JP2003026528A - Bleaching cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a bleaching cosmetic more positively acting on removal or reduction or protection of pigmentation which could not be satisfied in a conventional bleaching cosmetic. SOLUTION: (1) This bleaching cosmetic comprises one or more kinds of (A) glyoxylic acid, (B) pyruvic acid, (C) levulinic acid and (D) 5-ketohexanoic acid. (2) This bleaching cosmetic comprises two or more kinds of these components (A) to (D). (3) This bleaching cosmetic comprises a component in which the bleaching cosmetic described in the above (1) or (2) is further combined with one or more kinds of melanogenesis-suppressing ingredients.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition which eliminates, reduces or protects pigmentation such as spots and freckles to produce white and beautiful skin, and changes or maintains white and beautiful skin.

[0002]

2. Description of the Related Art Whitening cosmetics up to now include a component having an activity-inhibiting effect on tyrosinase, which is a main enzyme when melanin pigment is formed in the living body, a component for controlling the amount of melanin synthesis of melanin-producing cells, or A method in which a component having a reducing action or the like is blended and applied locally is adopted. However, many of these ingredients have weak efficacy and are unstable, and the actual whitening effect is not yet obtained.

[0003]

DISCLOSURE OF THE INVENTION The present invention provides a whitening cosmetic composition that acts more positively than before for the purpose of eliminating, reducing or protecting pigmentation, which was not satisfied with conventional whitening cosmetic compositions. It is provided.

As a result of intensive studies on the reduction of pigmentation, the present inventors have found that one of four kinds of glyoxylic acid, pyruvic acid, levulinic acid and 5-ketohexanoic acid is
Or glyoxylic acid, pyruvic acid, levulinic acid, 5-
Among the four ketohexanoic acids, it is characterized by containing a component that is a combination of two or more at the same time, or further containing a component that is a combination of one or more of these melanin production-inhibiting components. The inventors have found that the whitening cosmetic composition has an excellent effect of eliminating, reducing or protecting pigmentation, and completed the present invention.

[0005]

The present invention includes the following (1).
It is constituted by the claims (4). (1) 1 of carboxylic acids described in (A) to (D) below
A whitening cosmetic characterized by containing at least one kind. (A) glyoxylic acid (B) pyruvic acid (C) levulinic acid (D) 5-ketohexanoic acid (2) 2 of carboxylic acids described in (A) to (D) below.
A whitening cosmetic characterized by containing at least one kind. (A) glyoxylic acid (B) pyruvic acid (C) levulinic acid (D) 5-ketohexanoic acid (3) The whitening cosmetic composition according to claim 1 or 2, further comprising one or more melanin production-inhibiting components. A whitening cosmetic comprising a combination of ingredients. (4) The melanin production suppressing component is ascorbic acid, arbutin, ellagic acid, catechol, glutathione, kojic acid, cysteine, pantetheine-S-sulfonic acid, hydroquinone, resorcin, retinoic acid, lactic acid, hydrogen peroxide, bromic acid, chlorine. The whitening cosmetic composition according to claim 3, which is an acid, a placenta extract, or a derivative thereof. The reason for configuring the present invention as described above is the effect of eliminating, reducing or preventing pigmentation such as spots, freckles, etc., to make white beautiful skin, change to white beautiful skin, or maintain white beautiful skin. This is to obtain a whitening cosmetic product.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The whitening cosmetic composition of the present invention comprises at least one of glyoxylic acid, pyruvic acid, levulinic acid and 5-ketohexanoic acid, or glyoxylic acid, pyruvic acid, levulinic acid and 5-ketohexane. Of the four types of acids,
It is characterized in that it contains a component in which two or more kinds are always combined at the same time, or further contains a component in which one or more kinds of melanin production suppressing components are combined with these.

In the present invention, the amounts of the four types of glyoxylic acid, pyruvic acid, levulinic acid and 5-ketohexanoic acid are each 0.001 to 50.0% by weight, more preferably 0.1 to 20. It is in the range of 0% by weight. If the blending amount is less than 0.001% by weight, the effect of the present invention is poor, and if it exceeds 50.0% by weight, the effect commensurate with the blending amount cannot be expected.

