JP2024043617A - Powder preparations for dripping liquids, dripping liquids, and hot liquid dripping treatment methods - Google Patents

Abstract

[Problem] To provide a powder preparation for dripping liquid, the raw materials of which are relatively easy to obtain in Japan, do not cause allergies or pigmentation even when they come into contact with the skin (scalp) of Japanese people, and are smooth and easy to handle. [Solution] The powder preparation for dripping liquid of the present invention is a powder preparation for dripping liquid for adjusting a dripping liquid for a thermal liquid dripping device, and is characterized by containing Angelica or Angelica extract, cannabidiol, apatite-coated titanium oxide, guar gum, and glycine. The amount of each component is preferably 1 to 5 mass% Angelica or Angelica extract, 1 to 5 mass% cannabidiol, 0.1 to 1 mass% apatite-coated titanium oxide, 80 to 90 mass% guar gum, and the remainder is glycine. The apatite-coated titanium oxide is preferably porous apatite-coated titanium dioxide. The powder preparation of the present invention preferably further contains a fragrance such as horsetail powder or lavender extract. [Selected Figure] Figure 1

Description

The present invention relates to a powder preparation for a droplet solution, a droplet solution, and a heated liquid drop treatment method, and more specifically, a droplet warmed to the human head used in ancient Indian traditional medicine (Ayurveda). The present invention relates to a powder preparation for a drip solution, a drop solution, and a heated liquid drop treatment method used to perform head drop therapy (Shirodhara) in which various symptoms are cured by dropping the same.

Conventionally, in the thermal liquid dripping device for the head dripping therapy (Shirodhara), the dripping liquid is heated to about 40°C and dripped onto the human head. (a) Sesame oil has mainly been liquefied and used as the dripping liquid (oil) for Shirodhara (see JP 11-221261 A and Patent Document 1).

(b) In addition, there is also known a dripping solution of Shiro-Dala, which is made into a liquid by adding coconut oil, rice oil, extracts of medicinal herbs, etc. in addition to sesame oil.

Then, the dripping liquid of either (a) or (b) above is supplied to the storage tank provided in the thermal liquid dripping device in an appropriate amount, and then the dripping liquid is heated to an appropriate temperature with a heater, and the oil supply pipe is heated to an appropriate temperature. The nozzle is placed above the subject's head, and the drops are dropped onto the forehead of the subject over a predetermined period of time while being moved appropriately over the forehead. This provides a massage effect, brings about deep relaxation, purifies waste products, relieves stress, and relieves insomnia.

However, in the conventional examples described in (a) and (b) above, the hot liquid dripping device requires (i) sesame oil as the dripping agent, while (b) requires oil such as coconut oil or rice oil, so the oil on the forehead is difficult to remove even by shampooing and wiping it off, and the wiping process takes about 10 times, which is troublesome, and takes at least about 20 minutes.

(b) Another drawback is that the smell of oxidized oil remains.

(c) Furthermore, the dripping flow rate of the oil is normally 1.5 liters per subject and 3.0 liters/minute, and the oil after use is discharged to a waste tank or returned to a storage tank for circulation. It was intended to be reused. Therefore, in the former case, the waste oil in the waste tank was solidified with an oil coagulation sheet, etc., or adsorbed and solidified with newspaper, etc., and then disposed of as garbage, which took time to dispose of and was not good for the environment. was there.

(d) Moreover, the above-mentioned oils, especially sesame oil, are expensive.

(e) Furthermore, when using the hot liquid dripping device (Shirodhara machine), the oil dripped onto the forehead would adhere to the forehead, making cleaning with a towel or the like not only cumbersome but also time-consuming.

To solve the problems of the above-mentioned conventional technology, Patent Publication No. 5921854 proposes the following dripping agent for a thermal liquid dripping device.

In order to achieve the above object, the dripping agent for the hot liquid dripping device is made into a solid powder by blending guar gum and an extract of a material that does not have adhesiveness, and has adhesiveness. Contains henna extract, glycine, and at least one of the following: Melia adirachta extract, Anmalou extract, Takasaburo extract, Acaca cinnabar juice fruit extract, Centella asiatica extract, coconut fatty acid glyceryl, and lavender oil. ing.

