JP2023540904A - タンパク質および核酸をアッセイするための組成物および方法 - Google Patents

タンパク質および核酸をアッセイするための組成物および方法 Download PDF

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JP2023540904A
JP2023540904A JP2023513345A JP2023513345A JP2023540904A JP 2023540904 A JP2023540904 A JP 2023540904A JP 2023513345 A JP2023513345 A JP 2023513345A JP 2023513345 A JP2023513345 A JP 2023513345A JP 2023540904 A JP2023540904 A JP 2023540904A
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proteins
particles
biological sample
protein
nanoparticles
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JP2023540904A5 (https=
Inventor
ダニエル ホーンバーグ，
マイケル フィガ，
シャオヤン ジャオ，
アシム エス． シディキ，
フィリップ マ，
サンテ キム，
オミッド シー． ファロクザド，
マーガレット ドノヴァン，
ジョン イー． ブルーム，
セオドア プラット，
マーティン ゴールドバーグ，
ダミアン ハリス，
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シアー， インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
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    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/159—Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nanotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2023513345A 2020-08-25 2021-08-24 タンパク質および核酸をアッセイするための組成物および方法 Pending JP2023540904A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202063070205P 2020-08-25 2020-08-25
US63/070,205 2020-08-25
US202063112071P 2020-11-10 2020-11-10
US63/112,071 2020-11-10
US202163143738P 2021-01-29 2021-01-29
US63/143,738 2021-01-29
US202163166173P 2021-03-25 2021-03-25
US63/166,173 2021-03-25
US202163194612P 2021-05-28 2021-05-28
US63/194,612 2021-05-28
PCT/US2021/047397 WO2022046804A2 (en) 2020-08-25 2021-08-24 Compositions and methods for assaying proteins and nucleic acids

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JP2023540904A true JP2023540904A (ja) 2023-09-27
JP2023540904A5 JP2023540904A5 (https=) 2024-09-03

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US (2) US12276668B2 (https=)
EP (1) EP4204580A4 (https=)
JP (1) JP2023540904A (https=)
KR (1) KR20230079044A (https=)
CN (1) CN116529393A (https=)
AU (1) AU2021333661A1 (https=)
CA (1) CA3190719A1 (https=)
DE (1) DE112021004478T5 (https=)
IL (1) IL300826A (https=)
WO (1) WO2022046804A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260016611A (ko) 2018-11-07 2026-02-03 시어 인코퍼레이티드 단백질 코로나 분석을 위한 조성물, 방법 및 시스템 및 그것들의 용도
JP7518852B2 (ja) 2019-03-26 2024-07-18 シアー， インコーポレイテッド 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
IL300826A (en) 2020-08-25 2023-04-01 Seer Inc Compositions and methods for testing proteins and nucleic acids
CN114854859A (zh) * 2022-05-05 2022-08-05 四川省肿瘤医院 一种基于血小板内FlnA基因表达量的肺结节良恶性诊断方法
CN119731534A (zh) * 2022-06-15 2025-03-28 禧尔公司 用于生物分子测定的系统和方法
CN119856058A (zh) * 2022-07-08 2025-04-18 禧尔公司 用于分析生物样品的方法
WO2025184649A1 (en) * 2024-03-01 2025-09-04 University Of South Florida Methods of inhibiting m6a reader ythdf1 for treating neurodegenerative disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020096631A2 (en) * 2018-11-07 2020-05-14 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863873A (en) 1980-01-14 1989-09-05 Esa, Inc. Method for biological testing and/or developing pharmaceuticals for treatment of disorders
US4444879A (en) 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
CA1340966C (en) 1989-05-19 2000-04-18 Thomas R. Covey Method of protein analysis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5366140A (en) 1993-09-30 1994-11-22 Minnesota Mining And Manufacturing Company Patterned array of uniform metal microbeads
US5498545A (en) 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US5928952A (en) 1997-11-05 1999-07-27 Zymark Corporation Scheduled system and method for processing chemical products
US6413780B1 (en) 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
AU1725200A (en) 1998-11-16 2000-06-05 California Institute Of Technology Simultaneous determination of equilibrium and kinetic properties
DE19852928C1 (de) 1998-11-17 2000-08-03 Steffen Panzner Strukturen in Form von Hohlkugeln
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6969615B2 (en) 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules
WO2001018524A2 (en) 1999-08-30 2001-03-15 Illumina, Inc. Methods for improving signal detection from an array
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