The blending amount of the melanin production inhibiting component in the present invention is 0.001 to 20.0% by weight, and more preferably 0.01 to 10.0% by weight. The blending amount is
If it is less than 0.01% by weight, the effect of the present invention is poor, and if it exceeds 10.0% by weight, the effect commensurate with the compounding amount cannot be expected.

The whitening cosmetics of the present invention include facial cleansers, lotions, beauty essences, emulsions, creams, gels, packs, liposomes, liquids, clay-like, solid powdery cosmetics, aerosol cosmetics, and haptics. Make-up cosmetics such as skin care cosmetics, foundation creams, foundations, etc. are used as they are, or cosmetics sprayed by an aerosol type, a pump type, an extrusion type or a mechanism similar to these, and various dosage forms such as bath agents are provided. be able to.

The whitening cosmetic composition of the present invention includes water, alcohol, surfactants (cations, anions, nonions, amphoteric surfactants, etc.), moisturizers (glycerin, 1,3-butylene glycol, propylene glycol, amino acids, Urea, pyrrolidone carboxylate, nucleic acids, monosaccharides, oligosaccharides and their derivatives, etc., thickeners (polysaccharides, polyacrylates, carboxyvinyl polymers, polyvinylpyrrolidone, polyvinyl alcohol, chitin, chitosan,
Alginic acid, carrageenan, xanthan gum, methyl cellulose, etc. and their derivatives), wax, petrolatum, hydrocarbon saturated fatty acids, unsaturated fatty acids, silicone oil, etc. and their derivatives, glyceryl tri (capryl / capric acid), glyceryl trioctanoate, etc. Triglycerides, ester oils such as isopropyl stearate, natural oils and fats (olives oil, camellia oil, avocado oil, almond oil, cacao butter, evening primrose oil, grape seed oil, macadamian nut oil, eucalyptus oil, rosehip oil, squalane) , Orange laffy oil, lanolin, ceramide, etc.),
Preservatives (oxybenzoic acid derivatives, dehydroacetates, photosensitizers, sorbic acid, phenoxyethanol, etc. and their derivatives, etc.), bactericides (sulfur, trichlorocarbanilide, salicylic acid, zinc pyrithione, hinokitiol, etc. and their derivatives), UV rays Absorbents (para-aminobenzoic acid, methoxycinnamic acid, etc. and their derivatives, etc.), anti-inflammatory agents (allantoin, glycyrrhizinic acid, etc., and their derivatives, etc.), antioxidants (tocopherol, BHA, BHT, etc., and their derivatives, etc.) ),
Chelating agents (edetic acid, hydroxyethanediphosphonic acid, etc. and their derivatives, etc.), animal and plant extracts (Ashitaba, Aloe, Ages, Ougon, Oataku, Seaweed, Karin, Chamomile, Licorice, Kiwi, Cucumber, Mulberry, Birch, Touki, Garlic, button, hop, horse chestnut,
Lavender, rosemary, eucalyptus, milk, various peptides, placenta, royal jelly, etc. and purified products or fermented materials containing these, pH adjusters (inorganic acids, inorganic acid salts, organic acids, organic acid salts, etc. and their Derivatives), vitamins (vitamins A, vitamin B)
, Vitamin C, vitamin D, etc. and their derivatives), titanium oxide, talc, mica, silica, zinc oxide, iron oxide, silicon, and powders obtained by processing them to achieve the object of the present invention. 0.001-9 within the range
It can be blended in the range of 9.9% by weight. The components constituting the whitening cosmetic composition of the present invention are by no means limited to the above, and any component that can be used in the cosmetic composition can be freely selected.

In addition to the above-mentioned components, the haptics include a base (kaolin, bentonite, etc.) and a gelling agent (polyacrylate, polyvinyl alcohol, etc.) within a range of 0.001 to 10 within the range to achieve the object of the present invention. It can be blended in the range of 99.9% by weight.

In the bath agent, sulfates, hydrogencarbonates, borates, dyes, and moisturizers are appropriately blended within the range of 0.001 to 99.9% by weight within the range to achieve the object of the present invention. It can be prepared into powder type or liquid type.

