymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, (ammonium acryloyldimethyltaurate/beheneth-25 methacrylate) crosspolymer, (ammonium acryloyldimethyltaurate/steareth-25 methacrylate) crosspolymer, sodium polyacrylate, polyethylene acrylate, (acrylamidopropyltrimonium chloride/acrylates) copolymer, (acrylates/steareth-20 methacrylate) copolymer, (acrylates/beheneth-25 methacrylate) copolymer, (acrylates/steareth-20 itaconate) copolymer, steareth-10 allyl ether/acrylates copolymer, bisstearyl PEG/PPG-8/6 (SMDI/PEG-400) copolymer, etc.

Examples of moisturizing agents include glycerin, propylene glycol, maltitol, sorbitol, 1,3-butylene glycol, sodium lactate, polyethylene glycol, sodium pyrrolidone carboxylate, and sodium hyaluronate.

Examples of whitening agents include hydroquinone, α-arbutin, β-arbutin, kojic acid, kojic acid dipalmitate, nicotinamide, astaxanthin, histidine dithiooctanamide (Na/Zn), placenta extract, rosemary extract, rucinol, magnolignan, ellagic acid, chamomile extract, licorice extract, rucinol, rosemary extract, arbutin, tranexamic acid, tranexamic acid cetyl hydrochloride, linoleic acid, potassium 4-methoxysalicylate, ascorbic acid, ascorbic acid glucoside, and ascorbic acid derivatives such as magnesium ascorbyl phosphate.

Texture improvers include PPG-9 diglyceryl, PEG-11 methyl ether dimethicone, bisethoxydiglycol cyclohexane-1,4-dicarboxylate, amylopectin (amylose), acylated amino acids, polymethylmethacrylate, boron nitride, silica, alumina, aluminum hydroxide, metal soap, silicone powder, polymethylmethacrylate, and dimethylsilylated silica.

Examples of the drug include skin roughness prevention agents and anti-inflammatory agents. Examples of skin roughness prevention agents and anti-inflammatory agents include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, methyl salicylate, pyridoxine hydrochloride, allantoin, sea salt, mulberry bark extract, aloe extract, gardenia extract, chamomile extract, licorice extract, soapberry extract, apricot kernel extract, scutellaria extract, sweet tea extract, loquat extract, ginkgo extract, hypericum extract, yarrow extract, safflower extract, spruce extract, salvia extract, white birch extract, chinpi extract, and peach kernel extract. , Gaiyou extract, Althea extract, Arnica extract, Carrot extract, Peony extract, Cnidium extract, Gentian extract, Cordyceps sinensis extract, Phellodendron bark extract, Inchinko extract, Geranium herb extract, Peach leaf extract, Kumazasa extract, Coix seed extract, Horse chestnut extract, Hawthorn extract, Coptis japonica extract, Ganoderma lucidum extract, Calendula officinalis extract, Peppermint extract, Comfrey extract, Butcher's broom extract, Malva sylvestris extract, Cornflower extract, and Togenashi extract. Other examples of drugs include hair growth drugs, acne drugs, dandruff and itching drugs, and drugs to prevent underarm odor.

Examples of ultraviolet absorbers include benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sodium sulfonate, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, and tetrahydroxybenzophenone; para-aminobenzoic acid derivatives such as para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, amyl para-dimethylaminobenzoate, and octyl para-dimethylaminobenzoate; methoxycinnamic acid derivatives such as ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate (ethylhexyl methoxycinnamate), sodium paramethoxycinnamate, potassium paramethoxycinnamate, and glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate; octyl salicylate, salicylate, and the like. Salicylic acid derivatives such as phenyl licylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, and methyl salicylate; urocanic acid, ethyl urocanate, 4-tert-butyl-4'-methoxydibenzoylmethane (t-butyl methoxydibenzoylmethane), 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, methyl anthranilate, octocrylene (2-cyano-3,3-diphenylprop-2-enoate-2-ethylhexyl), 2-(4-diethylamino-2-hydroxybenzoyl)hexyl benzoate (diethylamino hydroxybenzoyl hexyl benzoate), ethylhexyl triazone, and bisethylhexyloxyphenol methoxyphenyl triazine, and microcapsules containing the above-mentioned ultraviolet absorbers can also be used.

Examples of proteins, protein hydrolysates, and derivatives thereof include milk protein, silk protein, wheat protein, rice protein, pea protein, collagen, keratin, soybean, sesame, conchiolin, marine collagen, and other proteins, as well as their hydrolysates and acylated, glycerylated, silylated, cationized, and alkyl esterified derivatives of protein hydrolysates.

Examples of amino acids or derivatives thereof include amino acids such as glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, arginine, lysine, asparagine, aspartic acid, glutamine, glutamic acid, cystine, cysteine, methionine, tryptophan, proline, and histidine, as well as acylated, alkylated, glycerylated, and esterified derivatives thereof.

Examples of antioxidants include sodium pyrosulfite, vitamin E or its derivatives, tannin, and BHT (butylhydroxytoluene).

Examples of sequestering agents include sodium edetate, phosphoric acid, citric acid, phytic acid, etidronic acid, sodium glutamate diacetate, etc.

Examples of pH adjusters include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, potassium carbonate, sodium bicarbonate, and ammonium bicarbonate.

Examples of preservatives include 1,2-alkanediols such as 1,2-pentanediol and 1,2-hexanediol, paraoxybenzoic acid alkyl esters such as methylparaben and propylparaben, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, phenoxyethanol, and ethylhexylglycerin.