DE60117556T2 (de) 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
JP4361271B2 (ja) 2000-10-10 2009-11-11 バイオトローブ・インコーポレイテツド アッセイ、合成、および保存用の器具、ならびに、その作製、使用、および操作の方法
US6482936B1 (en) 2001-04-17 2002-11-19 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
US6780602B2 (en) 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
US20070072250A1 (en) 2002-04-08 2007-03-29 Bioinfra Inc. Method and system for analysis of cancer biomarkers using proteome image mining
JP2005523692A (ja) 2002-04-26 2005-08-11 アボット・ラボラトリーズ 生物学的検定において磁性粒子を処理するための構造体および方法
JP4638225B2 (ja) 2002-05-30 2011-02-23 ザ スクリプス リサーチ インスティテュート 銅を触媒とするアジドとアセチレンのライゲーション
AU2003304434A1 (en) 2002-08-06 2005-03-07 The Johns Hopkins University System, software and methods for biomarker identification
DE10247896B4 (de) 2002-10-14 2007-01-18 Bruker Daltonik Gmbh Mehrdimensionale Trennung von Biosubstanzgemischen für massenspektrometrische Analysen
US7695738B2 (en) 2003-02-19 2010-04-13 Academia Sinica Carbohydrate encapsulated nanoparticles
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US8574590B2 (en) 2003-07-30 2013-11-05 Integral Molecular, Inc. Lipoparticles comprising proteins, methods of making, and using the same
US20040106131A1 (en) 2003-08-18 2004-06-03 Swapan Roy Compositions and methods for proteomic investigations
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
EP1580559B1 (en) 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methods for reducing the variance between analyte concentrations taken from complex sample mixtures
US9488655B2 (en) 2004-07-14 2016-11-08 The Regents Of The University Of California Biomarkers for detection of early- and late-stage endometrial cancer
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
DE102004051785B4 (de) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
TW200640596A (en) 2005-01-14 2006-12-01 Cabot Corp Production of metal nanoparticles
US8288169B2 (en) 2005-01-21 2012-10-16 Argylla Technologies Surface mediated self-assembly of nanoparticles
US9002652B1 (en) 2005-01-27 2015-04-07 Institute For Systems Biology Methods for identifying and using organ-specific proteins in blood
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
MX2008008231A (es) 2005-12-20 2008-11-26 Univ Ohio State Res Found Sustratos nanoporosos para metodos analiticos.
US9347945B2 (en) 2005-12-22 2016-05-24 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
US20070178504A1 (en) 2005-12-22 2007-08-02 Tracey Colpitts Methods and marker combinations for screening for predisposition to lung cancer
EP1982174A4 (en) 2006-01-27 2009-05-06 Univ George Mason EYES LIQUID MARKER
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
SG169356A1 (en) 2006-02-08 2011-03-30 Illumina Cambridge Ltd Method for sequencing a polynucleotide template
WO2008025016A2 (en) 2006-08-25 2008-02-28 The Trustees Of Columbia University In The City Of New York Systems and methods for high-throughput, minimally-invasive radiation biodosimetry
US7815803B2 (en) 2007-06-14 2010-10-19 Roche Diagnostics Operations, Inc. Preparation of samples for LC-MS/MS using magnetic particles
US8664358B2 (en) 2007-06-29 2014-03-04 Vermillion, Inc. Predictive markers for ovarian cancer
EP2207030A4 (en) 2007-10-05 2010-12-08 Univ Hokkaido DEVICE FOR AUTOMATIC PRE-TREATMENT OF A SUGAR CHAIN
ES2448426T3 (es) 2007-10-12 2014-03-13 Pronota Nv Uso de aptámeros en proteómica
CN101874061B (zh) 2007-10-29 2014-09-17 Csir公司 由乳液得到的颗粒
US8021891B2 (en) 2007-11-28 2011-09-20 University Of Massachusetts Methods and compositions for protein detection using nanoparticle-fluorescent polymer complexes
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
KR101039629B1 (ko) 2008-05-22 2011-06-08 성균관대학교산학협력단 생체물질의 검출방법, 생체물질 검출용 칩의 제조방법 및생물질 검출용 칩
US9333163B2 (en) 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains
WO2010078601A1 (en) 2009-01-05 2010-07-08 The Regents Of The University Of California High throughput biomolecule separation and analysis
CA2749601C (en) 2009-01-14 2020-07-21 Stephen M. Hewitt Ratio based biomarkers and methods of use thereof
EP2401619A1 (en) 2009-02-26 2012-01-04 University College Dublin National University Of Ireland, Dublin A method for the selective concentration of a specific low abundance biomolecule