Hereinafter, the structure of the present invention will be described in detail with reference to Examples, but the present invention is not limited thereto. Prior to the examples, the tests conducted in each example will be described.

(1) Tyrosinase activity inhibitory activity As tyrosinase, an enzyme solution was prepared so that the activity of mushroom-derived tyrosinase (Sigma) was 125 U / ml, and 0.1% L-dopa solution was prepared as a substrate. , The amount of dopachrome generated over time in the tyrosinase reaction system shown in Table 1 (end) is measured as the absorbance at 475 nm (microplate reader: BioRad),
The reaction rate was calculated and calculated as tyrosinase activity.

The results are shown in Table 2 (at the end of this document). According to Table 2, glyoxylic acid, pyruvic acid, levulinic acid, 5-
Addition of ketohexanoic acid (1.25% by weight) reduced the tyrosinase activity to about 1/3 of that of the system without addition (purified water).

(2) Inhibitory action of tyrosinase synthesis in melanin-producing cells B16 mouse melanoma cells were used as melanin-producing cells and seeded in 96-well microplates at 30,000 cells / well and precultured for 24 hours. After that, the medium was replaced with an Eagle MEM medium containing 10% fetal bovine serum, to which four kinds of glyoxylic acid, pyruvic acid, levulinic acid, and 5-ketohexanoic acid of the present invention were added, and the cells were cultured for 48 hours. Next, the medium is removed, the cells are washed with PBS, and then 1% Trito
50 mM phosphate buffer containing nX-100 (pH = 6.
8) Add 50 μl and 0.1% L-DOPA solution to 37
Incubation was carried out at 0 ° C for 6 hours. After the incubation, the absorbance at 475 nm was measured with a microplate reader (model 550: Bio Rad) and calculated as the amount of tyrosinase synthesis. Separately, as for the B16 cells cultured for 48 hours in the same manner as the above operation, M
The cell activity was measured by the TT method, and evaluation / judgment was performed as the amount of tyrosinase synthesis per activity.

Glyoxylic acid, pyruvic acid, levulinic acid, and 5-ketohexanoic acid were changed in concentration (0.050% by weight, 0.100% by weight, 0.200% by weight, 0.400% by weight). The inhibitory effect on tyrosinase synthesis in the melanin-producing cells was measured. The results are shown in Table 3.
Shown at the end of this document. According to the results of Table 3, 4 of glyoxylic acid, pyruvic acid, levulinic acid, and 5-ketohexanoic acid were used.
The species showed a tendency to suppress the synthesis of tyrosinase, which is the main enzyme for melanin production in B16 cells, depending on the concentration added. This inhibitory effect was stronger than the existing whitening agents kojic acid and arbutin.

(3) Pigmentation-improving action Ten subjects with pigmentation such as spots and freckles were observed.
For the cosmetics of Examples 1 to 21 and Comparative Examples 1 to 21 which will be described later as one group, the pigment deposits were applied twice in the morning and evening, and the bath agents of Examples 22 to 24 and Comparative Examples 22 to 24 were applied. About 200 liters of hot water bath agent
After dissolving the gram, the bath was used once a day, and the pigmentation improving effect was evaluated based on the criteria shown in Table 4 (at the end of the document). The judgment was made three times, two weeks after the start of use of the cosmetics and bath agents, one month later, and three months later. In addition,
No one complained of skin abnormalities throughout the study period.
The evaluation results are shown in Table 5 (at the end of this document). According to the results of Table 5, the cosmetics (Examples) of the present application are
In all cases, a strong pigmentation improving effect was observed. These effects are the effects that are first exhibited by the synergistic effect of the combination of the components of the present invention.

Examples and comparative examples of the cosmetics of the present invention will be shown below. The cosmetics of the present invention are not limited to the examples given below.

