JP2023541170A5 - - Google Patents

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Publication number
JP2023541170A5
JP2023541170A5 JP2023516545A JP2023516545A JP2023541170A5 JP 2023541170 A5 JP2023541170 A5 JP 2023541170A5 JP 2023516545 A JP2023516545 A JP 2023516545A JP 2023516545 A JP2023516545 A JP 2023516545A JP 2023541170 A5 JP2023541170 A5 JP 2023541170A5
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JP
Japan
Prior art keywords
pharmaceutical composition
approximately
dose
aat
subject
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023516545A
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English (en)
Japanese (ja)
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JP7846095B2 (ja
JP2023541170A (ja
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Priority claimed from PCT/US2021/050247 external-priority patent/WO2022060721A2/en
Publication of JP2023541170A publication Critical patent/JP2023541170A/ja
Publication of JP2023541170A5 publication Critical patent/JP2023541170A5/ja
Application granted granted Critical
Publication of JP7846095B2 publication Critical patent/JP7846095B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023516545A 2020-09-15 2021-09-14 Z-aatタンパク質のレベルを低下させる方法 Active JP7846095B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063078658P 2020-09-15 2020-09-15
US63/078,658 2020-09-15
US202163180487P 2021-04-27 2021-04-27
US63/180,487 2021-04-27
PCT/US2021/050247 WO2022060721A2 (en) 2020-09-15 2021-09-14 Methods for the reduction of z-aat protein levels

Publications (3)

Publication Number Publication Date
JP2023541170A JP2023541170A (ja) 2023-09-28
JP2023541170A5 true JP2023541170A5 (https=) 2024-09-24
JP7846095B2 JP7846095B2 (ja) 2026-04-14

Family

ID=78080560

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023516545A Active JP7846095B2 (ja) 2020-09-15 2021-09-14 Z-aatタンパク質のレベルを低下させる方法

Country Status (11)

Country Link
US (1) US20230348905A1 (https=)
EP (1) EP4214316A2 (https=)
JP (1) JP7846095B2 (https=)
KR (1) KR20230067648A (https=)
AU (1) AU2021345026A1 (https=)
BR (1) BR112023004756A2 (https=)
CA (1) CA3192372A1 (https=)
CO (1) CO2023003958A2 (https=)
MX (1) MX2023003066A (https=)
TW (1) TW202220675A (https=)
WO (1) WO2022060721A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201620526A (zh) 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
MX2021015003A (es) 2019-06-06 2022-01-24 Arrowhead Pharmaceuticals Inc Metodos para el tratamiento de la deficiencia de alfa-1 antitripsina (aatd).

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9201440A (nl) 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
WO2008016391A2 (en) 2006-01-31 2008-02-07 The Board Of Trustees Of The Leland Stanford Junior University Self-complementary parvoviral vectors, and methods for making and using the same
WO2012178033A2 (en) * 2011-06-23 2012-12-27 Alnylam Pharmaceuticals, Inc. Serpina1 sirnas: compositions of matter and methods of treatment
US9458457B2 (en) 2013-07-03 2016-10-04 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA
CA3011946A1 (en) 2016-03-07 2017-09-14 Arrowhead Pharmaceuticals, Inc. Targeting ligands for therapeutic compounds
SG11201901841TA (en) 2016-09-02 2019-03-28 Arrowhead Pharmaceuticals Inc Targeting ligands
CN110268060B (zh) 2017-01-10 2024-07-26 箭头药业股份有限公司 α-1抗胰蛋白酶(AAT)RNAi物质、包含AAT RNAi物质的组合物和使用方法
MX2021015003A (es) 2019-06-06 2022-01-24 Arrowhead Pharmaceuticals Inc Metodos para el tratamiento de la deficiencia de alfa-1 antitripsina (aatd).

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