US20120135446A1 (en) * 2009-03-04 2012-05-31 Maine Institute For Human Genetics & Health, Inc Microfluidic Device and Related Methods
JP6059014B2 (ja) 2009-06-19 2017-01-11 アリゾナ ボード オブ リージェンツ ア ボディー コーポレート アクティング オン ビハーフ オブ アリゾナ ステイト ユニバーシティＡＲＩＺＯＮＡ ＢＯＡＲＤ ＯＦ ＲＥＧＥＮＴＳ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ ａｃｔｉｎｇ ｏｎ ｂｅｈａｌｆ ｏｆ ＡＲＩＺＯＮＡ ＳＴＡＴＥ ＵＮＩＶＥＲＳＩＴＹ 試料の構成成分の検出において使用されるデバイスを製造する方法およびペプチドアレイ
EP2494364A1 (en) 2009-10-29 2012-09-05 Tethys Bioscience, Inc. Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
US9910040B2 (en) 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
CA2787201A1 (en) 2010-01-14 2011-07-21 University Of Central Florida Research Foundation, Inc. Methods for biomolecule and biomolecule complex (bmc) detection and analysis and the use of such for research and medical diagnosis
US9689039B2 (en) 2010-02-10 2017-06-27 The Regents Of The University Of California Salivary biomarkers for lung cancer detection
US9149432B2 (en) 2010-03-19 2015-10-06 Massachusetts Institute Of Technology Lipid vesicle compositions and methods of use
US20120171694A1 (en) 2010-07-30 2012-07-05 Vermillion, Inc. Predictive markers and biomarker panels for ovarian cancer
US9549901B2 (en) 2010-09-03 2017-01-24 The Brigham And Women's Hospital, Inc. Lipid-polymer hybrid particles
WO2012050920A1 (en) 2010-09-29 2012-04-19 Illumina, Inc. Compositions and methods for sequencing nucleic acids
US9329176B2 (en) 2010-11-18 2016-05-03 Academia Sinica Glycopeptide-functionalized nanoparticles arrays for capturing and detecting biomolecules
WO2012106385A2 (en) 2011-01-31 2012-08-09 Apprise Bio, Inc. Methods of identifying multiple epitopes in cells
GB201103726D0 (en) 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
CN103782174A (zh) 2011-06-07 2014-05-07 卡里斯生命科学卢森堡控股有限责任公司 用于癌症的循环生物标志物
US9624524B2 (en) 2011-06-15 2017-04-18 Massachusetts Institute Of Technology In vivo proteomic mapping
US20130058923A1 (en) 2011-08-03 2013-03-07 Qun Huo Biomolecular interactions and interaction products as biomarkers for detection, diagnosis, prognosis and predicting therapeutic responses of human diseases
KR20140067001A (ko) 2011-08-08 2014-06-03 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
US11262253B2 (en) 2017-08-14 2022-03-01 Sentons Inc. Touch input detection using a piezoresistive sensor
CN104781421B (zh) 2012-09-04 2020-06-05 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP3470513B1 (en) 2013-03-15 2020-05-13 Expression Pathology, Inc. Srm assay to indicate cancer therapy
US9618520B2 (en) 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
WO2015099985A2 (en) 2013-12-23 2015-07-02 The Brigham And Women's Hospital, Inc. Cationic materials and formulations for drug delivery
WO2015117133A1 (en) 2014-02-03 2015-08-06 Integrated Diagnostics, Inc. Integrated quantification method for protein measurements in clinical proteomics
ES2998535T3 (en) 2014-02-07 2025-02-20 European Molecular Biology Laboratory Proteomic sample preparation using paramagnetic beads
CR20170031A (es) 2014-10-06 2017-05-22 Mayo Found For Medical Educaction And Res Composiciones de portador-anticuerpo y métodos para realizarlas y utilizarlas
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
WO2016061201A1 (en) 2014-10-14 2016-04-21 The Brigham And Women's Hospital, Inc. Nanoparticles and methods of use
EP3766986B1 (en) 2014-12-31 2022-06-01 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
EP3259371B1 (en) * 2015-02-19 2020-09-02 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
WO2016145416A2 (en) 2015-03-11 2016-09-15 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
US10900975B2 (en) 2015-05-12 2021-01-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods of epitope binning and antibody profiling
US11474102B2 (en) 2015-11-23 2022-10-18 Massachusetts Institute Of Technology Protein corona phase molecular recognition
WO2017100697A1 (en) 2015-12-11 2017-06-15 The General Hospital Corporation Dextran nanoparticles for macrophage specific imaging and therapy
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
US20190117799A1 (en) 2016-04-01 2019-04-25 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
WO2017180652A1 (en) 2016-04-11 2017-10-19 Applied Proteomics, Inc. Mass spectrometric data analysis workflow
GB201615128D0 (en) 2016-09-06 2016-10-19 Univ Manchester Methods