[0020]     Example 1   Lotion 1     Ingredient weight%   Glyoxylic acid 2,000   L-arginine 2,000   Concentrated glycerin 2,000   1,3-butylene glycol 10.000   Xanthan gum 0.050   Sodium hyaluronate 0.010   Preservative Suitable amount   Amount of purified water 100,000

[0021]     Example 2   Lotion 2     Ingredient weight%   Levulinic acid 2,000   L-arginine 1.800   Ascorbic acid-2-glycoside 2,000   Concentrated glycerin 2,000   1,3-butylene glycol 10.000   Xanthan gum 0.050   Sodium hyaluronate 0.010   Preservative Suitable amount   Amount of purified water 100,000

[0022]     Example 3   Lotion 3     Ingredient weight%   Levulinic acid 2,000   L-arginine 2,000   Concentrated glycerin 2,000   1,3-butylene glycol 10.000   Xanthan gum 0.050   Glutathione 0.010   Preservative Suitable amount   Amount of purified water 100,000

[0023]     Example 4   Emulsion 1     Ingredient weight%   Glyceryl trioctanoate 3.000   Jojoba oil 1.000   Olive oil 1.000   Methyl polysiloxane 0.100   Natural Vitamin E 0.100   POE (20) sorbitan monooleate 1.500   Sorbitan monooleate 0.500   Pyruvate 2,000   L-arginine 2,000   L-serine 0.500   Sodium pyrrolidonecarboxylate 0.100   Polyvinylpyrrolidone 0.050   Preservative Suitable amount   Amount of purified water 100,000

[0024]     Example 5   Emulsion 2     Ingredient weight%   Glyceryl trioctanoate 3.000   Jojoba oil 1.000   Olive oil 1.000   Methyl polysiloxane 0.100   Natural Vitamin E 0.100   POE (20) sorbitan monooleate 1.500   Sorbitan monooleate 0.500   5-ketohexanoic acid 2,000   Arbutin 0.500   L-arginine 2,000   L-serine 0.500   Sodium pyrrolidonecarboxylate 0.100   Polyvinylpyrrolidone 0.050   Preservative Suitable amount   Amount of purified water 100,000

[0025]     Example 6   Emulsion 3     Ingredient weight%   Glyceryl trioctanoate 3.000   Jojoba oil 1.000   Olive oil 1.000   Methyl polysiloxane 0.100   Natural Vitamin E 0.100   POE (20) sorbitan monooleate 1.500   Sorbitan monooleate 0.500   Levulinic acid 1.000   Pyruvate 1.000   Cysteine 0.010   L-arginine 2,000   L-serine 0.500   Sodium pyrrolidonecarboxylate 0.100   Polyvinylpyrrolidone 0.050   Preservative Suitable amount   Amount of purified water 100,000

[0026]     Example 7   Cream 1     Ingredient weight%   Behenyl alcohol 2,000   Glyceryl trioctanoate 3.000   Jojoba oil 1.000   Olive oil 1.000   Methyl polysiloxane 0.100   Natural Vitamin E 0.100   POE (20) sorbitan monostearate 2.500   POE (80) hydrogenated castor oil 0.500   Glyoxylic acid 1.000   Levulinic acid 1.000   L-arginine 2,000   L-serine 0.500   Sodium pyrrolidonecarboxylate 0.100   Carboxy vinyl polymer 0.050   Potassium hydroxide 0.010   Preservative Suitable amount   Amount of purified water 100,000

[0027]     Example 8   Cream 2     Ingredient weight%   Behenyl alcohol 2,000   Glyceryl trioctanoate 3.000   Jojoba oil 1.000   Olive oil 1.000   Methyl polysiloxane 0.100   Natural Vitamin E 0.100   POE (20) sorbitan monostearate 2.500   POE (80) hydrogenated castor oil 0.500   Pyruvate 1.000   5-ketohexanoic acid 1.000   Ellagic acid 0.100   L-arginine 2,000   L-serine 0.500   Sodium pyrrolidonecarboxylate 0.100   Carboxy vinyl polymer 0.050   Potassium hydroxide 0.010   Preservative Suitable amount   Amount of purified water 100,000

[0028]     Example 9   Cream 3     Ingredient weight%   Behenyl alcohol 2,000   Glyceryl trioctanoate 3.000   Jojoba oil 1.000   Olive oil 1.000   Methyl polysiloxane 0.100   Natural Vitamin E 0.100   POE (20) sorbitan monostearate 2.500   POE (80) hydrogenated castor oil 0.500   Glyoxylic acid 1.000   Levulinic acid 1.000   L-arginine 1.000   L-serine 0.500   Hydroquinone 0.010   Sodium pyrrolidonecarboxylate 0.100   Carboxy vinyl polymer 0.050   Potassium hydroxide 0.010   Preservative Suitable amount   Amount of purified water 100,000