Japanese Patent Application Publication No. 11-221261 Patent No. 5921854

The dropping agent for the hot liquid dripping device proposed in the above patent publication is a powder or granular solid made by blending guar gum and an extract of a non-adhesive material. This solid is dissolved in hot water at about 40°C in the storage tank of the hot liquid dripping device (Shirodhara machine) to create a hot viscous liquid. When this hot viscous liquid is dripped onto a person's forehead from a nozzle during treatment, there is no oil to adhere to it, so the forehead and the hot liquid dripping device itself do not become sticky. This eliminates the need for cleaning work such as shampooing or wiping off oil that adheres to the forehead and hot liquid dripping device, as in the past, and eliminates odors caused by oxidation of oil. This also eliminates the risk of environmental pollution and fires that accompany the disposal of towels used for wiping, and is environmentally friendly because the dripping liquid used can be disposed of as domestic wastewater. Furthermore, since it does not use particularly expensive sesame oil, an economically inexpensive dripping liquid can be provided.

Furthermore, as mentioned above, the above-mentioned dropping agent becomes a warm viscous liquid when actually used in a thermal liquid dropping device, but before use, it becomes a solid powder or granular material. Therefore, like powdered or granular medicines, they can be stored or transported in medicine bags. Therefore, since the cargo is not bulky and does not take up much storage space, it not only reduces transportation costs, but also has the advantage of being light and easy to handle when carried.

Furthermore, since the above-mentioned drops contain guar gum, this guar gum component not only provides thickening as a thickener and gelling agent, but also has the effect of inhibiting blood sugar level rise, lowering cholesterol, and improving bowel movement. It has the effect of Furthermore, in addition to the above-mentioned effects, this drop contains henna extract, which helps create thicker hair, prevents dandruff and itchy scalp, and has antibacterial effects, as well as glycine It has a detoxifying effect and has the effect of acting as an inhibitory transmitter in the central nervous system.In addition to these effects, it also contains Melia adirachta extract, Anmarou extract, Takasaburo extract, Acacia cinnabar extract. Since it contains at least one of juice fruit extract, centella asiatica extract, coconut fatty acid glyceryl, and lavender oil, it has the effects of these ingredients. For example, when Melia adirachta (neem) extract is included, it makes the scalp healthy and has the effect of preventing dandruff and itching, Ammarou (amla) extract has the effect of beautifying hair and hair growth, and Takasaburo extract helps prevent hair loss, thinning hair, and hematemesis. Red chinese fruit (Shikakai) has the effect of dyeing gray hair, etc. Centella asiatica extract has the effect of treating skin sores and eczema, etc. Coconut fatty acid glyceryl has the effect of protecting the scalp, and lavender oil is also effective. It has a good fragrance and has a healing effect.

The drops described in the above patent publication have many effects as explained above, but because the main additives are extracts of plants native to India and other places, they are difficult to obtain and expensive. In addition, they are not suitable for Japanese people due to their constitution, and some people have experienced allergic reactions. Specifically, these include anaphylactic shock and pigmentation on the skin.

Therefore, the present invention is relatively easy to obtain in Japan, does not cause allergies or pigmentation when it comes into contact with the skin (scalp) of Japanese people, and is smooth and easy to handle like the drops described in the patent publication. The purpose of the present invention is to provide an inexpensive powder formulation for dropping liquids.