EP3548652B1 (en) 2016-12-01 2024-04-03 Nautilus Subsidiary, Inc. Methods of assaying proteins
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
CN116908452A (zh) 2016-12-16 2023-10-20 布里格姆及妇女医院股份有限公司 用于疾病的早期检测的蛋白质冠传感器阵列的系统和方法
WO2018112470A1 (en) 2016-12-16 2018-06-21 The Brigham And Women's Hospital, Inc. Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
CN109593835B (zh) 2017-09-29 2023-12-12 深圳华大基因股份有限公司 用于微量ffpe rna样本评估的方法、试剂盒及应用
WO2019083856A1 (en) 2017-10-23 2019-05-02 Ignite Biosciences, Inc. METHODS AND SYSTEMS FOR PROTEIN IDENTIFICATION
EP3700856A4 (en) 2017-10-26 2021-12-15 Ultima Genomics, Inc. METHODS AND SYSTEMS FOR SEQUENCE CALL
CA3081446A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
US10829815B2 (en) * 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
EP3502708B1 (en) 2017-12-21 2023-09-27 Tecan Trading AG Monitoring a laboratory automation device via a simulation model
KR20250152680A (ko) 2017-12-29 2025-10-23 노틸러스 서브시디어리, 인크. 단백질 식별을 위한 디코딩 접근법
WO2019209888A1 (en) 2018-04-23 2019-10-31 Seer, Inc. Systems and methods for complex biomolecule sampling and biomarker discovery
AU2019309870A1 (en) 2018-07-26 2021-02-18 Lexent Bio, Inc. Multiple sequencing using a single flow cell
CN112639136B (zh) 2018-08-30 2024-08-02 蒙特利尔大学 用于鉴定肿瘤特异性抗原的基于蛋白质基因组学的方法
US20210319907A1 (en) 2018-10-12 2021-10-14 Human Longevity, Inc. Multi-omic search engine for integrative analysis of cancer genomic and clinical data
EP3924971A1 (en) 2019-02-11 2021-12-22 Flagship Pioneering Innovations VI, LLC Machine learning guided polypeptide analysis
JP7518852B2 (ja) 2019-03-26 2024-07-18 シアー， インコーポレイテッド 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
US20220326241A1 (en) 2019-08-12 2022-10-13 Baylor College Of Medicine Proteogenomic methods for diagnosing cancer
WO2021087407A1 (en) 2019-11-02 2021-05-06 Seer, Inc. Systems for protein corona analysis
EP3901956A1 (en) 2020-04-21 2021-10-27 ETH Zürich Methods of determining correspondences between biological properties of cells
WO2021243285A1 (en) 2020-05-29 2021-12-02 Seer, Inc. Systems and methods for rapid identification of proteins
GB202010922D0 (en) 2020-07-15 2020-08-26 Univ London Queen Mary Method
CN116234925A (zh) 2020-07-20 2023-06-06 禧尔公司 颗粒和测定方法
WO2022026726A1 (en) 2020-07-30 2022-02-03 Frontier Medicines Corporation Processing biophysical screening data and identifying and characterizing protein sites for drug discovery
GB2597997A (en) 2020-08-14 2022-02-16 Victoria Yates Emma Method of identifying the presence and/or concentration and/or amount of proteins or proteomes
IL300826A (en) 2020-08-25 2023-04-01 Seer Inc Compositions and methods for testing proteins and nucleic acids
US20220260559A1 (en) 2020-11-04 2022-08-18 Seer, Inc. Biomarkers for diagnosing alzheimer's disease
WO2022108942A1 (en) 2020-11-17 2022-05-27 MOBILion Systems, Inc. Systems and methods for image and/or video processing of mass spectrometry data
EP4297903A4 (en) 2021-02-26 2024-12-18 Seer, Inc. DEVICE FOR DOSING BIOMOLECULES
EP4329793A4 (en) 2021-04-29 2025-03-05 Seer, Inc. PEPTIDE-DECORATED NANOPARTICLES FOR THE ENRICHMENT OF SPECIFIC PROTEIN SUBSETS
US20240280558A1 (en) 2021-07-13 2024-08-22 Seer, Inc. Systems and methods for processing mass spectrometry datasets
US20230160882A1 (en) 2021-08-24 2023-05-25 Seer, Inc. Compositions and methods for low-volume biomolecule assays
EP4460829A4 (en) 2022-01-07 2026-01-14 Seer Inc Peptide-focused analyses
WO2023141580A2 (en) 2022-01-20 2023-07-27 Seer, Inc. Particles and methods of assaying
US20230253113A1 (en) 2022-02-04 2023-08-10 Seer, Inc. Systems and methods for creating biomolecule embeddings
US20250157570A1 (en) 2022-02-15 2025-05-15 Seer, Inc. Systems and methods for analyzing omics data
US12437980B2 (en) 2022-05-20 2025-10-07 Sapient Bioanalytics, Llc Mass spectrometry retrieving of stray samples
WO2024040189A1 (en) 2022-08-18 2024-02-22 Seer, Inc. Methods for using a machine learning algorithm for omic analysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020096631A2 (en) * 2018-11-07 2020-05-14 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROTEOMICS, vol. 14, JPN6025038380, 2014, pages 2742 - 2749, ISSN: 0005689531 *

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