The above-mentioned ingredients typically used in cosmetics can be used alone or in combination of two or more.

The gel or gel-cream cosmetic composition of the present invention can be used, for example, as a skin care cosmetic, such as a lotion, milky lotion, cream, beauty essence, massage product, pack product, hand cream, body lotion, body cream, sunscreen, foundation, eye shadow, eyeliner, or concealer.

The present invention will now be described in detail with reference to examples, but the present invention is not limited to these examples. Note that all values shown in the tables of the examples are in mass % relative to the total mass of the cosmetic.

Examples 1 to 12 and Comparative Examples 1 to 3: Gel Cream (a) shown in Tables 1 and 2 was mixed and added to (c). Then, the mixture (a) was added to (b) to prepare a gel cream. In Table 2, a nonionic surfactant other than component (B) of the present invention was blended as (B2), and a thickener other than component (C) was blended as (C2).

[Stability evaluation]
The gel creams prepared above were stored in a thermostatic chamber at 50° C. for 4 and 8 weeks, and the stability was evaluated according to the following evaluation criteria. Viscosity was measured using a Brookfield LVT viscometer. The results are shown in Tables 1 and 2.
Stability:
⊚: Viscosity change from immediately after preparation was less than ±10%.
A: The viscosity change was ±10% or more but less than ±20% compared to immediately after preparation.
Δ: Viscosity change was ±20% or more but less than ±30% compared to immediately after preparation.
×: Viscosity change was ±30% or more compared to immediately after preparation.

In Table 1,
* 1 is Amitose MGA (containing 10% by mass of 2-O-tetradecyl-3-glyceryl ascorbic acid),
*2 is Amitose GMA (containing 20% by mass of 2-O-glyceryl-3-tetradecyl ascorbic acid) (all trade names, manufactured by Seiwa Kasei Co., Ltd.),
*3 is NIKKOL SG-DTD630,
*4 is NIKKOL BPS-30,
* 5 is NIKKOL HCO-60 (all product names, manufactured by Nikko Chemicals Co., Ltd.),
*6 is S Face 10G-L (product name, manufactured by Sakamoto Pharmaceutical Co., Ltd.),
*7 is SEPIPLUS S (containing approximately 60% of (hydroxyethyl acrylate / sodium acryloyldimethyl taurate) copolymer),
*8 is SIMULGEL NS (containing approximately 40% hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer),
*9 is SEPIMAX ZEN (all product names, manufactured by SEPPIC),
*10 is PEMUREN TR-1,
*11 is Carbopol 980 (above, product name, manufactured by Lubrizol Corporation)
*12 is Labolgum GS-C (product name, manufactured by Sumitomo Pharma Food & Chemical Co., Ltd.)
It was formulated as.

In Table 2, *1 to 3 and 8 are the same as in Table 1.
*13 is SEPIGEL 305 (containing approximately 40% polyacrylamide) (product name, manufactured by SEPPIC)
It was formulated as.

As is clear from the results in Tables 1 and 2, the gel creams of Examples 1 to 12, which contain components (A) to (C), show little change in viscosity during storage and are clearly excellent in stability over time. On the other hand, Comparative Examples 1 to 3, which contain a surfactant (B2) other than component (B) or a thickener (C2) other than component (C), show a significant change in viscosity during storage and are clearly not excellent in stability over time.

Furthermore, using the gel creams of Examples 1, 4-6, and 10 and Comparative Examples 1 and 2 prepared in Tables 1 and 2, sensory evaluations were conducted on two items, familiarity and stickiness, and the results were named Examples 13-17 and Comparative Examples 4 and 5, respectively. Each gel cream was applied to the forearms of 10 panelists, and evaluation was conducted according to the following criteria.

[Evaluation criteria for familiarity]
2: It feels familiar.
1: Somewhat unfamiliar.
0: Not familiar.

[Evaluation Criteria for Stickiness]
2: Does not feel sticky.
1: Feels slightly sticky.
0: Feels sticky.

The results of each evaluation were totaled and classified as follows. The results are shown in Table 3.
◎: 15-20 points ○: 10-14 points △: 5-9 points ×: 0-4 points

As is clear from the results in Table 3, the gel creams of Examples 13 to 17 prepared using components (A) to (C) had a texture equal to or greater than that of Comparative Examples 4 and 5, which contained components other than components (B) and (C), in terms of good compatibility and lack of stickiness.

Claims (4)

A gel or gel cream cosmetic preparation comprising the following components (A) to (C):
(A) one or more ascorbic acid derivatives selected from 2-O-alkyl-3-O-glyceryl ascorbic acid and/or 2-O-glyceryl-3-O-alkyl ascorbic acid, in which the alkyl group is a tetradecyl group or a hexadecyl group, or salts thereof; (B) one or more nonionic surfactants having an HLB of 10 to 18; (C) one or more thickeners selected from aqueous or amphiphilic polymers containing acryloyldimethyltaurine or a salt thereof as a constituent unit, acrylates/alkyl acrylate (C10-30) crosspolymers, carbomers, and xanthan gum. The gel or gel cream cosmetic preparation according to claim 1, characterized in that the alkyl group of component (A) is a tetradecyl group. The gel or gel-cream cosmetic preparation according to claim 1 or 2, characterized in that component (B) is selected from PPG-6-decyltetradeceth-30, PEG-30 phytosterol, and polyglyceryl-10 laurate. 4. The gel or gel-cream cosmetic preparation according to claim 1, wherein the component (C) is selected from the group consisting of hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer-6, acrylates/C10-30 alkyl acrylate crosspolymer, carbomer, and xanthan gum.