JP2023542640A - 幹細胞機能を向上させるための組成物及び方法 - Google Patents

幹細胞機能を向上させるための組成物及び方法 Download PDF

Info

Publication number
JP2023542640A
JP2023542640A JP2023515691A JP2023515691A JP2023542640A JP 2023542640 A JP2023542640 A JP 2023542640A JP 2023515691 A JP2023515691 A JP 2023515691A JP 2023515691 A JP2023515691 A JP 2023515691A JP 2023542640 A JP2023542640 A JP 2023542640A
Authority
JP
Japan
Prior art keywords
vitamin
cells
cell
composition
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023515691A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023542640A5 (https=
Inventor
ニコラ ヴァンニーニ，
ムクル ギロトラ，
ジョージ コウコス，
Original Assignee
ソシエテ・デ・プロデュイ・ネスレ・エス・アー
ルドウイグ インスティテュート フォー キャンサー リサーチ エルティーディー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ソシエテ・デ・プロデュイ・ネスレ・エス・アー, ルドウイグ インスティテュート フォー キャンサー リサーチ エルティーディー filed Critical ソシエテ・デ・プロデュイ・ネスレ・エス・アー
Publication of JP2023542640A publication Critical patent/JP2023542640A/ja
Publication of JP2023542640A5 publication Critical patent/JP2023542640A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides or bases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2023515691A 2020-09-28 2021-09-28 幹細胞機能を向上させるための組成物及び方法 Pending JP2023542640A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20198622.1 2020-09-28
EP20198622 2020-09-28
PCT/EP2021/076659 WO2022064063A1 (en) 2020-09-28 2021-09-28 Compositions and methods for increasing stem cell function

Publications (2)

Publication Number Publication Date
JP2023542640A true JP2023542640A (ja) 2023-10-11
JP2023542640A5 JP2023542640A5 (https=) 2024-06-07

Family

ID=72665075

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023515691A Pending JP2023542640A (ja) 2020-09-28 2021-09-28 幹細胞機能を向上させるための組成物及び方法

Country Status (8)

Country Link
US (1) US20230365933A1 (https=)
EP (1) EP4217470A1 (https=)
JP (1) JP2023542640A (https=)
CN (1) CN116391031A (https=)
AU (1) AU2021350472A1 (https=)
BR (1) BR112023005375A2 (https=)
CA (1) CA3188667A1 (https=)
WO (1) WO2022064063A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202319994D0 (en) * 2023-12-22 2024-02-07 Amazentis Sa Compositions for use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160348065A1 (en) * 2015-05-28 2016-12-01 Shenzhen Fulixin Health Industry Development Limited Culture medium for hematopoeitic stem cells and the applications thereof as well as the stem cells culture method
JP2017527572A (ja) * 2014-09-09 2017-09-21 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ （ウ・ペ・エフ・エル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ Ｄｅ Ｌａｕｓａｎｎｅ （Ｅｐｆｌ） 造血幹細胞医療において有用な方法および化合物
JP2019505504A (ja) * 2015-12-24 2019-02-28 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ニコチンアミドリボシド及びウロリチンを含む組成物
WO2020148445A1 (en) * 2019-01-18 2020-07-23 Société des Produits Nestlé S.A. Agents and methods for increasing stem cell function
JP2022526329A (ja) * 2019-03-29 2022-05-24 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Ｔ細胞機能を向上させるための組成物及び方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723315A (en) 1996-08-23 1998-03-03 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998005635A1 (en) 1996-08-07 1998-02-12 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017527572A (ja) * 2014-09-09 2017-09-21 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ （ウ・ペ・エフ・エル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ Ｄｅ Ｌａｕｓａｎｎｅ （Ｅｐｆｌ） 造血幹細胞医療において有用な方法および化合物
US20160348065A1 (en) * 2015-05-28 2016-12-01 Shenzhen Fulixin Health Industry Development Limited Culture medium for hematopoeitic stem cells and the applications thereof as well as the stem cells culture method
JP2019505504A (ja) * 2015-12-24 2019-02-28 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ニコチンアミドリボシド及びウロリチンを含む組成物
WO2020148445A1 (en) * 2019-01-18 2020-07-23 Société des Produits Nestlé S.A. Agents and methods for increasing stem cell function
JP2022526329A (ja) * 2019-03-29 2022-05-24 ソシエテ・デ・プロデュイ・ネスレ・エス・アー Ｔ細胞機能を向上させるための組成物及び方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VANNINI, NICOLA ET AL.: ""The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochon", CELL STEM CELL, vol. 24, JPN6025017333, 7 March 2019 (2019-03-07), pages 405 - 418, ISSN: 0005584027 *

Also Published As

Publication number Publication date
CN116391031A (zh) 2023-07-04
BR112023005375A2 (pt) 2023-04-25
EP4217470A1 (en) 2023-08-02
WO2022064063A1 (en) 2022-03-31
CA3188667A1 (en) 2022-03-31
AU2021350472A1 (en) 2023-03-02
US20230365933A1 (en) 2023-11-16

Similar Documents

Publication Publication Date Title
US6887704B2 (en) Methods of controlling proliferation and differentiation of stem and progenitor cells
US8202724B2 (en) Methods of controlling proliferation and differentiation of stem and progenitor cells
JP7677893B2 (ja) 幹細胞機能を向上させるための薬剤及び方法
JP2023542640A (ja) 幹細胞機能を向上させるための組成物及び方法
JP2023543149A (ja) 幹細胞機能を向上させるための組成物及び方法
US20240228966A1 (en) Urolithin for increasing stem cell function
HK40096626A (zh) 用於增加干细胞功能的组合物和方法
HK40095240A (zh) 用於增加干细胞功能的组合物和方法
HK40104930A (zh) 用於增加干细胞功能的尿石素
HK40058827A (en) Agents and methods for increasing stem cell function

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240530

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240530

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250425

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250430

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250731

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250924

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20260127