JP2023545665A - 操作されたパントテン酸キナーゼ改変体酵素 - Google Patents

操作されたパントテン酸キナーゼ改変体酵素 Download PDF

Info

Publication number
JP2023545665A
JP2023545665A JP2023519849A JP2023519849A JP2023545665A JP 2023545665 A JP2023545665 A JP 2023545665A JP 2023519849 A JP2023519849 A JP 2023519849A JP 2023519849 A JP2023519849 A JP 2023519849A JP 2023545665 A JP2023545665 A JP 2023545665A
Authority
JP
Japan
Prior art keywords
pantothenate kinase
seq
sequence
engineered
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023519849A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023545665A5 (enExample
Inventor
ジョヴァナ ネイザー，
ミケイラ ジャンホンシャ クラウチック，
ザラ マクシーン シーベル，
ナンディタ スブラマニアン，
ジョシュア コレヴ，
Original Assignee
コデクシス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by コデクシス， インコーポレイテッド filed Critical コデクシス， インコーポレイテッド
Publication of JP2023545665A publication Critical patent/JP2023545665A/ja
Publication of JP2023545665A5 publication Critical patent/JP2023545665A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01033—Pantothenate kinase (2.7.1.33)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2023519849A 2020-10-02 2021-09-29 操作されたパントテン酸キナーゼ改変体酵素 Pending JP2023545665A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063086688P 2020-10-02 2020-10-02
US63/086,688 2020-10-02
PCT/US2021/052644 WO2022072490A1 (en) 2020-10-02 2021-09-29 Engineered pantothenate kinase variant enzymes

Publications (2)

Publication Number Publication Date
JP2023545665A true JP2023545665A (ja) 2023-10-31
JP2023545665A5 JP2023545665A5 (enExample) 2024-10-04

Family

ID=80950864

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023519849A Pending JP2023545665A (ja) 2020-10-02 2021-09-29 操作されたパントテン酸キナーゼ改変体酵素

Country Status (8)

Country Link
US (1) US20240002817A1 (enExample)
EP (1) EP4222252A4 (enExample)
JP (1) JP2023545665A (enExample)
CN (1) CN116615534A (enExample)
AU (1) AU2021352979A1 (enExample)
CA (1) CA3196603A1 (enExample)
IL (1) IL301668A (enExample)
WO (1) WO2022072490A1 (enExample)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014050A1 (en) * 2018-07-09 2020-01-16 Codexis, Inc. Engineered pantothenate kinase variant enzymes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0206587A (pt) * 2001-01-19 2005-12-13 Basf Ag Processo para a produção de uma composição de pantotenato livre de hmbpa, produto, composição de pantotenato livre de hmbpa, composição sintetizada por um microorganismo possuindo uma rota biossintética de pantotenato desregulada, microorganismo recombinante para a produção de composições de pantotenato livres de hmbpa, e, processo para a produção de uma composição de pantotenato: hmbpa seletivamente misturada

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014050A1 (en) * 2018-07-09 2020-01-16 Codexis, Inc. Engineered pantothenate kinase variant enzymes

Also Published As

Publication number Publication date
EP4222252A1 (en) 2023-08-09
US20240002817A1 (en) 2024-01-04
EP4222252A4 (en) 2025-01-22
AU2021352979A1 (en) 2023-04-27
AU2021352979A9 (en) 2024-09-26
IL301668A (en) 2023-05-01
WO2022072490A1 (en) 2022-04-07
CN116615534A (zh) 2023-08-18
CA3196603A1 (en) 2022-04-07

Similar Documents

Publication Publication Date Title
KR20210031926A (ko) 조작된 퓨린 뉴클레오사이드 포스포릴라제 변이체 효소
US12110513B2 (en) Engineered pantothenate kinase variant enzymes
JP7678580B2 (ja) 操作されたスクロースホスホリラーゼバリアント酵素
JP2024040366A (ja) 操作されたホスホペントムターゼ改変体酵素
JP7726528B2 (ja) 操作された酢酸キナーゼバリアント酵素
JP2023544408A (ja) 操作されたガラクトースオキシダーゼ改変体酵素
JP2024500102A (ja) 操作されたウリジンホスホリラーゼ改変体酵素
JP2023544783A (ja) 操作されたホスホペントムターゼ改変体酵素
WO2022072490A1 (en) Engineered pantothenate kinase variant enzymes

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240926

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240926

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20251107

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20260427