JP2023548399A5 - - Google Patents

Info

Publication number
JP2023548399A5
JP2023548399A5 JP2023527452A JP2023527452A JP2023548399A5 JP 2023548399 A5 JP2023548399 A5 JP 2023548399A5 JP 2023527452 A JP2023527452 A JP 2023527452A JP 2023527452 A JP2023527452 A JP 2023527452A JP 2023548399 A5 JP2023548399 A5 JP 2023548399A5
Authority
JP
Japan
Prior art keywords
amino acid
seq
acid sequence
sequence described
antibody containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023527452A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023548399A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/057209 external-priority patent/WO2022098570A1/en
Publication of JP2023548399A publication Critical patent/JP2023548399A/ja
Publication of JP2023548399A5 publication Critical patent/JP2023548399A5/ja
Pending legal-status Critical Current

Links

JP2023527452A 2020-11-04 2021-10-29 Tgf-ベータファミリーの複数のリガンドを阻害する能力を有する新規の二機能性多特異性アンタゴニストおよびその使用 Pending JP2023548399A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063109814P 2020-11-04 2020-11-04
US63/109,814 2020-11-04
US202063113920P 2020-11-15 2020-11-15
US63/113,920 2020-11-15
PCT/US2021/057209 WO2022098570A1 (en) 2020-11-04 2021-10-29 Novel bifunctional multispecific antagonists capable of inhibiting multiple ligands of tgf-beta family and uses thereof

Publications (2)

Publication Number Publication Date
JP2023548399A JP2023548399A (ja) 2023-11-16
JP2023548399A5 true JP2023548399A5 (https=) 2024-11-08

Family

ID=81458297

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023527452A Pending JP2023548399A (ja) 2020-11-04 2021-10-29 Tgf-ベータファミリーの複数のリガンドを阻害する能力を有する新規の二機能性多特異性アンタゴニストおよびその使用

Country Status (8)

Country Link
US (1) US20240343788A1 (https=)
EP (1) EP4240388A4 (https=)
JP (1) JP2023548399A (https=)
KR (1) KR20230117348A (https=)
AU (1) AU2021376241A1 (https=)
CA (1) CA3196443A1 (https=)
MX (1) MX2023004726A (https=)
WO (1) WO2022098570A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025043075A1 (en) * 2023-08-24 2025-02-27 The Johns Hopkins University Methods of treating myocardial infarction, ischemia, and ischemia reperfusion injury

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41920B1 (fr) * 2015-04-06 2021-05-31 Acceleron Pharma Inc Protéines de fusion de récepteur type i et type ii à bras unique et leurs utilisations
EP3576773B1 (en) * 2017-02-01 2023-10-18 Acceleron Pharma Inc. Tgf beta and actrii antagonists for use in treating leukemia
US12103959B2 (en) * 2018-05-03 2024-10-01 Acceleron Pharma Inc. Multispecific binders of TGFBeta-superfamily ligands and uses thereof
CA3103427A1 (en) * 2018-06-15 2019-12-19 Acceleron Pharma Inc. Bi-and tri-functional fusion proteins and uses thereof

Similar Documents

Publication Publication Date Title
JP7438958B2 (ja) 新規な抗体分子、その調製方法及びその使用
JP2021510710A5 (https=)
Lu et al. Di-diabody: a novel tetravalent bispecific antibody molecule by design
EP2471814B1 (en) Anti-vegf monoclonal antibody and pharmaceutical composition comprising said antibody
JP2020063262A5 (https=)
JP2022515318A5 (https=)
JP2020510422A5 (https=)
JP2019524693A5 (https=)
JP2013507115A5 (https=)
JP2010518820A5 (https=)
JP2023527937A5 (https=)
JP2023508174A5 (https=)
JP2021512604A5 (https=)
US20240132579A1 (en) Vegfa-binding molecules
JP7737471B2 (ja) 抗bcam抗体又はその抗原結合フラグメント
JP2023546758A5 (https=)
JP7813704B2 (ja) 抗bcma/抗4-1bb二重特異性抗体及びその用途
JP2021529524A5 (https=)
JP2023548399A5 (https=)
EP4667491A1 (en) Anti-cntn4 antibody and uses thereof
CN119866346B (zh) 一种抗vegfa抗体或其抗原结合片段及其应用
Masuko et al. Towards therapeutic antibodies to membrane oncoproteins by a robust strategy using rats immunized with transfectants expressing target molecules fused to green fluorescent protein
JP2025535104A (ja) B7h3/pdl1二重特異性抗体およびその医薬組成物ならびにその使用
JP2023546759A5 (https=)
JP2023548346A5 (https=)