[0029]     Example 10   Beauty liquid 1     Ingredient weight%   Carboxy vinyl polymer (2% aqueous solution) 10.000   Carboxyethyl cellulose 3,000   Glycerin 10.000   Plant extract 0.500   Triethanolamine 0.150   Methylparaben 0.100   Quinn seed solution (1% aqueous solution) 10.000   Sodium hyaluronate solution (1% aqueous solution) 4.000   Pyruvate 1.000   Levulinic acid 1.000   L-arginine 2,000   Amount of purified water 100,000

[0030]     Example 11   Beauty liquid 2     Ingredient weight%   Carboxy vinyl polymer (2% aqueous solution) 10.000   Carboxyethyl cellulose 3,000   Glycerin 10.000   Allantoin 0.100   Triethanolamine 0.150   Methylparaben 0.100   Quinn seed solution (1% aqueous solution) 10.000   Sodium hyaluronate solution (1% aqueous solution) 4.000   Levulinic acid 1.000   5-ketohexanoic acid 1.000   L-arginine 2,000   Phosphoric acid-L-ascorbyl magnesium 3.000   Amount of purified water 100,000

[0031]     Example 12   Beauty essence 3     Ingredient weight%   Carboxy vinyl polymer (2% aqueous solution) 10.000   Carboxyethyl cellulose 3,000   Glycerin 10.000   Plant extract 0.500   Triethanolamine 0.150   Methylparaben 0.100   Quinn seed solution (1% aqueous solution) 10.000   Sodium hyaluronate solution (1% aqueous solution) 4.000   Levulinic acid 1.000   5-ketohexanoic acid 1.000   L-arginine 2,000   Resorcin 0.020   Amount of purified water 100,000

[0032]     Example 13   Pack 1     Ingredient weight%   Hydroxyethoxy cellulose 3,000   Carboxy vinyl polymer (2% aqueous solution) 10.000   Polyoxyethylene oleyl ether   (15EO) 1.000   Glyoxylic acid 1.000   Levulinic acid 1.000   L-arginine 2,000   Ethanol 5.000   Preservative Suitable amount   Amount of purified water 100,000

[0033]     Example 14   Pack 2     Ingredient weight%   Hydroxyethoxy cellulose 3,000   Carboxy vinyl polymer (2% aqueous solution) 10.000   Polyoxyethylene oleyl ether (15EO) 1.000   Pyruvate 1.000   5-ketohexanoic acid 1.000   Kojic acid 1.000   L-arginine 2,000   Ethanol 5.000   Preservative Suitable amount   Amount of purified water 100,000

[0034]     Example 15   Pack 3     Ingredient weight%   Hydroxyethoxy cellulose 3,000   Carboxy vinyl polymer (2% aqueous solution) 10.000   Polyoxyethylene oleyl ether   (15EO) 1.000   Glyoxylic acid 1.000   Pyruvate 1.000   Hydrogen peroxide 0.100   Placenta extract 0.100   L-arginine 2,000   Ethanol 5.000   Preservative Suitable amount   Amount of purified water 100,000

[0035]     Example 16   Face wash cream 1     Ingredient weight%   Stearic acid 4.000   Coconut oil fatty acid 8,000   Potassium hydroxide 0.200   1,3-butylene glycol 3,000   Concentrated glycerin 5.000   Glyoxylic acid 1.000   Pyruvate 1.000   Diethylene glycol distearate 1.000   L-arginine 2,000   Disodium edetate 0.050   Sodium benzoate 0.100   Amount of purified water 100,000

[0036]     Example 17   Face wash cream 2     Ingredient weight%   Stearic acid 4.000   Coconut oil fatty acid 8,000   Potassium hydroxide 0.200   1,3-butylene glycol 3,000   Concentrated glycerin 5.000   Diethylene glycol distearate 1.000   Disodium edetate 0.050   Sodium benzoate 0.100   Glyoxylic acid 1.000   Levulinic acid 1.000   L-arginine 2,000   Dipotassium glycyrrhizinate 0.100   Pantetheine-S-sulfonic acid 0.500   Amount of purified water 100,000