In order to solve the above problems, the powder formulation for dropwise administration of liquid of the present invention has the following configurations (1) to (14).
(1)
A powder preparation for dripping liquid for preparing a dripping liquid for a thermal liquid dripping device, the powder preparation for dripping liquid comprising angelica or angelica extract, cannabidiol, apatite-coated titanium oxide, guar gum, and glycine.
(2)
The powder preparation for a dropping liquid according to (1), comprising 1 to 5% by mass of Angelica extract, 1 to 5% by mass of cannabidiol, 0.1 to 1% by mass of apatite-coated titanium oxide, 80 to 90% by mass of guar gum, and the remainder being glycine.
(3)
The powder preparation for a drop liquid according to (1), comprising 1 to 5% by mass of powdered angelica, 1 to 5% by mass of cannabidiol, 0.1 to 1% by mass of apatite-coated titanium oxide, 80 to 90% by mass of guar gum, and the remainder being glycine.
(4)
The powder formulation for a dropwise liquid preparation according to (1), wherein the angelica tree is Yamato angelica tree or Hokkai angelica tree.
(5)
The powder formulation for a dropwise liquid preparation according to (4), wherein the angelica tree is Yamato angelica tree.
(6)
The powder preparation for a dropwise liquid preparation according to (1) above, wherein the apatite-coated titanium dioxide is porous apatite-coated titanium dioxide.
(7)
The powder formulation for a dropwise liquid preparation according to (1) or (6), wherein the apatite is a calcium phosphate apatite.
(8)
The powder formulation for a dropping liquid according to (1) above, further comprising horsetail powder added thereto.
(9)
The powder formulation for use in a dropwise liquid preparation according to any one of (1) to (8) above, further comprising a flavoring.
(10)
The powder preparation for a drop-based liquid preparation according to (9) above, wherein the flavoring is lavender or lavender extract in powder form.
(11)
A liquid preparation for dripping for a hot liquid dripping device, the liquid preparation being prepared by dissolving any one of the powder preparations for dripping liquid according to (1) to (10) in water.
(12)
The dropping liquid according to (11) above, further comprising fatty acid glyceryl added thereto.
(13)
A method for administering a thermal liquid drop therapy, comprising maintaining the temperature of the dropped liquid agent (12) at 38 to 41°C and carrying out an actual thermal liquid drop therapy.
(14)
A method for producing a powder preparation for dripping liquid, which is used to prepare a dripping liquid for a thermal liquid dripping device, and which contains Angelica or Angelica extract, cannabidiol, apatite-coated titanium dioxide, guar gum, and glycine, characterized in that at least Angelica or Angelica extract produced by a freeze-drying method is used.

It is an explanatory view for explaining an example of a hot liquid dripping device to which a dripping liquid agent for a hot liquid dripping device according to an embodiment of the present invention is applied.

First, a brief description will be given below of an example of a thermal liquid dripping device (a Shirodhara machine) to which the dripping liquid for the thermal liquid dripping device according to the embodiment of the present invention is applied.

The hot liquid dripping device 1 shown in this example includes a storage tank 3 for storing the dripped liquid, which is equipped with a heater 2 for heating the dripped liquid to an appropriate temperature, and a storage tank 3 for storing the dripped liquid, and the dripped liquid in the storage tank 3 is connected to the dripped liquid via pipes 4A and 4B. A dripping liquid tray 5 is supplied, a nozzle 6 hanging down from the bottom of the dripping liquid tray 5, a pump 7 for transferring the dripping liquid to the dripping liquid tray 5, and the heater 2 are controlled. A control device 8 such as a temperature regulator or a timer for adjusting the temperature of the dropped liquid agent transferred to the dripped liquid agent tray 5 via the pipes 4A and 4B, and a control device 8 such as a temperature regulator or a timer, and a human head. A support base 11 has a recess 12 formed on the upper surface to receive the used liquid dripped onto the human head from the nozzle 6, and the used drip liquid received in the recess of the support base 11. The structure includes a return pipe 9 for returning the liquid to the return port 10 of the storage tank 3.

A powder formulation for dropping liquid according to an embodiment of the present invention, which is used when carrying out head drop therapy (Shirodahler) using the above-described hot liquid dropping device (Shirodahler machine), will be described below.

A powder formulation for dropping liquid according to an embodiment of the present invention contains Toki or Toki extract, cannabidiol, apatite-coated titanium dioxide, guar gum, and glycine. Preferably, the powder preparation for dropping liquid according to the embodiment of the present invention further contains horsetail powder and fragrance.

The components of the powder formulation will be explained below.
Return
Examples of toki include Yamato toki, Hokkai touki, Tsukuba toki, Miyama toki, Karatouki, and St. canker, and any of them can be used. Hokkai toki is preferred, and Yamato toki is particularly preferred.

The roots of Angelica dahurica contain essential oils such as butylidenephthalide, carvacrol, and camphene, which have a sedative effect on the cerebral cortex and a mild stimulating effect on the medulla oblongata center, and are said to increase blood circulation and have a favorable effect on breathing and metabolism, and are effective in relieving pain caused by congestion. It is said to have the effect of draining pus and forming granulation tissue. Other active ingredients include sitosterol, palmitic acid, linoleic acid, vitamin _B1 , and nicotinic acid. In the Japanese Pharmacopoeia, the original plant of the "crude drug Angelica dahurica" is said to be Angelica dahurica and Hokkai Angelica dahurica.

