CN116615534A - 工程化泛酸激酶变体酶 - Google Patents

工程化泛酸激酶变体酶 Download PDF

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Publication number
CN116615534A
CN116615534A CN202180081229.0A CN202180081229A CN116615534A CN 116615534 A CN116615534 A CN 116615534A CN 202180081229 A CN202180081229 A CN 202180081229A CN 116615534 A CN116615534 A CN 116615534A
Authority
CN
China
Prior art keywords
pantothenate kinase
sequence
engineered
engineered pantothenate
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180081229.0A
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English (en)
Chinese (zh)
Inventor
约瓦娜·纳佐尔
米凯拉·姜红霞·克拉夫奇克
扎拉·玛克辛·塞贝尔
南希塔·苏布兰马尼安
约书亚·科列夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codexis Inc
Original Assignee
Codexis Inc
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Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of CN116615534A publication Critical patent/CN116615534A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01033—Pantothenate kinase (2.7.1.33)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN202180081229.0A 2020-10-02 2021-09-29 工程化泛酸激酶变体酶 Pending CN116615534A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063086688P 2020-10-02 2020-10-02
US63/086,688 2020-10-02
PCT/US2021/052644 WO2022072490A1 (en) 2020-10-02 2021-09-29 Engineered pantothenate kinase variant enzymes

Publications (1)

Publication Number Publication Date
CN116615534A true CN116615534A (zh) 2023-08-18

Family

ID=80950864

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180081229.0A Pending CN116615534A (zh) 2020-10-02 2021-09-29 工程化泛酸激酶变体酶

Country Status (8)

Country Link
US (1) US20240002817A1 (enExample)
EP (1) EP4222252A4 (enExample)
JP (1) JP2023545665A (enExample)
CN (1) CN116615534A (enExample)
AU (1) AU2021352979A1 (enExample)
CA (1) CA3196603A1 (enExample)
IL (1) IL301668A (enExample)
WO (1) WO2022072490A1 (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0206587A (pt) * 2001-01-19 2005-12-13 Basf Ag Processo para a produção de uma composição de pantotenato livre de hmbpa, produto, composição de pantotenato livre de hmbpa, composição sintetizada por um microorganismo possuindo uma rota biossintética de pantotenato desregulada, microorganismo recombinante para a produção de composições de pantotenato livres de hmbpa, e, processo para a produção de uma composição de pantotenato: hmbpa seletivamente misturada
JP7491588B2 (ja) * 2018-07-09 2024-05-28 コデクシス， インコーポレイテッド 操作されたパントテン酸キナーゼ改変体酵素

Also Published As

Publication number Publication date
EP4222252A1 (en) 2023-08-09
US20240002817A1 (en) 2024-01-04
EP4222252A4 (en) 2025-01-22
AU2021352979A1 (en) 2023-04-27
AU2021352979A9 (en) 2024-09-26
IL301668A (en) 2023-05-01
WO2022072490A1 (en) 2022-04-07
JP2023545665A (ja) 2023-10-31
CA3196603A1 (en) 2022-04-07

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