[0037]     Example 18   Liquid foundation 1     Ingredient weight%   Stearic acid 4.500   Squalane 8,000   Isopropyl myristate 6.000   Propylparaben 0.100   Triethanolamine 1.000   Glycerin 2.500   Methylparaben 0.100   Titanium oxide 10.000   Talc 4.000   Silica 1.000   Pyruvate 1.000   5-ketohexanoic acid 1.000   L-arginine 2,000   Suitable amount of pigment   Amount of purified water 100,000

[0038]     Example 19   Liquid foundation 2     Ingredient weight%   Stearic acid 4.500   Squalane 8,000   Isopropyl myristate 6.000   Propylparaben 0.100   Triethanolamine 1.000   Glycerin 2.500   Methylparaben 0.100   Titanium oxide 10.000   Talc 4.000   Silica 1.000   Suitable amount of pigment   Levulinic acid 1.000   5-ketohexanoic acid 1.000   L-arginine 2,000   Plant extract 0.500   Catechol 0.100   Amount of purified water 100,000

[0039]     Example 20   White powder 1     Ingredient weight%   Titanium oxide 15,000   Zinc oxide 20.000   Sericite 4.000   Silica 4.000   Zinc stearate 8.000   Levulinic acid 1.000   Pyruvate 1.000   Coloring agent   Total amount of talc is 100.000

[0040]     Example 21   White powder 2     Ingredient weight%   Titanium oxide 15,000   Zinc oxide 20.000   Sericite 4.000   Silica 4.000   Zinc stearate 8.000   Coloring agent   α-tocopherol 0.050   Glyoxylic acid 1.000   5-ketohexanoic acid 1.000   Retinoic acid 0.020   Total amount of talc is 100.000

[0041]     Example 22   Bath 1     Ingredient weight%   Anhydrous sodium sulfate 45.000   Sodium bicarbonate 50.000   Sodium borate 3,000   Levulinic acid 1.000   5-ketohexanoic acid 1.000   L-arginine 2,000

[0042]     Example 23   Bath salt 2     Ingredient weight%   Anhydrous sodium sulfate 45.000   Sodium bicarbonate 50.000   Sodium borate 3,000   Pyruvate 1.000   Levulinic acid 1.000   Lactic acid 0.500   L-arginine 2.500

[0043]     Example 24   Bath salt 3     Ingredient weight%   Anhydrous sodium sulfate 45.000   Sodium bicarbonate 50.000   Sodium borate 3,000   Levulinic acid 1.000   5-ketohexanoic acid 1.000   Sodium bromate 0.050   Sodium chlorate 0.050   L-arginine 1.000

Comparative Example 1 Comparative lotion 1 was prepared by using purified water instead of glyoxylic acid in Example 1.

Comparative Example 2 Comparative Lotion 2 Prepared using purified water instead of levulinic acid and ascorbic acid-2-glycoside of Example 2.

Comparative Example 3 Comparative Lotion 3 A preparation was prepared using purified water instead of levulinic acid and glutathione in Example 3.

Comparative Example 4 Comparative Emulsion 1 Prepared using purified water in place of the pyruvic acid of Example 4.

Comparative Example 5 Comparative Emulsion 2 Prepared by using purified water in place of 5-ketohexanoic acid and arbutin of Example 5.

Comparative Example 6 Comparative Emulsion 3 Prepared using purified water instead of levulinic acid and pyruvic acid of Example 6.

Comparative Example 7 Comparative Cream 1 Prepared by using purified water in place of the glyoxylic acid and levulinic acid of Example 5.

Comparative Example 8 Comparative Cream 2 Prepared using purified water instead of pyruvic acid, 5-ketohexanoic acid and ellagic acid of Example 8.

Comparative Example 9 Comparative Cream 3 Prepared using purified water instead of glyoxylic acid, levulinic acid and hydroquinone of Example 9.

Comparative Example 10 Comparative beauty essence 1 Prepared using purified water instead of pyruvic acid and levulinic acid of Example 10.