A dry powder of Toki itself can be produced using, for example, a freeze-drying method.
Here, freeze-drying is the process of rapidly freezing raw materials containing moisture (for example, roots) at around -30°C, and further reducing the pressure to sublimate the moisture in a vacuum and drying it. (Water is dried under pressure. If the raw material is cold, it becomes a gas regardless of the temperature, so if the pressure is sufficiently lowered while the raw material is frozen, the water in the raw material will directly change from solid [ice] to gas [steam], causing the raw material to cool down. It escapes from the surface to the outside.This allows only the moisture in the raw material to be easily removed and dried.)

The resulting dried powder of Angelica is preferably dispersed using a nanoparticle-oriented disperser (Ashizawa Finetech's Nano Getter (registered trademark)) to reduce the average particle size to 200 nm or less. This allows for better penetration into the recipient's hair and skin.

Powder of Toki extract can be produced, for example, by a method used in Chinese herbal medicine.
Specifically, the following method is used.
Raw materials → Hot water extraction of extract → Separation of extract from solid residue → Concentrate → Drying → Extract powder

Hot water extraction process
Extract the extract into hot water while strictly controlling the extraction temperature, heating rate, and heating time.

Separation process
Then, immediately separate the extract from the solid residue (using a centrifuge)
At this time, it is desirable to sterilize. Due to the use of naturally derived raw materials, microorganisms and bacteria are often attached to the raw materials.

Concentration process
The extract is made into a concentrated liquid using a vacuum concentration method. At this time, it is preferable to carry out at 60°C or lower.

Drying process
Using a spray drying method with high drying efficiency, the concentrated liquid is dried to obtain an extract powder. Preferably, the thermal history is shortened.

The dry powder or extract powder of the above-mentioned powder is preferably 1 to 5% by mass of the entire powder preparation for dropping liquid.
If the amount of the dry powder or extract powder is less than the above range, the effect will be extremely weak, and if it exceeds the above range, the cost performance of the effect will tend to deteriorate.

Cannabidiol , also known as CBD, is said to have sedative, analgesic, relaxing, and insomnia relieving effects. The CBD is preferably water-soluble and is commercially available in powder form.
The CBD preferably accounts for 1 to 5% by mass of the entire powder formulation for dropping liquid.

Apatite-coated titanium dioxide This apatite-coated titanium dioxide is preferably a photocatalytic composite composition in which the surface of a titanium dioxide substrate is coated with porous apatite (calcium phosphate). Such a photocatalytic composite composition is preferably that described in Japanese Patent No. 4652776, and this photocatalytic composite composition is produced by bringing a substrate having a photocatalytic function into contact with a treatment liquid (fibrous protein (silk fiber)) for synthesizing porous calcium phosphate, and coating the surface of the substrate with porous calcium phosphate (apatite or a compound analogous thereto). In this method for producing a photocatalytic composite composition, since fibrous protein is added to the treatment liquid, the generation of porous calcium phosphate on the substrate surface is incomplete, and only a portion of the substrate surface is coated with porous calcium phosphate. Furthermore, when fibrous protein is added to the treatment liquid, the generation of porous calcium phosphate on the substrate surface is incomplete, and the crystallinity of calcium phosphate is low. Therefore, even if the entire substrate surface is covered with porous calcium phosphate, or even if the substrate is lightly stirred with a ball mill, or stirred with a device with a smaller crushing force than a ball mill, a portion of the porous calcium phosphate falls off from the substrate surface, and only a portion of the substrate surface is coated with porous calcium phosphate. The photocatalytic composite composition thus produced has higher dispersibility in a solvent such as water as compared with conventional photocatalytic composite compositions, and is therefore extremely preferable for use in the dropping liquid agent of the present invention.
Such a photocatalytic composite composition is sold under the trade name "Trinity" by Aqua Project Co., Ltd. (Fukuoka).
The amount of the apatite-coated titanium dioxide is preferably 0.1 to 1% by mass based on the total amount of the powder preparation for drop-based liquid preparation.

Guar Gum
Guar gum is a water-soluble natural polysaccharide obtained from the so-called endosperm (more precisely, cotyledons) of guar beans. In the present invention, it is used in place of oil in order to give it a certain degree of viscosity when it is made into a dropping liquid. If the viscosity is too high, it is preferable to use a "guar gum decomposition product" with low viscosity.
The amount of guar gum is preferably 80 to 90% by mass of the entire powder formulation for dropping liquid.

Glycine accounts for the remainder of the powder formulation for instillation liquid.

