JP2023553490A5 - - Google Patents

Info

Publication number
JP2023553490A5
JP2023553490A5 JP2023536049A JP2023536049A JP2023553490A5 JP 2023553490 A5 JP2023553490 A5 JP 2023553490A5 JP 2023536049 A JP2023536049 A JP 2023536049A JP 2023536049 A JP2023536049 A JP 2023536049A JP 2023553490 A5 JP2023553490 A5 JP 2023553490A5
Authority
JP
Japan
Prior art keywords
sequence
expression
repressor
expression repressor
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023536049A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023553490A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/010059 external-priority patent/WO2022132195A2/en
Publication of JP2023553490A publication Critical patent/JP2023553490A/ja
Publication of JP2023553490A5 publication Critical patent/JP2023553490A5/ja
Pending legal-status Critical Current

Links

JP2023536049A 2020-12-15 2021-12-15 Myc発現を調節するための組成物及び方法 Pending JP2023553490A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063125833P 2020-12-15 2020-12-15
US63/125,833 2020-12-15
US202163137097P 2021-01-13 2021-01-13
US63/137,097 2021-01-13
US202163212991P 2021-06-21 2021-06-21
US63/212,991 2021-06-21
US202163281022P 2021-11-18 2021-11-18
US63/281,022 2021-11-18
PCT/US2021/010059 WO2022132195A2 (en) 2020-12-15 2021-12-15 Compositions and methods for modulation myc expression

Publications (2)

Publication Number Publication Date
JP2023553490A JP2023553490A (ja) 2023-12-21
JP2023553490A5 true JP2023553490A5 (enExample) 2024-12-23

Family

ID=82060102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023536049A Pending JP2023553490A (ja) 2020-12-15 2021-12-15 Myc発現を調節するための組成物及び方法

Country Status (8)

Country Link
US (1) US20240132559A1 (enExample)
EP (1) EP4262849A4 (enExample)
JP (1) JP2023553490A (enExample)
KR (1) KR20230120138A (enExample)
AU (1) AU2021401231A1 (enExample)
CA (1) CA3205133A1 (enExample)
MX (1) MX2023007116A (enExample)
WO (1) WO2022132195A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018049075A1 (en) 2016-09-07 2018-03-15 Flagship Pioneering, Inc. Methods and compositions for modulating gene expression
CN115192714B (zh) * 2022-07-08 2024-09-17 沈阳药科大学 Hdac6抑制剂在制备治疗dnmt3a基因缺失癌症的药物中的用途
TW202417012A (zh) * 2022-08-19 2024-05-01 美商旗艦先鋒創新公司 包含myc調節劑及檢查點抑制劑之組合療法
WO2024238723A1 (en) 2023-05-16 2024-11-21 Omega Therapeutics, Inc. Methods and compositions for modulating pcsk9 expression
JP2026518711A (ja) 2023-05-16 2026-06-09 フラッグシップ ラブズ 114, インコーポレイテッド 標的遺伝子のメチル化を調節するための方法及び組成物
EP4716741A2 (en) * 2023-05-23 2026-04-01 Flagship Labs 114, Inc. Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
WO2025019742A1 (en) 2023-07-19 2025-01-23 Omega Therapeutics, Inc. Methods and compositions for modulating ctnnb1 expression
WO2025064469A1 (en) * 2023-09-18 2025-03-27 Omega Therapeutics, Inc. Methods for assessing dosage for epigenetic modifying agents
WO2025144907A1 (en) * 2023-12-27 2025-07-03 Flagship Pioneering Innovations V, Inc. Kinase inhibitors and particles comprising myc modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997011972A1 (en) * 1995-09-28 1997-04-03 The Trustees Of Columbia University In The City Of New York Chimeric dna-binding/dna methyltransferase nucleic acid and polypeptide and uses thereof
GB201119904D0 (en) * 2011-11-17 2011-12-28 Univ Vilnius Analysis of methylation sites
WO2016103233A2 (en) * 2014-12-24 2016-06-30 Dana-Farber Cancer Institute, Inc. Systems and methods for genome modification and regulation
KR101900278B1 (ko) * 2016-04-18 2018-09-19 건국대학교 글로컬산학협력단 Myc-ap4 축 활성화된 암의 예방 또는 치료용 조성물의 스크리닝 방법
WO2018111944A1 (en) * 2016-12-12 2018-06-21 Whitehead Institute For Biomedical Research Regulation of transcription through ctcf loop anchors
WO2018183808A1 (en) * 2017-03-31 2018-10-04 Agenovir Corporation Antiviral therapeutic
US20190233805A1 (en) * 2017-10-04 2019-08-01 The Regents Of The University Of California Targetable proteins for epigenetic modification and methods for use thereof
EP3867368A4 (en) * 2018-10-15 2022-08-10 Flagship Pioneering Innovations V, Inc. DESTROYING THE ASSEMBLY OF A GENOMIC COMPLEX IN FUSION GENES
US11866469B2 (en) * 2019-02-06 2024-01-09 Klogenix Llc DNA binding proteins and uses thereof

Similar Documents

Publication Publication Date Title
Matchett et al. Ran GTPase in nuclear envelope formation and cancer metastasis
US10071129B2 (en) Method for identifying bromodomain inhibitors
CN110917352A (zh) Rock抑制剂在肿瘤免疫治疗中的新用法
CN108486247A (zh) piRNA-54265在结直肠癌的诊治和预后评价方面的应用
CN101528925A (zh) 双链断裂诱饵及其应用
AU2024259837B2 (en) ADP-ribose binding peptide having anticancer activity and use thereof
Larsen et al. From DNA damage to G~ 2 arrest: The many roles of topoisomerase II
Graziano et al. Mechanisms of oncogene-induced genomic instability
Wang et al. Cancer‐derived IgG involved in cisplatin resistance through PTP‐BAS/Src/PDK1/AKT signaling pathway
CN111671904A (zh) 一种含有抑制核酸内切酶功能的药物及其抗肿瘤的用途
KR20190040824A (ko) CRISP/Cas 시스템에 사용하기 위한 융합 단백질, 그를 포함하는 복합체 및 그의 용도
CN108410878B (zh) 一种lrpprc特异性核酸适配体及其应用
KR102618932B1 (ko) Runx3 단백질 및 CDK4 억제제 또는 mTOR 억제제 병행 투여를 포함하는 암의 예방 또는 치료를 위한 약학적 조성물
Zhang et al. BRD4 protein as a target for lung cancer and hematological cancer therapy: a review
KR102576855B1 (ko) Tsp1을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물
Fu et al. ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer
US9145554B2 (en) Cancer therapy method
US20220064238A1 (en) Methods And Compositions For Modifying Transcription Factor Activity by Targeting The Human Mediator Complex Using Cell Penetrating Memetic Peptides And Methods of Treating Cancer Using The Same
TW201628630A (zh) 細胞死亡誘導劑、細胞增殖抑制劑及起因於細胞增殖異常之疾病治療用醫藥組合物
US20250066420A1 (en) Pd-l1 inhibitory peptide for cancer immunotherapy
US20190030126A1 (en) Inhibitors of the Interaction BCL-2 L10 / IP3 Receptors
KR20260074247A (ko) 바이오마커로서의 drg2의 용도
HK40130287A (en) Lincrna-p21 and use thereof
CN117801064A (zh) 一种多肽、药物和用途
US20210401931A1 (en) Methods and materials for treating cancer