Comparative Example 11 Comparative beauty essence 2 Prepared by using purified water instead of levulinic acid, 5-ketohexanoic acid and magnesium L-ascorbyl phosphate in Example 11.

Comparative Example 12 Comparative beauty essence 3 Prepared by using purified water in place of levulinic acid, 5-ketohexanoic acid and resorcin of Example 12.

Comparative Example 13 Comparative Pack 1 Prepared using purified water instead of levulinic acid and glyoxylic acid of Example 13.

Comparative Example 14 Comparative Pack 2 Prepared using purified water instead of pyruvic acid, 5-ketohexanoic acid and kojic acid of Example 14.

Comparative Example 15 Comparative Pack 3 Prepared by using purified water in place of the glyoxylic acid, pyruvic acid, hydrogen peroxide and placenta extract of Example 15.

Comparative Example 16 Comparative Face-Cleansing Cream 1 Prepared by using purified water in place of the glyoxylic acid and pyruvic acid of Example 16.

Comparative Example 17 Comparative Face Wash Cream 2 Prepared by using purified water in place of the glyoxylic acid, levulinic acid and pantetheine-S-sulfonic acid of Example 17.

Comparative Example 18 Comparative liquid foundation 1 Prepared using purified water instead of the pyruvic acid and 5-ketohexanoic acid of Example 18.

Comparative Example 19 Comparative Liquid Foundation 2 Prepared by using levulinic acid, 5-ketohexanoic acid of Example 19 and purified water in place of catechol.

Comparative Example 20 Comparative White Powder 1 Prepared using talc instead of levulinic acid and pyruvic acid of Example 20.

Comparative Example 21 Comparative powder White powder 2 Prepared by using talc in place of the glyoxylic acid, 5-ketohexanoic acid and retinoic acid of Example 21.

Comparative Example 22 Comparative Bath Solution 1 Prepared by using sodium hydrogen carbonate instead of levulinic acid and 5-ketohexanoic acid of Example 5.

Comparative Example 23 Comparative Bath Solution 2 Prepared by using sodium hydrogen carbonate instead of levulinic acid, pyruvic acid and lactic acid of Example 23.

Comparative Example 24 Preparation was carried out by using sodium hydrogen carbonate instead of levulinic acid, 5-ketohexanoic acid, sodium bromate and sodium chlorate of Example 24.

[0068]

The present invention provides a whitening cosmetic composition containing glyoxylic acid, pyruvic acid, levulinic acid and 5-ketohexanoic acid.
Be sure to combine one or more of the four kinds of glyoxylic acid, pyruvic acid, levulinic acid, and 5-ketohexanoic acid at the same time, or to produce one or more kinds of melanin. Since the combination of the inhibitory components is contained, pigmentation such as spots and freckles can be eliminated, reduced or prevented. As a result, it makes white and beautiful skin, and changes to white and beautiful skin,
Alternatively, it is possible to obtain the effect of maintaining white and beautiful skin.

[0069]

[Table 1]

[0070]

[Table 2]

[0071]

[Table 3]

[0072]

[Table 4]

[0073]

[Table 5]

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Claims (4)

[Claims] 1. A whitening cosmetic composition comprising one or more of the carboxylic acids described in (A) to (D) below. (A) Glyoxylic acid (B) Pyruvate (C) Levulinic acid (D) 5-Ketohexanoic acid 2. A whitening cosmetic composition containing two or more of the carboxylic acids described in (A) to (D) below. (A) Glyoxylic acid (B) Pyruvate (C) Levulinic acid (D) 5-Ketohexanoic acid 3. A whitening cosmetic characterized in that the whitening cosmetic according to claim 1 or 2 further contains one or more components in combination with a melanin production inhibiting component. 4. The melanin production inhibiting component is ascorbic acid, arbutin, ellagic acid, catechol, glutathione, kojic acid, cysteine, pantetheine-S-sulfonic acid, hydroquinone, resorcin, retinoic acid, lactic acid, hydrogen peroxide, bromic acid. The whitening cosmetic composition according to claim 3, wherein the whitening cosmetic composition is chloric acid, placenta extract or a derivative thereof.