The present powder formulation for dropping liquid can contain horsetail powder and fragrance. As the fragrance, powdered lavender or lavender extract can be used. The amount of flavor added is arbitrary.
Horsetail powder is commercially available. Horsetail powder contains chlorophyll, water-soluble silicon, excetonin, calcium, magnesium, potassium, sodium, iron, zinc, etc. Among these ingredients, especially water-soluble silicon is accompanied by CBD, It can penetrate under the skin of people and have anti-inflammatory and mental stabilizing effects. The content of this horsetail powder is preferably about 0.5 to 1% by mass of the entire powder preparation.

A dropping liquid for a hot liquid dropping device can be formed by melting the above-described powder formulation for a dropping liquid in water. When this dripping liquid is used in a hot liquid dripping treatment method in which actual hot liquid dripping treatment is performed, it is preferably maintained at a temperature of 38° C. to 41° C. before use. The dropping liquid can contain fatty acid glyceryl.

Example 1
100 g of a powder formulation for a dropwise solution was prepared according to the following formulation.
Yamato Angelica Extract: 3 grams Cannabidiol: 0.5 grams Porous apatite-coated titanium dioxide: 0.5 grams Guar gum: 86.5 grams Glycine: 9.5 grams

A small amount of lavender extract was added to this to prepare a powder formulation for dropping liquid to be used for demonstration experiments, and 1,600 ml of purified water was added to 4 grams of the powder formulation for dropping liquid having the above composition. A dropwise solution was prepared by adding in portions and stirring.
This dropping solution was heated to about 39° C., and was dropped little by little onto the forehead of the subject.
When the above procedure was performed for 30 minutes on 70 female and 30 male subjects ranging from their teens to their 90s, 97 male and female subjects responded that they felt sufficiently relaxed. .
Also, everyone commented that it was refreshing and refreshing compared to conventional Shirodara. On the other hand, two people expressed the opinion that it was unsatisfactory compared to those using oil such as sesame oil.

From the above, the effects of the present invention are clear.

1 Hot liquid dripping device 2 Heater 3 Storage tank 5 Dripping liquid tray 6 Nozzle 7 Pump 8 Control device 11 Top cover 12 Recess

Claims (14)

A powder preparation for dripping liquid for use in a hot liquid dripping device, the powder preparation for dripping liquid containing angelica or angelica extract, cannabidiol, apatite-coated titanium dioxide, guar gum, and glycine. Contains 1-5% by mass of Toki extract, 1-5% by mass of cannabidiol, 0.1-1% by mass of apatite-coated titanium oxide, 80-90% by mass of guar gum, and the remainder is glycine. The powder formulation for dropping liquid according to claim 1. The powder preparation for dripping liquid of claim 1 contains 1-5% by mass of powdered angelica, 1-5% by mass of cannabidiol, 0.1-1% by mass of apatite-coated titanium oxide, 80-90% by mass of guar gum, and the remainder is glycine. The powder formulation for dripping liquid of claim 1, wherein the angelica is Yamato angelica or Hokkai angelica. 5. The powder preparation for dropping liquid according to claim 4, wherein said Toki is Yamato Toki. The powder formulation for dripping liquid according to claim 1, wherein the apatite-coated titanium dioxide is porous apatite-coated titanium dioxide. The powder preparation for dropping liquid according to claim 1 or 6, wherein the apatite is a calcium phosphate apatite. The powder formulation for dripping liquid of claim 1 further contains horsetail powder. The powder formulation for dripping liquid according to any one of claims 1 to 8, further comprising a flavoring. 10. The powder formulation for dropping liquid according to claim 9, wherein the fragrance is powdered lavender or lavender extract. A dropping liquid for a hot liquid dropping device, which is formed by melting the powder formulation for dropping liquid according to any one of claims 1 to 10 in water. The dropping liquid preparation according to claim 12, further comprising fatty acid glyceryl. A method for administering a thermal liquid drop therapy in which the drop liquid of claim 11 or 12 is maintained at 38°C to 41°C and actual thermal liquid drop therapy is performed. A powder formulation for a dropping liquid for preparing a dropping liquid for a hot liquid dropping device, which contains dōki or dōki extract, cannabidiol, apatite-coated titanium dioxide, guar gum, and glycine. A method for producing a powder preparation for a dropping liquid, characterized in that the method uses at least Toki or Toki extract produced by a freeze-dry manufacturing method.

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